DE69112344D1 - Verbessertes Verfahren zur Kristallisierung von Alpha-Aspartyl-L-Phenylalaninmethylester aus deren Lösung. - Google Patents

Verbessertes Verfahren zur Kristallisierung von Alpha-Aspartyl-L-Phenylalaninmethylester aus deren Lösung.

Info

Publication number
DE69112344D1
DE69112344D1 DE69112344T DE69112344T DE69112344D1 DE 69112344 D1 DE69112344 D1 DE 69112344D1 DE 69112344 T DE69112344 T DE 69112344T DE 69112344 T DE69112344 T DE 69112344T DE 69112344 D1 DE69112344 D1 DE 69112344D1
Authority
DE
Germany
Prior art keywords
aspartyl
crystallization
alpha
solution
methyl ester
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69112344T
Other languages
English (en)
Other versions
DE69112344T2 (de
Inventor
Hiroshi Ichiki
Ryoichi Taneda
Hiroyuki Itoh
Yoshitsugu Kono
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Mitsui Chemicals Inc
Original Assignee
Mitsui Toatsu Chemicals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mitsui Toatsu Chemicals Inc filed Critical Mitsui Toatsu Chemicals Inc
Application granted granted Critical
Publication of DE69112344D1 publication Critical patent/DE69112344D1/de
Publication of DE69112344T2 publication Critical patent/DE69112344T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D9/00—Crystallisation
    • B01D9/0004—Crystallisation cooling by heat exchange
    • B01D9/0009—Crystallisation cooling by heat exchange by direct heat exchange with added cooling fluid
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D9/00—Crystallisation
    • B01D9/0018—Evaporation of components of the mixture to be separated
    • B01D9/0022—Evaporation of components of the mixture to be separated by reducing pressure
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F27/00—Mixers with rotary stirring devices in fixed receptacles; Kneaders
    • B01F27/05—Stirrers
    • B01F27/11—Stirrers characterised by the configuration of the stirrers
    • B01F27/112—Stirrers characterised by the configuration of the stirrers with arms, paddles, vanes or blades
    • B01F27/1125—Stirrers characterised by the configuration of the stirrers with arms, paddles, vanes or blades with vanes or blades extending parallel or oblique to the stirrer axis
    • B01F27/11251—Stirrers characterised by the configuration of the stirrers with arms, paddles, vanes or blades with vanes or blades extending parallel or oblique to the stirrer axis having holes in the surface
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06104—Dipeptides with the first amino acid being acidic
    • C07K5/06113—Asp- or Asn-amino acid
    • C07K5/06121—Asp- or Asn-amino acid the second amino acid being aromatic or cycloaliphatic
    • C07K5/0613—Aspartame

Landscapes

  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Thermal Sciences (AREA)
  • Organic Chemistry (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Peptides Or Proteins (AREA)
DE69112344T 1990-11-05 1991-10-26 Verbessertes Verfahren zur Kristallisierung von Alpha-Aspartyl-L-Phenylalaninmethylester aus deren Lösung. Expired - Fee Related DE69112344T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP29711990 1990-11-05

Publications (2)

Publication Number Publication Date
DE69112344D1 true DE69112344D1 (de) 1995-09-28
DE69112344T2 DE69112344T2 (de) 1996-04-18

Family

ID=17842461

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69112344T Expired - Fee Related DE69112344T2 (de) 1990-11-05 1991-10-26 Verbessertes Verfahren zur Kristallisierung von Alpha-Aspartyl-L-Phenylalaninmethylester aus deren Lösung.

Country Status (2)

Country Link
EP (1) EP0484769B1 (de)
DE (1) DE69112344T2 (de)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5591886A (en) * 1990-11-05 1997-01-07 Mitsui Toatsu Chemicals, Incorporated Process for the crystallizing L-α-aspartyl-L-phenylalanine methyl ester from the solution
JPH05194587A (ja) * 1992-01-14 1993-08-03 Ajinomoto Co Inc α−Ｌ−アスパルチル−Ｌ−フェニルアラニンメチルエステルの精製法
JP3208874B2 (ja) * 1992-12-07 2001-09-17 味の素株式会社 α−Ｌ−アスパルチル−Ｌ−フェニルアラニンの製造法
JP2000513998A (ja) 1996-07-05 2000-10-24 バイエル・アクチエンゲゼルシヤフト 晶析機器及び方法
EP0976762A1 (de) * 1998-07-29 2000-02-02 Daesang Corporation Kristalliserung von Alpha-L-aspartyl-L-phenylalaninmethylester
US6090972A (en) * 1998-11-12 2000-07-18 Daesang Corporation Crystallization of α-L-aspartyl-L-phenylalanine methyl ester
US6657073B1 (en) 1999-08-18 2003-12-02 Daesang Corporation Crystallization of α-L-aspartyl-L-phenylalanine methyl ester
JP2001081100A (ja) * 1999-08-18 2001-03-27 Daesang Corp アルファ−ｌ−アスパルチル−ｌ−フェニルアラニンメチルエステルの結晶化

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2337317A (en) * 1942-05-06 1943-12-21 Zaremba Company Cooling apparatus
GB1489028A (en) * 1976-06-04 1977-10-19 Lobanov V Apparatus for crystallization of liquid solutions

Also Published As

Publication number Publication date
DE69112344T2 (de) 1996-04-18
EP0484769B1 (de) 1995-08-23
EP0484769A2 (de) 1992-05-13
EP0484769A3 (en) 1992-11-04

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: MITSUI CHEMICALS, INC., TOKIO/TOKYO, JP

8339 Ceased/non-payment of the annual fee