DE69103428D1 - Latente alkylierungsubstituenten enthaltende anthracycline-analoge. - Google Patents

Latente alkylierungsubstituenten enthaltende anthracycline-analoge.

Info

Publication number
DE69103428D1
DE69103428D1 DE69103428T DE69103428T DE69103428D1 DE 69103428 D1 DE69103428 D1 DE 69103428D1 DE 69103428 T DE69103428 T DE 69103428T DE 69103428 T DE69103428 T DE 69103428T DE 69103428 D1 DE69103428 D1 DE 69103428D1
Authority
DE
Germany
Prior art keywords
alkyl
alkylation
substitutes
latent
present
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69103428T
Other languages
English (en)
Other versions
DE69103428T2 (de
Inventor
David Farquhar
Abdallah Charif
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Texas System
Original Assignee
University of Texas System
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Texas System filed Critical University of Texas System
Publication of DE69103428D1 publication Critical patent/DE69103428D1/de
Application granted granted Critical
Publication of DE69103428T2 publication Critical patent/DE69103428T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/24—Condensed ring systems having three or more rings
    • C07H15/252—Naphthacene radicals, e.g. daunomycins, adriamycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Molecular Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Saccharide Compounds (AREA)
DE69103428T 1990-11-01 1991-10-16 Latente alkylierungsubstituenten enthaltende anthracycline-analoge. Expired - Fee Related DE69103428T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/608,149 US5196522A (en) 1990-11-01 1990-11-01 Anthracycline analogues bearing latent alkylating substituents
PCT/US1991/007687 WO1992007866A1 (en) 1990-11-01 1991-10-16 Anthracycline analogues bearing latent alkylating substituents

Publications (2)

Publication Number Publication Date
DE69103428D1 true DE69103428D1 (de) 1994-09-15
DE69103428T2 DE69103428T2 (de) 1995-03-30

Family

ID=24435271

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69103428T Expired - Fee Related DE69103428T2 (de) 1990-11-01 1991-10-16 Latente alkylierungsubstituenten enthaltende anthracycline-analoge.

Country Status (9)

Country Link
US (3) US5196522A (de)
EP (1) EP0555358B1 (de)
JP (1) JP3051170B2 (de)
AT (1) ATE109787T1 (de)
AU (1) AU642798B2 (de)
CA (1) CA2094914C (de)
DE (1) DE69103428T2 (de)
DK (1) DK0555358T3 (de)
WO (1) WO1992007866A1 (de)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5196522A (en) * 1990-11-01 1993-03-23 Board Of Regents, The University Of Texas System Anthracycline analogues bearing latent alkylating substituents
US5622929A (en) * 1992-01-23 1997-04-22 Bristol-Myers Squibb Company Thioether conjugates
US6218519B1 (en) 1996-04-12 2001-04-17 Pro-Neuron, Inc. Compounds and methods for the selective treatment of cancer and bacterial infections
US6677309B1 (en) 1997-04-11 2004-01-13 University Technology Corporation Anti-cancer drug aldehyde conjugate drugs with enhanced cytotoxicity compounds, compositions and methods
US20040038904A1 (en) * 2002-05-21 2004-02-26 Angela Ogden Method of treating multiple sclerosis
US20050208037A1 (en) * 2003-10-21 2005-09-22 Board Of Regents, The University Of Texas System Thioredoxin increases redox-cycling of anticancer agents thereby sensitizes cancer cells to apoptosis
US20080132458A1 (en) * 2004-03-10 2008-06-05 Threshold Pharmaceuticals, Inc. Hypoxia-Activated Anti-Cancer Agents
US20070060534A1 (en) * 2005-06-30 2007-03-15 Threshold Pharmaceuticals, Inc. Anthracycline analogs
US7470672B2 (en) * 2006-07-31 2008-12-30 Savvipharm Inc. Compositions and methods of reducing tissue levels of drugs when given as orotate derivatives
US7750018B2 (en) * 2006-12-06 2010-07-06 Tactical Therapeutics, Inc Use of carboxiamidotriazole (CAI) orotate in macular degeneration
EP2538929A4 (de) 2010-02-25 2014-07-09 Univ Johns Hopkins Verzögerte freisetzung von therapiemitteln in einen teil des auges
US10307372B2 (en) 2010-09-10 2019-06-04 The Johns Hopkins University Rapid diffusion of large polymeric nanoparticles in the mammalian brain
WO2012109363A2 (en) 2011-02-08 2012-08-16 The Johns Hopkins University Mucus penetrating gene carriers
CN104936620B (zh) 2012-01-19 2019-08-09 约翰霍普金斯大学 增强粘膜渗透的纳米粒子调配物
CN104363924B (zh) * 2012-03-16 2018-04-17 约翰霍普金斯大学 用于递送hif‑1抑制剂的控制释放调配物
EP2825207B1 (de) 2012-03-16 2020-08-19 The Johns Hopkins University Nichtlineare multiblock-copolymer-arzneimittelkonjugate zur verabreichung von wirkstoffen
CA2872519C (en) 2012-05-04 2017-09-05 The Johns Hopkins University Lipid-based drug carriers for rapid penetration through mucus linings
US9533068B2 (en) 2012-05-04 2017-01-03 The Johns Hopkins University Drug loaded microfiber sutures for ophthalmic application
US10568975B2 (en) 2013-02-05 2020-02-25 The Johns Hopkins University Nanoparticles for magnetic resonance imaging tracking and methods of making and using thereof
CA2895284A1 (en) 2013-02-07 2014-08-14 Immunomedics, Inc. Pro-drug form (p2pdox) of the highly potent 2-pyrrolinodoxorubicin conjugated to antibodies for targeted therapy of cancer
WO2015035002A1 (en) * 2013-09-06 2015-03-12 Vanda Pharmaceuticals Inc. Treatment of cyr61- and vegf-mediated conditions
WO2015127368A1 (en) 2014-02-23 2015-08-27 The Johns Hopkins University Hypotonic microbicidal formulations and methods of use
CN106999517A (zh) 2014-10-07 2017-08-01 免疫医疗公司 抗体‑药物缀合物的新辅助剂用途
WO2016123125A1 (en) 2015-01-27 2016-08-04 The Johns Hopkins University Hypotonic hydrogel formulations for enhanced transport of active agents at mucosal surfaces

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4035566A (en) * 1975-09-25 1977-07-12 Sidney Farber Cancer Institute, Inc. N-trifluoroacetyladriamycin-14-alkanoates and therapeutic compositions containing same
US4109076A (en) * 1977-09-08 1978-08-22 Sri International 5-iminodaunomycin
US4301277A (en) * 1980-10-20 1981-11-17 Sri International 3-Deamino-3-(4-morpholinyl) derivatives of daunorubicin and doxorubicin
US4950738A (en) * 1984-09-13 1990-08-21 Cytogen Corporation Amine derivatives of anthracycline antibiotics
US4464529A (en) * 1982-07-20 1984-08-07 Sri International Analogues of morpholinyl daunorubicin and morpholinyl doxorubicin
US4826964A (en) * 1982-07-20 1989-05-02 Sri International Bridged oxygen analogs of daunorubcin and doxorubicin
US4585859A (en) * 1983-05-24 1986-04-29 Sri International Analogues of morpholinyl daunorubicin and morpholinyl doxorubicin
GB8508508D0 (en) * 1985-04-01 1985-05-09 Creighton A M Pharmaceutical compositions
FR2591599B1 (fr) 1985-12-17 1988-08-05 Hoechst Lab Nouvelles anthracyclines et medicaments les contenant
US5091552A (en) 1986-06-30 1992-02-25 Board Of Regents, The University Of Texas System Novel antitumor aldophosphamide analogs
US4841085A (en) * 1986-06-30 1989-06-20 Board Of Regents, University Of Texas System Aldophosphamides
US5196522A (en) * 1990-11-01 1993-03-23 Board Of Regents, The University Of Texas System Anthracycline analogues bearing latent alkylating substituents

Also Published As

Publication number Publication date
EP0555358B1 (de) 1994-08-10
DK0555358T3 (da) 1994-12-05
US6433150B2 (en) 2002-08-13
DE69103428T2 (de) 1995-03-30
US6284737B1 (en) 2001-09-04
CA2094914C (en) 1998-02-10
ATE109787T1 (de) 1994-08-15
WO1992007866A1 (en) 1992-05-14
JPH06502417A (ja) 1994-03-17
EP0555358A1 (de) 1993-08-18
US20010053845A1 (en) 2001-12-20
JP3051170B2 (ja) 2000-06-12
CA2094914A1 (en) 1992-05-02
US5196522A (en) 1993-03-23
AU642798B2 (en) 1993-10-28
AU9029291A (en) 1992-05-26

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee