DK0555358T3 - Anthracyclin-analoge med latente alkylsubstituenter - Google Patents

Anthracyclin-analoge med latente alkylsubstituenter

Info

Publication number
DK0555358T3
DK0555358T3 DK91920574.0T DK91920574T DK0555358T3 DK 0555358 T3 DK0555358 T3 DK 0555358T3 DK 91920574 T DK91920574 T DK 91920574T DK 0555358 T3 DK0555358 T3 DK 0555358T3
Authority
DK
Denmark
Prior art keywords
alkyl
alkyl substituents
present
aldehyde
aryl
Prior art date
Application number
DK91920574.0T
Other languages
Danish (da)
English (en)
Inventor
David Farquhar
Abdallah Charif
Original Assignee
Univ Texas
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Texas filed Critical Univ Texas
Application granted granted Critical
Publication of DK0555358T3 publication Critical patent/DK0555358T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/24—Condensed ring systems having three or more rings
    • C07H15/252—Naphthacene radicals, e.g. daunomycins, adriamycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Biochemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Saccharide Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
DK91920574.0T 1990-11-01 1991-10-16 Anthracyclin-analoge med latente alkylsubstituenter DK0555358T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/608,149 US5196522A (en) 1990-11-01 1990-11-01 Anthracycline analogues bearing latent alkylating substituents

Publications (1)

Publication Number Publication Date
DK0555358T3 true DK0555358T3 (da) 1994-12-05

Family

ID=24435271

Family Applications (1)

Application Number Title Priority Date Filing Date
DK91920574.0T DK0555358T3 (da) 1990-11-01 1991-10-16 Anthracyclin-analoge med latente alkylsubstituenter

Country Status (9)

Country Link
US (3) US5196522A (de)
EP (1) EP0555358B1 (de)
JP (1) JP3051170B2 (de)
AT (1) ATE109787T1 (de)
AU (1) AU642798B2 (de)
CA (1) CA2094914C (de)
DE (1) DE69103428T2 (de)
DK (1) DK0555358T3 (de)
WO (1) WO1992007866A1 (de)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5196522A (en) * 1990-11-01 1993-03-23 Board Of Regents, The University Of Texas System Anthracycline analogues bearing latent alkylating substituents
US5622929A (en) * 1992-01-23 1997-04-22 Bristol-Myers Squibb Company Thioether conjugates
US6218519B1 (en) 1996-04-12 2001-04-17 Pro-Neuron, Inc. Compounds and methods for the selective treatment of cancer and bacterial infections
US6677309B1 (en) * 1997-04-11 2004-01-13 University Technology Corporation Anti-cancer drug aldehyde conjugate drugs with enhanced cytotoxicity compounds, compositions and methods
US20040038904A1 (en) * 2002-05-21 2004-02-26 Angela Ogden Method of treating multiple sclerosis
US20050208037A1 (en) * 2003-10-21 2005-09-22 Board Of Regents, The University Of Texas System Thioredoxin increases redox-cycling of anticancer agents thereby sensitizes cancer cells to apoptosis
WO2005086951A2 (en) * 2004-03-10 2005-09-22 Threshold Pharmaceuticals, Inc. Hypoxia-activated anti-cancer agents
US20070060534A1 (en) * 2005-06-30 2007-03-15 Threshold Pharmaceuticals, Inc. Anthracycline analogs
US7470672B2 (en) 2006-07-31 2008-12-30 Savvipharm Inc. Compositions and methods of reducing tissue levels of drugs when given as orotate derivatives
US7750018B2 (en) * 2006-12-06 2010-07-06 Tactical Therapeutics, Inc Use of carboxiamidotriazole (CAI) orotate in macular degeneration
CA2791278C (en) 2010-02-25 2015-11-24 The Johns Hopkins University Sustained delivery of therapeutic agents to an eye compartment
US10307372B2 (en) 2010-09-10 2019-06-04 The Johns Hopkins University Rapid diffusion of large polymeric nanoparticles in the mammalian brain
US9327037B2 (en) 2011-02-08 2016-05-03 The Johns Hopkins University Mucus penetrating gene carriers
US9415020B2 (en) 2012-01-19 2016-08-16 The Johns Hopkins University Nanoparticle formulations with enhanced mucosal penetration
WO2013138346A1 (en) 2012-03-16 2013-09-19 The Johns Hopkins University Non-linear multiblock copolymer-drug conjugates for the delivery of active agents
AU2013232297B2 (en) * 2012-03-16 2016-01-14 The Johns Hopkins University Controlled release formulations for the delivery of HIF-1 inhibitors
US9533068B2 (en) 2012-05-04 2017-01-03 The Johns Hopkins University Drug loaded microfiber sutures for ophthalmic application
EP2849728A1 (de) 2012-05-04 2015-03-25 The Johns Hopkins University Arzneimittelträger auf lipidbasis zur schnellen penetration durch schleimauskleidungen
WO2014124006A1 (en) 2013-02-05 2014-08-14 The Johns Hopkins University Nanoparticles for magnetic resonance imaging tracking and methods of making and using thereof
CN105209068A (zh) 2013-02-07 2015-12-30 免疫医疗公司 用于靶向癌症治疗的缀合至抗体的高效2-吡咯啉多柔比星的前药形式(p2pdox)
US11458154B2 (en) 2013-09-06 2022-10-04 Vanda Pharmaceuticals Inc. Treatment of CYR61- and VEGF-mediated conditions
WO2015127389A1 (en) 2014-02-23 2015-08-27 The Johns Hopkins University Hypotonic enema formulations and methods of use
PL3204018T3 (pl) 2014-10-07 2022-01-03 Immunomedics, Inc. Neoadiuwantowe zastosowanie koniugatów przeciwciało-lek
WO2016123125A1 (en) 2015-01-27 2016-08-04 The Johns Hopkins University Hypotonic hydrogel formulations for enhanced transport of active agents at mucosal surfaces

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4035566A (en) * 1975-09-25 1977-07-12 Sidney Farber Cancer Institute, Inc. N-trifluoroacetyladriamycin-14-alkanoates and therapeutic compositions containing same
US4109076A (en) * 1977-09-08 1978-08-22 Sri International 5-iminodaunomycin
US4301277A (en) * 1980-10-20 1981-11-17 Sri International 3-Deamino-3-(4-morpholinyl) derivatives of daunorubicin and doxorubicin
US4950738A (en) * 1984-09-13 1990-08-21 Cytogen Corporation Amine derivatives of anthracycline antibiotics
US4464529A (en) * 1982-07-20 1984-08-07 Sri International Analogues of morpholinyl daunorubicin and morpholinyl doxorubicin
US4826964A (en) * 1982-07-20 1989-05-02 Sri International Bridged oxygen analogs of daunorubcin and doxorubicin
US4585859A (en) * 1983-05-24 1986-04-29 Sri International Analogues of morpholinyl daunorubicin and morpholinyl doxorubicin
GB8508508D0 (en) * 1985-04-01 1985-05-09 Creighton A M Pharmaceutical compositions
FR2591599B1 (fr) 1985-12-17 1988-08-05 Hoechst Lab Nouvelles anthracyclines et medicaments les contenant
US4841085A (en) * 1986-06-30 1989-06-20 Board Of Regents, University Of Texas System Aldophosphamides
US5091552A (en) 1986-06-30 1992-02-25 Board Of Regents, The University Of Texas System Novel antitumor aldophosphamide analogs
US5196522A (en) * 1990-11-01 1993-03-23 Board Of Regents, The University Of Texas System Anthracycline analogues bearing latent alkylating substituents

Also Published As

Publication number Publication date
CA2094914A1 (en) 1992-05-02
CA2094914C (en) 1998-02-10
US20010053845A1 (en) 2001-12-20
ATE109787T1 (de) 1994-08-15
AU642798B2 (en) 1993-10-28
US6433150B2 (en) 2002-08-13
JP3051170B2 (ja) 2000-06-12
DE69103428T2 (de) 1995-03-30
EP0555358A1 (de) 1993-08-18
US5196522A (en) 1993-03-23
DE69103428D1 (de) 1994-09-15
EP0555358B1 (de) 1994-08-10
AU9029291A (en) 1992-05-26
JPH06502417A (ja) 1994-03-17
WO1992007866A1 (en) 1992-05-14
US6284737B1 (en) 2001-09-04

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