DE69034118D1 - Polypeptide mit Calpaininhibitionswirkung und Verfahren zu deren Herstellung - Google Patents

Polypeptide mit Calpaininhibitionswirkung und Verfahren zu deren Herstellung

Info

Publication number
DE69034118D1
DE69034118D1 DE69034118T DE69034118T DE69034118D1 DE 69034118 D1 DE69034118 D1 DE 69034118D1 DE 69034118 T DE69034118 T DE 69034118T DE 69034118 T DE69034118 T DE 69034118T DE 69034118 D1 DE69034118 D1 DE 69034118D1
Authority
DE
Germany
Prior art keywords
polypeptides
preparation
inhibitory activity
calpain inhibitory
calpain
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69034118T
Other languages
English (en)
Other versions
DE69034118T2 (de
Inventor
Kiyothoshi Sekiguchi
Toshinaga Maeda
Koiti Titani
Fusao Kimizuka
Ikunoshin Kato
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Fujita Health University
Takara Bio Inc
Original Assignee
Fujita Health University
Takara Bio Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fujita Health University, Takara Bio Inc filed Critical Fujita Health University
Application granted granted Critical
Publication of DE69034118D1 publication Critical patent/DE69034118D1/de
Publication of DE69034118T2 publication Critical patent/DE69034118T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
    • C07K14/8139—Cysteine protease (E.C. 3.4.22) inhibitors, e.g. cystatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/305—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Micrococcaceae (F)
    • C07K14/31—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Micrococcaceae (F) from Staphylococcus (G)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/33—Fusion polypeptide fusions for targeting to specific cell types, e.g. tissue specific targeting, targeting of a bacterial subspecies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
    • C07K2319/705—Fusion polypeptide containing domain for protein-protein interaction containing a protein-A fusion

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Analytical Chemistry (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
DE69034118T 1989-03-03 1990-02-22 Polypeptid mit Calpain-inhibierender Aktivität und Verfahren zur Herstellung davon Expired - Fee Related DE69034118T2 (de)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP4978489 1989-03-03
JP4978489 1989-03-03
JP1294033A JP2878341B2 (ja) 1989-03-03 1989-11-14 人工機能性ポリペプチド
JP29403389 1989-11-14

Publications (2)

Publication Number Publication Date
DE69034118D1 true DE69034118D1 (de) 2003-12-11
DE69034118T2 DE69034118T2 (de) 2004-08-26

Family

ID=26390237

Family Applications (2)

Application Number Title Priority Date Filing Date
DE69034118T Expired - Fee Related DE69034118T2 (de) 1989-03-03 1990-02-22 Polypeptid mit Calpain-inhibierender Aktivität und Verfahren zur Herstellung davon
DE69031925T Expired - Fee Related DE69031925T2 (de) 1989-03-03 1990-02-22 Multifunktionale Polypeptide und Verfahren zu deren Herstellung

Family Applications After (1)

Application Number Title Priority Date Filing Date
DE69031925T Expired - Fee Related DE69031925T2 (de) 1989-03-03 1990-02-22 Multifunktionale Polypeptide und Verfahren zu deren Herstellung

Country Status (3)

Country Link
EP (2) EP0385659B1 (de)
JP (1) JP2878341B2 (de)
DE (2) DE69034118T2 (de)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9023149D0 (en) * 1990-10-24 1990-12-05 British Bio Technology Proteins and nucleic acids
IL152466A0 (en) * 2000-04-26 2003-05-29 Mallinckrodt Inc RgD (Arg-Gly-Asp) COUPLED TO (NEURO) PEPTIDES
WO2005079859A1 (ja) * 2004-02-25 2005-09-01 Osaka University 標的指向性運搬体

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ212312A (en) * 1984-06-07 1988-09-29 John Richard Murphy Hybrid protein comprising fragments of diphtheria toxin and part of cell-specific ligand; and fused gene therefor
GB8516421D0 (en) * 1985-06-28 1985-07-31 Biotechnology Interface Ltd Fibronectins
US4683291A (en) * 1985-10-28 1987-07-28 Scripps Clinic And Research Foundation Platelet binding inhibitors
DE3716513A1 (de) * 1987-05-16 1988-11-24 Basf Ag Proteine mit tnf-wirkung
ATE125566T1 (de) * 1988-06-14 1995-08-15 Chiron Corp Superoxid-dismutaseanaloge mit neuen bindeeigenschaften.

Also Published As

Publication number Publication date
EP0385659B1 (de) 1998-01-14
EP0834562B1 (de) 2003-11-05
EP0385659A2 (de) 1990-09-05
JP2878341B2 (ja) 1999-04-05
DE69034118T2 (de) 2004-08-26
EP0834562A1 (de) 1998-04-08
JPH0334996A (ja) 1991-02-14
DE69031925T2 (de) 1998-08-27
DE69031925D1 (de) 1998-02-19
EP0385659A3 (de) 1991-02-27

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee