DE69031780D1 - Verfahren zur Herstellung von (trans)-4-substituierten-DL-Prolinederivaten - Google Patents

Verfahren zur Herstellung von (trans)-4-substituierten-DL-Prolinederivaten

Info

Publication number
DE69031780D1
DE69031780D1 DE69031780T DE69031780T DE69031780D1 DE 69031780 D1 DE69031780 D1 DE 69031780D1 DE 69031780 T DE69031780 T DE 69031780T DE 69031780 T DE69031780 T DE 69031780T DE 69031780 D1 DE69031780 D1 DE 69031780D1
Authority
DE
Germany
Prior art keywords
trans
substituted
preparation
proline derivatives
proline
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69031780T
Other languages
English (en)
Other versions
DE69031780T2 (de
Inventor
John Kloss
David Kronenthal
Christopher M Cimarusti
Richard H Mueller
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
ER Squibb and Sons LLC
Original Assignee
ER Squibb and Sons LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ER Squibb and Sons LLC filed Critical ER Squibb and Sons LLC
Application granted granted Critical
Publication of DE69031780D1 publication Critical patent/DE69031780D1/de
Publication of DE69031780T2 publication Critical patent/DE69031780T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pyrrole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
DE69031780T 1989-01-17 1990-01-11 Verfahren zur Herstellung von (trans)-4-substituierten-DL-Prolinederivaten Expired - Lifetime DE69031780T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/297,522 US4937355A (en) 1989-01-17 1989-01-17 Process for preparing (trans)-4-substituted-dl-proline derivatives

Publications (2)

Publication Number Publication Date
DE69031780D1 true DE69031780D1 (de) 1998-01-22
DE69031780T2 DE69031780T2 (de) 1998-07-16

Family

ID=23146656

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69031780T Expired - Lifetime DE69031780T2 (de) 1989-01-17 1990-01-11 Verfahren zur Herstellung von (trans)-4-substituierten-DL-Prolinederivaten

Country Status (5)

Country Link
US (1) US4937355A (de)
EP (1) EP0379063B1 (de)
JP (1) JPH02229153A (de)
CA (1) CA2006615A1 (de)
DE (1) DE69031780T2 (de)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1992018156A1 (en) * 1991-04-19 1992-10-29 Nova Technology Limited Partnership Bradykinin antagonist peptides
FR2780061B1 (fr) 1998-06-22 2001-09-07 Rhone Poulenc Rorer Sa Nouveau procede de preparation de derives de cyclosporine
JP2000044539A (ja) * 1998-07-27 2000-02-15 Sumitomo Chem Co Ltd 光学活性環式アミノ酸エステル誘導体およびその製造方法
IT1394407B1 (it) 2009-05-25 2012-06-15 Dipharma Francis Srl Procedimento per la preparazione di fosinopril e suoi intermedi
IT1406151B1 (it) 2010-12-06 2014-02-14 Dipharma Francis Srl Procedimento per la preparazione di fosinopril e suoi intermedi

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4316905A (en) * 1980-07-01 1982-02-23 E. R. Squibb & Sons, Inc. Mercaptoacyl derivatives of various 4-substituted prolines
US4462943A (en) * 1980-11-24 1984-07-31 E. R. Squibb & Sons, Inc. Carboxyalkyl amino acid derivatives of various substituted prolines
US4337201A (en) * 1980-12-04 1982-06-29 E. R. Squibb & Sons, Inc. Phosphinylalkanoyl substituted prolines
DE3137377C2 (de) * 1981-09-19 1984-03-08 Degussa Ag, 6000 Frankfurt Verfahren zur Herstellung von L-Prolin
US4501901A (en) * 1983-09-19 1985-02-26 E. R. Squibb & Sons, Inc. Method for making substituted prolines
US4588819A (en) * 1984-11-19 1986-05-13 E. R. Squibb & Sons, Inc. Process and intermediates for preparing trans-4-substituted-s-prolines
GB8511895D0 (en) * 1985-05-10 1985-06-19 Ici Plc Heterocyclic compounds
FR2585354B1 (fr) * 1985-07-29 1989-02-24 Poudres & Explosifs Ste Nale Procede stereoselectif de preparation de derives de la proline

Also Published As

Publication number Publication date
EP0379063A2 (de) 1990-07-25
CA2006615A1 (en) 1990-07-17
EP0379063A3 (de) 1991-05-02
DE69031780T2 (de) 1998-07-16
JPH02229153A (ja) 1990-09-11
US4937355A (en) 1990-06-26
EP0379063B1 (de) 1997-12-10

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition