DE69030189D1 - Hemmung des wachstums von tumoren durch blockade des protein-c-systems - Google Patents
Hemmung des wachstums von tumoren durch blockade des protein-c-systemsInfo
- Publication number
- DE69030189D1 DE69030189D1 DE69030189T DE69030189T DE69030189D1 DE 69030189 D1 DE69030189 D1 DE 69030189D1 DE 69030189 T DE69030189 T DE 69030189T DE 69030189 T DE69030189 T DE 69030189T DE 69030189 D1 DE69030189 D1 DE 69030189D1
- Authority
- DE
- Germany
- Prior art keywords
- protein
- blocking
- inhibition
- tumor growth
- compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 230000000903 blocking effect Effects 0.000 title abstract 4
- 230000005764 inhibitory process Effects 0.000 title abstract 2
- 230000004614 tumor growth Effects 0.000 title abstract 2
- 102000004169 proteins and genes Human genes 0.000 title 1
- 108090000623 proteins and genes Proteins 0.000 title 1
- 229960000856 protein c Drugs 0.000 abstract 4
- 101800004937 Protein C Proteins 0.000 abstract 3
- 102000017975 Protein C Human genes 0.000 abstract 3
- 101800001700 Saposin-D Proteins 0.000 abstract 3
- 108060008682 Tumor Necrosis Factor Proteins 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 3
- 102000003390 tumor necrosis factor Human genes 0.000 abstract 3
- 206010028980 Neoplasm Diseases 0.000 abstract 2
- 241000282465 Canis Species 0.000 abstract 1
- 241000282472 Canis lupus familiaris Species 0.000 abstract 1
- 102000006912 Complement C4b-Binding Protein Human genes 0.000 abstract 1
- 108010047548 Complement C4b-Binding Protein Proteins 0.000 abstract 1
- 102000004127 Cytokines Human genes 0.000 abstract 1
- 108090000695 Cytokines Proteins 0.000 abstract 1
- 201000008808 Fibrosarcoma Diseases 0.000 abstract 1
- 108010017213 Granulocyte-Macrophage Colony-Stimulating Factor Proteins 0.000 abstract 1
- 102100039620 Granulocyte-macrophage colony-stimulating factor Human genes 0.000 abstract 1
- 102000008070 Interferon-gamma Human genes 0.000 abstract 1
- 108010074328 Interferon-gamma Proteins 0.000 abstract 1
- 102000000589 Interleukin-1 Human genes 0.000 abstract 1
- 108010002352 Interleukin-1 Proteins 0.000 abstract 1
- 102000000588 Interleukin-2 Human genes 0.000 abstract 1
- 108010002350 Interleukin-2 Proteins 0.000 abstract 1
- 229940096437 Protein S Drugs 0.000 abstract 1
- 241000282887 Suidae Species 0.000 abstract 1
- 239000013543 active substance Substances 0.000 abstract 1
- 208000009956 adenocarcinoma Diseases 0.000 abstract 1
- 229940044627 gamma-interferon Drugs 0.000 abstract 1
- 201000001441 melanoma Diseases 0.000 abstract 1
- 230000004089 microcirculation Effects 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 230000005909 tumor killing Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/191—Tumor necrosis factors [TNF], e.g. lymphotoxin [LT], i.e. TNF-beta
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4702—Regulators; Modulating activity
- C07K14/4703—Inhibitors; Suppressors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/745—Blood coagulation or fibrinolysis factors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/36—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against blood coagulation factors
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6424—Serine endopeptidases (3.4.21)
- C12N9/6464—Protein C (3.4.21.69)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/21—Serine endopeptidases (3.4.21)
- C12Y304/21069—Protein C activated (3.4.21.69)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2405/00—Assays, e.g. immunoassays or enzyme assays, involving lipids
- G01N2405/04—Phospholipids, i.e. phosphoglycerides
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US07/389,617 US5147638A (en) | 1988-12-30 | 1989-08-04 | Inhibition of tumor growth by blockade of the protein C system |
PCT/US1990/004337 WO1991001753A1 (en) | 1989-08-04 | 1990-08-02 | Inhibition of tumor growth by blockade of the protein c system |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69030189D1 true DE69030189D1 (de) | 1997-04-17 |
DE69030189T2 DE69030189T2 (de) | 1997-07-10 |
Family
ID=23539002
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69030189T Expired - Fee Related DE69030189T2 (de) | 1989-08-04 | 1990-08-02 | Hemmung des wachstums von tumoren durch blockade des protein-c-systems |
Country Status (8)
Country | Link |
---|---|
US (1) | US5147638A (de) |
EP (1) | EP0489048B1 (de) |
JP (1) | JPH0729937B2 (de) |
AT (1) | ATE149842T1 (de) |
AU (1) | AU639014B2 (de) |
CA (1) | CA2064585C (de) |
DE (1) | DE69030189T2 (de) |
WO (1) | WO1991001753A1 (de) |
Families Citing this family (67)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5322838A (en) * | 1988-11-16 | 1994-06-21 | Brigham & Women's Hospital | Use of INHIB (the C3 β-chain) in the detection and inhibition of inflammation |
US5298599A (en) * | 1988-12-30 | 1994-03-29 | Oklahoma Medical Research Foundation | Expression and purification of recombinant soluble tissue factor |
US5202253A (en) * | 1988-12-30 | 1993-04-13 | Oklahoma Medical Research Foundation | Monoclonal antibody specific for protein C and antibody purification method |
US7247453B1 (en) | 1988-12-30 | 2007-07-24 | Oklahoma Medical Research Foundation | Calcium binding recombinant antibody against protein C |
US6423313B1 (en) * | 1988-12-30 | 2002-07-23 | Oklahoma Medical Research Foundation | Inhibition of tumor growth by blockade of the protein C system |
US5288612A (en) * | 1991-07-03 | 1994-02-22 | The Scripps Research Institute | Assay methods for detecting serum proteases, particularly activated protein C |
US5716795A (en) * | 1991-10-04 | 1998-02-10 | Matschiner; John T. | Thrombomodulin-based coagulometric assay of the protein C system |
AU2870992A (en) * | 1991-10-04 | 1993-05-03 | Board Of Regents Of The University Of Nebraska, The | A soluble thrombomodulin-based one-stage assay for vitamin k-dependent coagulation-inhibiting proteins |
EP0962529A1 (de) * | 1991-10-23 | 1999-12-08 | Thomas Jefferson University | Synthese von humanen Prokollagenen und Kollagenen in rekombinanten DNA-Systemen |
US6749853B1 (en) * | 1992-03-05 | 2004-06-15 | Board Of Regents, The University Of Texas System | Combined methods and compositions for coagulation and tumor treatment |
EP0651655A4 (de) * | 1992-07-24 | 1996-05-29 | Oklahoma Med Res Found | Blockierung der protein c aktivierung reduziert den blutverlust in mikrogefässen bei chirurgischen eingriffen. |
WO1994005328A1 (en) * | 1992-08-28 | 1994-03-17 | The Scripps Research Institute | Inhibition of tumor metastasis via neutralization of tissue factor function |
US7060484B1 (en) | 1993-11-12 | 2006-06-13 | Gilead Sciences, Inc. | Polypeptides and coagulation therapy |
EP0728210B1 (de) * | 1993-11-12 | 2005-04-13 | Gilead Sciences, Inc. | Thrombin mutanten |
WO1995016464A1 (en) * | 1993-12-14 | 1995-06-22 | Johns Hopkins University School Of Medicine | Controlled release of pharmaceutically active substances for immunotherapy |
WO1995030429A1 (en) * | 1994-05-04 | 1995-11-16 | Board Of Trustees Of The University Of Arkansas | Novel ophthalmologic uses of protein c |
WO1995034652A1 (en) * | 1994-06-10 | 1995-12-21 | Oklahoma Medical Research Foundation | Calcium binding recombinant antibody against protein c |
US5830448A (en) * | 1994-06-16 | 1998-11-03 | Genentech, Inc. | Compositions and methods for the treatment of tumors |
US5695993A (en) * | 1994-08-12 | 1997-12-09 | Oklahoma Medical Research Foundation | Cloning and regulation of an endothelial cell protein C/activated protein C receptor |
US7135458B1 (en) * | 1995-11-15 | 2006-11-14 | Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo | Interferon-γ inducing polypeptide, pharmaceutical composition thereof, monoclonal antibody thereto, and methods of use |
US6207641B1 (en) * | 1995-03-10 | 2001-03-27 | Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo | Pharmaceutical composition containing IFN-γ inducing polypeptide or factor for treating and/or preventing IFN-γ susceptive diseases |
US6013483A (en) | 1995-06-07 | 2000-01-11 | Human Genome Sciences, Inc. | DNA encoding endothelial monocyte activating polypeptide III |
US5902582A (en) * | 1995-09-05 | 1999-05-11 | Chiron Corporation | Use of TFPI inhibitor for treatment of cancer |
DE69628652T3 (de) | 1995-09-08 | 2012-05-03 | Genentech, Inc. | Vegf-verwandtes protein |
CN100333796C (zh) | 1997-01-22 | 2007-08-29 | 德克萨斯州立大学董事会 | 凝血和肿瘤治疗的组织因子及其组合物 |
ES2236634T3 (es) | 1997-04-07 | 2005-07-16 | Genentech, Inc. | Anticuerpos anti-vegf. |
KR100794454B1 (ko) | 1997-04-07 | 2008-01-16 | 제넨테크, 인크. | 항-vegf 항체 |
ES2389387T3 (es) | 1998-03-17 | 2012-10-25 | Genentech, Inc. | Polipéptidos homólogos de VEGF y de BMP1 |
US6620382B1 (en) | 1998-05-22 | 2003-09-16 | Biopheresis Technologies, Llc. | Method and compositions for treatment of cancers |
US8197430B1 (en) | 1998-05-22 | 2012-06-12 | Biopheresis Technologies, Inc. | Method and system to remove cytokine inhibitor in patients |
ATE300957T1 (de) | 1998-12-22 | 2005-08-15 | Genentech Inc | Antagonisten von vaskular-endothelialen zellwachstumsfaktoren und ihre anwendung |
US20030077603A1 (en) * | 1999-08-18 | 2003-04-24 | Parekh Rajesh Bhikhu | Methods and compositions for diagnosis of hepatoma |
GB9919597D0 (en) * | 1999-08-18 | 1999-10-20 | Oxford Glycosciences Uk Ltd | Methods and compositions for diagnosis of hepatoma |
WO2001037873A2 (en) | 1999-11-10 | 2001-05-31 | Lentz M Rigdon | Method and system to remove cytokine inhibitor in patients |
US6379708B1 (en) * | 1999-11-20 | 2002-04-30 | Cytologic, Llc | Method for enhancing immune responses in mammals |
DK2042597T3 (da) | 2000-06-23 | 2014-08-11 | Genentech Inc | Sammensætninger og fremgangsmåder til diagnose og behandling af sygdomme, der involverer angiogenese |
CA2709771A1 (en) | 2000-06-23 | 2002-01-03 | Genentech, Inc. | Compositions and methods for the diagnosis and treatment of disorders involving angiogenesis |
US20020168360A1 (en) * | 2001-03-02 | 2002-11-14 | Christine Dingivan | Methods of preventing or treating inflammatory or autoimmune disorders by administering integrin alphanubeta3 antagonists in combination with other prophylactic or therapeutic agents |
JP2005510516A (ja) * | 2001-11-09 | 2005-04-21 | ノボ ノルディスク ヘルス ケア アクチェンゲゼルシャフト | Vii因子ポリペプチドおよびプロテインs阻害剤を含む薬学的組成物 |
EP1499352A4 (de) | 2002-04-12 | 2006-10-11 | Medimmune Inc | Rekombinante anti-interleukin-9-antikörper |
US20040018197A1 (en) * | 2002-04-26 | 2004-01-29 | Promega Corporation | Treatment for weight loss |
EP2305710A3 (de) | 2002-06-03 | 2013-05-29 | Genentech, Inc. | Synthetische Antikörperphagenbibliotheken |
EP1586328B1 (de) * | 2002-12-27 | 2013-02-20 | The Chemo-Sero-Therapeutic Research Institute | Wirkstoff zur erhöhung der lebenserwartung bei der therapie bösartiger tumore |
US20070142272A1 (en) * | 2003-01-24 | 2007-06-21 | Zlokovic Berislav V | Neuroprotective activity of activated protein c independent of its anticoagulant activity |
KR20110094361A (ko) | 2003-04-11 | 2011-08-23 | 메디뮨 엘엘씨 | 재조합 il9 항체 및 그의 용도 |
BRPI0409936A (pt) | 2003-05-23 | 2006-04-25 | Novo Nordisk Healthcare Ag | uso de um material, recipiente pelo menos parcialmente cheio, e, kit médico |
WO2005014028A1 (en) | 2003-08-08 | 2005-02-17 | Novo Nordisk A/S | Interleukin-20 for treating and diagnosing conditions associated with neovascularisation |
RU2378016C2 (ru) * | 2004-04-30 | 2010-01-10 | Байофересиз Текнолоджиз, Инк. | Способ и система для удаления у пациентов растворимых tnfr1, tnfr2 и il2 |
US7351739B2 (en) * | 2004-04-30 | 2008-04-01 | Wellgen, Inc. | Bioactive compounds and methods of uses thereof |
JP2008507561A (ja) * | 2004-07-23 | 2008-03-13 | ザ ユニバーシティ オブ ロチェスター | 活性化プロテインcによる、脳内のプラスミノゲン活性化因子の不都合な作用の阻害 |
US20060121042A1 (en) | 2004-10-27 | 2006-06-08 | Medimmune, Inc. | Modulation of antibody specificity by tailoring the affinity to cognate antigens |
US20070065514A1 (en) * | 2005-09-22 | 2007-03-22 | Howell Mark D | Method for enhancing immune responses in mammals |
EP2851064A3 (de) | 2006-07-11 | 2015-08-05 | Roy C. Levitt | Prävention und Therapie von Rhinosinusitis mit proinflammatorischen Zytokinhemmern |
JP2010500360A (ja) | 2006-08-10 | 2010-01-07 | アルボア コーポレーション | 炎症性サイトカイン阻害剤による下気道炎症疾患の局所療法 |
US20080075690A1 (en) * | 2006-09-22 | 2008-03-27 | Mark Douglas Howell | Method for enhancing immune responses in mammals |
US7826800B2 (en) * | 2006-11-27 | 2010-11-02 | Orthosoft Inc. | Method and system for determining a time delay between transmission and reception of an RF signal in a noisy RF environment using phase detection |
PE20081250A1 (es) | 2006-11-28 | 2008-10-07 | Centelion | FUSIONES Fc CON RECEPTOR PARA FGF SOLUBLE MODIFICADAS, CON ACTIVIDAD BIOLOGICA MEJORADA |
EP2068925A4 (de) | 2007-05-07 | 2011-08-31 | Medimmune Llc | Anti-icos-antikörper und ihre verwendung für die behandlung von krebs, transplantationen und autoimmunerkrankungen |
BRPI0905660A2 (pt) | 2008-01-14 | 2015-07-07 | Genentech Inc | "método para reduzir ou inibir a angiogênese" |
EP3858854A1 (de) | 2008-06-25 | 2021-08-04 | Novartis AG | Stabile und lösliche tnf-inhibierende antikörper |
KR101671886B1 (ko) | 2008-06-25 | 2016-11-04 | 에스바테크 - 어 노바티스 컴파니 엘엘씨 | Vegf를 억제하는 안정하고 가용성인 항체 |
JP5933975B2 (ja) | 2008-11-12 | 2016-06-15 | メディミューン,エルエルシー | 抗体製剤 |
UY33679A (es) | 2010-10-22 | 2012-03-30 | Esbatech | Anticuerpos estables y solubles |
GB201223053D0 (en) | 2012-12-20 | 2013-02-06 | Medical Res Council | Receptor |
ES2870983T3 (es) | 2014-12-19 | 2021-10-28 | Univ Nantes | Anticuerpos anti-IL-34 |
CA3114179A1 (en) | 2018-09-28 | 2020-04-02 | Pierre Fabre Medicament | New immunocytokines for the treatment of cancer |
EP3889183A1 (de) | 2020-04-01 | 2021-10-06 | Pierre Fabre Medicament | Proteinkomplex mit einem immunzytokin |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4650674A (en) * | 1984-07-05 | 1987-03-17 | Genentech, Inc. | Synergistic cytotoxic composition |
US4677064A (en) * | 1984-11-09 | 1987-06-30 | Cetus Corporation | Human tumor necrosis factor |
US4775624A (en) * | 1985-02-08 | 1988-10-04 | Eli Lilly And Company | Vectors and compounds for expression of human protein C |
DE3705745A1 (de) * | 1987-02-23 | 1988-09-01 | Behringwerke Ag | Protein c-inhibitor (pci) als pharmazeutikum und in vitro-diagnostikum, verfahren zur herstellung eines solchen pharmazeutikums oder diagnostikums sowie ein mittel enthaltend pci |
JP2634218B2 (ja) * | 1987-03-02 | 1997-07-23 | 森永乳業株式会社 | Adcc療法を高める組成物 |
-
1989
- 1989-08-04 US US07/389,617 patent/US5147638A/en not_active Expired - Lifetime
-
1990
- 1990-08-02 EP EP90912282A patent/EP0489048B1/de not_active Expired - Lifetime
- 1990-08-02 JP JP2511545A patent/JPH0729937B2/ja not_active Expired - Fee Related
- 1990-08-02 WO PCT/US1990/004337 patent/WO1991001753A1/en active IP Right Grant
- 1990-08-02 AT AT90912282T patent/ATE149842T1/de not_active IP Right Cessation
- 1990-08-02 CA CA002064585A patent/CA2064585C/en not_active Expired - Fee Related
- 1990-08-02 DE DE69030189T patent/DE69030189T2/de not_active Expired - Fee Related
- 1990-08-02 AU AU61643/90A patent/AU639014B2/en not_active Ceased
Also Published As
Publication number | Publication date |
---|---|
EP0489048A1 (de) | 1992-06-10 |
CA2064585C (en) | 1999-04-27 |
JPH0729937B2 (ja) | 1995-04-05 |
DE69030189T2 (de) | 1997-07-10 |
AU6164390A (en) | 1991-03-11 |
JPH04504264A (ja) | 1992-07-30 |
EP0489048B1 (de) | 1997-03-12 |
CA2064585A1 (en) | 1991-02-05 |
ATE149842T1 (de) | 1997-03-15 |
US5147638A (en) | 1992-09-15 |
AU639014B2 (en) | 1993-07-15 |
WO1991001753A1 (en) | 1991-02-21 |
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