DE69024649D1 - Verfahren mit rekombinanter dns zur herstellung des parathyroidhormons - Google Patents

Verfahren mit rekombinanter dns zur herstellung des parathyroidhormons

Info

Publication number
DE69024649D1
DE69024649D1 DE69024649T DE69024649T DE69024649D1 DE 69024649 D1 DE69024649 D1 DE 69024649D1 DE 69024649 T DE69024649 T DE 69024649T DE 69024649 T DE69024649 T DE 69024649T DE 69024649 D1 DE69024649 D1 DE 69024649D1
Authority
DE
Germany
Prior art keywords
parathyroidhormone
producing
recombinant dna
recombinant
dna
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69024649T
Other languages
English (en)
Other versions
DE69024649T2 (de
Inventor
Henry Kronenberg
Samuel Nussbaum
Tomoko Protein Engineering Doi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
General Hospital Corp
Original Assignee
General Hospital Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by General Hospital Corp filed Critical General Hospital Corp
Application granted granted Critical
Publication of DE69024649D1 publication Critical patent/DE69024649D1/de
Publication of DE69024649T2 publication Critical patent/DE69024649T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/635—Parathyroid hormone, i.e. parathormone; Parathyroid hormone-related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/61—Growth hormone [GH], i.e. somatotropin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Endocrinology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Diabetes (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
DE69024649T 1989-05-12 1990-05-11 Verfahren mit rekombinanter dns zur herstellung des parathyroidhormons Expired - Fee Related DE69024649T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/350,979 US5171670A (en) 1989-05-12 1989-05-12 Recombinant dna method for production of parathyroid hormone
PCT/US1990/002650 WO1990014415A1 (en) 1989-05-12 1990-05-11 Recombinant dna method for production of parathyroid hormone

Publications (2)

Publication Number Publication Date
DE69024649D1 true DE69024649D1 (de) 1996-02-15
DE69024649T2 DE69024649T2 (de) 1996-08-29

Family

ID=23379057

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69024649T Expired - Fee Related DE69024649T2 (de) 1989-05-12 1990-05-11 Verfahren mit rekombinanter dns zur herstellung des parathyroidhormons

Country Status (5)

Country Link
US (1) US5171670A (de)
EP (1) EP0473701B1 (de)
JP (1) JP3054192B2 (de)
DE (1) DE69024649T2 (de)
WO (1) WO1990014415A1 (de)

Families Citing this family (44)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5420242A (en) * 1986-10-22 1995-05-30 Kaare M. Gautvik Production of human parathyroid hormone from microorganisms
JP2777132B2 (ja) 1986-10-22 1998-07-16 カーレ・エンム・ガウトビク 微生物によるヒト副甲状腺ホルモンの生産
USRE37919E1 (en) 1989-05-12 2002-12-03 The General Hospital Corporation Recombinant DNA method for production of parathyroid hormone
JPH05271279A (ja) * 1991-08-07 1993-10-19 Takeda Chem Ind Ltd ヒト副甲状腺ホルモンムテインおよびその製造法
DE69219242T2 (de) * 1991-08-07 1997-09-25 Takeda Chemical Industries Ltd Muteine des menschlichen Parathormons und ihre Herstellung
US5814603A (en) * 1992-06-12 1998-09-29 Affymax Technologies N.V. Compounds with PTH activity
US5977070A (en) * 1992-07-14 1999-11-02 Piazza; Christin Teresa Pharmaceutical compositions for the nasal delivery of compounds useful for the treatment of osteoporosis
US5821225A (en) * 1992-07-14 1998-10-13 Syntex (U.S.A.) Inc. Method for the treatment of corticosteroid induced osteopenia comprising administration of modified PTH or PTHrp
US5942496A (en) 1994-02-18 1999-08-24 The Regent Of The University Of Michigan Methods and compositions for multiple gene transfer into bone cells
US5763416A (en) * 1994-02-18 1998-06-09 The Regent Of The University Of Michigan Gene transfer into bone cells and tissues
US6074840A (en) * 1994-02-18 2000-06-13 The Regents Of The University Of Michigan Recombinant production of latent TGF-beta binding protein-3 (LTBP-3)
US5962427A (en) 1994-02-18 1999-10-05 The Regent Of The University Of Michigan In vivo gene transfer methods for wound healing
US6551618B2 (en) 1994-03-15 2003-04-22 University Of Birmingham Compositions and methods for delivery of agents for neuronal regeneration and survival
US5629205A (en) * 1995-05-19 1997-05-13 Allelix Biopharmaceuticals Inc. Promoters for gene expression
US20020168718A1 (en) * 1997-04-03 2002-11-14 California Institute Of Technology Enzyme-mediated modification of fibrin for tissue engineering
SE9702401D0 (sv) 1997-06-19 1997-06-19 Astra Ab Pharmaceutical use
KR100230578B1 (ko) * 1997-07-25 1999-12-01 허영섭 포스포리불로키나제를 융합파트너로 이용하는 재조합 인간 부갑상선호르몬의 발현벡터
US7923250B2 (en) 1997-07-30 2011-04-12 Warsaw Orthopedic, Inc. Methods of expressing LIM mineralization protein in non-osseous cells
EP1007673B1 (de) 1997-07-30 2008-12-17 Emory University Neue knochenmineralisierungsproteine, dna, vektoren, expressionssysteme
US7601685B2 (en) * 1998-08-27 2009-10-13 Eidgenossische Technische Hochschule Zurich Growth factor modified protein matrices for tissue engineering
US6894022B1 (en) * 1998-08-27 2005-05-17 Eidgenossische Technische Hochschule Zurich Growth factor modified protein matrices for tissue engineering
US7241730B2 (en) 1998-08-27 2007-07-10 Universitat Zurich Enzyme-mediated modification of fibrin for tissue engineering: fibrin formulations with peptides
US7893021B2 (en) * 1999-06-02 2011-02-22 Scantibodies Laboratory, Inc. Parathyroid hormone antagonists and uses thereof
US20080108086A1 (en) * 1999-06-02 2008-05-08 Cantor Thomas L Parathyroid hormone antagonists and uses thereof
US6756480B2 (en) * 2000-04-27 2004-06-29 Amgen Inc. Modulators of receptors for parathyroid hormone and parathyroid hormone-related protein
US20050124537A1 (en) * 2000-04-27 2005-06-09 Amgen Inc. Modulators of receptors for parathyroid hormone and parathyroid hormone-related protein
BR0214542A (pt) * 2001-12-12 2005-08-16 Lilly Co Eli Célula hospedeira, sistema de expressão, e, processos de preparação de uma célula hospedeira, e de uma proteìna alvo
BRPI0215192B8 (pt) * 2001-12-18 2021-07-27 Eidgenoessische Technische Hochschule Zuerich peptídeo de fusão, kit e matriz que compreendem o mesmo, e método para criar uma matriz
US7247609B2 (en) * 2001-12-18 2007-07-24 Universitat Zurich Growth factor modified protein matrices for tissue engineering
AU2003239869A1 (en) * 2002-05-23 2003-12-12 Michael Holick Use of a parathyroid hormone peptide analogs for the treatment of vaginal atrophy
US7153666B2 (en) * 2003-07-17 2006-12-26 General Atomics Methods and compositions for determination of glycated proteins
US7022494B2 (en) * 2003-09-19 2006-04-04 General Atomics Detection of potassium ions using ion-sensitive enzymes
US8187831B2 (en) * 2003-09-19 2012-05-29 General Atomics Determination of ions using ion-sensitive enzymes
AU2005318097A1 (en) * 2004-12-22 2006-06-29 Kuros Biosurgery Ag Michael-type addition reaction functionalised peg hydrogels with factor XIIIA incorporated biofactors
US8575101B2 (en) 2005-01-06 2013-11-05 Kuros Biosurgery Ag Supplemented matrices for the repair of bone fractures
ES2593051T3 (es) * 2005-01-06 2016-12-05 Kuros Biosurgery Ag Matrices suplementadas para la reparación de fracturas óseas
WO2006073711A2 (en) * 2005-01-06 2006-07-13 Kuros Biosurgery Ag Use of a matrix comprising a contrast agent in soft tissues
US7943385B2 (en) 2006-07-25 2011-05-17 General Atomics Methods for assaying percentage of glycated hemoglobin
US7855079B2 (en) * 2006-07-25 2010-12-21 General Atomics Methods for assaying percentage of glycated hemoglobin
CN101711168B (zh) 2007-04-13 2013-05-01 库罗斯生物外科股份公司 聚合物组织封闭剂
WO2009083544A2 (en) * 2007-12-28 2009-07-09 Kuros Biosurgery Ag Pdgf fusion proteins incorporated into fibrin foams
EP2283149A1 (de) * 2008-05-13 2011-02-16 General Atomics Elektrochemischer biosensor zur direkten bestimmung des prozentsatzes von glykosyliertem hämoglobin
WO2012123028A1 (en) 2011-03-16 2012-09-20 Kuros Biosurgery Ag Pharmaceutical formulation for use in spinal fusion
CN105473610A (zh) * 2013-08-21 2016-04-06 卡迪拉保健有限公司 用于pth的纯化方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4366246A (en) * 1977-11-08 1982-12-28 Genentech, Inc. Method for microbial polypeptide expression
US4738921A (en) * 1984-09-27 1988-04-19 Eli Lilly And Company Derivative of the tryptophan operon for expression of fused gene products
JP2777132B2 (ja) * 1986-10-22 1998-07-16 カーレ・エンム・ガウトビク 微生物によるヒト副甲状腺ホルモンの生産
NZ224663A (en) * 1987-05-28 1990-11-27 Amrad Corp Ltd Fusion proteins containing glutathione-s-transferase and expression of foreign polypeptides using glutathione-s-transferase encoding vectors
JPH01257491A (ja) * 1988-04-08 1989-10-13 Tosoh Corp 不溶性融合異種蛋白質の処理方法

Also Published As

Publication number Publication date
EP0473701B1 (de) 1996-01-03
EP0473701A4 (en) 1992-08-12
DE69024649T2 (de) 1996-08-29
WO1990014415A1 (en) 1990-11-29
JPH04505259A (ja) 1992-09-17
EP0473701A1 (de) 1992-03-11
US5171670A (en) 1992-12-15
JP3054192B2 (ja) 2000-06-19

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8328 Change in the person/name/address of the agent

Representative=s name: GROSSE, BOCKHORNI, SCHUMACHER, 45133 ESSEN

8328 Change in the person/name/address of the agent

Representative=s name: BOCKHORNI & KOLLEGEN, 80687 MUENCHEN

8339 Ceased/non-payment of the annual fee