DE69024071T2 - Chromogenische Merocyanin-Enzym-Substrate - Google Patents

Chromogenische Merocyanin-Enzym-Substrate

Info

Publication number
DE69024071T2
DE69024071T2 DE69024071T DE69024071T DE69024071T2 DE 69024071 T2 DE69024071 T2 DE 69024071T2 DE 69024071 T DE69024071 T DE 69024071T DE 69024071 T DE69024071 T DE 69024071T DE 69024071 T2 DE69024071 T2 DE 69024071T2
Authority
DE
Germany
Prior art keywords
enzyme substrates
chromogenic
merocyanine enzyme
chromogenic merocyanine
merocyanine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69024071T
Other languages
English (en)
Other versions
DE69024071D1 (de
Inventor
Paul F Corey
Teresa M Yip
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer AG
Bayer Corp
Original Assignee
Bayer AG
Bayer Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer AG, Bayer Corp filed Critical Bayer AG
Application granted granted Critical
Publication of DE69024071D1 publication Critical patent/DE69024071D1/de
Publication of DE69024071T2 publication Critical patent/DE69024071T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B23/00—Methine or polymethine dyes, e.g. cyanine dyes
    • C09B23/0091—Methine or polymethine dyes, e.g. cyanine dyes having only one heterocyclic ring at one end of the methine chain, e.g. hemicyamines, hemioxonol
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B23/00—Methine or polymethine dyes, e.g. cyanine dyes
    • C09B23/10—The polymethine chain containing an even number of >CH- groups
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B23/00—Methine or polymethine dyes, e.g. cyanine dyes
    • C09B23/10—The polymethine chain containing an even number of >CH- groups
    • C09B23/105—The polymethine chain containing an even number of >CH- groups two >CH- groups
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B23/00—Methine or polymethine dyes, e.g. cyanine dyes
    • C09B23/14—Styryl dyes
    • C09B23/145—Styryl dyes the ethylene chain carrying an heterocyclic residue, e.g. heterocycle-CH=CH-C6H5
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2334/00—O-linked chromogens for determinations of hydrolase enzymes, e.g. glycosidases, phosphatases, esterases

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Peptides Or Proteins (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Saccharide Compounds (AREA)
DE69024071T 1989-02-13 1990-01-31 Chromogenische Merocyanin-Enzym-Substrate Expired - Fee Related DE69024071T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/310,060 US5122602A (en) 1989-02-13 1989-02-13 Chromogenic merocyanine enzyme substrates

Publications (2)

Publication Number Publication Date
DE69024071D1 DE69024071D1 (de) 1996-01-25
DE69024071T2 true DE69024071T2 (de) 1996-05-15

Family

ID=23200833

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69024071T Expired - Fee Related DE69024071T2 (de) 1989-02-13 1990-01-31 Chromogenische Merocyanin-Enzym-Substrate

Country Status (6)

Country Link
US (1) US5122602A (de)
EP (1) EP0383092B1 (de)
JP (1) JP2926100B2 (de)
AU (2) AU617237B2 (de)
CA (1) CA2000596C (de)
DE (1) DE69024071T2 (de)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69213826T2 (de) * 1991-06-06 1997-01-30 Bayer Ag Teststreifen mit Merocyanin und Nitro- oder Nitroso-substituierten polyhalogenierten Phenolsulfonphthaleinen als Protein-Indikatoren
US5534416A (en) * 1993-04-13 1996-07-09 Molecular Probes, Inc. Fluorescent viability assay using cyclic-substituted unsymmetrical cyanine dyes
US5601986A (en) * 1994-07-14 1997-02-11 Amgen Inc. Assays and devices for the detection of extrahepatic biliary atresia
US5616502A (en) * 1995-05-19 1997-04-01 Molecular Probes, Inc. Non-specific protein staining using merocyanine dyes
GB9716476D0 (en) * 1997-08-04 1997-10-08 Amersham Int Plc Dye intermediate and method
FR2809820B1 (fr) * 2000-05-30 2002-10-25 Proteus Methode de detection d'une transformation d'un substrat et ses applications
FR2832729B1 (fr) * 2001-11-28 2004-01-16 Proteus Methode de detection d'une activite catalytique d'un echantillon mettant en oeuvre la detection de la transformation d'un substrat
US7776529B2 (en) * 2003-12-05 2010-08-17 Life Technologies Corporation Methine-substituted cyanine dye compounds
US7563891B2 (en) * 2004-05-21 2009-07-21 Becton, Dickinson & Company Long wavelength thiol-reactive fluorophores
JP5306811B2 (ja) * 2005-05-11 2013-10-02 ライフ テクノロジーズ コーポレーション ２本鎖ｄｎａへの高い選択性を有する蛍光化学物質及びそれらの使用
US7781187B2 (en) * 2005-12-30 2010-08-24 Corning Incorporated Fluorescent dyes
CA2664649A1 (en) 2006-09-28 2008-05-08 Ensemble Discovery Corporation Compositions and methods for biodetection by nucleic acid-templated chemistry
WO2011050323A1 (en) * 2009-10-22 2011-04-28 The Washington University Compounds and methods for treating bacterial infections
ES2732311T3 (es) 2011-02-07 2019-11-21 Univ Washington Compuestos de manósidos y procedimientos de uso de los mismos
EP3003322B1 (de) 2013-05-30 2023-09-13 Washington University Mannosederivate und deren verwendung bei der behandlung von bakteriellen infektionen
US10738070B2 (en) 2016-03-23 2020-08-11 Fimbrion Therapeutics, Inc. Mannose-derived antagonists of FimH useful for treating disease
CN106336442B (zh) * 2016-07-27 2018-11-27 昆药集团股份有限公司 天麻素衍生物、其制备方法、其应用与药物制剂
SG11202011066XA (en) 2018-07-10 2021-01-28 Glaxosmithkline Ip Dev Ltd C-mannoside compounds useful for the treatment of urinary tract infections
CN113234111A (zh) * 2021-02-22 2021-08-10 西北大学 同时检测β-半乳糖苷酶和溶酶体pH的荧光探针及其制备方法和应用

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0047470B1 (de) * 1980-09-02 1985-04-24 Fuji Photo Film Co., Ltd. Verfahren zur immunochemischen Bestimmung
US4536572A (en) * 1982-11-17 1985-08-20 University Of Utah Amido-phenyl-α-D-glucopyranoside derivatives
DE3345748A1 (de) * 1983-12-17 1985-08-29 Boehringer Mannheim Gmbh, 6800 Mannheim Phenolsulfonphthaleinyl-ss-d-galactoside, verfahren zu deren herstellung sowie deren verwendung zur bestimmung der ss-d-galactosidase
US4760136A (en) * 1984-04-27 1988-07-26 Ishihara Sangyo Kaisha, Ltd. Chartreusin derivatives and salts thereof
US4760135A (en) * 1984-09-06 1988-07-26 University Of Kentucky Research Foundation Phloretin and phlorizin derivative containing compounds
JPS61112092A (ja) * 1984-11-07 1986-05-30 Meiji Seika Kaisha Ltd 新規グルコサミン誘導体及びこれを基質として用いるＮ−アセチル−β−Ｄ−グルコサミニダ−ゼの活性測定試薬
GB8721302D0 (en) * 1987-09-10 1987-10-14 London King S College Substrates for assay of enzymes

Also Published As

Publication number Publication date
AU8367091A (en) 1991-11-07
AU617237B2 (en) 1991-11-21
US5122602A (en) 1992-06-16
EP0383092A2 (de) 1990-08-22
CA2000596C (en) 2000-12-05
EP0383092A3 (de) 1992-03-25
DE69024071D1 (de) 1996-01-25
AU4868290A (en) 1990-08-16
JPH02245200A (ja) 1990-09-28
EP0383092B1 (de) 1995-12-13
JP2926100B2 (ja) 1999-07-28
CA2000596A1 (en) 1990-08-13
AU640517B2 (en) 1993-08-26

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee