DE69019411T2 - Magnetisierbare Mikrokugeln aus vernetztem, hydrophobem Polymer, Verfahren zu ihrer Herstellung und ihre Verwendung in der Biologie. - Google Patents

Magnetisierbare Mikrokugeln aus vernetztem, hydrophobem Polymer, Verfahren zu ihrer Herstellung und ihre Verwendung in der Biologie.

Info

Publication number
DE69019411T2
DE69019411T2 DE69019411T DE69019411T DE69019411T2 DE 69019411 T2 DE69019411 T2 DE 69019411T2 DE 69019411 T DE69019411 T DE 69019411T DE 69019411 T DE69019411 T DE 69019411T DE 69019411 T2 DE69019411 T2 DE 69019411T2
Authority
DE
Germany
Prior art keywords
biology
linked
preparation
cross
hydrophobic polymer
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69019411T
Other languages
German (de)
English (en)
Other versions
DE69019411D1 (de
Inventor
Dominique Charmot
Christine Vidil
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Prolabo SA
Original Assignee
Prolabo SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Prolabo SA filed Critical Prolabo SA
Application granted granted Critical
Publication of DE69019411D1 publication Critical patent/DE69019411D1/de
Publication of DE69019411T2 publication Critical patent/DE69019411T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
    • G01N33/54326—Magnetic particles
    • G01N33/5434—Magnetic particles using magnetic particle immunoreagent carriers which constitute new materials per se
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F292/00—Macromolecular compounds obtained by polymerising monomers on to inorganic materials
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08K—Use of inorganic or non-macromolecular organic substances as compounding ingredients
    • C08K9/00—Use of pretreated ingredients
    • C08K9/10—Encapsulated ingredients
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2446/00—Magnetic particle immunoreagent carriers
    • G01N2446/20—Magnetic particle immunoreagent carriers the magnetic material being present in the particle core
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2446/00—Magnetic particle immunoreagent carriers
    • G01N2446/30—Magnetic particle immunoreagent carriers the magnetic material being dispersed in the polymer composition before their conversion into particulate form
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2446/00—Magnetic particle immunoreagent carriers
    • G01N2446/60—Magnetic particle immunoreagent carriers the magnetic material being dispersed in a medium other than the main solvent prior to incorporation into the polymer particle
    • G01N2446/64—Magnetic material dispersed in oil drop
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2446/00—Magnetic particle immunoreagent carriers
    • G01N2446/60—Magnetic particle immunoreagent carriers the magnetic material being dispersed in a medium other than the main solvent prior to incorporation into the polymer particle
    • G01N2446/66—Magnetic material dispersed in surfactant
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2446/00—Magnetic particle immunoreagent carriers
    • G01N2446/80—Magnetic particle immunoreagent carriers characterised by the agent used to coat the magnetic particles, e.g. lipids
    • G01N2446/84—Polymer coating, e.g. gelatin
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
    • Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]
    • Y10T428/2991—Coated
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
    • Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]
    • Y10T428/2991—Coated
    • Y10T428/2998—Coated including synthetic resin or polymer

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Organic Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • Inorganic Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Biotechnology (AREA)
  • Food Science & Technology (AREA)
  • Cell Biology (AREA)
  • Microbiology (AREA)
  • Materials Engineering (AREA)
  • Soft Magnetic Materials (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
  • Polymerisation Methods In General (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Compounds Of Iron (AREA)
  • Processes Of Treating Macromolecular Substances (AREA)
  • Powder Metallurgy (AREA)
  • Hard Magnetic Materials (AREA)
  • Materials For Medical Uses (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Saccharide Compounds (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
  • Macromonomer-Based Addition Polymer (AREA)
DE69019411T 1989-03-31 1990-03-16 Magnetisierbare Mikrokugeln aus vernetztem, hydrophobem Polymer, Verfahren zu ihrer Herstellung und ihre Verwendung in der Biologie. Expired - Fee Related DE69019411T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR8904231A FR2645160B1 (US06515009-20030204-C00004.png) 1989-03-31 1989-03-31

Publications (2)

Publication Number Publication Date
DE69019411D1 DE69019411D1 (de) 1995-06-22
DE69019411T2 true DE69019411T2 (de) 1995-11-09

Family

ID=9380242

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69019411T Expired - Fee Related DE69019411T2 (de) 1989-03-31 1990-03-16 Magnetisierbare Mikrokugeln aus vernetztem, hydrophobem Polymer, Verfahren zu ihrer Herstellung und ihre Verwendung in der Biologie.

Country Status (12)

Country Link
US (1) US5356713A (US06515009-20030204-C00004.png)
EP (1) EP0390634B1 (US06515009-20030204-C00004.png)
JP (1) JP2623358B2 (US06515009-20030204-C00004.png)
AT (1) ATE122704T1 (US06515009-20030204-C00004.png)
AU (1) AU5239690A (US06515009-20030204-C00004.png)
CA (1) CA2013459A1 (US06515009-20030204-C00004.png)
DE (1) DE69019411T2 (US06515009-20030204-C00004.png)
ES (1) ES2072996T3 (US06515009-20030204-C00004.png)
FI (1) FI901628A0 (US06515009-20030204-C00004.png)
FR (1) FR2645160B1 (US06515009-20030204-C00004.png)
IL (1) IL93947A0 (US06515009-20030204-C00004.png)
NO (1) NO178376C (US06515009-20030204-C00004.png)

Families Citing this family (71)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5272216A (en) * 1990-12-28 1993-12-21 Westinghouse Electric Corp. System and method for remotely heating a polymeric material to a selected temperature
US5811447A (en) * 1993-01-28 1998-09-22 Neorx Corporation Therapeutic inhibitor of vascular smooth muscle cells
US6515009B1 (en) 1991-09-27 2003-02-04 Neorx Corporation Therapeutic inhibitor of vascular smooth muscle cells
US6251920B1 (en) 1993-05-13 2001-06-26 Neorx Corporation Prevention and treatment of cardiovascular pathologies
US5770609A (en) * 1993-01-28 1998-06-23 Neorx Corporation Prevention and treatment of cardiovascular pathologies
US6306421B1 (en) 1992-09-25 2001-10-23 Neorx Corporation Therapeutic inhibitor of vascular smooth muscle cells
US6395494B1 (en) 1993-05-13 2002-05-28 Neorx Corporation Method to determine TGF-β
US6491938B2 (en) 1993-05-13 2002-12-10 Neorx Corporation Therapeutic inhibitor of vascular smooth muscle cells
US5595722A (en) * 1993-01-28 1997-01-21 Neorx Corporation Method for identifying an agent which increases TGF-beta levels
US5981568A (en) 1993-01-28 1999-11-09 Neorx Corporation Therapeutic inhibitor of vascular smooth muscle cells
US6663881B2 (en) * 1993-01-28 2003-12-16 Neorx Corporation Therapeutic inhibitor of vascular smooth muscle cells
DE69435137D1 (de) 1993-05-13 2008-10-16 Poniard Pharmaceuticals Inc Prävention und behandlung von pathologien, die mit einer abnormalen proliferationglatter muskelzellen verbunden sind
US5628407A (en) * 1994-12-05 1997-05-13 Bolt Beranek And Newman, Inc. Method and apparatus for separation of magnetically responsive spheres
US5684130A (en) * 1995-06-05 1997-11-04 Solid Phase Sciences Corporation Process for synthesis of organic compounds using magnetic particles
CA2223595C (en) 1995-06-07 2008-08-05 Neorx Corporation Prevention and treatment of cardiovascular pathologies with tamoxifen analogues
FR2735778B1 (fr) * 1995-06-22 1997-08-22 Prolabo Sa Nouveau latex de microspheres magnetisables monodisperses calibrees, procede de preparation et utilisation dudit latex en chimie ou en biologie
US5834121A (en) * 1996-01-16 1998-11-10 Solid Phase Sciences Corp. Composite magnetic beads
WO1997040385A1 (en) 1996-04-25 1997-10-30 Bioarray Solutions, Llc Light-controlled electrokinetic assembly of particles near surfaces
EP0845790B1 (de) * 1996-11-28 2002-07-10 Fludicon GmbH Magnetorheologische Flüssigkeiten und mit Polymer beschichtete, magnetische Teilchen
FR2758884B1 (fr) 1997-01-30 1999-04-02 Bio Merieux Procede pour isoler, notamment detecter ou quantifier un analyte dans un milieu
FR2773416B1 (fr) * 1998-01-06 2000-02-11 Bio Merieux Particules magnetiques perfectionnees, leurs procedes d'obtention et leurs utilisations dans la separation de molecules
US6423410B1 (en) * 1998-09-04 2002-07-23 Mds Proteomics, Inc. Ultrasonically generated paramagnetic polymer particles
CN1105741C (zh) * 1998-11-10 2003-04-16 中国科学院化工冶金研究所 超顺磁性聚合物微球及其制造方法
FR2800635B1 (fr) * 1999-11-05 2002-07-26 Bio Merieux Nanospheres composites, conjugues derives, procede de preparation et leurs utilisations
FR2800636A1 (fr) * 1999-11-05 2001-05-11 Bio Merieux Particules composites, conjugues derives, leur procede de preparation et utilisations
WO2001078087A2 (en) * 2000-04-06 2001-10-18 Luminex Corporation Magnetically-responsive microspheres
US20040009614A1 (en) * 2000-05-12 2004-01-15 Ahn Chong H Magnetic bead-based arrays
EP1311839B1 (en) 2000-06-21 2006-03-01 Bioarray Solutions Ltd Multianalyte molecular analysis using application-specific random particle arrays
US9709559B2 (en) * 2000-06-21 2017-07-18 Bioarray Solutions, Ltd. Multianalyte molecular analysis using application-specific random particle arrays
DE10033583A1 (de) 2000-07-11 2002-01-24 Bayer Ag Superparamagnetische Perlpolymerisate
FR2824563B1 (fr) * 2001-05-10 2004-12-03 Bio Merieux Particules composites, conjugues derives, procede de preparation et applications
US7262063B2 (en) 2001-06-21 2007-08-28 Bio Array Solutions, Ltd. Directed assembly of functional heterostructures
US7285412B2 (en) 2001-07-27 2007-10-23 Surface Logix Inc. Device for magnetic immobilization of cells
US7169577B2 (en) 2001-07-27 2007-01-30 Surface Logix, Inc. Cell isolation and screening device and method of using same
US7169578B2 (en) 2001-07-27 2007-01-30 Surface Logix, Inc. Cell isolation and screening device and method of using same
JP4377689B2 (ja) 2001-10-15 2009-12-02 バイオアレイ ソリューションズ リミテッド 同時尋問及び酵素仲介検出による多型遺伝子座の複合分析
WO2004047007A1 (en) 2002-11-15 2004-06-03 Bioarray Solutions, Ltd. Analysis, secure access to, and transmission of array images
US7255895B2 (en) * 2003-01-21 2007-08-14 Bioarray Solutions, Ltd. Method for controlling solute loading of polymer microparticles
US6964747B2 (en) * 2003-01-21 2005-11-15 Bioarray Solutions, Ltd. Production of dyed polymer microparticles
WO2005029705A2 (en) 2003-09-18 2005-03-31 Bioarray Solutions, Ltd. Number coding for identification of subtypes of coded types of solid phase carriers
JP4564959B2 (ja) 2003-09-22 2010-10-20 バイオアレイ ソリューションズ リミテッド 生体分子に共有結合できる、複数の官能基を持つ表面固定化高分子電解質
CA2899287A1 (en) 2003-10-28 2005-05-12 Bioarray Solutions Ltd. Optimization of gene expression analysis using immobilized capture probes
AU2004287069B2 (en) 2003-10-29 2009-07-16 Bioarray Solutions, Ltd. Multiplexed nucleic acid analysis by fragmentation of double-stranded DNA
US20050106576A1 (en) * 2003-11-17 2005-05-19 Hashem Akhavan-Tafti Methods of using cleavable solid phases for isolating nucleic acids
US20050106577A1 (en) * 2003-11-17 2005-05-19 Hashem Akhavan-Tafti Cleavable solid phases for isolating nucleic acids
KR20070037708A (ko) * 2004-03-23 2007-04-06 커먼웰쓰 사이언티픽 앤드 인더스트리얼 리서치 오가니제이션 산화철 입자가 함입된 중합체 비드
US8563213B2 (en) * 2004-07-16 2013-10-22 Transitions Optical, Inc. Methods for producing photosensitive microparticles
US8563212B2 (en) 2004-07-16 2013-10-22 Transitions Optical, Inc. Methods for producing photosensitive microparticles, non-aqueous dispersions thereof and articles prepared therewith
US8153344B2 (en) * 2004-07-16 2012-04-10 Ppg Industries Ohio, Inc. Methods for producing photosensitive microparticles, aqueous compositions thereof and articles prepared therewith
US7848889B2 (en) 2004-08-02 2010-12-07 Bioarray Solutions, Ltd. Automated analysis of multiplexed probe-target interaction patterns: pattern matching and allele identification
JP4811565B2 (ja) * 2005-03-31 2011-11-09 Ｊｓｒ株式会社 多孔質表面を有する磁性粒子およびその製造方法、生化学用担体、ならびにビオチン類結合用粒子
US8486629B2 (en) 2005-06-01 2013-07-16 Bioarray Solutions, Ltd. Creation of functionalized microparticle libraries by oligonucleotide ligation or elongation
FR2894970B1 (fr) * 2005-12-15 2008-01-25 Biomerieux Sa Procede de preparation de particules composites, particules composites obtenues et leur utilisation dans un test diagnostic
WO2007110917A1 (ja) 2006-03-27 2007-10-04 Tokyo Institute Of Technology ポリマー被覆強磁性粒子の製造方法及びポリマー被覆強磁性粒子
TWI322793B (en) * 2006-10-02 2010-04-01 Chung Cheng Inst Of Technology Nat Defense University Functionalized magnetizable microspheres and preparation thereof
US7981688B2 (en) * 2007-03-08 2011-07-19 University Of Washington Stimuli-responsive magnetic nanoparticles and related methods
US8426214B2 (en) * 2009-06-12 2013-04-23 University Of Washington System and method for magnetically concentrating and detecting biomarkers
US20110117668A1 (en) * 2009-11-09 2011-05-19 University Of Washington Through Its Center For Commercialization Self-powered smart diagnostic devices
US9080933B2 (en) 2009-11-09 2015-07-14 University Of Washington Through Its Center For Commercialization Stimuli-responsive polymer diagnostic assay comprising magnetic nanoparticles and capture conjugates
US8747677B2 (en) 2010-04-09 2014-06-10 Luminex Corporation Magnetic separation device
ES2648899T3 (es) 2011-12-09 2018-01-08 Institut Pasteur Inmunoensayo de cribado múltiplex
EP2961386B1 (en) 2013-02-28 2019-07-10 The General Hospital Corporation Mirna profiling compositions and methods of use
WO2015095398A1 (en) * 2013-12-17 2015-06-25 Kevin Hagedorn Method and apparatus for manufacturing isotropic magnetic nanocolloids
CN105126714B (zh) * 2015-08-05 2020-04-14 浙江东方基因生物制品股份有限公司 一种功能性纳米颗粒复合微球及其制备与应用
CA3033911A1 (en) 2016-08-26 2018-03-01 Juno Therapeutics, Inc. Methods of enumerating particles present in a cell composition
MX2020000900A (es) 2017-07-29 2021-01-08 Juno Therapeutics Inc Reactivos para expandir celulas que expresan receptores recombinantes.
KR20200136409A (ko) 2018-02-28 2020-12-07 주노 쎄러퓨티크스 인코퍼레이티드 세포 조성물에 존재하는 입자를 검출하는 방법
US20200041518A1 (en) 2018-08-03 2020-02-06 CellMax Life, Inc. Lipid vesicle-coated magnetic beads and uses of the same
WO2022020234A2 (en) * 2020-07-20 2022-01-27 Bio-Rad Laboratories, Inc. Immunoassay for sars-cov-2 neutralizing antibodies and materials therefor
EP4314814A1 (en) 2021-03-22 2024-02-07 Juno Therapeutics, Inc. Methods of determining potency of a therapeutic cell composition
JP2024511420A (ja) 2021-03-22 2024-03-13 ジュノー セラピューティクス インコーポレイテッド ウイルスベクター粒子の効力を評価する方法

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3228881A (en) * 1963-01-04 1966-01-11 Chevron Res Dispersions of discrete particles of ferromagnetic metals
US3714102A (en) * 1970-12-02 1973-01-30 Gulf Oil Canada Ltd Polymer encapsulation of finely divided solids
US3843540A (en) * 1972-07-26 1974-10-22 Us Interior Production of magnetic fluids by peptization techniques
IT1145696B (it) * 1979-08-24 1986-11-05 Rhone Poulenc Ind Procedimento di preparazione di perle magnetiche di polimeri vinilaromatici
FR2480764B1 (fr) * 1980-04-18 1985-10-04 Rhone Poulenc Spec Chim Latex de polymeres magnetiques et procede de preparation
US4421660A (en) * 1980-12-15 1983-12-20 The Dow Chemical Company Colloidal size hydrophobic polymers particulate having discrete particles of an inorganic material dispersed therein
US4454234A (en) * 1981-12-30 1984-06-12 Czerlinski George H Coated magnetizable microparticles, reversible suspensions thereof, and processes relating thereto
US4695392A (en) * 1983-05-12 1987-09-22 Advanced Magnetics Inc. Magnetic particles for use in separations
JPS59221302A (ja) * 1983-05-31 1984-12-12 Japan Synthetic Rubber Co Ltd 磁性重合体粒子の製造方法
EP0156537A3 (en) * 1984-03-02 1987-05-13 Board Of Regents University Of Texas System Biological magnetic fluids
US4680200A (en) * 1985-07-22 1987-07-14 The Dow Chemical Company Method for preparing colloidal size particulate
FR2613372B1 (fr) * 1987-04-03 1989-06-09 Rhone Poulenc Chimie Particules composites polymere/metal compactes, dispersions aqueuses desdites particules, leur procede de preparation et leur application en biologie
JPS63305149A (ja) * 1987-06-05 1988-12-13 Mitsubishi Kasei Corp 磁性を有する多孔質架橋共重合体粒子およびその製造方法
FR2618084B1 (fr) * 1987-07-15 1989-11-10 Rhone Poulenc Chimie Microspheres magnetisables a base de polysiloxane, leur procede de preparation et leur application en biologie
FR2624873B1 (fr) * 1987-12-18 1992-01-10 Rhone Poulenc Chimie Particules composites magnetisables a base d'organopolysiloxane reticule, leur procede de preparation et leur application en biologie

Also Published As

Publication number Publication date
JPH02286729A (ja) 1990-11-26
ES2072996T3 (es) 1995-08-01
NO178376C (no) 1996-03-13
NO901440D0 (no) 1990-03-29
FR2645160B1 (US06515009-20030204-C00004.png) 1992-10-02
EP0390634B1 (fr) 1995-05-17
US5356713A (en) 1994-10-18
NO901440L (no) 1990-10-01
ATE122704T1 (de) 1995-06-15
EP0390634A1 (fr) 1990-10-03
FR2645160A1 (US06515009-20030204-C00004.png) 1990-10-05
FI901628A0 (fi) 1990-03-30
JP2623358B2 (ja) 1997-06-25
CA2013459A1 (fr) 1990-09-30
AU5239690A (en) 1990-10-04
DE69019411D1 (de) 1995-06-22
NO178376B (no) 1995-12-04
IL93947A0 (en) 1990-12-23

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