DE69018092D1 - Aerosolzubereitung von glutathion und verfahren zur erhöhung des glutathionspiegels in der lunge. - Google Patents

Aerosolzubereitung von glutathion und verfahren zur erhöhung des glutathionspiegels in der lunge.

Info

Publication number
DE69018092D1
DE69018092D1 DE69018092T DE69018092T DE69018092D1 DE 69018092 D1 DE69018092 D1 DE 69018092D1 DE 69018092 T DE69018092 T DE 69018092T DE 69018092 T DE69018092 T DE 69018092T DE 69018092 D1 DE69018092 D1 DE 69018092D1
Authority
DE
Germany
Prior art keywords
glutathion
level
lung
increasing
aerosol preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69018092T
Other languages
English (en)
Other versions
DE69018092T2 (de
Inventor
Ronald Crystal
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
US Department of Health and Human Services
US Department of Commerce
Original Assignee
US Department of Health and Human Services
US Department of Commerce
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by US Department of Health and Human Services, US Department of Commerce filed Critical US Department of Health and Human Services
Publication of DE69018092D1 publication Critical patent/DE69018092D1/de
Application granted granted Critical
Publication of DE69018092T2 publication Critical patent/DE69018092T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/0078—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a nebulizer such as a jet nebulizer, ultrasonic nebulizer, e.g. in the form of aqueous drug solutions or dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/06—Tripeptides
    • A61K38/063—Glutathione
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Pulmonology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Dispersion Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Otolaryngology (AREA)
  • Immunology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
DE69018092T 1989-11-24 1990-11-23 Aerosolzubereitung von glutathion und verfahren zur erhöhung des glutathionspiegels in der lunge. Expired - Lifetime DE69018092T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/441,521 US5238683A (en) 1989-11-24 1989-11-24 Aerosol preparation of glutathione and a method for augmenting glutathione level in lungs
PCT/US1990/006825 WO1991007997A1 (en) 1989-11-24 1990-11-23 An aerosol preparation of glutathione and a method for augmenting glutathione level in lungs

Publications (2)

Publication Number Publication Date
DE69018092D1 true DE69018092D1 (de) 1995-04-27
DE69018092T2 DE69018092T2 (de) 1995-07-27

Family

ID=23753204

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69018092T Expired - Lifetime DE69018092T2 (de) 1989-11-24 1990-11-23 Aerosolzubereitung von glutathion und verfahren zur erhöhung des glutathionspiegels in der lunge.

Country Status (11)

Country Link
US (2) US5238683A (de)
EP (1) EP0502054B1 (de)
JP (1) JPH0669957B2 (de)
AT (1) ATE120087T1 (de)
AU (1) AU631711B2 (de)
CA (1) CA2069440A1 (de)
DE (1) DE69018092T2 (de)
DK (1) DK0502054T3 (de)
ES (1) ES2069755T3 (de)
GR (1) GR3015530T3 (de)
WO (1) WO1991007997A1 (de)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6030950A (en) * 1987-07-09 2000-02-29 Ohlenschlaeger; Gerhard Pharmaceutical therapeutic use of glutathione derivative
USRE36460E (en) * 1990-10-10 1999-12-21 Life Science Holdings, Inc. Method of providing circulation via lung expansion and deflation
US5653685A (en) * 1990-10-10 1997-08-05 Lrt, Inc. Method of providing circulation via lung expansion and deflation
US6180596B1 (en) 1995-05-18 2001-01-30 Wisconsin Alumni Research Foundation Methods of inhibiting phospholipase A2 and phospholipase A2 stimulator activities
US5658877A (en) * 1995-05-18 1997-08-19 Wisconsin Alumni Research Foundation Method to treat endotoxin effects by administration of 33 kilodalton phospholipid binding protein
AU713362B2 (en) * 1996-03-08 1999-12-02 Life Resuscitation Technologies, Inc. Liquid ventilation method and apparatus
EP0957901B1 (de) 1996-12-31 2009-11-18 Antioxidant Pharmaceuticals Corporation Pharmazeutische glutathionpräparate und methoden zu dern verabreichung
US6896899B2 (en) * 1996-12-31 2005-05-24 Antioxidant Pharmaceuticals Corp. Pharmaceutical preparations of glutathione and methods of administration thereof
ATE444760T1 (de) * 1997-01-13 2009-10-15 Univ Emory Glutathion zur behandlung von influenzainfektionen
KR100585242B1 (ko) * 1998-06-23 2006-12-05 교와 핫꼬 고교 가부시끼가이샤 인플루엔자감염증치료용화합물및조성물
DE60112741T2 (de) 2000-05-02 2006-06-01 F. Hoffmann-La Roche Ag Gamma-selektive retinoide
US7179791B2 (en) * 2001-01-11 2007-02-20 Duke University Inhibiting GS-FDH to modulate NO bioactivity
US7790762B2 (en) * 2002-10-31 2010-09-07 National Jewish Health Compounds and methods for thiol-containing compound efflux and cancer treatment
US20080221029A1 (en) * 2002-10-31 2008-09-11 Regents Of The University Of Colorado Methods for treatment of thiol-containing compound deficient conditions
US20040087527A1 (en) * 2002-10-31 2004-05-06 Day Brian J. Methods for treatment of thiol-containing compound deficient conditions
ES2395555T3 (es) * 2004-11-07 2013-02-13 Your Energy Systems, LLC Formulación liposomal para la administración oral de glutatión (reducido)
US20090068253A1 (en) * 2005-09-06 2009-03-12 Guilford F Timothy Method for the treatment of infection with hhv-6 virus and the amelioration of symptoms related to virus using liposomal encapsulation for delivery of reduced glutathione
CA2925546C (en) 2012-10-29 2022-06-14 The University Of North Carolina At Chapel Hill Methods and compositions for treating mucosal tissue disorders
EP2956153A4 (de) * 2013-02-15 2017-03-22 Your Energy Systems, LLC Behandlung von klebsiella-pneumoniae-vermittelten krankheiten mit sich entwickelnder antibakterieller resistenz mithilfe von liposomal formuliertem glutathion
MX2019005751A (es) 2016-11-17 2019-11-12 Renovion Inc Tratamiento de enfermedades e infecciones de las vias respiratorias con composiciones de acido ascorbico.
AU2018367674A1 (en) 2017-11-17 2020-06-04 Renovion, Inc. Stable ascorbic acid compositions and methods of using the same
US10722465B1 (en) 2017-12-08 2020-07-28 Quicksilber Scientific, Inc. Transparent colloidal vitamin supplement
US11344497B1 (en) 2017-12-08 2022-05-31 Quicksilver Scientific, Inc. Mitochondrial performance enhancement nanoemulsion
US11291702B1 (en) 2019-04-15 2022-04-05 Quicksilver Scientific, Inc. Liver activation nanoemulsion, solid binding composition, and toxin excretion enhancement method
IT202000009553A1 (it) 2020-04-30 2021-10-30 Innbiotec Pharma S R L Composizione farmaceutica di derivati del glutatione per l’uso nel trattamento di sindromi respiratorie
CN113252896B (zh) * 2021-05-13 2022-08-09 四川大学华西医院 一款利用肺泡灌洗液中nd1预测急性呼吸窘迫综合征预后的试剂盒
MX2024008001A (es) 2022-01-04 2024-07-12 Renovion Inc Solucion acuosa que comprende una sal de glutation.

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA909679A (en) * 1972-09-12 Calbiochem Process of and composition for mucolysis
BE788945A (de) * 1971-09-20 1973-03-19 Oreal
US4424216A (en) * 1979-07-31 1984-01-03 The Rockefeller University Method for the reduction of mucin viscosity
DK283180A (da) * 1980-07-01 1982-01-02 Novo Industri As Polypeptider og derivater deraf
US4513005A (en) * 1981-06-18 1985-04-23 Lilly Industries Limited SRS-A antagonists
IT1176983B (it) * 1984-10-16 1987-08-26 Zambon Spa Dipeptidi ad attivita' farmacologica
GB8505285D0 (en) * 1985-03-01 1985-04-03 Beecham Group Plc Compounds
US4710489A (en) * 1985-04-22 1987-12-01 Cornell Research Foundation, Inc. Glutathione delivery system
DE3872635T2 (de) * 1987-04-09 1992-12-17 Fisons Plc Pentamidin enthaltende pharmazeutische zusammensetzungen.

Also Published As

Publication number Publication date
CA2069440A1 (en) 1991-05-25
JPH05501263A (ja) 1993-03-11
AU6885791A (en) 1991-06-26
WO1991007997A1 (en) 1991-06-13
AU631711B2 (en) 1992-12-03
EP0502054A1 (de) 1992-09-09
EP0502054A4 (en) 1993-02-24
US5238683A (en) 1993-08-24
ATE120087T1 (de) 1995-04-15
US5989521A (en) 1999-11-23
JPH0669957B2 (ja) 1994-09-07
ES2069755T3 (es) 1995-05-16
EP0502054B1 (de) 1995-03-22
DE69018092T2 (de) 1995-07-27
DK0502054T3 (da) 1995-06-06
GR3015530T3 (en) 1995-06-30

Similar Documents

Publication Publication Date Title
DE69018092D1 (de) Aerosolzubereitung von glutathion und verfahren zur erhöhung des glutathionspiegels in der lunge.
GR3019901T3 (en) Osteoinductive pharmaceutical formulations
DK1025124T3 (da) Human interferon-alfa-analoge med lav toksicitet
ATE212854T1 (de) Verfahren zur behandlung von festhaltenden lungensekreten
DE68922427D1 (de) Verfahren zur Zurückgewinnung von sauerstoffreichem Gas.
DE3888205D1 (de) Verfahren zur behandlung von lungenaffektionen und zubereitungen dafür.
BG100974A (en) Vaccines against papillomavirus
EP0652011A4 (de) Prophylaktisches mittel und arzneimittel für virale erkrankungen der atemwege.
DE59706180D1 (de) Verfahren zur herstellung von pulverförmigen lungensurfactant-zubereitungen
DK0673948T3 (da) Peptider, der stammer fra et retrovirus fra HIV-gruppen, og deres anvendelse
DE69131929D1 (de) Methoden zur trans-destabilisierung von spezifischen proteinen in vivo
ATE164065T1 (de) Neues verfahren zur behandlung von depression
DE69421120D1 (de) Verfahren zur Unterdrückung des bitteren Geschmacks von oralen Präparaten
DK610888D0 (da) Cardiodilatinfragmentet, fremgangsmaade til fremstilling deraf samt dets anvendelse
DE69332654D1 (de) Fragmente eines oberflächenaktiven lungenproteins
DK0551077T3 (da) Anvendelse af humant atrialt natriuretisk peptid til fremstilling af farmaceutiske præparater til behandling af akut lungeb
DE68918246D1 (de) Verbindungen zur Verhinderung von Thrombose.
EP0257312A3 (de) Vom Knorpel abstammende Leukozytenelastase hemmende Substanz
ES557463A0 (es) Procedimiento de preparar proteinas.
NO912271L (no) Somatostatinpreparater, deres fremstilling og anvendelse.
DE69103473D1 (de) Verfahren zur Herstellung von 1-Chlor-1,2,2-trifluorethylen oder von 1,2,2-trifluorethylen.
DE69429812D1 (de) Niedermolekulare dna aus störmilch, methode zur gewinnung der dna und ein pharmazeutisches präparat darauf basierend
DE3875359D1 (de) Dipeptide, verfahren zur herstellung und verwendung in der bestimmung von proteasen.
DE69607524D1 (de) Verfahren zur Herstellung von einem Bicyclohexanderivat
DK76191D0 (da) Filamentoest haemagglutinin fra b.pertussis

Legal Events

Date Code Title Description
8364 No opposition during term of opposition