DE69013689T2 - Subcarrier for direct pressing. - Google Patents

Subcarrier for direct pressing.

Info

Publication number
DE69013689T2
DE69013689T2 DE69013689T DE69013689T DE69013689T2 DE 69013689 T2 DE69013689 T2 DE 69013689T2 DE 69013689 T DE69013689 T DE 69013689T DE 69013689 T DE69013689 T DE 69013689T DE 69013689 T2 DE69013689 T2 DE 69013689T2
Authority
DE
Germany
Prior art keywords
direct tabletting
weight
intimate mixture
tabletting auxiliary
calcium
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69013689T
Other languages
German (de)
Other versions
DE69013689D1 (en
Inventor
Siegfried Dr Lang
Ta-Shuong Yeh
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
WEI MING PHARMACEUTICAL Manufacturing CO
Original Assignee
WEI MING PHARMACEUTICAL Manufacturing CO
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by WEI MING PHARMACEUTICAL Manufacturing CO filed Critical WEI MING PHARMACEUTICAL Manufacturing CO
Publication of DE69013689D1 publication Critical patent/DE69013689D1/en
Application granted granted Critical
Publication of DE69013689T2 publication Critical patent/DE69013689T2/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2009—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2059—Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin

Abstract

A direct tabletting auxiliary contains, in an intimate mixture, the essential components A) from 60 to 98% by weight, based on the direct tabletting auxiliary, of microcrystalline cellulose, cornstarch, mannitol, lactose, sorbitol, cellulose powder, calcium sulfate, calciuöm phosphate, calcium carbonate, sodium starch glycolate or calcium carboxymethyl cellulose, B) from 2 to 40% by weight, based on the direct tabletting auxiliary, of a binder selected from the group comprising hydroxypropylmethylcellulose, hydroxypropylcellulose, hydroxyethylcellulose, methylcellulose, pregelatinized starch maltodextrin, polyvinylpyrrolidone, gelatin and alpha -, beta - or gamma -cyclodextrin, where the intimate mixture of A and B has been produced in the presence of water using a wet mixing process and simultaneous or subsequent drying. t
DE69013689T 1990-11-29 1990-11-29 Subcarrier for direct pressing. Expired - Fee Related DE69013689T2 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP90122804A EP0487774B1 (en) 1990-11-29 1990-11-29 A direct tabletting auxiliary

Publications (2)

Publication Number Publication Date
DE69013689D1 DE69013689D1 (en) 1994-12-01
DE69013689T2 true DE69013689T2 (en) 1995-03-02

Family

ID=8204768

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69013689T Expired - Fee Related DE69013689T2 (en) 1990-11-29 1990-11-29 Subcarrier for direct pressing.

Country Status (6)

Country Link
EP (1) EP0487774B1 (en)
AT (1) ATE113202T1 (en)
DE (1) DE69013689T2 (en)
DK (1) DK0487774T3 (en)
ES (1) ES2066092T3 (en)
TW (1) TW221279B (en)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4318577A1 (en) * 1993-06-04 1994-12-08 Merck Patent Gmbh Lubricant-free, medicament-containing tablets
DK0701449T3 (en) * 1993-06-08 2003-11-10 Novartis Ag Process for the preparation of an oral solid dosage form containing diclofenac
FR2710637B1 (en) * 1993-09-28 1995-12-08 Roquette Freres Mannitol powder of moderate friability and its preparation process.
CA2159419C (en) * 1994-10-17 2006-07-04 Pieter De Haan Solid pharmaceutical composition comprising an excipient capable of binding water
ES2079327B1 (en) * 1994-12-13 1996-08-01 Lilly Sa PHARMACEUTICAL FORMULATIONS OF CEFACLOR.
FR2766710B1 (en) * 1997-08-04 1999-10-29 Inst Pharma De Rech Applic Et PHARMACEUTICAL COMPOSITION, TABLET FORMED THEREFROM AND USE THEREOF AS LONG-ACTING VAGINAL ANTISEPTIC
GB9716432D0 (en) * 1997-08-05 1997-10-08 Cerestar Holding Bv Tableting of erythritol
AR016827A1 (en) 1997-08-22 2001-08-01 Smithkline Beecham Corp PROCEDURE FOR THE PREPARATION OF A PHARMACEUTICAL TABLET
AR017512A1 (en) 1997-08-22 2001-09-12 Smithkline Beecham Corp TABLETS OF QUICKLY DISPOSABLE METILCELLULOSE FOR ORAL ROUTE ADMINISTRATION AND PROCEDURE TO PREPARE THEM
AU5904698A (en) * 1997-12-29 1999-07-19 Procter & Gamble Company, The Tablet composition
GB9825033D0 (en) 1998-11-13 1999-01-13 Nycomed Pharma As Process
EP1133984B1 (en) * 2000-03-17 2005-05-11 Shin-Etsu Chemical Co., Ltd. Solid preparation containing low-substituted hydroxypropyl cellulose and production process thereof
US6242003B1 (en) 2000-04-13 2001-06-05 Novartis Ag Organic compounds
US20060127474A1 (en) 2001-04-11 2006-06-15 Oskar Kalb Pharmaceutical compositions comprising fluvastatin
US6761905B2 (en) * 2001-05-01 2004-07-13 Wei Ming Pharmaceutical Mfg. Co., Ltd. Process for the preparation of direct tabletting formulations and aids
FR2826549A1 (en) * 2001-06-28 2003-01-03 Roquette Freres PROCESS FOR THE PREPARATION OF A COMPRESSED EDULCORANT TABLET AND A COMPRESSED EDULCORANT THUS OBTAINED
AUPS244002A0 (en) 2002-05-20 2002-06-13 John Kohnke Products Pty Ltd Agent delivery system
US20040109889A1 (en) 2002-12-04 2004-06-10 Bunick Frank J. Surface treatment composition for soft substrates
CN101098678A (en) 2004-04-23 2008-01-02 锡德克斯公司 Dpi formulation containing sulfoalkyl ether cyclodextrin
CN103479582A (en) 2005-02-03 2014-01-01 武田奈科明有限公司 Fast wet-massing method for the preparation of calcium-containing compositions
MX2007010519A (en) * 2005-03-04 2008-01-18 Nycomed Pharma As Process for the production of calcium compositions in a continuous fluid bed.
AU2006272978B2 (en) 2005-07-26 2012-06-07 Bial - Portela & Ca, S.A. Nitrocatechol derivatives as COMT inhibitors
US7629331B2 (en) 2005-10-26 2009-12-08 Cydex Pharmaceuticals, Inc. Sulfoalkyl ether cyclodextrin compositions and methods of preparation thereof
EP1845097A1 (en) * 2006-04-10 2007-10-17 Portela & Ca., S.A. Oxadiazole derivatives as COMT inhibitors
RU2518483C2 (en) 2007-01-31 2014-06-10 Биал-Портела Энд Ка, С.А. Comt inhibitor dosage regimen
DE102008014237A1 (en) * 2008-03-14 2009-09-17 J. Rettenmaier & Söhne Gmbh + Co. Kg Directly compressible tableting aid
JP2011514380A (en) 2008-03-17 2011-05-06 バイアル−ポルテラ アンド シーエー，エス．エー． 5- [3- (2,5-dichloro-4,6-dimethyl-1-oxy-pyridin-3-yl) [1,2,4] oxadiazol-5-yl] -3-nitrobenzene-1, 2-Diol crystal form
BRPI1014865B1 (en) 2009-04-01 2020-03-17 Bial - Portela & C.A., S.A. Composition comprising granules comprising 2,5-dichloro-3- (5- (3,4-dihydroxy-5-nitrophenyl) - 1,2,4-oxadiazol-3-yl) - 4,6-dimethylpyridine 1-oxide and pharmaceutical formulation
US20140045900A1 (en) 2011-02-11 2014-02-13 Bial-Portela & Ca, S.A. Administration regime for nitrocatechols
SI2791134T1 (en) 2011-12-13 2020-01-31 Bial - Portela & Ca S.A. Chemical compound useful as intermediate for preparing a catechol-o-methyltransferase inhibitor
AR086505A1 (en) 2012-05-21 2013-12-18 Consejo Nac Invest Cient Tec A CO-PROCESSED EXCIPIENT, OBTAINED BY DRYING ATOMIZATION, USED AS A PHARMACEUTICAL EXCIPIENT OR FOOD ADDITIVE
RU2017120184A (en) 2014-11-28 2018-12-28 БИАЛ - ПОРТЕЛА ЭНД Ка, С.А. DRUGS TO DELAY THE COURSE OF PARKINSON'S DISEASE
CN112076166A (en) * 2020-09-21 2020-12-15 湖州展望药业有限公司 Direct-pressed starch and production method thereof

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3337802A1 (en) 1983-10-18 1985-04-25 Merck Patent Gmbh, 6100 Darmstadt PHARMACEUTICAL PREPARATION
DE3505433A1 (en) * 1985-02-16 1986-08-21 Basf Ag, 6700 Ludwigshafen DIRECT TABLETING AIDS
CA1325707C (en) 1986-10-31 1994-01-04 Chihang Raymond Chu Granular tricalcium phosphate compositions suitable for direct compression tableting

Also Published As

Publication number Publication date
DE69013689D1 (en) 1994-12-01
TW221279B (en) 1994-02-21
EP0487774B1 (en) 1994-10-26
ATE113202T1 (en) 1994-11-15
EP0487774A1 (en) 1992-06-03
DK0487774T3 (en) 1994-11-21
ES2066092T3 (en) 1995-03-01

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee