DE69004964T2 - Zellenzuchtverfahren für die produktion von aktiviertem protein-c. - Google Patents

Zellenzuchtverfahren für die produktion von aktiviertem protein-c.

Info

Publication number
DE69004964T2
DE69004964T2 DE90912701T DE69004964T DE69004964T2 DE 69004964 T2 DE69004964 T2 DE 69004964T2 DE 90912701 T DE90912701 T DE 90912701T DE 69004964 T DE69004964 T DE 69004964T DE 69004964 T2 DE69004964 T2 DE 69004964T2
Authority
DE
Germany
Prior art keywords
activated protein
production
growing process
cell growing
cells
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE90912701T
Other languages
English (en)
Other versions
DE69004964D1 (de
Inventor
Anur Kumar
Donald Foster
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Zymogenetics Inc
Original Assignee
Zymogenetics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zymogenetics Inc filed Critical Zymogenetics Inc
Publication of DE69004964D1 publication Critical patent/DE69004964D1/de
Application granted granted Critical
Publication of DE69004964T2 publication Critical patent/DE69004964T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6464—Protein C (3.4.21.69)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21069—Protein C activated (3.4.21.69)

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
DE90912701T 1989-08-11 1990-08-07 Zellenzuchtverfahren für die produktion von aktiviertem protein-c. Expired - Fee Related DE69004964T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US39286189A 1989-08-11 1989-08-11
PCT/US1990/004419 WO1991002065A1 (en) 1989-08-11 1990-08-07 Cell culture methods for producing activated protein c

Publications (2)

Publication Number Publication Date
DE69004964D1 DE69004964D1 (de) 1994-01-13
DE69004964T2 true DE69004964T2 (de) 1994-03-24

Family

ID=23552314

Family Applications (1)

Application Number Title Priority Date Filing Date
DE90912701T Expired - Fee Related DE69004964T2 (de) 1989-08-11 1990-08-07 Zellenzuchtverfahren für die produktion von aktiviertem protein-c.

Country Status (10)

Country Link
EP (1) EP0485504B1 (de)
JP (1) JP3045307B2 (de)
AT (1) ATE97958T1 (de)
AU (1) AU6295390A (de)
CA (1) CA2064774C (de)
DE (1) DE69004964T2 (de)
DK (1) DK0485504T3 (de)
ES (1) ES2047946T3 (de)
IE (1) IE66340B1 (de)
WO (1) WO1991002065A1 (de)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1991009960A1 (en) * 1989-12-29 1991-07-11 Zymogenetics, Inc. Hybrid protein c
US5618714A (en) * 1993-12-15 1997-04-08 Eli Lilly And Company Methods for producing protein C
DE19710190A1 (de) * 1997-03-12 1998-09-17 Immuno Ag Aktivierter Vitamin K-abhängiger Blutfaktor und Verfahren zu dessen Herstellung
GB9810999D0 (en) * 1998-05-21 1998-07-22 Goken Joop Materials and methods relating to the expression of genes

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0215548B2 (de) * 1985-06-27 1998-01-07 Zymogenetics, Inc. Expression von Protein C
US4959318A (en) * 1985-06-27 1990-09-25 Zymogenetics, Inc. Expression of protein C
EP0238551A4 (de) * 1985-09-06 1988-02-01 Codon Wiedergewinnungsverfahren von gewebeplasminogen-aktivator.
EP0254076B1 (de) * 1986-07-11 1991-05-08 Miles Inc. Herstellung von rekombinantem Protein
JPH0387173A (ja) * 1987-09-10 1991-04-11 Teijin Ltd ヒト活性化天然型ファクター８ｃの製造方法及びそれに用いる形質転換体
US4992373A (en) * 1987-12-04 1991-02-12 Eli Lilly And Company Vectors and compounds for direct expression of activated human protein C

Also Published As

Publication number Publication date
ES2047946T3 (es) 1994-03-01
WO1991002065A1 (en) 1991-02-21
JPH04507347A (ja) 1992-12-24
EP0485504B1 (de) 1993-12-01
EP0485504A1 (de) 1992-05-20
DK0485504T3 (da) 1994-04-18
ATE97958T1 (de) 1993-12-15
IE66340B1 (en) 1995-12-27
AU6295390A (en) 1991-03-11
CA2064774A1 (en) 1991-02-12
DE69004964D1 (de) 1994-01-13
CA2064774C (en) 2000-01-11
JP3045307B2 (ja) 2000-05-29
IE902912A1 (en) 1991-02-27

Similar Documents

Publication Publication Date Title
ATE406435T1 (de) Methoden zur züchtung von tierzellen
NO975674L (no) Fremgangsmåte for å regulere sialyleringen av proteiner fremstilt av pattedyrceller i kultur
DE3889665T2 (de) Serumfreie wachstumsmedien für insektenzellen und expression von produkten damit.
ATE123295T1 (de) Rezeptor-proteine für humanen b-zellen stimulierenden faktor 2.
EP0474790A4 (en) Media for cell growth and method for making them
HUT46362A (en) Process for the enhancement of the production of a/16686 antibiotic complex and for the selective increase of the proportion of certain components of the complex
EP0649900A3 (de) Verfahren zur Herstellung von Proteinen.
ES8403524A1 (es) Un procedimiento para obtener s-adenosil-metionina.
DE69004964T2 (de) Zellenzuchtverfahren für die produktion von aktiviertem protein-c.
EP0241578A3 (de) Verfahren zur In-vitro-Reproduzierung von Knochenmark
ES8105384A1 (es) Procedimiento para la produccion de un material de proteina unicelular
DE69425809T2 (de) Methoden zur Herstellung von Protein C
HUT46360A (en) Process for producing proteins
DE69939876D1 (de) Methoden zur massenkultivierung von zellen die rekombinantes menschliches erythropoietin produzieren
DE69116240T2 (de) Verfahren zur Herstellung von Zellprotein mit Anti-HIV-Wirkung
ATE115183T1 (de) Zellzüchtungsverfahren.
CA2058785A1 (en) Method of producing proteins with fviii activity and/or fviii derivatives
JPS6486895A (en) Production of 3',5'-cyclicadenylic acid
HUT53935A (en) Process for producing plasminogene activator from cells cultured in lectin containing culture medium
SU1692145A1 (ru) Способ получения клеточной культуры
KR850001803A (ko) 펩티드(peptide)의 제조방법

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee