DE68928705D1 - Technetium-99m-komplex zur untersuchung der nierenfunktion - Google Patents

Technetium-99m-komplex zur untersuchung der nierenfunktion

Info

Publication number
DE68928705D1
DE68928705D1 DE68928705T DE68928705T DE68928705D1 DE 68928705 D1 DE68928705 D1 DE 68928705D1 DE 68928705 T DE68928705 T DE 68928705T DE 68928705 T DE68928705 T DE 68928705T DE 68928705 D1 DE68928705 D1 DE 68928705D1
Authority
DE
Germany
Prior art keywords
acooh
symbols
complex
technetium
unsubstituted
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE68928705T
Other languages
English (en)
Other versions
DE68928705T2 (de
Inventor
Dennis Nosco
Alfons Verbruggen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Mallinckrodt Inc
Original Assignee
Mallinckrodt Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mallinckrodt Inc filed Critical Mallinckrodt Inc
Application granted granted Critical
Publication of DE68928705D1 publication Critical patent/DE68928705D1/de
Publication of DE68928705T2 publication Critical patent/DE68928705T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F13/00—Compounds containing elements of Groups 7 or 17 of the Periodic Table
    • C07F13/005—Compounds without a metal-carbon linkage
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0474—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group
    • A61K51/0478—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group complexes from non-cyclic ligands, e.g. EDTA, MAG3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2123/00—Preparations for testing in vivo

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Physics & Mathematics (AREA)
  • Medicinal Chemistry (AREA)
  • Optics & Photonics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • External Artificial Organs (AREA)
DE68928705T 1988-11-16 1989-11-16 Technetium-99m-komplex zur untersuchung der nierenfunktion Expired - Fee Related DE68928705T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/272,177 US4925650A (en) 1988-11-16 1988-11-16 Technetium -99m complex for examining the renal function
PCT/US1989/005132 WO1990005733A1 (en) 1988-11-16 1989-11-16 TECHNETIUM-99m COMPLEX FOR EXAMINING THE RENAL FUNCTION

Publications (2)

Publication Number Publication Date
DE68928705D1 true DE68928705D1 (de) 1998-07-16
DE68928705T2 DE68928705T2 (de) 1998-10-15

Family

ID=23038736

Family Applications (1)

Application Number Title Priority Date Filing Date
DE68928705T Expired - Fee Related DE68928705T2 (de) 1988-11-16 1989-11-16 Technetium-99m-komplex zur untersuchung der nierenfunktion

Country Status (9)

Country Link
US (1) US4925650A (de)
EP (1) EP0444130B1 (de)
JP (1) JP3129431B2 (de)
AT (1) ATE167188T1 (de)
AU (1) AU629880B2 (de)
CA (1) CA2002850C (de)
DE (1) DE68928705T2 (de)
IL (3) IL92211A (de)
WO (1) WO1990005733A1 (de)

Families Citing this family (45)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4980147A (en) * 1984-06-25 1990-12-25 University Of Utah Research Foundation Radiolabeled technetium chelates for use in renal function determinations
US5071636A (en) * 1987-12-29 1991-12-10 Nihon Medi-Physics Co., Ltd. Chelating compounds and their use
US5164176A (en) * 1989-06-16 1992-11-17 Neorx Corporation Radionuclide metal chelates for the radiolabeling of proteins
AU645258B2 (en) * 1989-06-16 1994-01-13 Neorx Corporation Radionuclide metal chelates for the radiolabeling of proteins
US5250666A (en) * 1989-06-16 1993-10-05 Neorx Corporation Radionuclide metal chelates for the radiolabeling of proteins
EP0639082B1 (de) * 1990-04-17 1998-09-09 Mallinckrodt Medical, Inc. Methode und reagentien um technetium-99m-komplexe herzustellen
US5143713A (en) * 1990-05-30 1992-09-01 Board Of Regents, The University Of Texas System 99m Tc labeled liposomes
US5158760A (en) * 1990-05-30 1992-10-27 Board Of Regents, The University Of Texas System 99m TC labeled liposomes
US5104638A (en) * 1990-10-29 1992-04-14 Mallinckrodt Medical, Inc. Method of making a radiopharmaceutical complex from a kit
US5037631A (en) * 1990-10-29 1991-08-06 Mallinckrodt Medical, Inc. Technetium-99M complex for examinating the renal function
US5116598A (en) * 1990-10-29 1992-05-26 Mallinckrodt Medical, Inc. N4 technetium-99 m complexes for use as radiopharmaceuticals
JP2860157B2 (ja) * 1990-10-31 1999-02-24 日本メジフィジックス株式会社 腎機能測定用の既放射能標識テクネチウムキレート注射剤の製造方法
US5243073A (en) * 1990-12-14 1993-09-07 Mallinckrodt Medical, Inc. Hexadentate ligands useful in radiographic imaging agents
US5443815A (en) * 1991-11-27 1995-08-22 Diatech, Inc. Technetium-99m labeled peptides for imaging
US5849261A (en) * 1991-02-08 1998-12-15 Diatide, Inc. Radiolabeled vasoactive intestinal peptides for diagnosis and therapy
US7238340B1 (en) 1991-11-27 2007-07-03 Cis Bio International Monoamine, diamide, thiol-containing metal chelating agents
AU1995392A (en) * 1991-05-08 1992-12-21 Mallinckrodt Medical, Inc. Technetium chelates to be used for determining the renal function
US5562894A (en) * 1991-08-09 1996-10-08 Regents Of The University Of California Amino-acyl-type and catecholamine-type contrast agents for MRI
NZ244613A (en) * 1991-10-29 1996-05-28 Bracco International B V Subst A ligand containing a hypoxia-localising moiety, preparation thereof; a kit (optionally multivial) for preparing a metal complex containing the ligand
US5808091A (en) 1991-10-29 1998-09-15 Bracco International B.V. Rhenium and technetium complexes containing a hypoxia localizing moiety
EP0542216A1 (de) * 1991-11-13 1993-05-19 Hoechst Aktiengesellschaft Diaminomercapto (thio)ether als Komplexbildner für in der Nuklearmedizin einsetzbare Nuklide, Verfahren zur Herstellung der Komplexe, sowie Markierungskits, enthaltend diese Komplexe
US5783170A (en) * 1991-11-27 1998-07-21 Diatide, Inc. Peptide-metal chelate conjugates
US5496533A (en) * 1992-07-31 1996-03-05 Australian Nuclear Science & Technology Organisation Rhenium complexes
AU658310B2 (en) * 1992-07-31 1995-04-06 Australian Nuclear Science & Technology Organisation Rhenium complexes
US5688485A (en) * 1992-12-31 1997-11-18 The Dupont Merck Pharmaceutical Company Radiolabelled complexes of ester-substituted diaminethiols
US5879657A (en) * 1993-03-30 1999-03-09 The Dupont Merck Pharmaceutical Company Radiolabeled platelet GPIIb/IIIa receptor antagonists as imaging agents for the diagnosis of thromboembolic disorders
MXPA94002323A (es) * 1993-03-31 2002-06-18 Mallinckrodt Medical Inc Formulaciones radiofarmaceuticas que tienen reductores no estanosos.
EP0618191A1 (de) * 1993-04-02 1994-10-05 AMERSHAM INTERNATIONAL plc Metall-chelatierende Verbindungen
US5464934A (en) * 1993-05-14 1995-11-07 Mallinckrodt Medical, Inc. Metal chelates as spacer compounds in biologically active peptides
US5608110A (en) * 1993-06-15 1997-03-04 Bracco International B.V. Heteroatom-bearing ligands and metal complexes thereof
CA2190727C (en) * 1994-05-19 2006-07-18 Sudhakar Kasina Aromatic amine substituted bridged nitrogen and sulfur donor atom ligands for imaging
WO1996007629A1 (en) * 1994-09-08 1996-03-14 Mallinckrodt Medical, Inc. Technetium chelates to be used for determining the renal function
US5955053A (en) * 1996-05-06 1999-09-21 Emory University Metal chelates as pharmaceutical imaging agents, processes of making such and uses thereof
US5986074A (en) * 1996-05-06 1999-11-16 Emory University Metal chelates as pharmaceutical imaging agents, processes of making such and uses thereof
US5919934A (en) * 1997-02-19 1999-07-06 The George Washington University Compounds, compositions, and methods for cancer imaging and therapy
US6005083A (en) * 1997-03-28 1999-12-21 Neorx Corporation Bridged aromatic substituted amine ligands with donor atoms
US7067111B1 (en) * 1999-10-25 2006-06-27 Board Of Regents, University Of Texas System Ethylenedicysteine (EC)-drug conjugates, compositions and methods for tissue specific disease imaging
KR100784120B1 (ko) * 2000-06-02 2007-12-12 보드 오브 리전츠, 더 유니버시티 오브 텍사스 시스템 에틸렌디시스테인(ｅｃ)-약물 접합체
US7354567B2 (en) * 2002-02-26 2008-04-08 Bio Med Core Incorporation Method of encapsulating metal complex within liposomes
US20050118099A1 (en) * 2003-03-10 2005-06-02 Braslawsky Gary R. Thiol-mediated drug attachment to targeting peptides
US9050378B2 (en) * 2003-12-10 2015-06-09 Board Of Regents, The University Of Texas System N2S2 chelate-targeting ligand conjugates
US7414137B2 (en) 2006-03-23 2008-08-19 Inspire Pharmaceuticals, Inc. Process for the preparation of 3,4-disubstituted-thiazolidin-2-ones
US8758723B2 (en) 2006-04-19 2014-06-24 The Board Of Regents Of The University Of Texas System Compositions and methods for cellular imaging and therapy
US10925977B2 (en) 2006-10-05 2021-02-23 Ceil>Point, LLC Efficient synthesis of chelators for nuclear imaging and radiotherapy: compositions and applications
KR102040476B1 (ko) * 2012-03-26 2019-11-06 보드 오브 리전츠, 더 유니버시티 오브 텍사스 시스템 촬상 및 치료를 위한 에틸렌디시스테인-당 콘쥬게이트의 효율적 합성법

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2810753A (en) * 1954-05-24 1957-10-22 Dow Chemical Co Metal ion chelating agents
US4673562A (en) * 1983-08-19 1987-06-16 The Children's Medical Center Corporation Bisamide bisthiol compounds useful for making technetium radiodiagnostic renal agents
US4670545A (en) * 1984-05-11 1987-06-02 University Patents, Inc. Chelating agents for technetium-99M
CA1336076C (en) * 1985-01-14 1995-06-27 Alan R. Fritzberg Metal radionuclide labeled proteins for diagnosis and therapy
ATE52516T1 (de) * 1986-05-28 1990-05-15 Mallinckrodt Inc Technetiumchelate fuer die bestimmung der nierenfunktion.
US5279811A (en) * 1987-02-18 1994-01-18 The Du Pont Merck Pharmaceutical Company Ester-substituted diaminedithiols and radiolabeled complexes thereof

Also Published As

Publication number Publication date
JPH04505152A (ja) 1992-09-10
AU629880B2 (en) 1992-10-15
EP0444130B1 (de) 1998-06-10
JP3129431B2 (ja) 2001-01-29
CA2002850C (en) 2000-01-25
US4925650A (en) 1990-05-15
IL92211A0 (en) 1990-07-26
WO1990005733A1 (en) 1990-05-31
CA2002850A1 (en) 1990-05-16
AU4648989A (en) 1990-06-12
DE68928705T2 (de) 1998-10-15
IL107560A0 (en) 1994-02-27
EP0444130A1 (de) 1991-09-04
ATE167188T1 (de) 1998-06-15
IL92211A (en) 1995-01-24
IL107560A (en) 1996-11-14

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee