DE68928106T2 - Nachweis, quantifizierung und klassifizierung von ras-proteinen in körperflüssigkeiten und geweben - Google Patents

Nachweis, quantifizierung und klassifizierung von ras-proteinen in körperflüssigkeiten und geweben

Info

Publication number
DE68928106T2
DE68928106T2 DE68928106T DE68928106T DE68928106T2 DE 68928106 T2 DE68928106 T2 DE 68928106T2 DE 68928106 T DE68928106 T DE 68928106T DE 68928106 T DE68928106 T DE 68928106T DE 68928106 T2 DE68928106 T2 DE 68928106T2
Authority
DE
Germany
Prior art keywords
tissues
detection
ras
quantification
classification
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE68928106T
Other languages
English (en)
Other versions
DE68928106D1 (de
Inventor
Walter Carney
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
OSI Pharmaceuticals LLC
Original Assignee
Oncogene Science Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Oncogene Science Inc filed Critical Oncogene Science Inc
Application granted granted Critical
Publication of DE68928106D1 publication Critical patent/DE68928106D1/de
Publication of DE68928106T2 publication Critical patent/DE68928106T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57484—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites
    • G01N33/57488—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites involving compounds identifable in body fluids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/32—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/5748—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving oncogenic proteins
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57484—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites
    • G01N33/57492—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites involving compounds localized on the membrane of tumor or cancer cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Cell Biology (AREA)
  • Oncology (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Analytical Chemistry (AREA)
  • Biotechnology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Food Science & Technology (AREA)
  • Hospice & Palliative Care (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
DE68928106T 1988-04-22 1989-04-20 Nachweis, quantifizierung und klassifizierung von ras-proteinen in körperflüssigkeiten und geweben Expired - Lifetime DE68928106T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US18558288A 1988-04-22 1988-04-22
US33482389A 1989-04-11 1989-04-11
PCT/US1989/001615 WO1989010565A1 (en) 1988-04-22 1989-04-20 Detection, quantitation and classification of ras proteins in body fluids and tissues

Publications (2)

Publication Number Publication Date
DE68928106D1 DE68928106D1 (de) 1997-07-10
DE68928106T2 true DE68928106T2 (de) 1997-12-04

Family

ID=26881267

Family Applications (2)

Application Number Title Priority Date Filing Date
DE68928106T Expired - Lifetime DE68928106T2 (de) 1988-04-22 1989-04-20 Nachweis, quantifizierung und klassifizierung von ras-proteinen in körperflüssigkeiten und geweben
DE1989629511 Expired - Lifetime DE68929511T2 (de) 1988-04-22 1989-04-20 Nachweis, Quantifizierung und Klassifizierung von RAS-Proteinen in Körperflüssigkeiten und Geweben

Family Applications After (1)

Application Number Title Priority Date Filing Date
DE1989629511 Expired - Lifetime DE68929511T2 (de) 1988-04-22 1989-04-20 Nachweis, Quantifizierung und Klassifizierung von RAS-Proteinen in Körperflüssigkeiten und Geweben

Country Status (9)

Country Link
EP (2) EP0411018B1 (de)
JP (1) JPH0816679B2 (de)
AT (2) ATE258686T1 (de)
AU (1) AU634961B2 (de)
CA (1) CA1340368C (de)
DE (2) DE68928106T2 (de)
DK (1) DK254390A (de)
FI (1) FI905189A0 (de)
WO (1) WO1989010565A1 (de)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5028527A (en) * 1988-02-22 1991-07-02 Applied Bio Technology Monoclonal antibodies against activated ras proteins with amino acid mutations at position 13 of the protein
GB9103974D0 (en) * 1991-02-26 1991-04-10 Norsk Hydro As Therapeutically useful peptides or peptide fragments
US6087188A (en) * 1992-11-13 2000-07-11 Alk A/S Two-site immunoassay for an antibody with chemiluminescent label and biotin bound ligand
WO1998021585A1 (en) * 1996-11-15 1998-05-22 Cornell Research Foundation, Inc. Activated ras interaction assay
ATE476652T1 (de) * 2005-06-23 2010-08-15 Siemens Healthcare Diagnostics Quantitative assays für ras p21 in körperflüssigkeiten
US20100255514A1 (en) 2007-08-16 2010-10-07 The Royal Institution For The Advancement Of Learning/Mcgill University Tumor cell-derived microvesicles
CA2733672C (en) * 2007-08-16 2018-09-11 The Royal Institution For The Advancement Of Learning/Mcgill University Tumor cell-derived microvesicles

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4228237A (en) * 1978-09-21 1980-10-14 Calbiochem-Behring Corp. Methods for the detection and determination of ligands
JPS5837713B2 (ja) 1978-12-01 1983-08-18 富士通株式会社 半導体レ−ザ−装置の製造方法
SE447028B (sv) * 1980-06-30 1986-10-20 Erik Audunn Cerven Bestemning av endstaende sackaridgrupper i glykoprotein
US4535058A (en) 1982-10-01 1985-08-13 Massachusetts Institute Of Technology Characterization of oncogenes and assays based thereon
US4504585A (en) * 1982-04-05 1985-03-12 Aalto Scientific, Ltd. Affinity immunoassay system
US4699877A (en) * 1982-11-04 1987-10-13 The Regents Of The University Of California Methods and compositions for detecting human tumors
CA1219232A (en) * 1983-08-17 1987-03-17 Richard A. Lerner Polypeptide-induced monoclonal receptors to protein ligands
US4725550A (en) * 1984-01-19 1988-02-16 Research Foundation Of State University Of New York Novel mutation of the c-K-ras oncogene activated in a human lung carcinoma
US4798787A (en) * 1984-09-19 1989-01-17 Cetus Corporation Peptide antibodies and their use in detecting oncogene products
US4762706A (en) * 1984-10-17 1988-08-09 Cetus Corporation Peptide antibodies and their use in detecting oncogene products
JPS6185327A (ja) * 1984-09-19 1986-04-30 シタス　コーポレイシヨン 発癌遺伝子生成物に対する抗体
GB8501563D0 (en) * 1985-01-22 1985-02-20 Kodak Ltd Uv-absorbing polymers
CA1296660C (en) * 1985-01-29 1992-03-03 Walter P. Carney Monoclonal antibody against a ras oncogene p21 related dodecapeptide
US5028527A (en) * 1988-02-22 1991-07-02 Applied Bio Technology Monoclonal antibodies against activated ras proteins with amino acid mutations at position 13 of the protein
WO1989010375A1 (en) * 1988-04-22 1989-11-02 E.I. Du Pont De Nemours And Company Monoclonal antibodies specific for the harvey, kirsten and n ras proteins and their use as diagnostic reagents
TWI228804B (en) 2003-07-02 2005-03-01 Lite On Semiconductor Corp Chip package substrate having flexible printed circuit board and method for fabricating the same

Also Published As

Publication number Publication date
EP0767381A1 (de) 1997-04-09
EP0767381B1 (de) 2004-01-28
DE68929511T2 (de) 2004-11-18
DK254390D0 (da) 1990-10-22
EP0411018A4 (en) 1991-08-21
JPH03505250A (ja) 1991-11-14
EP0411018B1 (de) 1997-06-04
DE68928106D1 (de) 1997-07-10
ATE154134T1 (de) 1997-06-15
DE68929511D1 (de) 2004-03-04
DK254390A (da) 1990-12-21
AU634961B2 (en) 1993-03-11
CA1340368C (en) 1999-02-02
WO1989010565A1 (en) 1989-11-02
JPH0816679B2 (ja) 1996-02-21
EP0411018A1 (de) 1991-02-06
FI905189A0 (fi) 1990-10-22
ATE258686T1 (de) 2004-02-15
AU3447989A (en) 1989-11-24

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Owner name: OSI PHARMACEUTICALS,INC.(N.D.GES.D.STAATES DELAWAR