DE68927277D1 - CD40 kodierende DNA - Google Patents
CD40 kodierende DNAInfo
- Publication number
- DE68927277D1 DE68927277D1 DE68927277T DE68927277T DE68927277D1 DE 68927277 D1 DE68927277 D1 DE 68927277D1 DE 68927277 T DE68927277 T DE 68927277T DE 68927277 T DE68927277 T DE 68927277T DE 68927277 D1 DE68927277 D1 DE 68927277D1
- Authority
- DE
- Germany
- Prior art keywords
- dna encoding
- cdna
- image
- host cell
- expression vector
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/1034—Isolating an individual clone by screening libraries
- C12N15/1086—Preparation or screening of expression libraries, e.g. reporter assays
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/1034—Isolating an individual clone by screening libraries
- C12N15/1037—Screening libraries presented on the surface of microorganisms, e.g. phage display, E. coli display
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
-
- C—CHEMISTRY; METALLURGY
- C40—COMBINATORIAL TECHNOLOGY
- C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
- C40B40/00—Libraries per se, e.g. arrays, mixtures
- C40B40/02—Libraries contained in or displayed by microorganisms, e.g. bacteria or animal cells; Libraries contained in or displayed by vectors, e.g. plasmids; Libraries containing only microorganisms or vectors
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
- G01N33/56966—Animal cells
- G01N33/56972—White blood cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US16041688A | 1988-02-25 | 1988-02-25 |
Publications (2)
Publication Number | Publication Date |
---|---|
DE68927277D1 true DE68927277D1 (de) | 1996-11-07 |
DE68927277T2 DE68927277T2 (de) | 1997-03-20 |
Family
ID=22576817
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE68927277T Expired - Lifetime DE68927277T2 (de) | 1988-02-25 | 1989-02-23 | CD40 kodierende DNA |
DE68929329T Expired - Fee Related DE68929329T2 (de) | 1988-02-25 | 1989-02-23 | CD 19 Kodierende DNA |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE68929329T Expired - Fee Related DE68929329T2 (de) | 1988-02-25 | 1989-02-23 | CD 19 Kodierende DNA |
Country Status (6)
Country | Link |
---|---|
EP (2) | EP0739980B1 (de) |
AT (2) | ATE143690T1 (de) |
DE (2) | DE68927277T2 (de) |
ES (2) | ES2164794T3 (de) |
HU (1) | HUT53672A (de) |
WO (1) | WO1989008114A1 (de) |
Families Citing this family (77)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0449828A1 (de) * | 1988-05-27 | 1991-10-09 | Schering Biotech Corporation | Humaner fc-gamma-rezeptor iii |
US5767077A (en) * | 1988-05-27 | 1998-06-16 | Applied Research Systems Ars Holding N.V. | Human Fc-γ receptor III |
ATE146222T1 (de) * | 1989-03-09 | 1996-12-15 | Blood Res Center | Interzellulares adhäsions-molekül-2 und seine bindungsliganden |
DK0939121T4 (da) * | 1989-09-12 | 2008-02-04 | Ahp Mfg B V | TNF-bindende proteiner |
US5264554A (en) * | 1990-01-19 | 1993-11-23 | The Blood Center Of Southeastern Wisconsin, Inc. | Platelet cell adhesion molecule and variants thereof |
US5580756A (en) * | 1990-03-26 | 1996-12-03 | Bristol-Myers Squibb Co. | B7Ig fusion protein |
US5622853A (en) * | 1990-05-01 | 1997-04-22 | Becton Dickinson And Company | T lymphocyte precursor |
CS156891A3 (en) * | 1990-06-01 | 1992-04-15 | Regeneron Pharma | Receptor of a cilary neurotropic factor |
WO1992001049A2 (en) * | 1990-07-13 | 1992-01-23 | The General Hospital Corporation | Cd53 cell surface antigen and use thereof |
DE4029227A1 (de) * | 1990-09-14 | 1992-03-19 | Imtox Gmbh | Arzneimittel enthaltend cd14 |
US6071716A (en) | 1990-10-01 | 2000-06-06 | Dana-Farber Cancer Institute | DNA encoding, B7, a new member of the IG superfamily with unique expression on activated and neoplastic B cells |
US6238875B1 (en) * | 1991-03-12 | 2001-05-29 | The Scripps Research Institute | Diagnostic methods useful in the characterization of lymphoproliferative disease characterized by increased EPR-1 |
US5185438A (en) * | 1991-04-02 | 1993-02-09 | The Trustees Of Princeton University | Nucleic acids encoding hencatoporetic stem cell receptor flk-2 |
US5367057A (en) | 1991-04-02 | 1994-11-22 | The Trustees Of Princeton University | Tyrosine kinase receptor flk-2 and fragments thereof |
CA2067031C (en) * | 1991-04-26 | 2003-02-18 | Shigekazu Nagata | Dna coding for human cell surface antigen |
US5962406A (en) * | 1991-10-25 | 1999-10-05 | Immunex Corporation | Recombinant soluble CD40 ligand polypeptide and pharmaceutical composition containing the same |
US7405270B2 (en) | 1991-10-25 | 2008-07-29 | Immunex Corporation | CD40-Ligand lacking native-pattern glycosylation |
US5961974A (en) * | 1991-10-25 | 1999-10-05 | Immunex Corporation | Monoclonal antibodies to CD40 ligand, pharmaceutical composition comprising the same and hybridomas producing the same |
US5981724A (en) | 1991-10-25 | 1999-11-09 | Immunex Corporation | DNA encoding CD40 ligand, a cytokine that binds CD40 |
US5540926A (en) * | 1992-09-04 | 1996-07-30 | Bristol-Myers Squibb Company | Soluble and its use in B cell stimulation |
AU6123894A (en) * | 1993-01-29 | 1994-08-15 | Board Of Trustees Of The Leland Stanford Junior University | Modulation of physiological responses of lymphocytes by cd38 or antibodies thereto |
AU7640494A (en) * | 1993-09-03 | 1995-03-22 | Cellpro, Incorporated | Methods for quantifying the number of cells containing a selected nucleic acid sequence in a heterogenous population of cells |
IL111748A0 (en) * | 1993-12-03 | 1995-01-24 | Zeneca Ltd | Proteins |
GB9404513D0 (en) * | 1994-03-09 | 1994-04-20 | Medical Res Council | Method of cloning |
US5587299A (en) * | 1994-04-20 | 1996-12-24 | Memorial Sloan-Kettering Cancer Center | Isolated nucleic acid molecule coding for fibroblast activation protein alpha and uses thereof |
CA2188165C (en) | 1994-04-28 | 2007-08-28 | Marilyn Kehry | Methods for proliferating and differentiating b cells, and uses thereof |
US5925557A (en) * | 1994-09-29 | 1999-07-20 | The Regents Of The University Of California | DNA encoding mitogen activated protein kinase, FRK |
AU701106B2 (en) | 1995-06-07 | 1999-01-21 | Promega Biosciences, Inc. | Novel carbamate-based cationic lipids |
AU4825699A (en) * | 1998-06-19 | 2000-01-05 | Genzyme Corporation | Identification and use of differentially expressed genes and polynucleotide sequences |
PL200134B1 (pl) | 1999-05-07 | 2008-12-31 | Genentech Inc | Zastosowanie przeciwciała anty-CD20 |
US7105149B1 (en) | 1999-11-29 | 2006-09-12 | The Trustees Of Columbia University In The City Of New York | Isolation of five novel genes coding for new Fc receptors-type melanoma involved in the pathogenesis of lymphoma/myeloma |
JP2003532378A (ja) * | 1999-11-29 | 2003-11-05 | ザ・トラスティーズ・オブ・コランビア・ユニバーシティー・イン・ザ・シティー・オブ・ニューヨーク | リンパ腫/黒色腫の発症に関与する新規Fc受容体型黒色腫をコードする5つの新規遺伝子の単離 |
US7067252B2 (en) | 2000-06-21 | 2006-06-27 | Novozymes A/S | Method for genome mining for secreted protein genes |
DK1297123T3 (da) * | 2000-06-21 | 2007-10-08 | Novozymes As | Fremgangsmåde til genomudvinding af sekreterede proteingener |
US20030133939A1 (en) | 2001-01-17 | 2003-07-17 | Genecraft, Inc. | Binding domain-immunoglobulin fusion proteins |
US7754208B2 (en) | 2001-01-17 | 2010-07-13 | Trubion Pharmaceuticals, Inc. | Binding domain-immunoglobulin fusion proteins |
EP1572744B1 (de) | 2002-12-16 | 2010-06-09 | Genentech, Inc. | Immunoglobulinvarianten und deren verwendungen |
DK1613350T3 (da) | 2003-04-09 | 2009-06-22 | Genentech Inc | Behandling af autoimmun sygdom hos en patient med et utilstrækkeligt respons på en TNF-alfa-inhibitor |
PT2272868E (pt) | 2003-06-05 | 2015-07-07 | Genentech Inc | Terapêutica de combinação para distúrbios de células b |
WO2005075640A1 (ja) * | 2004-02-10 | 2005-08-18 | Nihon University | イヌcd20遺伝子 |
CN1993143A (zh) | 2004-06-04 | 2007-07-04 | 健泰科生物技术公司 | 用于治疗多发性硬化的方法 |
EP2377555A3 (de) | 2004-11-18 | 2011-11-23 | Imclone LLC | Antikörper gegen den vaskulären endothelialen Wachstumsfaktorrezeptor-1 |
SG10201912554TA (en) | 2005-03-23 | 2020-02-27 | Genmab As | Antibodies against cd38 for treatment of multiple myeloma |
US7601335B2 (en) | 2005-05-20 | 2009-10-13 | Genentech, Inc. | Pretreatment of a biological sample from an autoimmune disease subject |
SI1912675T1 (sl) | 2005-07-25 | 2014-07-31 | Emergent Product Development Seattle, Llc | zmanjšanje števila celic B z uporabo molekul, ki se specifično vežejo na CD37 in CD20 |
EP1919505A2 (de) | 2005-07-25 | 2008-05-14 | Trubion Pharmaceuticals, Inc. | Einzeldosisverwendung cd-20-spezifischer bindemoleküle |
MY149159A (en) | 2005-11-15 | 2013-07-31 | Hoffmann La Roche | Method for treating joint damage |
MX363905B (es) | 2006-06-12 | 2019-04-08 | Aptevo Res & Development Llc | Proteinas de union multivalentes monocatenarias con funcion efectora. |
SI2081595T1 (sl) | 2006-09-26 | 2019-10-30 | Genmab As | Anti-cd38 plus kortikosteroidi plus ne-kortikosteroidni kemoterapevtik za zdravljenje tumorjev |
US20090053786A1 (en) | 2007-07-09 | 2009-02-26 | Yung-Hsiang Kao | Prevention of disulfide bond reduction during recombinant production of polypeptides |
WO2009052293A1 (en) | 2007-10-16 | 2009-04-23 | Zymogenetics, Inc. | Combination of blys inhibition and anti-cd 20 agents for treatment of autoimmune disease |
EP2077281A1 (de) | 2008-01-02 | 2009-07-08 | Bergen Teknologioverforing AS | Anti-CD20-Antikörper oder Fragmente davon zur Behandlung von chronischen Ermüdungssyndrom |
US7914785B2 (en) | 2008-01-02 | 2011-03-29 | Bergen Teknologieverforing As | B-cell depleting agents, like anti-CD20 antibodies or fragments thereof for the treatment of chronic fatigue syndrome |
EP2132228B1 (de) | 2008-04-11 | 2011-06-22 | Emergent Product Development Seattle, LLC | Cd37-immuntherapeutikum und kombination mit bifunktionellem chemotherapeutikum davon |
TW201014605A (en) | 2008-09-16 | 2010-04-16 | Genentech Inc | Methods for treating progressive multiple sclerosis |
WO2010075249A2 (en) | 2008-12-22 | 2010-07-01 | Genentech, Inc. | A method for treating rheumatoid arthritis with b-cell antagonists |
EP3760712A1 (de) | 2009-08-11 | 2021-01-06 | F. Hoffmann-La Roche AG | Herstellung von proteinen in glutamin-freien zellkulturmedien |
AU2011215900A1 (en) | 2010-02-10 | 2012-07-26 | Immunogen, Inc. | CD20 antibodies and uses thereof |
NZ623807A (en) | 2010-04-13 | 2016-03-31 | Celldex Therapeutics Inc | Antibodies that bind human cd27 and uses thereof |
SI2580243T1 (sl) | 2010-06-09 | 2020-02-28 | Genmab A/S | Protitelesa proti humanemu CD38 |
CA2853138A1 (en) | 2011-12-05 | 2013-06-13 | Immunomedics, Inc. | Therapeutic use of anti-cd22 antibodies for inducing trogocytosis |
US9732154B2 (en) | 2014-02-28 | 2017-08-15 | Janssen Biotech, Inc. | Anti-CD38 antibodies for treatment of acute lymphoblastic leukemia |
US9603927B2 (en) | 2014-02-28 | 2017-03-28 | Janssen Biotech, Inc. | Combination therapies with anti-CD38 antibodies |
WO2016040294A2 (en) | 2014-09-09 | 2016-03-17 | Janssen Biotech, Inc. | Combination therapies with anti-cd38 antibodies |
SG11201704390PA (en) | 2014-12-04 | 2017-06-29 | Janssen Biotech Inc | Anti-cd38 antibodies for treatment of acute myeloid leukemia |
BR112017024877A2 (pt) | 2015-05-20 | 2019-09-17 | Janssen Biotech, Inc. | anticorpo anti-cd38 e seu uso no tratamento de amiloidose de cadeia leve e outras malignidades hematológicas positivas para cd38 |
CA2987051A1 (en) | 2015-05-29 | 2016-12-08 | Abbvie Inc. | Anti-cd40 antibodies and uses thereof |
CA2990406A1 (en) | 2015-06-22 | 2016-12-29 | Janssen Biotech, Inc. | Combination therapies for heme malignancies with anti-cd38 antibodies and survivin inhibitors |
HRP20220304T1 (hr) | 2015-06-24 | 2022-05-13 | F. Hoffmann - La Roche Ag | Anti-transferinska receptorska protutijela s prilagođenim afinitetom |
US20170044265A1 (en) | 2015-06-24 | 2017-02-16 | Janssen Biotech, Inc. | Immune Modulation and Treatment of Solid Tumors with Antibodies that Specifically Bind CD38 |
WO2017053469A2 (en) | 2015-09-21 | 2017-03-30 | Aptevo Research And Development Llc | Cd3 binding polypeptides |
PE20181004A1 (es) | 2015-10-02 | 2018-06-26 | Hoffmann La Roche | Anticuerpos biespecificos contra el cd20 humano y el receptor de transferrina humano y metodos de uso |
AR106189A1 (es) | 2015-10-02 | 2017-12-20 | Hoffmann La Roche | ANTICUERPOS BIESPECÍFICOS CONTRA EL A-b HUMANO Y EL RECEPTOR DE TRANSFERRINA HUMANO Y MÉTODOS DE USO |
EA202190808A2 (ru) | 2015-11-03 | 2021-12-31 | Янссен Байотек, Инк. | Составы антител к cd38 для подкожного введения и их применение |
US10781261B2 (en) | 2015-11-03 | 2020-09-22 | Janssen Biotech, Inc. | Subcutaneous formulations of anti-CD38 antibodies and their uses |
MA50514A (fr) | 2017-10-31 | 2020-09-09 | Janssen Biotech Inc | Méthodes de traitement du myélome multiple à haut risque |
AU2019256383A1 (en) | 2018-04-17 | 2020-11-26 | Celldex Therapeutics, Inc. | Anti-CD27 and anti-PD-L1 antibodies and bispecific constructs |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5340921A (en) * | 1986-07-03 | 1994-08-23 | T Cell Sciences, Inc. | Γ, δT cell receptor and methods and detection |
-
1988
- 1988-08-16 WO PCT/US1988/002809 patent/WO1989008114A1/en unknown
- 1988-08-16 HU HU89958A patent/HUT53672A/hu unknown
-
1989
- 1989-02-23 EP EP96104493A patent/EP0739980B1/de not_active Expired - Lifetime
- 1989-02-23 EP EP89103127A patent/EP0330191B1/de not_active Expired - Lifetime
- 1989-02-23 AT AT89103127T patent/ATE143690T1/de not_active IP Right Cessation
- 1989-02-23 DE DE68927277T patent/DE68927277T2/de not_active Expired - Lifetime
- 1989-02-23 ES ES96104493T patent/ES2164794T3/es not_active Expired - Lifetime
- 1989-02-23 ES ES89103127T patent/ES2094113T3/es not_active Expired - Lifetime
- 1989-02-23 AT AT96104493T patent/ATE206161T1/de not_active IP Right Cessation
- 1989-02-23 DE DE68929329T patent/DE68929329T2/de not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
DE68929329T2 (de) | 2002-07-04 |
HUT53672A (en) | 1990-11-28 |
DE68929329D1 (de) | 2001-10-31 |
HU890958D0 (en) | 1990-09-28 |
ES2094113T3 (es) | 1997-01-16 |
ES2164794T3 (es) | 2002-03-01 |
EP0330191A2 (de) | 1989-08-30 |
ATE206161T1 (de) | 2001-10-15 |
AU627710B2 (en) | 1992-09-03 |
EP0739980B1 (de) | 2001-09-26 |
EP0330191B1 (de) | 1996-10-02 |
WO1989008114A1 (en) | 1989-09-08 |
EP0739980A2 (de) | 1996-10-30 |
ATE143690T1 (de) | 1996-10-15 |
DE68927277T2 (de) | 1997-03-20 |
AU2947389A (en) | 1989-09-22 |
EP0330191A3 (de) | 1990-08-16 |
EP0739980A3 (de) | 1996-12-18 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition |