DE68921674D1 - Peptide, deren Verwendung als Immuno-Suppressanten und Verfahren zu deren Herstellung. - Google Patents

Peptide, deren Verwendung als Immuno-Suppressanten und Verfahren zu deren Herstellung.

Info

Publication number
DE68921674D1
DE68921674D1 DE68921674T DE68921674T DE68921674D1 DE 68921674 D1 DE68921674 D1 DE 68921674D1 DE 68921674 T DE68921674 T DE 68921674T DE 68921674 T DE68921674 T DE 68921674T DE 68921674 D1 DE68921674 D1 DE 68921674D1
Authority
DE
Germany
Prior art keywords
lys
bonded
arg
peptides
suppressants
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE68921674T
Other languages
English (en)
Other versions
DE68921674T2 (de
Inventor
Istvan Dr Schoen
Olga Nyeki
Lajos Dr Kisfaludy
Laszlo Dr Denes
Gyoergy Dr Hajos
Laszlo Dr Szporny
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Richter Gedeon Vegyeszeti Gyar Nyrt
Original Assignee
Richter Gedeon Vegyeszeti Gyar RT
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Richter Gedeon Vegyeszeti Gyar RT filed Critical Richter Gedeon Vegyeszeti Gyar RT
Application granted granted Critical
Publication of DE68921674D1 publication Critical patent/DE68921674D1/de
Publication of DE68921674T2 publication Critical patent/DE68921674T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0815—Tripeptides with the first amino acid being basic
    • C07K5/0817—Tripeptides with the first amino acid being basic the first amino acid being Arg
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06086—Dipeptides with the first amino acid being basic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0815—Tripeptides with the first amino acid being basic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1019—Tetrapeptides with the first amino acid being basic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Transplantation (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
DE68921674T 1988-06-14 1989-06-13 Peptide, deren Verwendung als Immuno-Suppressanten und Verfahren zu deren Herstellung. Expired - Fee Related DE68921674T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HU883037A HU201095B (en) 1988-06-14 1988-06-14 New peptides inhibiting the activity of the immune system and pharmaceutical compositions comprising same, as well as process for producing these peptides and compositions

Publications (2)

Publication Number Publication Date
DE68921674D1 true DE68921674D1 (de) 1995-04-20
DE68921674T2 DE68921674T2 (de) 1995-08-03

Family

ID=10962229

Family Applications (1)

Application Number Title Priority Date Filing Date
DE68921674T Expired - Fee Related DE68921674T2 (de) 1988-06-14 1989-06-13 Peptide, deren Verwendung als Immuno-Suppressanten und Verfahren zu deren Herstellung.

Country Status (13)

Country Link
US (1) US5008246A (de)
EP (1) EP0348086B1 (de)
JP (1) JPH0778075B2 (de)
CN (1) CN1038817A (de)
AT (1) ATE119914T1 (de)
AU (1) AU620406B2 (de)
CA (1) CA1327867C (de)
DE (1) DE68921674T2 (de)
DK (1) DK288789A (de)
ES (1) ES2068893T3 (de)
GR (1) GR3015890T3 (de)
HU (1) HU201095B (de)
IL (1) IL90391A0 (de)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH03502930A (ja) * 1988-09-30 1991-07-04 イミユノバイオロジー・リサーチ・インスチチユート・インコーポレーテツド Ｔ細胞のサプレツサー活性を有するペプチド
EP0445606B1 (de) * 1990-02-27 1997-01-22 The Agency of Industrial Science and Technology Oligopeptide, sie enthaltende pharmazeutische und Futterzusammensetzung und Benützung von Oligopeptiden
US6194376B1 (en) 1991-03-11 2001-02-27 Creative Biomolecules, Inc. Method for modulating inflammatory response comprising administering morphogen
US6077823A (en) * 1991-03-11 2000-06-20 Creative Biomolecules, Inc. Method for reducing tissue damage associated with ischemia-reperfusion or hypoxia injury
JP3973050B2 (ja) 1992-09-16 2007-09-05 キュリス，インコーポレイテッド モルフォゲン誘発性肝再生
US5639729A (en) * 1993-08-26 1997-06-17 Immunobiology Research Institute, Inc. Tripeptides useful in immune and CNS therapy
RU2107691C1 (ru) 1995-03-02 1998-03-27 Дейгин Владислав Исакович Пептид и способ его получения
US6159940A (en) * 1996-02-28 2000-12-12 Immunotech Developments Inc. Method for modulating hemopoiesis
EP0904093A4 (de) 1996-03-22 2004-11-17 Gen Hospital Corp Die verabreichung von wachstumsfaktor-polypeptiden nach einer ischemie des zentralen nervensystems oder einem trauma
KR100575069B1 (ko) * 1997-05-17 2006-05-02 바이오겐 아이덱 엠에이 인코포레이티드 역적응성 면역 반응, 특히 이식 거부반응을 예방하기 위한ｃｄ40:ｃｄ154 결합 저해제의 용도
EP1754490A3 (de) 1997-06-20 2010-01-20 Biogen Idec MA Inc. CD154-Blockadetherapie der Pankreasinselzellentransplantation bei Primaten
CN1927879B (zh) * 2006-09-25 2010-11-24 吉林大学 胸腺五肽活性异构体及其在药物制备中的应用

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU185263B (en) * 1981-06-12 1984-12-28 Richter Gedeon Vegyeszet Process for producing peptides effective on the immuncontroll analogous with the tp5
US4505853A (en) * 1983-11-18 1985-03-19 Ortho Pharmaceutical Corporation Enzyme-resistant immunomodulatory peptides
WO1986004334A1 (en) * 1985-01-18 1986-07-31 MERCK Patent Gesellschaft mit beschränkter Haftung Immunoregulatory peptides
NZ229004A (en) * 1988-05-19 1993-09-27 Immunobiology Res Inst Inc Tetrapeptides having t cell helper acitivity

Also Published As

Publication number Publication date
JPH0778075B2 (ja) 1995-08-23
EP0348086B1 (de) 1995-03-15
EP0348086A3 (en) 1990-09-12
DE68921674T2 (de) 1995-08-03
CN1038817A (zh) 1990-01-17
IL90391A0 (en) 1990-01-18
EP0348086A2 (de) 1989-12-27
DK288789A (da) 1989-12-15
JPH0232095A (ja) 1990-02-01
AU3629389A (en) 1990-01-04
DK288789D0 (da) 1989-06-13
HU201095B (en) 1990-09-28
GR3015890T3 (en) 1995-07-31
CA1327867C (en) 1994-03-15
US5008246A (en) 1991-04-16
ATE119914T1 (de) 1995-04-15
HUT50195A (en) 1989-12-28
AU620406B2 (en) 1992-02-20
ES2068893T3 (es) 1995-05-01

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee