DE68917394T2 - Verfahren zur Herstellung von Oxazolinderivaten. - Google Patents

Verfahren zur Herstellung von Oxazolinderivaten.

Info

Publication number
DE68917394T2
DE68917394T2 DE68917394T DE68917394T DE68917394T2 DE 68917394 T2 DE68917394 T2 DE 68917394T2 DE 68917394 T DE68917394 T DE 68917394T DE 68917394 T DE68917394 T DE 68917394T DE 68917394 T2 DE68917394 T2 DE 68917394T2
Authority
DE
Germany
Prior art keywords
preparation
oxazoline derivatives
alcohol solvent
oxazoline
mixtures
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE68917394T
Other languages
English (en)
Other versions
DE68917394D1 (de
Inventor
Doris P Schumacher
Jon E Clark
Bruce L Murphy
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Sharp and Dohme Corp
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Corp filed Critical Schering Corp
Application granted granted Critical
Publication of DE68917394D1 publication Critical patent/DE68917394D1/de
Publication of DE68917394T2 publication Critical patent/DE68917394T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D263/10—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D263/14—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D263/10—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D263/12—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with radicals containing only hydrogen and carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
DE68917394T 1988-09-14 1989-09-12 Verfahren zur Herstellung von Oxazolinderivaten. Expired - Lifetime DE68917394T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US24412688A 1988-09-14 1988-09-14

Publications (2)

Publication Number Publication Date
DE68917394D1 DE68917394D1 (de) 1994-09-15
DE68917394T2 true DE68917394T2 (de) 1994-12-01

Family

ID=22921470

Family Applications (1)

Application Number Title Priority Date Filing Date
DE68917394T Expired - Lifetime DE68917394T2 (de) 1988-09-14 1989-09-12 Verfahren zur Herstellung von Oxazolinderivaten.

Country Status (12)

Country Link
EP (2) EP0434731A1 (de)
JP (1) JPH0670022B2 (de)
AT (1) ATE109775T1 (de)
CY (1) CY1834A (de)
DE (1) DE68917394T2 (de)
ES (1) ES2057137T3 (de)
FI (1) FI94635C (de)
HK (1) HK62295A (de)
HU (1) HU215919B (de)
NO (1) NO180633C (de)
SG (1) SG25995G (de)
WO (1) WO1990002738A1 (de)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5227494A (en) * 1988-09-14 1993-07-13 Schering Corporation Process for preparing oxazoline compounds
ES2067958T3 (es) * 1990-10-25 1995-04-01 Schering Corp Procedimiento para preparar florfenicol, sus analogos y productos intermedios de la oxazolina para dicho procedimiento.
US5973160A (en) * 1992-12-23 1999-10-26 Poss; Michael A. Methods for the preparation of novel sidechain-bearing taxanes
CA2170661A1 (en) 1995-03-22 1996-09-23 John K. Thottathil Novel methods for the preparation of taxanes using oaxzolidine intermediates
US6228868B1 (en) 1998-07-27 2001-05-08 Abbott Laboratories Oxazoline antiproliferative agents
PL366100A1 (en) 2000-09-22 2005-01-24 Bristol-Myers Squibb Company Method for reducing toxicity of combined chemotherapies

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2402198A (en) * 1944-09-06 1946-06-18 Du Pont Preparation of oxazolines
HU167760B (de) * 1972-10-20 1975-12-25
DE3310905A1 (de) * 1983-03-25 1984-09-27 Henkel KGaA, 4000 Düsseldorf Verfahren zur herstellung von 2-isopropenyloxazolinen

Also Published As

Publication number Publication date
HK62295A (en) 1995-05-05
JPH03504726A (ja) 1991-10-17
WO1990002738A1 (en) 1990-03-22
ES2057137T3 (es) 1994-10-16
EP0359516B1 (de) 1994-08-10
HU895577D0 (en) 1991-06-28
NO180633B (no) 1997-02-10
JPH0670022B2 (ja) 1994-09-07
SG25995G (en) 1995-08-18
FI94635C (fi) 1995-10-10
AU617542B2 (en) 1991-11-28
AU4311489A (en) 1990-04-02
NO180633C (no) 1997-05-21
FI911237A0 (fi) 1991-03-13
HU215919B (hu) 1999-03-29
NO910911D0 (no) 1991-03-07
EP0434731A1 (de) 1991-07-03
DE68917394D1 (de) 1994-09-15
FI94635B (fi) 1995-06-30
HUT56083A (en) 1991-07-29
ATE109775T1 (de) 1994-08-15
EP0359516A1 (de) 1990-03-21
CY1834A (en) 1996-09-27
NO910911L (no) 1991-03-07

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition