DE68913555T2 - Sonden aus nukleinsäuren. - Google Patents
Sonden aus nukleinsäuren.Info
- Publication number
- DE68913555T2 DE68913555T2 DE68913555T DE68913555T DE68913555T2 DE 68913555 T2 DE68913555 T2 DE 68913555T2 DE 68913555 T DE68913555 T DE 68913555T DE 68913555 T DE68913555 T DE 68913555T DE 68913555 T2 DE68913555 T2 DE 68913555T2
- Authority
- DE
- Germany
- Prior art keywords
- nucleic acid
- particles
- acid probe
- disclosed
- monodisperse
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
- G01N33/54326—Magnetic particles
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/1096—Processes for the isolation, preparation or purification of DNA or RNA cDNA Synthesis; Subtracted cDNA library construction, e.g. RT, RT-PCR
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6809—Methods for determination or identification of nucleic acids involving differential detection
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6816—Hybridisation assays characterised by the detection means
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6834—Enzymatic or biochemical coupling of nucleic acids to a solid phase
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6844—Nucleic acid amplification reactions
- C12Q1/686—Polymerase chain reaction [PCR]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6844—Nucleic acid amplification reactions
- C12Q1/6862—Ligase chain reaction [LCR]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6869—Methods for sequencing
Applications Claiming Priority (8)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB888827167A GB8827167D0 (en) | 1988-11-21 | 1988-11-21 | In vitro mutagenesis |
GB888827158A GB8827158D0 (en) | 1988-11-21 | 1988-11-21 | Process for producing cdna |
GB888827166A GB8827166D0 (en) | 1988-11-21 | 1988-11-21 | Obtention & purification of rna |
GB888827159A GB8827159D0 (en) | 1988-11-21 | 1988-11-21 | Subtraction cdna library construction |
GB888827157A GB8827157D0 (en) | 1988-11-21 | 1988-11-21 | Sequencing nucleic acids |
GB888827160A GB8827160D0 (en) | 1988-11-21 | 1988-11-21 | Detection & quantitative determination of rna & dna |
GB898906643A GB8906643D0 (en) | 1989-03-22 | 1989-03-22 | Sequencing nucleic acids |
PCT/EP1989/001419 WO1990006045A2 (en) | 1988-11-21 | 1989-11-21 | Nucleic acid probes |
Publications (2)
Publication Number | Publication Date |
---|---|
DE68913555D1 DE68913555D1 (de) | 1994-04-07 |
DE68913555T2 true DE68913555T2 (de) | 1994-07-07 |
Family
ID=27562808
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE68913555T Expired - Lifetime DE68913555T2 (de) | 1988-11-21 | 1989-11-21 | Sonden aus nukleinsäuren. |
Country Status (7)
Country | Link |
---|---|
EP (1) | EP0446260B1 (de) |
JP (1) | JP3020271B2 (de) |
AT (1) | ATE102256T1 (de) |
AU (1) | AU640626B2 (de) |
CA (1) | CA2003508C (de) |
DE (1) | DE68913555T2 (de) |
WO (1) | WO1990006045A2 (de) |
Families Citing this family (63)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU7575291A (en) * | 1990-04-06 | 1991-10-30 | Syngene, Inc. | Process and composition for performing dna assays |
US5660985A (en) | 1990-06-11 | 1997-08-26 | Nexstar Pharmaceuticals, Inc. | High affinity nucleic acid ligands containing modified nucleotides |
WO1992005443A1 (en) * | 1990-09-15 | 1992-04-02 | Medical Research Council | Reagent separation |
US5665582A (en) * | 1990-10-29 | 1997-09-09 | Dekalb Genetics Corp. | Isolation of biological materials |
WO1992008133A1 (en) * | 1990-10-29 | 1992-05-14 | Dekalb Plant Genetics | Isolation of biological materials using magnetic particles |
US5734020A (en) * | 1991-11-20 | 1998-03-31 | Cpg, Inc. | Production and use of magnetic porous inorganic materials |
US6300058B1 (en) | 1992-01-29 | 2001-10-09 | Hitachi Chemical Research Center, Inc. | Method for measuring messenger RNA |
KR100289793B1 (ko) * | 1992-01-29 | 2001-12-01 | 테츠오 토미나가 | 폴리누클레오티드고정지지체 |
GB9212164D0 (en) * | 1992-06-09 | 1992-07-22 | Medical Res Council | Preparation of nucleic acids |
US5580971A (en) * | 1992-07-28 | 1996-12-03 | Hitachi Chemical Company, Ltd. | Fungal detection system based on rRNA probes |
JPH07509361A (ja) * | 1992-07-28 | 1995-10-19 | 日立化成工業株式会社 | 遺伝子検出システム |
US5591841A (en) * | 1993-01-14 | 1997-01-07 | Ji; Huamin | Rapid purification of circular DNA by triplex-mediated affinity capture |
ES2055661B1 (es) * | 1993-01-20 | 1995-03-01 | Univ Malaga | Determinacion de la expresion genica por captura especifica de arn y su cuantificacion directa por electroforesis capilar en zona libre. |
GB9314394D0 (en) * | 1993-07-12 | 1993-08-25 | Slater James H | A security device using an ultrasensitive microtrace for protecting materials,articles and items |
US5683875A (en) * | 1995-05-04 | 1997-11-04 | Hewlett-Packard Company | Method for detecting a target nucleic acid analyte in a sample |
JP2965131B2 (ja) * | 1995-07-07 | 1999-10-18 | 東洋紡績株式会社 | 核酸結合用磁性担体およびそれを用いる核酸単離方法 |
DE69636553T2 (de) * | 1995-07-07 | 2007-05-31 | Toyo Boseki K.K. | Nukleinsäuren bindender magnetischer Träger und Verfahren für die Nukleinsäureisolierung unter dessen Verwendung |
JP4264134B2 (ja) * | 1996-02-25 | 2009-05-13 | プレシジョン・システム・サイエンス株式会社 | 複数種類の磁性体粒子を用いる生体高分子、微生物又は物質の処理方法 |
DE19610354C1 (de) * | 1996-03-15 | 1997-11-20 | Innova Gmbh | Vorrichtung, Verfahren und Einrichtung zur Isolierung von Nukleinsäuren |
FR2749082B1 (fr) * | 1996-05-24 | 1998-06-26 | Bio Merieux | Particules superparamagnetiques et monodispersees |
DE19622885A1 (de) * | 1996-06-07 | 1997-12-11 | Boehringer Mannheim Gmbh | Reagenzzubereitung enthaltend magnetische Partikel in Form einer Tablette |
DE69836587T2 (de) * | 1997-04-16 | 2007-10-11 | Applera Corp., Foster City | Nukleinsäuresammlung |
US6534273B2 (en) | 1997-05-02 | 2003-03-18 | Gen-Probe Incorporated | Two-step hybridization and capture of a polynucleotide |
KR20010012175A (ko) | 1997-05-02 | 2001-02-15 | 다니엘 엘. 캐시앙, 헨리 엘. 노르호프, 피터 알. 쉬어리 | 폴리뉴클레오티드의 2단계 혼성화 및 포획법 |
EP0937497B9 (de) | 1997-12-25 | 2003-10-29 | Tosoh Corporation | Magnetischer Träger, seine Herstellung, und Verfahren zum Extrahieren von Nukleinsäuren |
FR2773416B1 (fr) | 1998-01-06 | 2000-02-11 | Bio Merieux | Particules magnetiques perfectionnees, leurs procedes d'obtention et leurs utilisations dans la separation de molecules |
US6297010B1 (en) * | 1998-01-30 | 2001-10-02 | Genzyme Corporation | Method for detecting and identifying mutations |
EP1121469A2 (de) * | 1998-10-12 | 2001-08-08 | Attomol GmbH Molekulare Diagnostika | Verfahren und kit zum direkten nachweis von nukleotidsequenzen, aminosäuresequenzen oder antigenen |
US5973138A (en) | 1998-10-30 | 1999-10-26 | Becton Dickinson And Company | Method for purification and manipulation of nucleic acids using paramagnetic particles |
DE19938372A1 (de) * | 1999-08-09 | 2001-03-08 | Diagnostikforschung Inst | Verfahren und Vorrichtung zur Trennung magnetischer Teilchen |
FR2803913B1 (fr) | 2000-01-13 | 2002-08-16 | Pasteur Sanofi Diagnostics | Procede d'immobilisation de reactif(s) affin(s) sur phase solide hydrophobe |
WO2002016571A1 (fr) * | 2000-08-21 | 2002-02-28 | National Institute Of Advanced Industrial Science And Technology | Particules magnetiques ayant une temperature de solution critique de limite inferieure |
AU2002320058A1 (en) | 2001-06-06 | 2002-12-16 | The General Hspital Corporation | Magnetic-nanoparticle conjugates and methods of use |
AU2003236461B2 (en) | 2002-08-29 | 2009-05-28 | Epigenomics Ag | Improved method for bisulfite treatment |
US20050059024A1 (en) | 2003-07-25 | 2005-03-17 | Ambion, Inc. | Methods and compositions for isolating small RNA molecules |
US7501240B2 (en) | 2003-12-02 | 2009-03-10 | Roche Molecular Systems, Inc. | Method for bisulfite treatment |
WO2005063977A1 (ja) | 2003-12-25 | 2005-07-14 | Riken | 核酸の増幅法およびこれを利用した変異核酸の検出法 |
CA2502549C (en) | 2004-04-23 | 2016-02-16 | Becton, Dickinson And Company | Use of an extraction control in a method of extracting nucleic acids |
JP4735926B2 (ja) * | 2004-05-27 | 2011-07-27 | アイシン精機株式会社 | 核酸の高効率回収方法 |
JP4710283B2 (ja) * | 2004-09-08 | 2011-06-29 | 富士レビオ株式会社 | 核酸配列の増幅法および検出法 |
EP1871913A2 (de) | 2005-03-25 | 2008-01-02 | Ambion, Inc. | Verfahren und zusammensetzungen zur verringerung abundanter rna-transkripte |
WO2006122083A2 (en) | 2005-05-09 | 2006-11-16 | The General Hospital Corporation | Water relaxation-based sensors |
WO2007027843A2 (en) | 2005-08-31 | 2007-03-08 | T2 Biosystems, Inc. | Nmr device for detection of analytes involving magnetic particles |
CA2622712A1 (en) * | 2005-09-16 | 2007-03-29 | Primera Biosystems, Inc. | Compositions and methods for purifying nucleic acids |
WO2008057578A1 (en) | 2006-11-08 | 2008-05-15 | T2 Biosystems, Inc. | Nmr systems for in vivo detection of analytes |
US7947447B2 (en) | 2007-01-16 | 2011-05-24 | Somalogic, Inc. | Method for generating aptamers with improved off-rates |
US9097644B2 (en) | 2007-08-17 | 2015-08-04 | Massachusetts Institute Of Technology | Magnetic resonance-based viscometers and methods |
CA2700970A1 (en) | 2007-09-28 | 2009-04-09 | T2 Biosystems, Inc. | Nmr diagnostics by means of a plastic sample container |
US8519708B2 (en) | 2007-11-06 | 2013-08-27 | T2 Biosystems, Inc. | Small magnet and RF coil for magnetic resonance relaxometry |
JP4545200B2 (ja) * | 2008-02-04 | 2010-09-15 | 積水メディカル株式会社 | 核酸固定用磁性粒子 |
EP2143496A1 (de) | 2008-07-09 | 2010-01-13 | F. Hoffmann-Roche AG | Lysereagenzformulierung mit magnetischen Partikeln in Tablettenform |
AU2009308841B2 (en) | 2008-10-29 | 2014-07-17 | T2 Biosystems, Inc. | NMR detection of coagulation time |
EP2189218A1 (de) | 2008-11-12 | 2010-05-26 | F. Hoffmann-Roche AG | Trennung in einer Mikrowell platte unter Zuhilfenahme des Deckels |
US20110236900A1 (en) | 2008-11-27 | 2011-09-29 | Riken | Novel muts protein and method for determing mutation using the same |
CN103052713A (zh) * | 2010-07-07 | 2013-04-17 | 陶氏益农公司 | 官能化线性dna盒的生成及植物中量子点/纳米颗粒介导的投递 |
WO2012054639A2 (en) | 2010-10-22 | 2012-04-26 | T2 Biosystems, Inc. | Nmr systems and methods for the rapid detection of analytes |
US8409807B2 (en) | 2010-10-22 | 2013-04-02 | T2 Biosystems, Inc. | NMR systems and methods for the rapid detection of analytes |
EP3321373B1 (de) | 2011-07-13 | 2020-01-15 | T2 Biosystems, Inc. | Nmr-verfahren zur überwachung der blutgerinnselbildung |
US9586987B2 (en) | 2011-09-08 | 2017-03-07 | Kabushiki Kaisha Dnaform | Primer set for isothermal amplication of a target nucleic acid sequence |
US10620205B2 (en) | 2011-09-21 | 2020-04-14 | T2 Biosystems, Inc. | NMR methods for endotoxin analysis |
WO2013158281A1 (en) | 2012-04-20 | 2013-10-24 | T2 Biosystems, Inc. | Compositions and methods for detection of candida species |
JP2016500443A (ja) | 2012-12-07 | 2016-01-12 | ティー2 バイオシステムズ,インコーポレーテッド | 強固な血餅形成をモニタリングするための方法 |
CA3011901A1 (en) | 2016-01-21 | 2017-07-27 | T2 Biosystems, Inc. | Nmr methods and systems for the rapid detection of bacteria |
Family Cites Families (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU530410B2 (en) * | 1978-02-21 | 1983-07-14 | Sintef | Preparing aqueous emulsions |
NO155316C (no) * | 1982-04-23 | 1987-03-11 | Sintef | Fremgangsmaate for fremstilling av magnetiske polymerpartikler. |
US4554088A (en) * | 1983-05-12 | 1985-11-19 | Advanced Magnetics Inc. | Magnetic particles for use in separations |
US4775619A (en) * | 1984-10-16 | 1988-10-04 | Chiron Corporation | Polynucleotide determination with selectable cleavage sites |
GB8507706D0 (en) * | 1985-03-25 | 1985-05-01 | Genetics Int Inc | Magnetic nucleic acid sequences |
ES8706823A1 (es) * | 1985-03-28 | 1987-06-16 | Cetus Corp | Un procedimiento para detectar la presencia o ausencia de al menos una secuencia especifica de acidos nucleicos en una muestra |
EP0224126A3 (de) * | 1985-11-25 | 1989-02-01 | The University of Calgary | Kovalent gekoppelte komplementäre Oligodeoxynukleotide zur Verwendung als "Primer Linkers" bei Sequenzierung von Nukleinsäuren |
EP0230768B1 (de) * | 1985-12-20 | 1992-03-18 | Syntex (U.S.A.) Inc. | Teilchentrennungsverfahren |
ZA877772B (en) * | 1986-10-23 | 1988-04-20 | Amoco Corporation | Target and background capture methods and apparatus for affinity assays |
ES2054797T3 (es) * | 1987-03-02 | 1994-08-16 | Gen Probe Inc | Soportes policationicos para purificar, separar e hibridar acidos nucleicos. |
AU620838B2 (en) * | 1987-10-26 | 1992-02-27 | Dade International Inc. | Process for producing magnetically responsive polymer particles and application thereof |
DE3852299T2 (de) * | 1987-10-26 | 1995-07-20 | Baxter Diagnostics Inc | Verfahren zur herstellung magnetisch empfindlicher polymerteilchen und deren anwendung. |
SE8704158L (sv) * | 1987-10-26 | 1989-04-27 | Carbomatrix Ab C O Ulf Schroed | Mikrosfaerer, foerfarande foer framstaellning daerav och anvaendning daerav |
SE8801070D0 (sv) * | 1988-03-23 | 1988-03-23 | Pharmacia Ab | Method for immobilizing a dna sequence on a solid support |
NO165894C (no) * | 1988-05-24 | 1991-04-24 | Gunnar Paulsen | Analysemetode for gener. |
-
1989
- 1989-11-21 CA CA002003508A patent/CA2003508C/en not_active Expired - Lifetime
- 1989-11-21 EP EP90900184A patent/EP0446260B1/de not_active Expired - Lifetime
- 1989-11-21 AU AU47586/90A patent/AU640626B2/en not_active Expired
- 1989-11-21 WO PCT/EP1989/001419 patent/WO1990006045A2/en active IP Right Grant
- 1989-11-21 AT AT90900184T patent/ATE102256T1/de not_active IP Right Cessation
- 1989-11-21 DE DE68913555T patent/DE68913555T2/de not_active Expired - Lifetime
- 1989-11-21 JP JP2501005A patent/JP3020271B2/ja not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
ATE102256T1 (de) | 1994-03-15 |
JP3020271B2 (ja) | 2000-03-15 |
DE68913555D1 (de) | 1994-04-07 |
CA2003508C (en) | 2000-01-25 |
EP0446260B1 (de) | 1994-03-02 |
WO1990006045A2 (en) | 1990-06-14 |
AU640626B2 (en) | 1993-09-02 |
CA2003508A1 (en) | 1990-05-21 |
EP0446260A1 (de) | 1991-09-18 |
WO1990006045A3 (en) | 1991-03-21 |
AU4758690A (en) | 1990-06-26 |
JPH04501959A (ja) | 1992-04-09 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
DE68913555D1 (de) | Sonden aus nukleinsäuren. | |
AU581577B2 (en) | Nucleic acid hybridization assay and detectable molecules useful in such assay | |
DK0463144T3 (da) | På magnetisme reagerende fluorscerende polymerpartikler og anvendelse deraf | |
HK38196A (en) | Water-insoluble reagent nucleic acid probe test kit and diagnostic and purification methods | |
FI893526A (fi) | Material och metod foer oekning av nukleinsyrahybridisering. | |
EP0353985A3 (de) | Nukleinsäureprobe zur Detektion von Neisseria gonorrhoea | |
EP0065069A3 (en) | Latex for immobilizing biologically active substances | |
CA2003500A1 (en) | Process for producing cdna | |
IL81695A0 (en) | Quantitative determination of nucleic acid molecules and the reagent kit used | |
WO1990015159A3 (en) | Nucleic acid probes for the detection of chlamydia trachomatis | |
IT1206777B (it) | Procedimento di analisi immunologica o chimica per la determinazione di proteine in fluidi biologici e relativo completo (kit) di mezzi analitici. | |
DE59307931D1 (de) | Spezifische Gensonden und Verfahren zur Diagnostik von Candida albicans | |
Holbrook Jr | Effects of toxicants on nucleic acid and protein metabolism. | |
ATE163449T1 (de) | Voraktivierte proteine zur markierung von oligonukleotidsonden | |
EP0353868A3 (de) | Fluoreszierende Phenalenimin-Farbstoffe und deren Verwendung für analytische Zusammensetzungen, Elemente und Verfahren | |
LTIP1517A (en) | Nucleic acids, proteins, organisms, cells, monoclonal antibody, methods of identification and diagnosis, analytical and model systems, pharmaceutical compositions | |
GB2236852B (en) | DNA probe based assays and intermediates useful in the synthesis of cleavable nucleic acids for use in such assays | |
IT1217933B (it) | Dispositivo e metodo per la modifica di attivita' di microorganismi contenuti in liquidi senza aggiunta di reagenti chimici | |
CA2099543A1 (en) | Photochemical labelling of nucleic acids with digoxigenin reagents and their use in gene probe test systems | |
DE3886450D1 (de) | Aus Nukleinsäuren von menschlichen Papillomaviren bestehende Hybridisierungsproben und Methoden für deren Anwendung. | |
AU562021B2 (en) | Assay for free portion of substances in biological fluid | |
ES2017153A6 (es) | Portadores inmunorreactivos que tienen un nuevo recubrimiento intermedio biocompatible y su procedimiento de fabricacion. | |
FR2624523B1 (fr) | Acide desoxyribonucleique portant l'information genetique de la l-(alpha)-glycerophosphate oxydase et son application | |
Evreinova et al. | The interaction of biological macromolecules in coacervate systems | |
IT1223484B (it) | Prodotti per la marcatura non radioattiva di sonde biologiche e loro uso |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition | ||
8328 | Change in the person/name/address of the agent |
Representative=s name: PFENNING MEINIG & PARTNER GBR, 80339 MUENCHEN |
|
8328 | Change in the person/name/address of the agent |
Representative=s name: MAIWALD PATENTANWALTSGESELLSCHAFT MBH, 80335 MUENC |