DE68911192D1 - Phosphonoalkylpurin-Derivate. - Google Patents

Phosphonoalkylpurin-Derivate.

Info

Publication number
DE68911192D1
DE68911192D1 DE89400974T DE68911192T DE68911192D1 DE 68911192 D1 DE68911192 D1 DE 68911192D1 DE 89400974 T DE89400974 T DE 89400974T DE 68911192 T DE68911192 T DE 68911192T DE 68911192 D1 DE68911192 D1 DE 68911192D1
Authority
DE
Germany
Prior art keywords
phosphonoalkylpurin
derivatives
phosphonoalkylpurin derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE89400974T
Other languages
English (en)
Other versions
DE68911192T2 (de
Inventor
Serge Halazy
Charles Danzin
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aventis Pharmaceuticals Inc
Original Assignee
Merrell Dow Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merrell Dow Pharmaceuticals Inc filed Critical Merrell Dow Pharmaceuticals Inc
Publication of DE68911192D1 publication Critical patent/DE68911192D1/de
Application granted granted Critical
Publication of DE68911192T2 publication Critical patent/DE68911192T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
    • C07F9/65616—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings containing the ring system having three or more than three double bonds between ring members or between ring members and non-ring members, e.g. purine or analogs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
DE89400974T 1988-04-19 1989-04-10 Phosphonoalkylpurin-Derivate. Expired - Fee Related DE68911192T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP88400948A EP0338168A1 (de) 1988-04-19 1988-04-19 Phosphonoalkylpurin-Derivate

Publications (2)

Publication Number Publication Date
DE68911192D1 true DE68911192D1 (de) 1994-01-20
DE68911192T2 DE68911192T2 (de) 1994-05-05

Family

ID=8200380

Family Applications (1)

Application Number Title Priority Date Filing Date
DE89400974T Expired - Fee Related DE68911192T2 (de) 1988-04-19 1989-04-10 Phosphonoalkylpurin-Derivate.

Country Status (19)

Country Link
US (1) US4988680A (de)
EP (1) EP0338168A1 (de)
JP (1) JP2756579B2 (de)
KR (1) KR0139534B1 (de)
CN (1) CN1037342A (de)
AU (1) AU613478B2 (de)
CA (1) CA1341027C (de)
DE (1) DE68911192T2 (de)
DK (1) DK186189A (de)
ES (1) ES2062056T3 (de)
FI (1) FI891842A (de)
HU (1) HU204280B (de)
IE (1) IE891247L (de)
IL (1) IL90002A0 (de)
NO (1) NO891588L (de)
NZ (1) NZ228749A (de)
PH (1) PH27602A (de)
PT (1) PT90301B (de)
ZA (1) ZA892723B (de)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0405748A1 (de) * 1989-05-30 1991-01-02 Beecham Group p.l.c. Phosphonoderivate des Purins mit antiviraler Wirkung
CZ285420B6 (cs) * 1990-04-24 1999-08-11 Ústav Organické Chemie A Biochemie Avčr N-(3-Fluor-2-fosfonylmethoxypropyl)deriváty purinových a pyrimidinových heterocyklických bazí, způsoby jejich přípravy a použití
DE69116750T2 (de) * 1990-07-04 1996-11-14 Merrell Dow Pharma 9-Purinyl-Phosphonsäurederivate
US5208221A (en) * 1990-11-29 1993-05-04 Bristol-Myers Squibb Company Antiviral (phosphonomethoxy) methoxy purine/pyrimidine derivatives
US5494912A (en) * 1991-06-26 1996-02-27 Merrell Pharmaceuticals Inc. 9-purinyl phosphonic acid derivitives for treating gout
US7371852B2 (en) * 2003-01-22 2008-05-13 Serenex, Inc. Alkyl-linked nucleotide compositions
CA2571710A1 (en) 2004-06-24 2006-11-02 Nicholas Valiante Small molecule immunopotentiators and assays for their detection
US20130018018A1 (en) * 2009-08-27 2013-01-17 Epiphany Biosciences ,Inc. Novel nucleoside phosphonates and analogs
US9011817B2 (en) * 2009-09-03 2015-04-21 The Board Of Trustees Of The Leland Stanford Junior University Compounds and methods of making compounds
CN112110784B (zh) * 2020-09-02 2022-03-15 天津科技大学 一种新型高含水量造雾剂

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4421767A (en) * 1981-06-01 1983-12-20 Merrell Toraude Et Compagnie Compounds and methods for treating depression
DE3490262T1 (de) * 1983-05-24 1985-11-28 Sri International, Menlo Park, Calif. Antivirus-Mittel
CA1288098C (en) * 1984-08-24 1991-08-27 Richard L. Tolman 4-(guanin-9-yl)butanals and their 3-oxa, 3-thia and 2-ene derivatives having antiviral and antitumor activity
US4719313A (en) * 1985-08-21 1988-01-12 Merrell Dow Pharmaceuticals Inc. Gem-dihalo and tetrahalo-1,12-diamino-4,9-diaza-dodecanes
US4695654A (en) * 1985-08-21 1987-09-22 Merrell Dow Pharmaceuticals Inc. Gem-dihalo-1,8-diamino-4-aza-octanes
US4730006A (en) * 1986-01-27 1988-03-08 Merrell Dow Pharmaceuticals Inc. Derivatives of 2,6-diamino-3-haloheptanedioic acid
AU613592B2 (en) * 1986-11-18 1991-08-08 Institute Of Organic Chemistry And Biochemistry Of The Academy Of Sciences Of The Czech Republic Antiviral phosophonomethoxy-alkyene purine and pyrimide derivatives

Also Published As

Publication number Publication date
NO891588L (no) 1989-10-20
KR0139534B1 (ko) 1998-06-15
NZ228749A (en) 1991-05-28
FI891842A (fi) 1989-10-20
ES2062056T3 (es) 1994-12-16
DK186189D0 (da) 1989-04-18
FI891842A0 (fi) 1989-04-18
US4988680A (en) 1991-01-29
IE891247L (en) 1989-10-19
JPH026497A (ja) 1990-01-10
DK186189A (da) 1989-10-20
NO891588D0 (no) 1989-04-18
DE68911192T2 (de) 1994-05-05
AU613478B2 (en) 1991-08-01
JP2756579B2 (ja) 1998-05-25
KR890016059A (ko) 1989-11-28
PT90301B (pt) 1994-09-30
IL90002A0 (en) 1989-12-15
PT90301A (pt) 1989-11-10
EP0338168A1 (de) 1989-10-25
PH27602A (en) 1993-08-31
AU3315889A (en) 1989-10-26
ZA892723B (en) 1989-12-27
HU204280B (en) 1991-12-30
CN1037342A (zh) 1989-11-22
CA1341027C (en) 2000-06-13

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee