DE68905313T2 - Enzym-immunoassay zur messung des cyclosporin-a-spiegels in vollblut-proben. - Google Patents

Enzym-immunoassay zur messung des cyclosporin-a-spiegels in vollblut-proben.

Info

Publication number
DE68905313T2
DE68905313T2 DE8989313499T DE68905313T DE68905313T2 DE 68905313 T2 DE68905313 T2 DE 68905313T2 DE 8989313499 T DE8989313499 T DE 8989313499T DE 68905313 T DE68905313 T DE 68905313T DE 68905313 T2 DE68905313 T2 DE 68905313T2
Authority
DE
Germany
Prior art keywords
mirrors
whole blood
blood samples
enzyme immunoassay
cyclosporin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE8989313499T
Other languages
English (en)
Other versions
DE68905313D1 (de
Inventor
Hon-Peng Phillip Lau
Warren Keene Miller
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Dade Behring Inc
Original Assignee
EI Du Pont de Nemours and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by EI Du Pont de Nemours and Co filed Critical EI Du Pont de Nemours and Co
Application granted granted Critical
Publication of DE68905313D1 publication Critical patent/DE68905313D1/de
Publication of DE68905313T2 publication Critical patent/DE68905313T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/581—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with enzyme label (including co-enzymes, co-factors, enzyme inhibitors or substrates)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/54—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving glucose or galactose
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/94—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving narcotics or drugs or pharmaceuticals, neurotransmitters or associated receptors
    • G01N33/9493—Immunosupressants
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/962—Prevention or removal of interfering materials or reactants or other treatment to enhance results, e.g. determining or preventing nonspecific binding
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/815—Test for named compound or class of compounds
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/25—Chemistry: analytical and immunological testing including sample preparation
    • Y10T436/25375—Liberation or purification of sample or separation of material from a sample [e.g., filtering, centrifuging, etc.]
    • Y10T436/255—Liberation or purification of sample or separation of material from a sample [e.g., filtering, centrifuging, etc.] including use of a solid sorbent, semipermeable membrane, or liquid extraction
DE8989313499T 1988-12-23 1989-12-22 Enzym-immunoassay zur messung des cyclosporin-a-spiegels in vollblut-proben. Expired - Fee Related DE68905313T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/288,912 US5151348A (en) 1988-12-23 1988-12-23 Enzyme-linked immunoassay for measurement of cyclosporin a levels in whole blood samples

Publications (2)

Publication Number Publication Date
DE68905313D1 DE68905313D1 (de) 1993-04-15
DE68905313T2 true DE68905313T2 (de) 1993-06-24

Family

ID=23109198

Family Applications (1)

Application Number Title Priority Date Filing Date
DE8989313499T Expired - Fee Related DE68905313T2 (de) 1988-12-23 1989-12-22 Enzym-immunoassay zur messung des cyclosporin-a-spiegels in vollblut-proben.

Country Status (7)

Country Link
US (1) US5151348A (de)
EP (1) EP0375454B1 (de)
JP (1) JPH0737983B2 (de)
AU (1) AU615823B2 (de)
CA (1) CA2004773A1 (de)
DE (1) DE68905313T2 (de)
DK (1) DK660889A (de)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5650288A (en) * 1995-07-14 1997-07-22 Macfarlane; Gordon D. Immunophilin-bound immunosuppressant assay
DE19531173A1 (de) * 1995-08-24 1997-02-27 Boehringer Mannheim Gmbh Verfahren zum Stabilisieren des Gehalts glykierten Proteins einer Probe auf einem Matrixmaterial
US6855562B1 (en) 1996-07-30 2005-02-15 Horiba, Ltd. Immunoassay method for lyzed whole blood
US5990274A (en) * 1997-11-25 1999-11-23 Dade Behring Inc. Cyclosporine derivatives and uses thereof
US6231982B1 (en) 1997-12-10 2001-05-15 Dade Behring Inc. Particle reagents having reduced matrix effects and containing an aldehyde-reactive functional group
GB0212825D0 (en) * 2002-05-31 2002-07-10 Dna Res Innovations Ltd Methods compositions and kits for cell separation
US20060216762A1 (en) * 2005-03-24 2006-09-28 Bayer Healthcare Llc Extracting reagent for hydrophobic analyte in whole blood
US7790401B2 (en) 2007-08-06 2010-09-07 Siemens Healthcare Diagnostics Methods for detection of immunosuppressant drugs
US7910378B2 (en) 2007-12-14 2011-03-22 Siemens Healthcare Diagnostics Inc. Methods for detection of hydrophobic drugs
US20120107804A1 (en) * 2008-07-25 2012-05-03 Sebo Gmbh Disintegration of cellular components in body fluids
EP2149793A1 (de) * 2008-07-25 2010-02-03 SeBo GmbH Desintegration zellulärer Teilchen in Körperflüssigkeiten
US8329424B2 (en) 2010-06-25 2012-12-11 Siemens Healthcare Diagnostics Reduction in false results in assay measurements
US9658218B2 (en) 2012-05-07 2017-05-23 Siemens Healthcare Diagnostics Inc. Determination of total analyte concentration
US9244083B2 (en) 2012-11-30 2016-01-26 Siemens Healthcare Diagnostics Inc. Compositions and methods for detecting vitamin D
US9121859B2 (en) 2012-12-04 2015-09-01 Siemens Healthcare Diagnostics Inc. Compounds and methods for determination of FKBP-binding immunosuppressant drugs
ES2740851T3 (es) 2013-12-13 2020-02-06 Siemens Healthcare Diagnostics Inc Agente de tratamiento previo en ensayos sin aglutinación
BR112016030560A8 (pt) 2014-06-27 2021-07-13 Siemens Healthcare Diagnostics Inc parceiros de ligação específicos para epímeros de vitamina d, anticorpo e método para separar uma vitamina d epimérica de uma amostra suspeita de conter uma vitamina d epimérica
EP3161005B1 (de) 2014-06-27 2020-11-25 Siemens Healthcare Diagnostics Inc. Spezifische bindungspartner für vitamin d in epimeren in vitamin-d-assays

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4235960A (en) * 1977-07-29 1980-11-25 The Medical College Of Wisconsin, Inc. Competitive enzyme-linked immunoassay
DE3345748A1 (de) * 1983-12-17 1985-08-29 Boehringer Mannheim Gmbh, 6800 Mannheim Phenolsulfonphthaleinyl-ss-d-galactoside, verfahren zu deren herstellung sowie deren verwendung zur bestimmung der ss-d-galactosidase
DE3411574A1 (de) * 1984-03-29 1985-10-10 Boehringer Mannheim Gmbh, 6800 Mannheim Glycoside von resorufin-derivaten, verfahren zu deren herstellung sowie deren verwendung zur bestimmung der aktivitaet von glycosidasen
US4727035A (en) * 1984-11-14 1988-02-23 Mahoney Walter C Immunoassay for cyclosporin
ZA878431B (en) * 1986-12-09 1988-05-05 Miles Inc. Substantially pure enzyme-antibody conjugate preparations
EP0283801A3 (de) * 1987-03-27 1990-05-30 Abbott Laboratories Fluoreszenz-Polarisations-Test für Cyclosporin A und Metaboliten und verwandte Immunogene und Antikörper

Also Published As

Publication number Publication date
JPH02226067A (ja) 1990-09-07
DK660889A (da) 1990-06-24
US5151348A (en) 1992-09-29
DE68905313D1 (de) 1993-04-15
EP0375454A1 (de) 1990-06-27
AU615823B2 (en) 1991-10-10
EP0375454B1 (de) 1993-03-10
CA2004773A1 (en) 1990-06-23
DK660889D0 (da) 1989-12-22
JPH0737983B2 (ja) 1995-04-26
AU4727389A (en) 1990-06-28

Similar Documents

Publication Publication Date Title
DE68905313D1 (de) Enzym-immunoassay zur messung des cyclosporin-a-spiegels in vollblut-proben.
DE3888577D1 (de) Gerät zur Messung von Elektrolyten.
DE69021638T2 (de) Sensoranordnung zur Messung von Substanzen in Flüssigkeiten.
DE3861463D1 (de) Messfuehler.
IL91879A0 (en) Assay and sensing means for determining analyte
DE68907766D1 (de) Vorrichtung zur bestimmung des alkoholinhaltes.
DE3783645T2 (de) Festkoerpersystem zur messung sich anhaeufender betriebszeit.
DE3578098D1 (de) Randdetektionsvorrichtung in optischem messinstrument.
DE69013013D1 (de) Vorrichtung zur Messung des Herzzeitvolumens.
DE3853826D1 (de) Messgerät zur messung des herzflusses.
DE3788054T2 (de) Fühler für zusammengesetzten analysator-tester.
DE3853560D1 (de) Analytisches Element zur Vollblutuntersuchung.
DE3874605D1 (de) Mikrosonde in integrierter schalttechnik zur feststellung bestimmter gase.
DE3879240D1 (de) Vermessungsinstrument.
DE68912151D1 (de) Elektrochemische Sensoren für immunologische Testverfahren.
DE3776752D1 (de) Drei-achsen-messfuehler.
DE58902460D1 (de) Messeinrichtung zur bestimmung des drehwinkels.
AU591352B2 (en) Sensor of the enzyme-electrode type and its use for determining an analyte
DE68907437T2 (de) Verfahren zur Messung von Verunreinigungen.
ATA264988A (de) Elektrochemischer sensor
DE58903750D1 (de) Elektrochemischer messfuehler.
DE68920290D1 (de) Signal-Analyse.
DE59005231D1 (de) Sensor für Mess- und Analysengeräte.
DE3787834D1 (de) Reagenz-Kit zur Verwendung in Sandwich-Immunotesten.
ATE103389T1 (de) Geraet zur messung von elektrolyten.

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: DADE CHEMISTRY SYSTEMS INC. (N.D.GES.D. STAATES DE

8327 Change in the person/name/address of the patent owner

Owner name: DADE BEHRING, INC.(N.D.GES.DES STAATES DELAWARE),

8339 Ceased/non-payment of the annual fee