DE68903226T2 - Dideoxydidehydrocarbocyclische nukleoside. - Google Patents

Dideoxydidehydrocarbocyclische nukleoside.

Info

Publication number
DE68903226T2
DE68903226T2 DE8989300510T DE68903226T DE68903226T2 DE 68903226 T2 DE68903226 T2 DE 68903226T2 DE 8989300510 T DE8989300510 T DE 8989300510T DE 68903226 T DE68903226 T DE 68903226T DE 68903226 T2 DE68903226 T2 DE 68903226T2
Authority
DE
Germany
Prior art keywords
dideoxydidehydrocarbocyclic
nucleosides
hydrogen
4alkyl
nrr
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE8989300510T
Other languages
English (en)
Other versions
DE68903226D1 (de
Inventor
Robert Vince
Mei Hua
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Minnesota
Original Assignee
University of Minnesota
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26843711&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE68903226(T2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from US07/146,252 external-priority patent/US4916224A/en
Application filed by University of Minnesota filed Critical University of Minnesota
Application granted granted Critical
Publication of DE68903226D1 publication Critical patent/DE68903226D1/de
Publication of DE68903226T2 publication Critical patent/DE68903226T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
DE8989300510T 1988-01-20 1989-01-19 Dideoxydidehydrocarbocyclische nukleoside. Expired - Lifetime DE68903226T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/146,252 US4916224A (en) 1988-01-20 1988-01-20 Dideoxycarbocyclic nucleosides
US07/278,652 US4931559A (en) 1988-01-20 1988-12-05 Optically-active isomers of dideoxycarbocyclic nucleosides

Publications (2)

Publication Number Publication Date
DE68903226D1 DE68903226D1 (de) 1992-11-26
DE68903226T2 true DE68903226T2 (de) 1993-03-04

Family

ID=26843711

Family Applications (1)

Application Number Title Priority Date Filing Date
DE8989300510T Expired - Lifetime DE68903226T2 (de) 1988-01-20 1989-01-19 Dideoxydidehydrocarbocyclische nukleoside.

Country Status (9)

Country Link
US (1) US4931559A (de)
EP (1) EP0325460B1 (de)
JP (1) JP2738946B2 (de)
AT (1) ATE81653T1 (de)
CA (1) CA1339803C (de)
DE (1) DE68903226T2 (de)
ES (1) ES2052897T3 (de)
GR (1) GR3006490T3 (de)
PH (1) PH30732A (de)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5631370A (en) * 1988-01-20 1997-05-20 Regents Of The University Of Minnesota Optically-active isomers of dideoxycarbocyclic nucleosides
US5175292A (en) * 1988-01-20 1992-12-29 Regents Of The University Of Minnesota Intermediates for the preparation of dideoxycarbocyclic nucleosides
US5015739A (en) * 1988-04-22 1991-05-14 Schering Corporation Processes for preparation of cyclopentyl purine derivatives
US5122517A (en) * 1988-06-10 1992-06-16 Regents Of The University Of Minnesota Antiviral combination comprising nucleoside analogs
GB8815265D0 (en) * 1988-06-27 1988-08-03 Wellcome Found Therapeutic nucleosides
WO1991013549A1 (en) * 1990-03-06 1991-09-19 Virachem, Inc. Methods and compositions for the prophylaxis and treatment of cytomegalovirus infections
US6001840A (en) * 1990-03-06 1999-12-14 Southern Research Institute Methods of treatment of viral infections using carbocyclic deoxyguanosine analogs
US5144034A (en) * 1990-04-06 1992-09-01 Glaxo Inc. Process for the synthesis of cyclopentene derivatives of purines
US5126452A (en) * 1990-04-06 1992-06-30 Glaxo Inc. Synthesis of purine substituted cyclopentene derivatives
AU677851B2 (en) 1993-06-21 1997-05-08 Merrell Pharmaceuticals Inc. Novel carbocyclic nucleoside agents useful as selective inhibitors of proinflammatory cytokines
US5750578A (en) * 1997-02-11 1998-05-12 Regents Of The University Of Minnesota Use of betulin and analogs thereof to treat herpesvirus infection
SK285228B6 (sk) * 1997-05-13 2006-09-07 Lonza Ag Spôsob výroby racemického alebo opticky aktívnehoderivátu 4-(hydroxymetyl)-2-cyklopenténu a racemicky N-butyryl-1-amino-4- (hydroxymetyl)-2-cyklopentén
US6433170B1 (en) 1998-10-30 2002-08-13 Lonza Group Method for producing 4-[2',5'-diamino-6'-halopyrimidine-4'-yl)amino]- cyclopent-2-enylmethanols
US6369101B1 (en) 1999-02-26 2002-04-09 Regents Of The University Of Minnesota Therapeutic method to treat herpes virus infection
GB0320738D0 (en) 2003-09-04 2003-10-08 Glaxo Group Ltd Novel process
AR072938A1 (es) * 2008-08-20 2010-09-29 Southern Res Inst Derivados de piridina y pirimidina azosustituidos y su uso en el tratamiento de infecciones virales
CA2862006C (en) * 2012-01-03 2016-10-25 Cellceutix Corporation Carbocyclic nucleosides and their pharmaceutical use and compositions

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3817982A (en) * 1971-12-29 1974-06-18 Syntex Inc 2{40 ,3{40 -unsaturated nucleosides and method of making
US3917837A (en) * 1974-10-21 1975-11-04 American Cyanamid Co Method of using trans-2-(6-amino-9H-purin-9-yl)-cyclopentanol
US4076711A (en) * 1976-04-05 1978-02-28 Schering Corporation Triazolo [4,5-d]-pyrimidines
US4383114A (en) * 1977-02-09 1983-05-10 Regents Of The University Of Minnesota Adenosine deaminase resistant antiviral purine arabinonucleosides
US4268672A (en) * 1977-02-09 1981-05-19 The Regents Of The University Of Minnesota Adenosine deaminase resistant antiviral purine nucleosides and method of preparation
US4138562A (en) * 1977-02-09 1979-02-06 The Regents Of The University Of Minnesota Adenosine deaminase resistant antiviral purine nucleosides and method of preparation
US4362729A (en) * 1980-06-23 1982-12-07 The Regents Of The University Of Minnesota Alkoxyalkanoate esters of cyclaradine
JPS59219284A (ja) * 1983-05-27 1984-12-10 Toyo Jozo Co Ltd ３′−デオキシネプラノシンａおよびその製造法
US4543255A (en) * 1984-05-10 1985-09-24 Southern Research Institute Carbocyclic analogs of purine 2'-deoxyribofuranosides
US4742064A (en) * 1985-09-10 1988-05-03 Regents Of The University Of Minnesota Antiviral carbocyclic analogs of xylofuranosylpurines
IN164556B (de) * 1986-03-06 1989-04-08 Takeda Chemical Industries Ltd
DE3715666A1 (de) * 1987-05-11 1988-11-24 Kodak Ag Kassettenentlade- und beladegeraet

Also Published As

Publication number Publication date
DE68903226D1 (de) 1992-11-26
US4931559A (en) 1990-06-05
GR3006490T3 (de) 1993-06-21
EP0325460B1 (de) 1992-10-21
JP2738946B2 (ja) 1998-04-08
ATE81653T1 (de) 1992-11-15
EP0325460A1 (de) 1989-07-26
PH30732A (en) 1997-10-17
JPH01308282A (ja) 1989-12-12
ES2052897T3 (es) 1994-07-16
CA1339803C (en) 1998-04-07

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