DE68902706D1 - Therapeutische zusammensetzung fuer leber-gehirnkomplikationen. - Google Patents
Therapeutische zusammensetzung fuer leber-gehirnkomplikationen.Info
- Publication number
- DE68902706D1 DE68902706D1 DE8989110959T DE68902706T DE68902706D1 DE 68902706 D1 DE68902706 D1 DE 68902706D1 DE 8989110959 T DE8989110959 T DE 8989110959T DE 68902706 T DE68902706 T DE 68902706T DE 68902706 D1 DE68902706 D1 DE 68902706D1
- Authority
- DE
- Germany
- Prior art keywords
- valiolamine
- hyperammonemia
- compound
- formula
- treatment
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 230000001225 therapeutic effect Effects 0.000 title 1
- -1 valiolamine compound Chemical class 0.000 abstract 5
- 206010020575 Hyperammonaemia Diseases 0.000 abstract 3
- VDLOJRUTNRJDJO-UHFFFAOYSA-N Valiolamine Natural products NC1CC(O)(CO)C(O)C(O)C1O VDLOJRUTNRJDJO-UHFFFAOYSA-N 0.000 abstract 3
- 150000003839 salts Chemical class 0.000 abstract 3
- 125000002015 acyclic group Chemical group 0.000 abstract 1
- 125000000837 carbohydrate group Chemical group 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 125000002541 furyl group Chemical group 0.000 abstract 1
- 125000001183 hydrocarbyl group Chemical group 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
- 125000004076 pyridyl group Chemical group 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP15384588 | 1988-06-22 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE68902706D1 true DE68902706D1 (de) | 1992-10-08 |
| DE68902706T2 DE68902706T2 (de) | 1993-02-25 |
Family
ID=15571358
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE8989110959T Expired - Fee Related DE68902706T2 (de) | 1988-06-22 | 1989-06-16 | Therapeutische zusammensetzung fuer leber-gehirnkomplikationen. |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US4996236A (de) |
| EP (1) | EP0350650B1 (de) |
| AT (1) | ATE80032T1 (de) |
| CA (1) | CA1336072C (de) |
| DE (1) | DE68902706T2 (de) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6346382B1 (en) | 1999-06-01 | 2002-02-12 | Vanderbilt University | Human carbamyl phosphate synthetase I polymorphism and diagnostic methods related thereto |
| US9486429B2 (en) * | 1999-06-01 | 2016-11-08 | Vanderbilt University | Therapeutic methods employing nitric oxide precursors |
| US7256202B2 (en) * | 2003-12-31 | 2007-08-14 | Halow George M | Composition and method for treatment of hepatic encephalopathy |
| SG196863A1 (en) | 2008-01-31 | 2014-02-13 | Univ Vanderbilt | Methods and compositions for treatment for coronary and arterial aneurysmal subarachnoid hemorrhage |
| JP2011511006A (ja) * | 2008-01-31 | 2011-04-07 | バンダービルト・ユニバーシティ | 肺病態に対する治療 |
| US9616075B2 (en) | 2012-07-20 | 2017-04-11 | University Of Rochester | Method of treating and preventing brain impairment using Na+-K+-2Cl-cotransporter isoform 1 inhibitors |
| CN108059603B (zh) * | 2017-12-29 | 2020-08-14 | 山东新华制药股份有限公司 | 伏格列波糖杂质n-甲基井岗酶醇胺的精制工艺 |
| CN108003042B (zh) * | 2017-12-29 | 2020-08-14 | 山东新华制药股份有限公司 | 伏格列波糖杂质n‐甲基井岗酶醇胺的制备工艺 |
-
1989
- 1989-05-15 US US07/351,462 patent/US4996236A/en not_active Expired - Fee Related
- 1989-05-29 CA CA000600944A patent/CA1336072C/en not_active Expired - Fee Related
- 1989-06-16 EP EP89110959A patent/EP0350650B1/de not_active Expired - Lifetime
- 1989-06-16 DE DE8989110959T patent/DE68902706T2/de not_active Expired - Fee Related
- 1989-06-16 AT AT89110959T patent/ATE80032T1/de not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| EP0350650B1 (de) | 1992-09-02 |
| DE68902706T2 (de) | 1993-02-25 |
| CA1336072C (en) | 1995-06-27 |
| US4996236A (en) | 1991-02-26 |
| EP0350650A1 (de) | 1990-01-17 |
| ATE80032T1 (de) | 1992-09-15 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition | ||
| 8339 | Ceased/non-payment of the annual fee |