DE68900582D1 - Verfahren zur herstellung von 1-hydroxyalkyl-5-nitro-imidazolen. - Google Patents
Verfahren zur herstellung von 1-hydroxyalkyl-5-nitro-imidazolen.Info
- Publication number
- DE68900582D1 DE68900582D1 DE8989400095T DE68900582T DE68900582D1 DE 68900582 D1 DE68900582 D1 DE 68900582D1 DE 8989400095 T DE8989400095 T DE 8989400095T DE 68900582 T DE68900582 T DE 68900582T DE 68900582 D1 DE68900582 D1 DE 68900582D1
- Authority
- DE
- Germany
- Prior art keywords
- formula
- hydroxyalkyl
- iii
- image
- imidazoles
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/91—Nitro radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/91—Nitro radicals
- C07D233/92—Nitro radicals attached in position 4 or 5
- C07D233/94—Nitro radicals attached in position 4 or 5 with hydrocarbon radicals, substituted by oxygen or sulfur atoms, attached to other ring members
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR8800415A FR2625998B1 (fr) | 1988-01-15 | 1988-01-15 | Procede de preparation d'hydroxyalkyl-1 methyl-2 nitro-5 imidazoles |
Publications (1)
Publication Number | Publication Date |
---|---|
DE68900582D1 true DE68900582D1 (de) | 1992-02-06 |
Family
ID=9362336
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE8989400095T Expired - Fee Related DE68900582D1 (de) | 1988-01-15 | 1989-01-12 | Verfahren zur herstellung von 1-hydroxyalkyl-5-nitro-imidazolen. |
Country Status (22)
Country | Link |
---|---|
US (1) | US4925952A (de) |
EP (1) | EP0324691B1 (de) |
JP (1) | JPH01216976A (de) |
KR (1) | KR890011855A (de) |
CN (1) | CN1023318C (de) |
AT (1) | ATE70831T1 (de) |
AU (1) | AU608933B2 (de) |
CA (1) | CA1310326C (de) |
DE (1) | DE68900582D1 (de) |
DK (1) | DK14889A (de) |
ES (1) | ES2028444T3 (de) |
FI (1) | FI890186A (de) |
FR (1) | FR2625998B1 (de) |
GR (1) | GR3003445T3 (de) |
HU (1) | HU200447B (de) |
IL (1) | IL88944A0 (de) |
MX (1) | MX169604B (de) |
NO (1) | NO172798C (de) |
PT (1) | PT89443B (de) |
SU (1) | SU1657060A3 (de) |
YU (1) | YU46997B (de) |
ZA (1) | ZA89307B (de) |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2625999B1 (fr) * | 1988-01-15 | 1990-06-08 | Rhone Poulenc Sante | Procede de preparation d'hydroxyalkyl-1 methyl-2 nitro-5 imidazoles |
IL88943A (en) * | 1988-01-15 | 1994-05-30 | Rhone Poulenc Sante | Process for the preparation of 1-alkyl-5-nitroimidazoles |
FR2659326A1 (fr) * | 1990-03-12 | 1991-09-13 | Rhone Poulenc Sante | Procede de preparation d'hydroxyalkyl-1 nitro-5 imidazoles. |
UA88925C2 (en) * | 2002-10-15 | 2009-12-10 | Оцука Фармасьютикал Ко., Лтд. | 4-nitroimidazole derivatives |
CN102321028B (zh) * | 2011-06-30 | 2013-12-25 | 湖北省宏源药业有限公司 | 一种合成2-甲基-5-硝基咪唑-1-乙醇的方法 |
RU2531616C1 (ru) * | 2013-03-29 | 2014-10-27 | Федеральное государственное бюджетное образовательное учреждение высшего профессионального образования "Национальный исследовательский Томский государственный университет" (ТГУ) | Способ получения метронидазола |
WO2015198107A1 (en) * | 2014-06-24 | 2015-12-30 | Kiany Fard Taghi | Synthesis of metronidazole |
AU2015311674B2 (en) | 2014-09-05 | 2018-03-08 | Lupin Inc. | Secnidazole for use in the treatment of bacterial vaginosis |
CA2988082C (en) | 2015-06-01 | 2020-09-29 | Symbiomix Therapeutics, Llc | Novel nitroimidazole formulations and uses thereof |
CN110749682A (zh) * | 2019-10-24 | 2020-02-04 | 湖北省宏源药业科技股份有限公司 | 一种2-甲基-5-硝基咪唑含量检测方法 |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3178446A (en) * | 1961-07-27 | 1965-04-13 | Luso Farmaco Inst | Oxyethylation of imidazole compounds |
FR3270M (fr) * | 1963-10-10 | 1965-04-26 | Rhone Poulenc Sa | Nouveaux dérivés de l'imidazole et compositions les contenant. |
FR1427627A (fr) * | 1963-10-10 | 1966-02-11 | Rhone Poulenc Sa | Nouveaux dérivés de l'imidazole et leur préparation |
US3743653A (en) * | 1970-12-28 | 1973-07-03 | Merck & Co Inc | Hydroxyethylation with ethylene sulfate |
DE3400531A1 (de) * | 1984-01-10 | 1985-07-18 | Basf Ag, 6700 Ludwigshafen | Verfahren zur gewinnung von hochreinem 1(2-hydroxiethyl)-2-methyl-5-nitroimidazol |
FR2625999B1 (fr) * | 1988-01-15 | 1990-06-08 | Rhone Poulenc Sante | Procede de preparation d'hydroxyalkyl-1 methyl-2 nitro-5 imidazoles |
IL88943A (en) * | 1988-01-15 | 1994-05-30 | Rhone Poulenc Sante | Process for the preparation of 1-alkyl-5-nitroimidazoles |
-
1988
- 1988-01-15 FR FR8800415A patent/FR2625998B1/fr not_active Expired - Lifetime
-
1989
- 1989-01-12 AT AT89400095T patent/ATE70831T1/de not_active IP Right Cessation
- 1989-01-12 EP EP89400095A patent/EP0324691B1/de not_active Expired - Lifetime
- 1989-01-12 IL IL88944A patent/IL88944A0/xx unknown
- 1989-01-12 ES ES198989400095T patent/ES2028444T3/es not_active Expired - Lifetime
- 1989-01-12 DE DE8989400095T patent/DE68900582D1/de not_active Expired - Fee Related
- 1989-01-13 PT PT89443A patent/PT89443B/pt not_active IP Right Cessation
- 1989-01-13 AU AU28452/89A patent/AU608933B2/en not_active Ceased
- 1989-01-13 FI FI890186A patent/FI890186A/fi not_active Application Discontinuation
- 1989-01-13 CA CA000588181A patent/CA1310326C/fr not_active Expired - Lifetime
- 1989-01-13 CN CN89100185A patent/CN1023318C/zh not_active Expired - Fee Related
- 1989-01-13 MX MX014534A patent/MX169604B/es unknown
- 1989-01-13 DK DK014889A patent/DK14889A/da not_active Application Discontinuation
- 1989-01-13 NO NO890157A patent/NO172798C/no unknown
- 1989-01-13 JP JP1005078A patent/JPH01216976A/ja active Pending
- 1989-01-13 ZA ZA89307A patent/ZA89307B/xx unknown
- 1989-01-13 HU HU89128A patent/HU200447B/hu not_active IP Right Cessation
- 1989-01-13 US US07/296,710 patent/US4925952A/en not_active Expired - Fee Related
- 1989-01-13 SU SU894613302A patent/SU1657060A3/ru active
- 1989-01-13 YU YU7289A patent/YU46997B/sh unknown
- 1989-01-14 KR KR1019890000395A patent/KR890011855A/ko not_active Application Discontinuation
-
1991
- 1991-12-30 GR GR91401113T patent/GR3003445T3/el unknown
Also Published As
Publication number | Publication date |
---|---|
JPH01216976A (ja) | 1989-08-30 |
YU7289A (en) | 1990-12-31 |
FI890186A0 (fi) | 1989-01-13 |
CN1023318C (zh) | 1993-12-29 |
NO890157L (no) | 1989-07-17 |
AU2845289A (en) | 1989-07-20 |
HU200447B (en) | 1990-06-28 |
FR2625998B1 (fr) | 1990-06-08 |
IL88944A0 (en) | 1989-08-15 |
US4925952A (en) | 1990-05-15 |
MX169604B (es) | 1993-07-14 |
FR2625998A1 (fr) | 1989-07-21 |
ZA89307B (en) | 1989-10-25 |
GR3003445T3 (en) | 1993-02-17 |
CN1035288A (zh) | 1989-09-06 |
HUT49586A (en) | 1989-10-30 |
PT89443B (pt) | 1993-09-30 |
EP0324691B1 (de) | 1991-12-27 |
YU46997B (sh) | 1994-11-15 |
ATE70831T1 (de) | 1992-01-15 |
EP0324691A1 (de) | 1989-07-19 |
DK14889D0 (da) | 1989-01-13 |
PT89443A (pt) | 1990-02-08 |
CA1310326C (fr) | 1992-11-17 |
SU1657060A3 (ru) | 1991-06-15 |
NO172798C (no) | 1993-09-08 |
AU608933B2 (en) | 1991-04-18 |
ES2028444T3 (es) | 1992-07-01 |
DK14889A (da) | 1989-07-16 |
NO172798B (no) | 1993-06-01 |
FI890186A (fi) | 1989-07-16 |
NO890157D0 (no) | 1989-01-13 |
KR890011855A (ko) | 1989-08-22 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition | ||
8339 | Ceased/non-payment of the annual fee |