DE660703C - Process for the production of durable solutions of dioxydiaminoarsenobenzene and its derivatives - Google Patents

Process for the production of durable solutions of dioxydiaminoarsenobenzene and its derivatives

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Publication number
DE660703C
DE660703C DEH143871D DEH0143871D DE660703C DE 660703 C DE660703 C DE 660703C DE H143871 D DEH143871 D DE H143871D DE H0143871 D DEH0143871 D DE H0143871D DE 660703 C DE660703 C DE 660703C
Authority
DE
Germany
Prior art keywords
dioxydiaminoarsenobenzene
derivatives
solutions
production
durable
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
DEH143871D
Other languages
German (de)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
HOFFMANNI LA ROCHE and CO AKT GE
Original Assignee
HOFFMANNI LA ROCHE and CO AKT GE
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by HOFFMANNI LA ROCHE and CO AKT GE filed Critical HOFFMANNI LA ROCHE and CO AKT GE
Application granted granted Critical
Publication of DE660703C publication Critical patent/DE660703C/en
Expired legal-status Critical Current

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Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/66Arsenic compounds
    • C07F9/70Organo-arsenic compounds
    • C07F9/74Aromatic compounds

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Description

Verfahren zur Herstellung haltbarer Lösungen von Dioxydiaminoarsenobenzol und seinen Derivaten Lösungen von Dioxydiaminoarsenobenzol und seinen Derivaten fallen sehr leicht und rasch Zersetzungen anheim, die sie für eine therapeutische Verwendung unbrauchbar machen. Diese Veränderungen dürften auf oxydative Einflüsse zurückzuführen sein. Es wurde nun gefunden, daß die Oxydation und damit die unerwünschte Veränderung derartiger Lösungen verhindert werden kann, wenn man denselben Ascorbinsäure oder Salze der Ascorbinsäure zusetzt.Process for the preparation of durable solutions of dioxydiaminoarsenobenzene and its derivatives Solutions of dioxydiaminoarsenobenzene and its derivatives very easily and quickly fall prey to decomposition, which makes them therapeutic Make use unusable. These changes are likely to be due to oxidative influences be due. It has now been found that the oxidation and thus the undesirable Alteration of such solutions can be prevented by using the same ascorbic acid or adding salts of ascorbic acid.

Beispiel i 6 Teile dioxydiaminoarsenobenzolmethylensulfosaures Natrium werden gelöst in einer Lösung von 3 Teilen Ascorbinsäure in 6o Volumteilen Wasser unter Zusatz von so viel Natronlauge, dali das PH = 6,5 beträgt. Die erhaltene i o %ige Lösung von dioxydiaminoarsenobenzolm.ethylensulfosaurem Natrium ist klar hellgelb gefärbt und verändert sich auch bei längerem Stehen an der Luft nicht, während die gleiche Lösung ohne Ascorbinsäurezusatz rasch dunkelbraun wird.Example i 6 parts of sodium dioxydiaminoarsenobenzolmethylene sulfonic acid are dissolved in a solution of 3 parts of ascorbic acid in 60 parts by volume of water with the addition of so much sodium hydroxide solution that the pH is 6.5. The i o% solution of sodium dioxydiaminoarsenobenzolm.ethylenesulfosaurem is clear light yellow in color and does not change even when standing in the air for a long time, while the same solution without the addition of ascorbic acid quickly turns dark brown.

Beispiel 2 4,66 Teile dioxydiaminoarsenobenzolmethylensulfosaures Natrium werden mit q. Teilen ascorbinsaurem Natrium gemischt. Das erhaltene Pulver gibt neutrale wässerige Lösungen, die stabil sind.Example 2 4.66 parts of dioxydiaminoarsenobenzolmethylene sulfonic acid Sodium with q. Parts of sodium ascorbate mixed. The powder obtained gives neutral aqueous solutions that are stable.

Claims (1)

PATENTANSPRUCII: Verfahren zur Herstellung haltbarer Lösungen von Dioxydiaminoarsenobenzol und seinen Derivaten, dadurch gekennzeichnet, daß man den Lösungen Ascorbinsäure oder Salze der Ascorbinsäure zusetzt.PATENT CLAIM: Process for the preparation of durable solutions of Dioxydiaminoarsenobenzene and its derivatives, characterized in that the Solutions of ascorbic acid or salts of ascorbic acid added.
DEH143871D 1934-07-06 1935-06-01 Process for the production of durable solutions of dioxydiaminoarsenobenzene and its derivatives Expired DE660703C (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH660703X 1934-07-06

Publications (1)

Publication Number Publication Date
DE660703C true DE660703C (en) 1938-06-01

Family

ID=4526867

Family Applications (1)

Application Number Title Priority Date Filing Date
DEH143871D Expired DE660703C (en) 1934-07-06 1935-06-01 Process for the production of durable solutions of dioxydiaminoarsenobenzene and its derivatives

Country Status (1)

Country Link
DE (1) DE660703C (en)

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