DE660703C - Process for the production of durable solutions of dioxydiaminoarsenobenzene and its derivatives - Google Patents
Process for the production of durable solutions of dioxydiaminoarsenobenzene and its derivativesInfo
- Publication number
- DE660703C DE660703C DEH143871D DEH0143871D DE660703C DE 660703 C DE660703 C DE 660703C DE H143871 D DEH143871 D DE H143871D DE H0143871 D DEH0143871 D DE H0143871D DE 660703 C DE660703 C DE 660703C
- Authority
- DE
- Germany
- Prior art keywords
- dioxydiaminoarsenobenzene
- derivatives
- solutions
- production
- durable
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 238000000034 method Methods 0.000 title claims description 3
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 claims description 12
- 235000010323 ascorbic acid Nutrition 0.000 claims description 6
- 239000011668 ascorbic acid Substances 0.000 claims description 6
- 229960005070 ascorbic acid Drugs 0.000 claims description 6
- 238000002360 preparation method Methods 0.000 claims description 2
- 150000003839 salts Chemical class 0.000 claims description 2
- 239000000243 solution Substances 0.000 description 7
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 3
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 3
- 229910052708 sodium Inorganic materials 0.000 description 3
- 239000011734 sodium Substances 0.000 description 3
- LSNNMFCWUKXFEE-UHFFFAOYSA-M Bisulfite Chemical compound OS([O-])=O LSNNMFCWUKXFEE-UHFFFAOYSA-M 0.000 description 2
- 230000004075 alteration Effects 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 238000000354 decomposition reaction Methods 0.000 description 1
- 230000007935 neutral effect Effects 0.000 description 1
- 230000003647 oxidation Effects 0.000 description 1
- 238000007254 oxidation reaction Methods 0.000 description 1
- 230000001590 oxidative effect Effects 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 235000010378 sodium ascorbate Nutrition 0.000 description 1
- PPASLZSBLFJQEF-RKJRWTFHSA-M sodium ascorbate Substances [Na+].OC[C@@H](O)[C@H]1OC(=O)C(O)=C1[O-] PPASLZSBLFJQEF-RKJRWTFHSA-M 0.000 description 1
- 229960005055 sodium ascorbate Drugs 0.000 description 1
- PPASLZSBLFJQEF-RXSVEWSESA-M sodium-L-ascorbate Chemical compound [Na+].OC[C@H](O)[C@H]1OC(=O)C(O)=C1[O-] PPASLZSBLFJQEF-RXSVEWSESA-M 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/66—Arsenic compounds
- C07F9/70—Organo-arsenic compounds
- C07F9/74—Aromatic compounds
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Description
Verfahren zur Herstellung haltbarer Lösungen von Dioxydiaminoarsenobenzol und seinen Derivaten Lösungen von Dioxydiaminoarsenobenzol und seinen Derivaten fallen sehr leicht und rasch Zersetzungen anheim, die sie für eine therapeutische Verwendung unbrauchbar machen. Diese Veränderungen dürften auf oxydative Einflüsse zurückzuführen sein. Es wurde nun gefunden, daß die Oxydation und damit die unerwünschte Veränderung derartiger Lösungen verhindert werden kann, wenn man denselben Ascorbinsäure oder Salze der Ascorbinsäure zusetzt.Process for the preparation of durable solutions of dioxydiaminoarsenobenzene and its derivatives Solutions of dioxydiaminoarsenobenzene and its derivatives very easily and quickly fall prey to decomposition, which makes them therapeutic Make use unusable. These changes are likely to be due to oxidative influences be due. It has now been found that the oxidation and thus the undesirable Alteration of such solutions can be prevented by using the same ascorbic acid or adding salts of ascorbic acid.
Beispiel i 6 Teile dioxydiaminoarsenobenzolmethylensulfosaures Natrium werden gelöst in einer Lösung von 3 Teilen Ascorbinsäure in 6o Volumteilen Wasser unter Zusatz von so viel Natronlauge, dali das PH = 6,5 beträgt. Die erhaltene i o %ige Lösung von dioxydiaminoarsenobenzolm.ethylensulfosaurem Natrium ist klar hellgelb gefärbt und verändert sich auch bei längerem Stehen an der Luft nicht, während die gleiche Lösung ohne Ascorbinsäurezusatz rasch dunkelbraun wird.Example i 6 parts of sodium dioxydiaminoarsenobenzolmethylene sulfonic acid are dissolved in a solution of 3 parts of ascorbic acid in 60 parts by volume of water with the addition of so much sodium hydroxide solution that the pH is 6.5. The i o% solution of sodium dioxydiaminoarsenobenzolm.ethylenesulfosaurem is clear light yellow in color and does not change even when standing in the air for a long time, while the same solution without the addition of ascorbic acid quickly turns dark brown.
Beispiel 2 4,66 Teile dioxydiaminoarsenobenzolmethylensulfosaures Natrium werden mit q. Teilen ascorbinsaurem Natrium gemischt. Das erhaltene Pulver gibt neutrale wässerige Lösungen, die stabil sind.Example 2 4.66 parts of dioxydiaminoarsenobenzolmethylene sulfonic acid Sodium with q. Parts of sodium ascorbate mixed. The powder obtained gives neutral aqueous solutions that are stable.
Claims (1)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH660703X | 1934-07-06 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE660703C true DE660703C (en) | 1938-06-01 |
Family
ID=4526867
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DEH143871D Expired DE660703C (en) | 1934-07-06 | 1935-06-01 | Process for the production of durable solutions of dioxydiaminoarsenobenzene and its derivatives |
Country Status (1)
| Country | Link |
|---|---|
| DE (1) | DE660703C (en) |
-
1935
- 1935-06-01 DE DEH143871D patent/DE660703C/en not_active Expired
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