DE657279C - Process for the extraction of physiologically active substances from internal secretory organs - Google Patents

Process for the extraction of physiologically active substances from internal secretory organs

Info

Publication number
DE657279C
DE657279C DEC40228D DEC0040228D DE657279C DE 657279 C DE657279 C DE 657279C DE C40228 D DEC40228 D DE C40228D DE C0040228 D DEC0040228 D DE C0040228D DE 657279 C DE657279 C DE 657279C
Authority
DE
Germany
Prior art keywords
active substances
organs
physiologically active
extraction
secretory organs
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
DEC40228D
Other languages
German (de)
Inventor
Dr Max Dohrn
Dr Werner Faure
Dr Walter Schoeller
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer Pharma AG
Original Assignee
Schering AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering AG filed Critical Schering AG
Priority to DEC40228D priority Critical patent/DE657279C/en
Application granted granted Critical
Publication of DE657279C publication Critical patent/DE657279C/en
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/48—Reproductive organs
    • A61K35/50—Placenta; Placental stem cells; Amniotic fluid; Amnion; Amniotic stem cells

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Cell Biology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Pregnancy & Childbirth (AREA)
  • Reproductive Health (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Immunology (AREA)
  • Virology (AREA)
  • Zoology (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Extraction Or Liquid Replacement (AREA)

Description

Verfahren zur Gewinnung von physiologisch wirksamen Stoffen aus innersekretorischen Organen Das Hauptpatent 647 437 schützt ,ein Verfahren, um aus innersekretorischen Organen Hormone dadurcn zu gewinnen, daß man wirksame Extrakte solcher Organe mit durch Wasser verdünnten organischen Lösungsmitteln bei Gegenwart von Erdalkalien behandelt. Es bat sich gezeigt, daß es sich erübrigt, aus den betreffenden Orgänen zuerst einen Extrakt zu bereiten, vielmehr läßt sich das Verfahren auf die frischen zerkleinerten Organe unmittelbar anwenden. Dadurch wird eine Stufe der Darstellung erspart.Process for obtaining physiologically active substances from internal secretory organs The main patent 647 437 protects a process for obtaining hormones from internal secretory organs by treating effective extracts of such organs with organic solvents diluted with water in the presence of alkaline earths. It turned out that there is no need to first prepare an extract from the organs in question; rather, the process can be applied directly to the freshly minced organs. This saves one level of representation.

Der Zusatz von Adsorbentien; wie Kaolin usw., zeigt sich als vorteilhaft bei der Behandlung.The addition of adsorbents; such as kaolin, etc., are found to be beneficial in treatment.

Beispiel z Y o kg frische Placenten werden zerkleinert und mit 5 kg eines Gemisches von Calciumhydroxyd und Silicagel vermischt unter Zulauf von zokg 40%igem Methylalkohol. Nach 2stündiger Digerierung bei 6o° wird filtriert und das Filtrat eingedampft. Der Rückstand wird mit wenig, Wasser aufgenommen und ausgeäth:ert.Example z Y o kg of fresh placenta are crushed and mixed with 5 kg of a mixture of calcium hydroxide and silica gel with the addition of 40% methyl alcohol. After digestion for 2 hours at 60 °, it is filtered and the filtrate is evaporated. The residue is taken up with a little water and extracted with ether.

Beispiel 2 Mit besonderem Vorteil werden auf die gleiche Weise Hoden oder Prostatadrüsen verarbeitet.Example 2 With particular advantage testicles are made in the same way or prostate glands processed.

Claims (1)

PATENTANSPRUCH: Ausführungsform des durch Patent 647 437 geschützten Verfahrens. zur Geudnnung von physiologisch wirksamen Stoffen aus innersekretorischen Organen, dadurch gekennzeichnet, daß man an Stelle der aus den innersekretorischen Organen gewonnenen wirksamen Extrakte die zerkleinerten frischen Organe selbst mit durch Wasser verdünnten, organischen Lösungsmitteln bei Gegenwart von Erdalkalien behandelt,Claim: Embodiment of the protected by Patent 647,437 procedure. for the dilution of physiologically active substances from internal secretory organs, characterized in that, instead of the active extracts obtained from the internal secretory organs, the comminuted fresh organs themselves are treated with organic solvents diluted with water in the presence of alkaline earths,
DEC40228D 1927-07-30 1927-07-30 Process for the extraction of physiologically active substances from internal secretory organs Expired DE657279C (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
DEC40228D DE657279C (en) 1927-07-30 1927-07-30 Process for the extraction of physiologically active substances from internal secretory organs

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DEC40228D DE657279C (en) 1927-07-30 1927-07-30 Process for the extraction of physiologically active substances from internal secretory organs

Publications (1)

Publication Number Publication Date
DE657279C true DE657279C (en) 1938-03-01

Family

ID=7024084

Family Applications (1)

Application Number Title Priority Date Filing Date
DEC40228D Expired DE657279C (en) 1927-07-30 1927-07-30 Process for the extraction of physiologically active substances from internal secretory organs

Country Status (1)

Country Link
DE (1) DE657279C (en)

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