DE624061C - Process for the production of water-soluble silver salts of acetylsalicylic acid - Google Patents
Process for the production of water-soluble silver salts of acetylsalicylic acidInfo
- Publication number
- DE624061C DE624061C DER87343D DER0087343D DE624061C DE 624061 C DE624061 C DE 624061C DE R87343 D DER87343 D DE R87343D DE R0087343 D DER0087343 D DE R0087343D DE 624061 C DE624061 C DE 624061C
- Authority
- DE
- Germany
- Prior art keywords
- acetylsalicylic acid
- water
- silver
- silver salts
- production
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
Description
Verfahren zur Herstellung wasserlöslicher Silbersalze der Acetylsalicylsäure Es wurde gefunden, daß man das durch Umsetzung von löslichen Silbersalzen mit acetylsaRcylsauren Alkalien erhaltene schwerlösliche acetylsalicylsaure Silber mit Hexamethylentetramin in Lösung bringen kann.Process for the preparation of water-soluble silver salts of acetylsalicylic acid It has been found that this can be achieved by reacting soluble silver salts with acetylsacyl acids Hardly soluble silver acetylsalicylic acid obtained in alkalis with hexamethylenetetramine can bring into solution.
Sehr wichtig für die Therapie und als technische Neuheit zu betrachten ist, daß sich keine kolloidale, sondern eine molekular disperse Verbindung bildet, ein Umstand, der besonders von der Ärzteschaft angenehm empfunden wird, weil die wäßrigen Lösungen fast wasserklar sind.Very important for therapy and to be regarded as a technical novelty is that not a colloidal, but a molecularly disperse compound is formed, a fact that is particularly pleasant among the medical profession because the aqueous solutions are almost as clear as water.
Außerdem bedingen molekular disperse Lösungen ein besseres Durchdringungsvermögen des Zellgewebes und dadurch eine schnellere und kräftigere therapeutische Wirkung.In addition, molecularly disperse solutions require better penetration of the cell tissue and thus a faster and more powerful therapeutic effect.
Ein weiterer Vorteil dieser Verbindung ist, daß die wäßrige Lösung sehr haltbar ist.Another advantage of this compound is that the aqueous solution is very durable.
In der Literatur (v91. Altpeter, Das Hexamethylentetramin und seine Verwendung 1931, S- 33, 35 u. 36) werden verschiedene. Kombinationen des Hexamethylentetramins mit Silbersalzen, z. B. Silberoxalat, Süberbenzoat und Silbersalicylat, erwähnt. Diese Silbersalze geben aber mit Hexamethylentetramin keine wasserlöslichen Verbindungen, sondern dieselben sind nur mit Ammoniak in Lösung zu bringen.In the literature (v91. Altpeter, Das Hexamethylenetetramin und seine Use 1931, pp. 33, 35 and 36) are different. Combinations of hexamethylenetetramine with silver salts, e.g. B. silver oxalate, silver benzoate and silver salicylate mentioned. These silver salts do not give any water-soluble compounds with hexamethylenetetramine, but they can only be brought into solution with ammonia.
Wie weiter bekannt ist, sind die Silbersalze der Eiweißspaltungsprodukte und der Gallensäuren unlöslich und können mit Hexamethylentetramin in lösliche Produkte übergeführt werden. Diese Lösungen sind aber kolloidal und nicht haltbar. Die desinfizierende Wirkung der neuen Verbindung erhöht sich in saurer Lösung. Diese Erfahrung wurde hauptsächlich bei der Behandlung tuberkulöser Erkrankungen beobachtet.As is also known, the silver salts are the products of protein breakdown and the bile acids are insoluble and can be converted into soluble products with hexamethylenetetramine be transferred. However, these solutions are colloidal and cannot be kept. The disinfectant The effect of the new compound increases in acidic solution. That experience was mainly observed in the treatment of tuberculous diseases.
Aus der trockenen Substanz läßt sich mit Chloroform nichts herauslösen.Nothing can be extracted from the dry substance with chloroform.
Beispiel 1o Teile acetylsalicylsaures Natrium oder Kalium werden in 3oo Teilen destilliertem Wasser gelöst und mit 1o Teilen Silbernitrat oder der entsprechenden Menge eines anderen löslichen Silbersalzes (gelöst in Zoo Teilen destilliertem Wasser) unter Rühren versetzt; das ausgefällte Silbersalz wird mit destilliertem Wasser oder mit verdünntem Alkohol gewaschen und nach dem Absaugen mit Hexamethylentetramin in Lösung gebracht und -im Vakuum getrocknet.Example 1o parts of sodium or potassium acetylsalicylic acid are used in 300 parts of distilled water and dissolved with 10 parts of silver nitrate or the equivalent Amount of another soluble silver salt (dissolved in Zoo parts of distilled water) added with stirring; the precipitated silver salt is mixed with distilled water or washed with dilute alcohol and after suctioning off with hexamethylenetetramine brought into solution and dried in vacuo.
Claims (1)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DER87343D DE624061C (en) | 1933-02-23 | 1933-02-23 | Process for the production of water-soluble silver salts of acetylsalicylic acid |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DER87343D DE624061C (en) | 1933-02-23 | 1933-02-23 | Process for the production of water-soluble silver salts of acetylsalicylic acid |
Publications (1)
Publication Number | Publication Date |
---|---|
DE624061C true DE624061C (en) | 1936-01-11 |
Family
ID=7417745
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DER87343D Expired DE624061C (en) | 1933-02-23 | 1933-02-23 | Process for the production of water-soluble silver salts of acetylsalicylic acid |
Country Status (1)
Country | Link |
---|---|
DE (1) | DE624061C (en) |
-
1933
- 1933-02-23 DE DER87343D patent/DE624061C/en not_active Expired
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