DE436780C - Process for the preparation of bismuth salts of mercured, organic compounds containing an acid radical - Google Patents
Process for the preparation of bismuth salts of mercured, organic compounds containing an acid radicalInfo
- Publication number
- DE436780C DE436780C DEF51069D DEF0051069D DE436780C DE 436780 C DE436780 C DE 436780C DE F51069 D DEF51069 D DE F51069D DE F0051069 D DEF0051069 D DE F0051069D DE 436780 C DE436780 C DE 436780C
- Authority
- DE
- Germany
- Prior art keywords
- bismuth
- mercured
- compounds containing
- preparation
- acid radical
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 239000002253 acid Substances 0.000 title claims description 11
- 150000001621 bismuth Chemical class 0.000 title claims description 5
- 238000000034 method Methods 0.000 title claims description 3
- 238000002360 preparation method Methods 0.000 title claims description 3
- 150000002894 organic compounds Chemical class 0.000 title claims 2
- 229910052797 bismuth Inorganic materials 0.000 claims description 7
- JCXGWMGPZLAOME-UHFFFAOYSA-N bismuth atom Chemical compound [Bi] JCXGWMGPZLAOME-UHFFFAOYSA-N 0.000 claims description 7
- 150000001447 alkali salts Chemical class 0.000 claims description 2
- 150000002731 mercury compounds Chemical class 0.000 claims description 2
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 15
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 9
- 239000002244 precipitate Substances 0.000 description 7
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 6
- QSHDDOUJBYECFT-UHFFFAOYSA-N mercury Chemical compound [Hg] QSHDDOUJBYECFT-UHFFFAOYSA-N 0.000 description 4
- 229910052753 mercury Inorganic materials 0.000 description 4
- WFDIJRYMOXRFFG-UHFFFAOYSA-N Acetic anhydride Chemical compound CC(=O)OC(C)=O WFDIJRYMOXRFFG-UHFFFAOYSA-N 0.000 description 3
- GRYLNZFGIOXLOG-UHFFFAOYSA-N Nitric acid Chemical compound O[N+]([O-])=O GRYLNZFGIOXLOG-UHFFFAOYSA-N 0.000 description 3
- JHXKRIRFYBPWGE-UHFFFAOYSA-K bismuth chloride Chemical compound Cl[Bi](Cl)Cl JHXKRIRFYBPWGE-UHFFFAOYSA-K 0.000 description 3
- 150000001875 compounds Chemical class 0.000 description 3
- 238000001035 drying Methods 0.000 description 3
- RXPAJWPEYBDXOG-UHFFFAOYSA-N hydron;methyl 4-methoxypyridine-2-carboxylate;chloride Chemical compound Cl.COC(=O)C1=CC(OC)=CC=N1 RXPAJWPEYBDXOG-UHFFFAOYSA-N 0.000 description 3
- 229910017604 nitric acid Inorganic materials 0.000 description 3
- WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical compound OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 description 2
- 239000005711 Benzoic acid Substances 0.000 description 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
- 235000010233 benzoic acid Nutrition 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 231100001231 less toxic Toxicity 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- -1 silver anthranilic acid anhydride Chemical compound 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 208000006379 syphilis Diseases 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/94—Bismuth compounds
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Treating Waste Gases (AREA)
Description
Verfahren zur Darstellung von Wismutsalzen mercurierter, organischer, einen Säurerest enthaltender Verbindungen. Es wurde gefunden, daß man zu therapeutisch wichtigen, gleichzeitig Quecksilber und Wismut enthaltenden Verbindungen gelangen kann, wenn man quecksilberorganische Verbindungen, die einen Säurerest enthalten, in Form ihrer Alkalisalze mit Wismutsalzen zusammenbringt. Die neuen Verbindungen zeichnen sich durch eine kräftige Wirkung bei Lues aus und sind weniger giftig, als nach ihrem Gehalt an mercurierter Verbindung erwartet werden sollte. Beispiele. i. io g Mercurisalicy lsäure werden in ioo ccm Wasser unter Zugabe von Natronlauge gelöst und mit einer Lösung von 9,5 g Wismutchlorid in io ccm konzentrierter Salzsäure und 5o ccm Wasser vereinigt. Es entsteht ein weißer, voluminöser Niederschlag, der nach dem Trocknen 33,9 Prozent Quecksilber und 36 Prozent Wismut enthält.Process for the preparation of bismuth salts of mercured, organic, compounds containing an acid residue. It has been found to be too therapeutic important compounds containing mercury and bismuth at the same time can, if one uses organic mercury compounds that contain an acid residue, brings together in the form of their alkali salts with bismuth salts. The new connections are characterized by a powerful effect on syphilis and are less toxic, than should be expected from their mercured compound content. Examples. i. 10 g of mercuric acid are dissolved in 100 cc of water with the addition of sodium hydroxide solution dissolved and treated with a solution of 9.5 g of bismuth chloride in 10 cc of concentrated hydrochloric acid and 50 cc of water are combined. A white, voluminous precipitate forms, the after drying, contains 33.9 percent mercury and 36 percent bismuth.
2. 7,7 g o-Oxyquecksilberbenzoesäure (Berichte der Deutsch. Chem. Ges. 35, S. 2870 [19o2]) werden in 25 ccm doppeltnormaler Natronlauge unter Zugabe von 700 ccm Wasser gelöst und mit 6,3 g Wismutchlorid, das in io ccm konzentrierter Salzsäure und 2o ccm Wasser gelöst ist, versetzt. Es entsteht ein weißer, flockiger Niederschlag, der nach dem Trocknen 38 Prozent Quecksilber und 33 Prozent Wismut enthält.2. 7.7 g of o-oxymercuric benzoic acid (reports from Deutsch. Chem. Ges. 35, p. 2870 [19o2]) are dissolved in 25 cc of double normal sodium hydroxide solution with the addition of 700 cc of water and treated with 6.3 g of bismuth chloride, which is contained in 10 ccm of concentrated hydrochloric acid and 2o ccm of water are added. A white, flaky precipitate is formed which, after drying, contains 38 percent mercury and 33 percent bismuth.
3. 3,5 g Oxyqueclcsilberanthranilsäureanhydrid (Berichte der Deutsch. Chem. Ges. ¢7 [191q.], S. 1937) werden in 12 ccm doppeltnormaler Natronlauge und 8oo ccm Wasser gelöst und mit 3,15 g Wismutchlorid, gelöst in 5 ccm konzentrierter Salzsäure und 2o ccm Wasser, versetzt. Das als weißer Niederschlag abgeschiedene Salz enthält nach dem Trocknen 28 Prozent Quecksilber und 38 Prozent Wismut.3. 3.5 g of oxyquecyl silver anthranilic acid anhydride (reports from Deutsch. Chem. Ges. [7 [191q.], P. 1937) are dissolved in 12 cc of double normal sodium hydroxide solution and 800 cc of water and mixed with 3.15 g of bismuth chloride, dissolved in 5 cc concentrated hydrochloric acid and 2o ccm of water. The salt deposited as a white precipitate contains 28 percent mercury and 38 percent bismuth after drying.
q.. .4 g Oxyquecksilberessigsäureanhydrid (Berichte der Deutsch. Chem. Ges. 41 [19o8], S. 2o9o) werden mit 15 ccm Wasser und der nötigen Menge doppeltnormaler Natronlauge (etwa 12 ccm) in Lösung gebracht und mit q. g Wismutnitrat, die in möglichst wenig verdünnter Salpetersäure gelöst sind, versetzt. Man erhält so das oxymercuriessigsaure Wismut als weißen Niederschlag.q ... 4 g of oxymercury acetic anhydride (Reports of Deutsch. Chem. Ges. 41 [19o8], p. 2o9o) are brought into solution with 15 ccm of water and the necessary amount of double normal sodium hydroxide solution (about 12 ccm) and with q. g bismuth nitrate dissolved in as little dilute nitric acid as possible. The oxymercuric acid bismuth is thus obtained as a white precipitate.
5. 3,5 g Oxymercuriphenoxyessigsäure (Patentschrift 261229, F r i e d 1 ä n d e r XI, 1105) werden in 15 ccm Wasser unter Zusatz von _io ccm doppeltnormaler Natronlauge gelöst und mit einer Lösung von 2,5 g Wismutnitrat in möglichst wenig verdünnter Salpetersäure versetzt. Das oxymercuriphenoxyessigsaure Wismut fällt als weißer Niederschlag aus.5. 3.5 g of oxymercuriphenoxyacetic acid (Patent 261229, Frederick 1 ä nder XI, 1105) are dissolved in 15 cc of water with the addition of 1 cc of double normal sodium hydroxide solution and mixed with a solution of 2.5 g of bismuth nitrate in as little dilute nitric acid as possible. The bismuth oxymercuriphenoxyacetic acid precipitates out as a white precipitate.
6. Eine Lösung von 8,8 g oxymercurisulfosalicvlsaurem Natrium (Patentschrift 2i6267, F r i e d l ä n d e r IX, 1070) in 20o ccm Wasesr werden mit 3,2 g Wismutnitrat in wenig verdünnter Salpetersäure gelöst, versetzt, wobei das Wismutsalz der Oxyrnercurisulfosalicylsäure als weißer Niederschlag sich abscheidet.6. A solution of 8.8 g of sodium oxymercurisulfosalic acid (patent specification 2i6267, F r i e d l ä n d e r IX, 1070) in 20o cc water are mixed with 3.2 g bismuth nitrate dissolved in a little dilute nitric acid, added, the bismuth salt of oxyrnercurisulfosalicylic acid as a white precipitate separates out.
Claims (1)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DEF51069D DE436780C (en) | 1922-01-26 | 1922-01-26 | Process for the preparation of bismuth salts of mercured, organic compounds containing an acid radical |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DEF51069D DE436780C (en) | 1922-01-26 | 1922-01-26 | Process for the preparation of bismuth salts of mercured, organic compounds containing an acid radical |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE436780C true DE436780C (en) | 1926-11-08 |
Family
ID=7104311
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DEF51069D Expired DE436780C (en) | 1922-01-26 | 1922-01-26 | Process for the preparation of bismuth salts of mercured, organic compounds containing an acid radical |
Country Status (1)
| Country | Link |
|---|---|
| DE (1) | DE436780C (en) |
-
1922
- 1922-01-26 DE DEF51069D patent/DE436780C/en not_active Expired
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