DE617153C - Process for the production of water-soluble silver salts of glycerol phosphoric acids - Google Patents
Process for the production of water-soluble silver salts of glycerol phosphoric acidsInfo
- Publication number
- DE617153C DE617153C DER87315D DER0087315D DE617153C DE 617153 C DE617153 C DE 617153C DE R87315 D DER87315 D DE R87315D DE R0087315 D DER0087315 D DE R0087315D DE 617153 C DE617153 C DE 617153C
- Authority
- DE
- Germany
- Prior art keywords
- silver salts
- phosphoric acids
- water
- production
- glycerol phosphoric
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- XYZZKVRWGOWVGO-UHFFFAOYSA-N Glycerol-phosphate Chemical class OP(O)(O)=O.OCC(O)CO XYZZKVRWGOWVGO-UHFFFAOYSA-N 0.000 title claims description 5
- 238000000034 method Methods 0.000 title claims description 4
- 238000004519 manufacturing process Methods 0.000 title claims description 3
- SQGYOTSLMSWVJD-UHFFFAOYSA-N silver(1+) nitrate Chemical compound [Ag+].[O-]N(=O)=O SQGYOTSLMSWVJD-UHFFFAOYSA-N 0.000 claims description 4
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 3
- 229910001961 silver nitrate Inorganic materials 0.000 claims description 2
- 239000000243 solution Substances 0.000 claims 2
- VGGSQFUCUMXWEO-UHFFFAOYSA-N Ethene Chemical compound C=C VGGSQFUCUMXWEO-UHFFFAOYSA-N 0.000 claims 1
- 239000005977 Ethylene Substances 0.000 claims 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims 1
- 239000007864 aqueous solution Substances 0.000 claims 1
- 159000000001 potassium salts Chemical class 0.000 claims 1
- 229910052708 sodium Inorganic materials 0.000 claims 1
- 239000011734 sodium Substances 0.000 claims 1
- AGGKEGLBGGJEBZ-UHFFFAOYSA-N tetramethylenedisulfotetramine Chemical compound C1N(S2(=O)=O)CN3S(=O)(=O)N1CN2C3 AGGKEGLBGGJEBZ-UHFFFAOYSA-N 0.000 claims 1
- 238000005406 washing Methods 0.000 claims 1
- VKYKSIONXSXAKP-UHFFFAOYSA-N hexamethylenetetramine Chemical compound C1N(C2)CN3CN1CN2C3 VKYKSIONXSXAKP-UHFFFAOYSA-N 0.000 description 14
- 235000010299 hexamethylene tetramine Nutrition 0.000 description 7
- 239000004312 hexamethylene tetramine Substances 0.000 description 7
- 229960004011 methenamine Drugs 0.000 description 7
- 150000003378 silver Chemical class 0.000 description 6
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 4
- 150000001875 compounds Chemical class 0.000 description 3
- 239000012153 distilled water Substances 0.000 description 3
- 239000000047 product Substances 0.000 description 3
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 description 2
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 description 2
- BQCADISMDOOEFD-UHFFFAOYSA-N Silver Chemical compound [Ag] BQCADISMDOOEFD-UHFFFAOYSA-N 0.000 description 2
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 1
- 229910021529 ammonia Inorganic materials 0.000 description 1
- 239000003613 bile acid Substances 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 238000000354 decomposition reaction Methods 0.000 description 1
- 239000000645 desinfectant Substances 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 230000000149 penetrating effect Effects 0.000 description 1
- 230000035515 penetration Effects 0.000 description 1
- PYPGFWPYXNDBGD-UHFFFAOYSA-N phosphoric acid;propane-1,2,3-triol;sodium Chemical compound [Na].OP(O)(O)=O.OCC(O)CO PYPGFWPYXNDBGD-UHFFFAOYSA-N 0.000 description 1
- 229910052700 potassium Inorganic materials 0.000 description 1
- 239000011591 potassium Substances 0.000 description 1
- 239000002244 precipitate Substances 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- NBYLLBXLDOPANK-UHFFFAOYSA-M silver 2-carboxyphenolate hydrate Chemical compound C1=CC=C(C(=C1)C(=O)O)[O-].O.[Ag+] NBYLLBXLDOPANK-UHFFFAOYSA-M 0.000 description 1
- 229940100890 silver compound Drugs 0.000 description 1
- XNGYKPINNDWGGF-UHFFFAOYSA-L silver oxalate Chemical compound [Ag+].[Ag+].[O-]C(=O)C([O-])=O XNGYKPINNDWGGF-UHFFFAOYSA-L 0.000 description 1
- CLDWGXZGFUNWKB-UHFFFAOYSA-M silver;benzoate Chemical compound [Ag+].[O-]C(=O)C1=CC=CC=C1 CLDWGXZGFUNWKB-UHFFFAOYSA-M 0.000 description 1
- GGCZERPQGJTIQP-UHFFFAOYSA-N sodium;9,10-dioxoanthracene-2-sulfonic acid Chemical compound [Na+].C1=CC=C2C(=O)C3=CC(S(=O)(=O)O)=CC=C3C(=O)C2=C1 GGCZERPQGJTIQP-UHFFFAOYSA-N 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
- A61K33/38—Silver; Compounds thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/06—Phosphorus compounds without P—C bonds
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Inorganic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Description
Verfahren zur Herstellung wasserlöslicher Silbersalze der Glycerinphosphorsäuren Es wurde gefunden, daß man die durch Umsetzung von löslichen Silbersalzen mit glycerinphosphorsauren Alkalien erhaltenen schwer löslichen glycexinphosphorsauren Silbersalze mit Hexamethylentetramin in Lösung bringen kann. Sehr wichtig für die Therapie und als technische Neuheit zu betrachten ist, daß sich .keine kolloidale Silberverbindung bildet, sondern eine molekular disperse Verbindung, ein Vorteil, der besonders von der Ärzteschaft angenehm empfunden wird, weil die dunklen kolloidalen Silberverbindungen unbequem -und unhandlich sind. Außerdem besitzen die molekular dispersen Lösungen ein besseres Durchdringungsvermögen des Zellgewebes und dadurch eine schnellere und kräftigere therapeutische Wirkung.Process for the production of water-soluble silver salts of glycerol phosphoric acids It has been found that the reaction of soluble silver salts with glycerol phosphoric acids Alkalis obtained sparingly soluble glycexinphosphoric silver salts with hexamethylenetetramine can bring into solution. Very important for therapy and as a technical novelty it is to be considered that no colloidal silver compound is formed, but one molecularly disperse compound, an advantage that is particularly pleasant for the medical profession is felt because the dark colloidal silver compounds are uncomfortable and unwieldy are. In addition, the molecularly disperse solutions have a better penetration capacity of the cell tissue and thus a faster and more powerful therapeutic effect.
Ein weiterer Vorteil dieser Verbindungen ist, daß sie fast farblos löslich in destillier, tem Wasser sind. Mit Chloroform läßt sich aus den trockenen Produkten nichts herauslösen.Another advantage of these compounds is that they are almost colorless are soluble in distilled water. With chloroform can be from the dry Products.
Es ist zwar bekannt (vgl. Das Hexamethylentetramin und seine Verwendung [i931] S. 35 ff), daß Silbersalze mit Hexamethylentetramin Verbindungen einzugehen vermögen, z. B. Hexarnethylentetraminsilberoxalat, Hexamethylentetraminsilberbenzoat, HexametUylentetraniinsilbersalicylat. Diese Silbersalze sind aber nicht wasserlöslich, sondern nur mit Ammoniak in Lösung zu bringen.It is known (see. Hexamethylenetetramine and its use [1931] p. 35 ff) that silver salts enter into compounds with hexamethylenetetramine fortune, e.g. B. Hexamethylene tetramine silver oxalate, hexamethylene tetramine silver benzoate, Hexametuylenetetraniine silver salicylate. These silver salts are not soluble in water, but only to bring it into solution with ammonia.
Bekannt ist ferner, daß die Silbersalze der Eiweißspaltungsprodukte und der Gallensäuren unlöslich sind und mit Hexamethylentetramin in lösliche Produkte übergeführt werden können. Diese Lösungen sind aber kolloidal ,und nicht haltbar.It is also known that the silver salts of the protein decomposition products and the bile acids are insoluble and with hexamethylenetetramine into soluble products can be transferred. However, these solutions are colloidal and not durable.
Der Wertdes neuen Verfahrens liegt darin, daß die neuen Präparate molekular disperse Lösungen bilden, dadurch tiefer in die Zellgewebsschichten eindringen und deshalb-, wie die klinischen Versuche ergeben haben, eine kräftigere Desinfektionswirkung entwickeln. Beispiel i o Teile glycerinphosphorsaures Natrium oder Kalium werden in zoo Teilen destilliertem Wasser gelöst und unter Rühren mit 13 Teilen, Silbernitrat oder der entsprechenden Menge eines anderen löslichen Silbersalzes (gelöst in ioo Teilen destilliertem Wasser;) ausgefällt, mit dem gleichen Volumenabsolutem Alkohol versetzt und abgesaugt; der Niederschlag wird mit einer 44%igen Hexamethylentetraminlmsung gelöst, filtriert und im Vakuum zur Trockne gebracht.The value of the new process is that the new preparations Form molecularly disperse solutions, thereby penetrating deeper into the cell tissue layers and therefore, as the clinical trials have shown, a more powerful disinfectant effect to develop. Example i o parts of glycerol phosphoric acid sodium or potassium Dissolved in zoo parts of distilled water and, while stirring, with 13 parts, silver nitrate or the corresponding amount of another soluble silver salt (dissolved in ioo Parts of distilled water;) precipitated with the same volume of absolute alcohol offset and sucked off; the precipitate is treated with a 44% strength hexamethylenetetramine solution dissolved, filtered and brought to dryness in vacuo.
Claims (1)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DER87315D DE617153C (en) | 1933-02-21 | 1933-02-21 | Process for the production of water-soluble silver salts of glycerol phosphoric acids |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DER87315D DE617153C (en) | 1933-02-21 | 1933-02-21 | Process for the production of water-soluble silver salts of glycerol phosphoric acids |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE617153C true DE617153C (en) | 1935-08-14 |
Family
ID=7417741
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DER87315D Expired DE617153C (en) | 1933-02-21 | 1933-02-21 | Process for the production of water-soluble silver salts of glycerol phosphoric acids |
Country Status (1)
| Country | Link |
|---|---|
| DE (1) | DE617153C (en) |
-
1933
- 1933-02-21 DE DER87315D patent/DE617153C/en not_active Expired
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