DE622298C - Process for the production of durable pharmaceutical solutions - Google Patents
Process for the production of durable pharmaceutical solutionsInfo
- Publication number
- DE622298C DE622298C DEI27695D DEI0027695D DE622298C DE 622298 C DE622298 C DE 622298C DE I27695 D DEI27695 D DE I27695D DE I0027695 D DEI0027695 D DE I0027695D DE 622298 C DE622298 C DE 622298C
- Authority
- DE
- Germany
- Prior art keywords
- production
- water
- pharmaceutical solutions
- durable
- durable pharmaceutical
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Dermatology (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Description
Verfahren zur Herstellung von haltbaren Arzneimittellösungen Das Patent -46 290 und das Zusatzpatent 4.47161 haben Verfahren zum Gegenstand, bei denen wasserlösliche Äther und Ester mehrwertiger Alkohole, beispielsweise die Äther des Glvcerins und des Glykols, als Lösungsmittel für Kampfer und Schlafmittel verwendet werden.Process for the production of durable drug solutions The patent -46 290 and the additional patent 4.47161 have processes for the subject in which water-soluble Ethers and esters of polyhydric alcohols, for example the ethers of glycerine and of glycol, used as a solvent for camphor and sleeping pills.
Es wurde nun festgestellt, daß die Äther drei- und mehrwertiger Alkohole ein hervorragendes Lösungsvermögen für die meisten - in Wasser nicht oder schwer löslichen - Arzneistoffe organischer Natur der verschiedensten Indikationsgebiete besitzen. Es gelingt so, haltbare und therapeutisch verwendbare konzentrierte Lösungen herzustellen. Diese Lösungen lassen sich zumeist, wenn sie nicht zu konzentriert sind, beliebig mit Wasser verdünnen.It has now been established that the ethers of trihydric and polyhydric alcohols an excellent solvent power for most - not or difficult in water soluble - medicinal substances of an organic nature in a wide variety of indications own. This makes it possible to produce long-lasting concentrated solutions that can be used therapeutically to manufacture. These solutions can mostly be found if they are not too focused can be diluted with water as required.
Man hat bereits vorgeschlagen, i # 3-Butylenglykol als Ersatz für Glycerin und Glvcerinester unter ariderem in der pharmazeutischen Industrie zu verwenden. Auch ist bereits angegeben worden, daß (slvkolmonohenz\-liither infolge seiner Löslichkeit in Wasser, Fetten und Ölen als Salbengrundlage Verwendung finden könne.It has already been suggested that i # 3 butylene glycol be used as a substitute for Glycerine and glycerine esters, among others, are used in the pharmaceutical industry. It has also already been stated that (slvkolmonohenz \ -liither as a result of its solubility can be used as an ointment base in water, fats and oils.
Endlich ist auch die Verwendbarkeit des Glycerinesters der Carbaminsäure bekanntgewesen. Aus diesen Angaben war jedoch nicht zu entnehmen, daß es mit Hilfe der Äther drei- und mehrwertiger Alkohole gelingen würde, Lösungen solcher Arzneistore organischer Natur, deren Wasserunlöslichkeit bisher ihrer parenteralen Anwendung im Wege stand, herzustellen.Finally, the glycerol ester of carbamic acid can also be used known. From this information, however, it could not be inferred that it was with help the ethers of trihydric and polyhydric alcohols would be the solution of such medicinals of an organic nature, whose insolubility in water has so far been their parenteral use stood in the way of establishing.
Beispiele i. Man löst 0,5 g 3 # 9-Diamino-7-:ithOxvacridin in io ccm Diäth_vlin unter Erwärmen auf.Examples i. Dissolve 0.5 g of 3 # 9-diamino-7-: ithOxvacridine in 10 cc of dieth_vlin with warming.
2. 20 g Dimethylaminophenyldimethylpyrazolon werden in einer Mischung von 2o g Diäthylin und 3o g Wasser gelöst.2. 20 g of dimethylaminophenyldimethylpyrazolone are in a mixture dissolved by 20 g of diethyline and 3o g of water.
3. o,5 g Acetylsalicylsäure werden in io ccm Dimethoxytrioxyhexan gelöst.3. 0.5 g of acetylsalicylic acid are dissolved in 10 cc of dimethoxytrioxyhexane solved.
4. o,2 g Diacetylaminoazotoluol werden in 4 ccm Dimethoxytrioxvhexan gelöst.4. 0.2 g of diacetylaminoazotoluene are dissolved in 4 cc of dimethoxytrioxy hexane solved.
Claims (1)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DEI27695D DE622298C (en) | 1926-03-19 | 1926-03-19 | Process for the production of durable pharmaceutical solutions |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DEI27695D DE622298C (en) | 1926-03-19 | 1926-03-19 | Process for the production of durable pharmaceutical solutions |
Publications (1)
Publication Number | Publication Date |
---|---|
DE622298C true DE622298C (en) | 1935-11-25 |
Family
ID=7186834
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DEI27695D Expired DE622298C (en) | 1926-03-19 | 1926-03-19 | Process for the production of durable pharmaceutical solutions |
Country Status (1)
Country | Link |
---|---|
DE (1) | DE622298C (en) |
-
1926
- 1926-03-19 DE DEI27695D patent/DE622298C/en not_active Expired
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