DE60336772D1 - Chroman- und Thiochroman-3-yl-1,3-dihydroimidazole als Hemmer der Dopamin-beta-hydroxylase und Verfahren zu ihrer Herstellung - Google Patents
Chroman- und Thiochroman-3-yl-1,3-dihydroimidazole als Hemmer der Dopamin-beta-hydroxylase und Verfahren zu ihrer HerstellungInfo
- Publication number
- DE60336772D1 DE60336772D1 DE60336772T DE60336772T DE60336772D1 DE 60336772 D1 DE60336772 D1 DE 60336772D1 DE 60336772 T DE60336772 T DE 60336772T DE 60336772 T DE60336772 T DE 60336772T DE 60336772 D1 DE60336772 D1 DE 60336772D1
- Authority
- DE
- Germany
- Prior art keywords
- dihydroimidazoles
- thiochroman
- chroman
- preparation
- methods
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- FVVJXNLMRXNHCY-UHFFFAOYSA-N 3-(3,4-dihydro-2h-thiochromen-3-yl)-1,2-dihydroimidazole Chemical class C1NC=CN1C1CC2=CC=CC=C2SC1 FVVJXNLMRXNHCY-UHFFFAOYSA-N 0.000 title 1
- 108010015720 Dopamine beta-Hydroxylase Proteins 0.000 title 1
- 102100033156 Dopamine beta-hydroxylase Human genes 0.000 title 1
- VZWXIQHBIQLMPN-UHFFFAOYSA-N chromane Chemical compound C1=CC=C2CCCOC2=C1 VZWXIQHBIQLMPN-UHFFFAOYSA-N 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/22—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains four or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/409—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil having four such rings, e.g. porphine derivatives, bilirubin, biliverdine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/84—Sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Epidemiology (AREA)
- Hospice & Palliative Care (AREA)
- Gastroenterology & Hepatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0223719A GB2393958A (en) | 2002-10-11 | 2002-10-11 | Peripherally-selective imidazole inhibitors of dopamine-beta-hydroxylase |
| GB0224306A GB2394223B (en) | 2002-10-11 | 2002-10-18 | Peripherally-selective inhibitors of dopamine-beta-hydroxylase and method of their preparation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE60336772D1 true DE60336772D1 (de) | 2011-05-26 |
Family
ID=9945777
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE60336772T Expired - Lifetime DE60336772D1 (de) | 2002-10-11 | 2003-10-10 | Chroman- und Thiochroman-3-yl-1,3-dihydroimidazole als Hemmer der Dopamin-beta-hydroxylase und Verfahren zu ihrer Herstellung |
| DE60336275T Expired - Lifetime DE60336275D1 (de) | 2002-10-11 | 2003-10-10 | Verfahren zur Herstellung von 3-(1,3-Dihydroimidazol-2-thion-1-yl)-chromanen und thiochromanen als Dopamin-beta-hydroxylase Inhibitor |
| DE60322642T Expired - Lifetime DE60322642D1 (de) | 2002-10-11 | 2003-10-10 | Imidazolderivate und deren Verwendung als peripheral-selektive Inhibitoren von Dopamin-beta-Hydroxylasen |
| DE60336276T Expired - Lifetime DE60336276D1 (de) | 2002-10-11 | 2003-10-10 | Silyl-geschützte Hydroxymethyl-carbamoylalkyl-ketone als Intermediate in der Herstellung von Dopamine-beta-hydroxylase inhibitoren |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE60336275T Expired - Lifetime DE60336275D1 (de) | 2002-10-11 | 2003-10-10 | Verfahren zur Herstellung von 3-(1,3-Dihydroimidazol-2-thion-1-yl)-chromanen und thiochromanen als Dopamin-beta-hydroxylase Inhibitor |
| DE60322642T Expired - Lifetime DE60322642D1 (de) | 2002-10-11 | 2003-10-10 | Imidazolderivate und deren Verwendung als peripheral-selektive Inhibitoren von Dopamin-beta-Hydroxylasen |
| DE60336276T Expired - Lifetime DE60336276D1 (de) | 2002-10-11 | 2003-10-10 | Silyl-geschützte Hydroxymethyl-carbamoylalkyl-ketone als Intermediate in der Herstellung von Dopamine-beta-hydroxylase inhibitoren |
Country Status (11)
| Country | Link |
|---|---|
| KR (1) | KR101350741B1 (es) |
| CN (1) | CN100393715C (es) |
| AR (2) | AR041589A1 (es) |
| AT (5) | ATE500248T1 (es) |
| CY (2) | CY1108452T1 (es) |
| DE (4) | DE60336772D1 (es) |
| DK (2) | DK1408038T3 (es) |
| ES (5) | ES2384118T3 (es) |
| GB (2) | GB2393958A (es) |
| HK (1) | HK1116188A1 (es) |
| SI (2) | SI1408038T1 (es) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0708818D0 (en) * | 2007-05-08 | 2007-06-13 | Portela & Ca Sa | Compounds |
| CN103380128B (zh) * | 2010-12-22 | 2017-03-01 | 拜欧波尔特拉及正大有限公司 | 晶型及其制备方法 |
| GB201316410D0 (en) * | 2013-09-13 | 2013-10-30 | Bial Portela & Ca Sa | Processes for preparing peripherally-selective inhibitors of dopamine-?-hydroxylase and intermediates for use therein |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL82401A0 (en) * | 1986-05-06 | 1987-11-30 | Merrell Dow Pharma | Dopamine beta hydroxy-lase inhibiting imidazole derivatives and pharmaceutical compositions containing them |
| US4868210A (en) | 1988-03-30 | 1989-09-19 | Warner-Lambert Company | Antihyperlipidemic and antiatherosclerotic compounds and compositions |
| EP0757677B1 (en) * | 1994-04-26 | 2003-06-18 | Syntex (U.S.A.) LLC | Benzocyclohexylimidazolethione derivatives |
-
2002
- 2002-10-11 GB GB0223719A patent/GB2393958A/en not_active Withdrawn
- 2002-10-18 GB GB0224306A patent/GB2394223B/en not_active Expired - Lifetime
-
2003
- 2003-10-10 ES ES07076123T patent/ES2384118T3/es not_active Expired - Lifetime
- 2003-10-10 DE DE60336772T patent/DE60336772D1/de not_active Expired - Lifetime
- 2003-10-10 DE DE60336275T patent/DE60336275D1/de not_active Expired - Lifetime
- 2003-10-10 DE DE60322642T patent/DE60322642D1/de not_active Expired - Lifetime
- 2003-10-10 AT AT07076122T patent/ATE500248T1/de not_active IP Right Cessation
- 2003-10-10 AT AT03256420T patent/ATE403652T1/de active
- 2003-10-10 SI SI200331309T patent/SI1408038T1/sl unknown
- 2003-10-10 AR ARP030103711A patent/AR041589A1/es active IP Right Grant
- 2003-10-10 DK DK03256420T patent/DK1408038T3/da active
- 2003-10-10 DK DK07076125.9T patent/DK1908760T3/da active
- 2003-10-10 AT AT07076125T patent/ATE505465T1/de active
- 2003-10-10 AT AT07076124T patent/ATE500247T1/de not_active IP Right Cessation
- 2003-10-10 AT AT07076123T patent/ATE550335T1/de active
- 2003-10-10 ES ES07076122T patent/ES2361938T3/es not_active Expired - Lifetime
- 2003-10-10 ES ES07076125T patent/ES2364919T3/es not_active Expired - Lifetime
- 2003-10-10 DE DE60336276T patent/DE60336276D1/de not_active Expired - Lifetime
- 2003-10-10 ES ES07076124T patent/ES2361939T3/es not_active Expired - Lifetime
- 2003-10-10 SI SI200331986T patent/SI1908760T1/sl unknown
- 2003-10-10 ES ES03256420T patent/ES2309279T3/es not_active Expired - Lifetime
- 2003-10-10 CN CNB2003801059426A patent/CN100393715C/zh not_active Expired - Fee Related
- 2003-10-10 KR KR1020127005102A patent/KR101350741B1/ko active IP Right Grant
-
2008
- 2008-10-09 HK HK08111214.9A patent/HK1116188A1/xx not_active IP Right Cessation
- 2008-10-24 CY CY20081101204T patent/CY1108452T1/el unknown
-
2011
- 2011-07-01 CY CY20111100639T patent/CY1112457T1/el unknown
-
2014
- 2014-03-18 AR ARP140101283A patent/AR095674A2/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AR095674A2 (es) | 2015-11-04 |
| DE60336275D1 (de) | 2011-04-14 |
| ES2364919T3 (es) | 2011-09-16 |
| ATE500248T1 (de) | 2011-03-15 |
| ATE550335T1 (de) | 2012-04-15 |
| SI1908760T1 (sl) | 2011-05-31 |
| CY1112457T1 (el) | 2015-12-09 |
| GB0223719D0 (en) | 2002-11-20 |
| ES2384118T3 (es) | 2012-06-29 |
| CY1108452T1 (el) | 2014-04-09 |
| DK1408038T3 (da) | 2008-11-24 |
| GB2394223A (en) | 2004-04-21 |
| GB2393958A (en) | 2004-04-14 |
| DK1908760T3 (da) | 2011-07-25 |
| GB2394223B (en) | 2007-05-16 |
| ATE500247T1 (de) | 2011-03-15 |
| DE60336276D1 (de) | 2011-04-14 |
| ATE505465T1 (de) | 2011-04-15 |
| CN100393715C (zh) | 2008-06-11 |
| ES2309279T3 (es) | 2008-12-16 |
| KR20120038014A (ko) | 2012-04-20 |
| ES2361938T3 (es) | 2011-06-24 |
| ATE403652T1 (de) | 2008-08-15 |
| ES2361939T3 (es) | 2011-06-24 |
| AR041589A1 (es) | 2005-05-26 |
| KR101350741B1 (ko) | 2014-01-10 |
| SI1408038T1 (sl) | 2008-10-31 |
| CN1726211A (zh) | 2006-01-25 |
| HK1116188A1 (en) | 2008-12-19 |
| GB0224306D0 (en) | 2002-11-27 |
| DE60322642D1 (de) | 2008-09-18 |
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| DE60336772D1 (de) | Chroman- und Thiochroman-3-yl-1,3-dihydroimidazole als Hemmer der Dopamin-beta-hydroxylase und Verfahren zu ihrer Herstellung | |
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