DE60336772D1 - Chroman and thiochroman-3-yl-1,3-dihydroimidazoles as dopamine beta-hydroxylase inhibitors and methods for their preparation - Google Patents

Chroman and thiochroman-3-yl-1,3-dihydroimidazoles as dopamine beta-hydroxylase inhibitors and methods for their preparation

Info

Publication number
DE60336772D1
DE60336772D1 DE60336772T DE60336772T DE60336772D1 DE 60336772 D1 DE60336772 D1 DE 60336772D1 DE 60336772 T DE60336772 T DE 60336772T DE 60336772 T DE60336772 T DE 60336772T DE 60336772 D1 DE60336772 D1 DE 60336772D1
Authority
DE
Germany
Prior art keywords
dihydroimidazoles
thiochroman
chroman
preparation
methods
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60336772T
Other languages
German (de)
Inventor
David Alexander Learmonth
Da Silva Patricio Manuel Vieira Araujo Soares
Alexander Beliaev
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bial Portela and Cia SA
Original Assignee
Bial Portela and Cia SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bial Portela and Cia SA filed Critical Bial Portela and Cia SA
Application granted granted Critical
Publication of DE60336772D1 publication Critical patent/DE60336772D1/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/22—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains four or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/409—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil having four such rings, e.g. porphine derivatives, bilirubin, biliverdine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/84—Sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Epidemiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
DE60336772T 2002-10-11 2003-10-10 Chroman and thiochroman-3-yl-1,3-dihydroimidazoles as dopamine beta-hydroxylase inhibitors and methods for their preparation Expired - Lifetime DE60336772D1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB0223719A GB2393958A (en) 2002-10-11 2002-10-11 Peripherally-selective imidazole inhibitors of dopamine-beta-hydroxylase
GB0224306A GB2394223B (en) 2002-10-11 2002-10-18 Peripherally-selective inhibitors of dopamine-beta-hydroxylase and method of their preparation

Publications (1)

Publication Number Publication Date
DE60336772D1 true DE60336772D1 (en) 2011-05-26

Family

ID=9945777

Family Applications (4)

Application Number Title Priority Date Filing Date
DE60336276T Expired - Lifetime DE60336276D1 (en) 2002-10-11 2003-10-10 Silyl-protected hydroxymethyl-carbamoylalkyl ketones as intermediates in the preparation of dopamine-beta-hydroxylase inhibitors
DE60336275T Expired - Lifetime DE60336275D1 (en) 2002-10-11 2003-10-10 Process for the preparation of 3- (1,3-dihydroimidazole-2-thion-1-yl) -chromans and thiochromans as dopamine-beta-hydroxylase inhibitor
DE60336772T Expired - Lifetime DE60336772D1 (en) 2002-10-11 2003-10-10 Chroman and thiochroman-3-yl-1,3-dihydroimidazoles as dopamine beta-hydroxylase inhibitors and methods for their preparation
DE60322642T Expired - Lifetime DE60322642D1 (en) 2002-10-11 2003-10-10 Imidazole derivatives and their use as peripheral-selective inhibitors of dopamine beta-hydroxylases

Family Applications Before (2)

Application Number Title Priority Date Filing Date
DE60336276T Expired - Lifetime DE60336276D1 (en) 2002-10-11 2003-10-10 Silyl-protected hydroxymethyl-carbamoylalkyl ketones as intermediates in the preparation of dopamine-beta-hydroxylase inhibitors
DE60336275T Expired - Lifetime DE60336275D1 (en) 2002-10-11 2003-10-10 Process for the preparation of 3- (1,3-dihydroimidazole-2-thion-1-yl) -chromans and thiochromans as dopamine-beta-hydroxylase inhibitor

Family Applications After (1)

Application Number Title Priority Date Filing Date
DE60322642T Expired - Lifetime DE60322642D1 (en) 2002-10-11 2003-10-10 Imidazole derivatives and their use as peripheral-selective inhibitors of dopamine beta-hydroxylases

Country Status (11)

Country Link
KR (1) KR101350741B1 (en)
CN (1) CN100393715C (en)
AR (2) AR041589A1 (en)
AT (5) ATE505465T1 (en)
CY (2) CY1108452T1 (en)
DE (4) DE60336276D1 (en)
DK (2) DK1908760T3 (en)
ES (5) ES2384118T3 (en)
GB (2) GB2393958A (en)
HK (1) HK1116188A1 (en)
SI (2) SI1408038T1 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0708818D0 (en) * 2007-05-08 2007-06-13 Portela & Ca Sa Compounds
EP2655363B1 (en) * 2010-12-22 2017-04-12 Bial-Portela & CA, S.A. Crystalline forms and processes for their preparation
GB201316410D0 (en) 2013-09-13 2013-10-30 Bial Portela & Ca Sa Processes for preparing peripherally-selective inhibitors of dopamine-?-hydroxylase and intermediates for use therein

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL82401A0 (en) * 1986-05-06 1987-11-30 Merrell Dow Pharma Dopamine beta hydroxy-lase inhibiting imidazole derivatives and pharmaceutical compositions containing them
US4868210A (en) 1988-03-30 1989-09-19 Warner-Lambert Company Antihyperlipidemic and antiatherosclerotic compounds and compositions
CZ290082B6 (en) * 1994-04-26 2002-05-15 Syntex (U. S. A.) Inc. Benzocycloalkylazolethione derivatives, pharmaceutical preparation containing thereof, process of their preparation and intermediates of the preparation process

Also Published As

Publication number Publication date
GB2394223B (en) 2007-05-16
CY1108452T1 (en) 2014-04-09
AR095674A2 (en) 2015-11-04
DK1908760T3 (en) 2011-07-25
ES2384118T3 (en) 2012-06-29
DE60336276D1 (en) 2011-04-14
DE60336275D1 (en) 2011-04-14
GB0224306D0 (en) 2002-11-27
CY1112457T1 (en) 2015-12-09
SI1908760T1 (en) 2011-05-31
AR041589A1 (en) 2005-05-26
CN100393715C (en) 2008-06-11
ATE500248T1 (en) 2011-03-15
KR20120038014A (en) 2012-04-20
ATE550335T1 (en) 2012-04-15
DK1408038T3 (en) 2008-11-24
ATE505465T1 (en) 2011-04-15
GB2394223A (en) 2004-04-21
HK1116188A1 (en) 2008-12-19
ATE403652T1 (en) 2008-08-15
ES2361939T3 (en) 2011-06-24
ATE500247T1 (en) 2011-03-15
GB2393958A (en) 2004-04-14
GB0223719D0 (en) 2002-11-20
KR101350741B1 (en) 2014-01-10
CN1726211A (en) 2006-01-25
SI1408038T1 (en) 2008-10-31
ES2309279T3 (en) 2008-12-16
DE60322642D1 (en) 2008-09-18
ES2364919T3 (en) 2011-09-16
ES2361938T3 (en) 2011-06-24

Similar Documents

Publication Publication Date Title
CY2015036I2 (en) NEW OXAZOLIDINONE DERIVATIVES
ATE400271T1 (en) ARYL-PYRIDINE DERIVATIVES AS 11-BETA-HSD1 INHIBITORS
DE602006019731D1 (en) 2,6-CHINOLINE DERIVATIVES AND METHOD FOR THEIR PREPARATION AND USE AS MEDICAMENTS
ATE420076T1 (en) INDOZOLONE DERIVATIVES AS 11B-HSD1 INHIBITORS
ATE478049T1 (en) PHOSPHODIESTERASE-4 INHIBITORS, INCLUDING N-SUBSTITUTED DIARYLAMINE ANALOGS
ATE426599T1 (en) THIAZOLYLPIPERIDINE DERIVATIVES AS MTP INHIBITORS
IL199668A0 (en) New benzimidazole derivatives
DE602004012154D1 (en) PYRIDOÄ2,3-DÜPYRIMIDIN-2,4-DIAMINE AS PDE-2 INHIBITORS
ATE482207T1 (en) CYCLIC UREA DERIVATIVES, METHOD FOR THEIR PRODUCTION AND THEIR PHARMACEUTICAL USE AS KINASE INHIBITORS
DE502004010595D1 (en) 4-PYRIDINYLMETHYLSULFONAMIDE DERIVATIVES AS FUNGICIDE-EFFECTIVE PLANT PROTECTION AGENTS
ATE384697T1 (en) 2-AMINO-PYRIDINE DERIVATIVES AS BETA-2 ADRENORECEPTOR AGONISTS
DE112005002085A5 (en) Cutting tool and method for its production
DE602004028125D1 (en) 1-SULPHONYLINDOL DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THEIR USE AS 5-HT6 LIGANDS
ATE440821T1 (en) ISOQUINOLINE DERIVATIVES AS MAO-B INHIBITORS
ATE323092T1 (en) PYRIDOPYRIMIDINONE DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME
ATE372992T1 (en) INDANYL-PIPERAZINE DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME
ATE428420T1 (en) SUBSTITUTED 8-ARYLCINOLINES AS PHOSPHODIESTERASE-4 INHIBITORS
DE60316383D1 (en) Amine composition and process for its preparation
DE60336772D1 (en) Chroman and thiochroman-3-yl-1,3-dihydroimidazoles as dopamine beta-hydroxylase inhibitors and methods for their preparation
IS7991A (en) Sets p-diaminobenzene derivatives
CY2017041I2 (en) COMPOSITIONS FOR AFFECTING WEIGHT LOSS COMPRISING AN OPIOID ANTAGONIST AND BUPROPION
DE60322132D1 (en) Hydroxyphenyladamantanes and process for their preparation
DE60107055D1 (en) THIENOPYRIDE DERIVATIVES FOR USE AS AN ANTI-FLAMMING AGENT
ATE435221T1 (en) SULFAMATE BENZOTHIOPHENE DERIVATIVES AS STEROID SULFATESE INHIBITORS
ATE384047T1 (en) PIPERIDINE DERIVATIVES FOR USE AS 2,3-OXIDOSQUALENE-LANOSTEROL CYCLASE INHIBITORS