DE60336276D1 - Silyl-protected hydroxymethyl-carbamoylalkyl ketones as intermediates in the preparation of dopamine-beta-hydroxylase inhibitors - Google Patents

Silyl-protected hydroxymethyl-carbamoylalkyl ketones as intermediates in the preparation of dopamine-beta-hydroxylase inhibitors

Info

Publication number
DE60336276D1
DE60336276D1 DE60336276T DE60336276T DE60336276D1 DE 60336276 D1 DE60336276 D1 DE 60336276D1 DE 60336276 T DE60336276 T DE 60336276T DE 60336276 T DE60336276 T DE 60336276T DE 60336276 D1 DE60336276 D1 DE 60336276D1
Authority
DE
Germany
Prior art keywords
carbamoylalkyl
dopamine
silyl
intermediates
ketones
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60336276T
Other languages
German (de)
Inventor
David Alexander Learmonth
Da Silva Patricio Manuel Vieira Araujo Soares
Alexander Beliaev
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bial Portela and Cia SA
Original Assignee
Bial Portela and Cia SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bial Portela and Cia SA filed Critical Bial Portela and Cia SA
Application granted granted Critical
Publication of DE60336276D1 publication Critical patent/DE60336276D1/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/22—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains four or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/409—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil having four such rings, e.g. porphine derivatives, bilirubin, biliverdine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/84—Sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Epidemiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
DE60336276T 2002-10-11 2003-10-10 Silyl-protected hydroxymethyl-carbamoylalkyl ketones as intermediates in the preparation of dopamine-beta-hydroxylase inhibitors Expired - Lifetime DE60336276D1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB0223719A GB2393958A (en) 2002-10-11 2002-10-11 Peripherally-selective imidazole inhibitors of dopamine-beta-hydroxylase
GB0224306A GB2394223B (en) 2002-10-11 2002-10-18 Peripherally-selective inhibitors of dopamine-beta-hydroxylase and method of their preparation

Publications (1)

Publication Number Publication Date
DE60336276D1 true DE60336276D1 (en) 2011-04-14

Family

ID=9945777

Family Applications (4)

Application Number Title Priority Date Filing Date
DE60336276T Expired - Lifetime DE60336276D1 (en) 2002-10-11 2003-10-10 Silyl-protected hydroxymethyl-carbamoylalkyl ketones as intermediates in the preparation of dopamine-beta-hydroxylase inhibitors
DE60336275T Expired - Lifetime DE60336275D1 (en) 2002-10-11 2003-10-10 Process for the preparation of 3- (1,3-dihydroimidazole-2-thion-1-yl) -chromans and thiochromans as dopamine-beta-hydroxylase inhibitor
DE60336772T Expired - Lifetime DE60336772D1 (en) 2002-10-11 2003-10-10 Chroman and thiochroman-3-yl-1,3-dihydroimidazoles as dopamine beta-hydroxylase inhibitors and methods for their preparation
DE60322642T Expired - Lifetime DE60322642D1 (en) 2002-10-11 2003-10-10 Imidazole derivatives and their use as peripheral-selective inhibitors of dopamine beta-hydroxylases

Family Applications After (3)

Application Number Title Priority Date Filing Date
DE60336275T Expired - Lifetime DE60336275D1 (en) 2002-10-11 2003-10-10 Process for the preparation of 3- (1,3-dihydroimidazole-2-thion-1-yl) -chromans and thiochromans as dopamine-beta-hydroxylase inhibitor
DE60336772T Expired - Lifetime DE60336772D1 (en) 2002-10-11 2003-10-10 Chroman and thiochroman-3-yl-1,3-dihydroimidazoles as dopamine beta-hydroxylase inhibitors and methods for their preparation
DE60322642T Expired - Lifetime DE60322642D1 (en) 2002-10-11 2003-10-10 Imidazole derivatives and their use as peripheral-selective inhibitors of dopamine beta-hydroxylases

Country Status (11)

Country Link
KR (1) KR101350741B1 (en)
CN (1) CN100393715C (en)
AR (2) AR041589A1 (en)
AT (5) ATE505465T1 (en)
CY (2) CY1108452T1 (en)
DE (4) DE60336276D1 (en)
DK (2) DK1908760T3 (en)
ES (5) ES2384118T3 (en)
GB (2) GB2393958A (en)
HK (1) HK1116188A1 (en)
SI (2) SI1408038T1 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0708818D0 (en) * 2007-05-08 2007-06-13 Portela & Ca Sa Compounds
EP2655363B1 (en) * 2010-12-22 2017-04-12 Bial-Portela & CA, S.A. Crystalline forms and processes for their preparation
GB201316410D0 (en) 2013-09-13 2013-10-30 Bial Portela & Ca Sa Processes for preparing peripherally-selective inhibitors of dopamine-?-hydroxylase and intermediates for use therein

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL82401A0 (en) * 1986-05-06 1987-11-30 Merrell Dow Pharma Dopamine beta hydroxy-lase inhibiting imidazole derivatives and pharmaceutical compositions containing them
US4868210A (en) 1988-03-30 1989-09-19 Warner-Lambert Company Antihyperlipidemic and antiatherosclerotic compounds and compositions
CZ290082B6 (en) * 1994-04-26 2002-05-15 Syntex (U. S. A.) Inc. Benzocycloalkylazolethione derivatives, pharmaceutical preparation containing thereof, process of their preparation and intermediates of the preparation process

Also Published As

Publication number Publication date
GB2394223B (en) 2007-05-16
CY1108452T1 (en) 2014-04-09
AR095674A2 (en) 2015-11-04
DK1908760T3 (en) 2011-07-25
ES2384118T3 (en) 2012-06-29
DE60336772D1 (en) 2011-05-26
DE60336275D1 (en) 2011-04-14
GB0224306D0 (en) 2002-11-27
CY1112457T1 (en) 2015-12-09
SI1908760T1 (en) 2011-05-31
AR041589A1 (en) 2005-05-26
CN100393715C (en) 2008-06-11
ATE500248T1 (en) 2011-03-15
KR20120038014A (en) 2012-04-20
ATE550335T1 (en) 2012-04-15
DK1408038T3 (en) 2008-11-24
ATE505465T1 (en) 2011-04-15
GB2394223A (en) 2004-04-21
HK1116188A1 (en) 2008-12-19
ATE403652T1 (en) 2008-08-15
ES2361939T3 (en) 2011-06-24
ATE500247T1 (en) 2011-03-15
GB2393958A (en) 2004-04-14
GB0223719D0 (en) 2002-11-20
KR101350741B1 (en) 2014-01-10
CN1726211A (en) 2006-01-25
SI1408038T1 (en) 2008-10-31
ES2309279T3 (en) 2008-12-16
DE60322642D1 (en) 2008-09-18
ES2364919T3 (en) 2011-09-16
ES2361938T3 (en) 2011-06-24

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Legal Events

Date Code Title Description
8327 Change in the person/name/address of the patent owner

Owner name: BIAL - PORTELA & CA., S.A., S. MAMEDE DO CORON, PT