ATE500248T1 - SILYL-PROTECTED HYDROXYMETHYL-CARBAMOYLALKYL KETONES AS INTERMEDIATE IN THE PRODUCTION OF DOPAMINE BETA-HYDROXYLASE INHIBITORS - Google Patents
SILYL-PROTECTED HYDROXYMETHYL-CARBAMOYLALKYL KETONES AS INTERMEDIATE IN THE PRODUCTION OF DOPAMINE BETA-HYDROXYLASE INHIBITORSInfo
- Publication number
- ATE500248T1 ATE500248T1 AT07076122T AT07076122T ATE500248T1 AT E500248 T1 ATE500248 T1 AT E500248T1 AT 07076122 T AT07076122 T AT 07076122T AT 07076122 T AT07076122 T AT 07076122T AT E500248 T1 ATE500248 T1 AT E500248T1
- Authority
- AT
- Austria
- Prior art keywords
- carbamoylalkyl
- silyl
- ketones
- production
- hydroxylase inhibitors
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/22—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains four or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/409—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil having four such rings, e.g. porphine derivatives, bilirubin, biliverdine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/84—Sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Epidemiology (AREA)
- Hospice & Palliative Care (AREA)
- Gastroenterology & Hepatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0223719A GB2393958A (en) | 2002-10-11 | 2002-10-11 | Peripherally-selective imidazole inhibitors of dopamine-beta-hydroxylase |
| GB0224306A GB2394223B (en) | 2002-10-11 | 2002-10-18 | Peripherally-selective inhibitors of dopamine-beta-hydroxylase and method of their preparation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE500248T1 true ATE500248T1 (en) | 2011-03-15 |
Family
ID=9945777
Family Applications (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT07076125T ATE505465T1 (en) | 2002-10-11 | 2003-10-10 | CHROMAN- AND THIOCHROMAN-3-YL-1,3-DIHYDROIMIDAZOLE AS INHIBITORS OF DOPAMINE BETA-HYDROXYLASE AND METHOD FOR THE PRODUCTION THEREOF |
| AT07076122T ATE500248T1 (en) | 2002-10-11 | 2003-10-10 | SILYL-PROTECTED HYDROXYMETHYL-CARBAMOYLALKYL KETONES AS INTERMEDIATE IN THE PRODUCTION OF DOPAMINE BETA-HYDROXYLASE INHIBITORS |
| AT03256420T ATE403652T1 (en) | 2002-10-11 | 2003-10-10 | IMIDAZOLE DERIVATIVES AND THEIR USE AS PERIPHERAL-SELECTIVE INHIBITORS OF DOPAMINE BETA-HYDROXYLASES |
| AT07076124T ATE500247T1 (en) | 2002-10-11 | 2003-10-10 | METHOD FOR PRODUCING 3-(1,3-DIHYDROIMIDAZOLE-2-THION-1-YL)-CHROMANES AND THIOCHROMANES AS A DOPAMINE BETA-HYDROXYLASE INHIBITOR |
| AT07076123T ATE550335T1 (en) | 2002-10-11 | 2003-10-10 | 3,4-DIHYDRO-3-AMINO-2H-1-BENZOPYRAN AND - BENZOTHIOPYRAN DERIVATIVES AS DOPAMINE BETA-HYDROXYLASE INHIBITORS AND METHOD FOR THE PRODUCTION THEREOF |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT07076125T ATE505465T1 (en) | 2002-10-11 | 2003-10-10 | CHROMAN- AND THIOCHROMAN-3-YL-1,3-DIHYDROIMIDAZOLE AS INHIBITORS OF DOPAMINE BETA-HYDROXYLASE AND METHOD FOR THE PRODUCTION THEREOF |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT03256420T ATE403652T1 (en) | 2002-10-11 | 2003-10-10 | IMIDAZOLE DERIVATIVES AND THEIR USE AS PERIPHERAL-SELECTIVE INHIBITORS OF DOPAMINE BETA-HYDROXYLASES |
| AT07076124T ATE500247T1 (en) | 2002-10-11 | 2003-10-10 | METHOD FOR PRODUCING 3-(1,3-DIHYDROIMIDAZOLE-2-THION-1-YL)-CHROMANES AND THIOCHROMANES AS A DOPAMINE BETA-HYDROXYLASE INHIBITOR |
| AT07076123T ATE550335T1 (en) | 2002-10-11 | 2003-10-10 | 3,4-DIHYDRO-3-AMINO-2H-1-BENZOPYRAN AND - BENZOTHIOPYRAN DERIVATIVES AS DOPAMINE BETA-HYDROXYLASE INHIBITORS AND METHOD FOR THE PRODUCTION THEREOF |
Country Status (11)
| Country | Link |
|---|---|
| KR (1) | KR101350741B1 (en) |
| CN (1) | CN100393715C (en) |
| AR (2) | AR041589A1 (en) |
| AT (5) | ATE505465T1 (en) |
| CY (2) | CY1108452T1 (en) |
| DE (4) | DE60336276D1 (en) |
| DK (2) | DK1908760T3 (en) |
| ES (5) | ES2384118T3 (en) |
| GB (2) | GB2393958A (en) |
| HK (1) | HK1116188A1 (en) |
| SI (2) | SI1408038T1 (en) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0708818D0 (en) * | 2007-05-08 | 2007-06-13 | Portela & Ca Sa | Compounds |
| EP2655363B1 (en) * | 2010-12-22 | 2017-04-12 | Bial-Portela & CA, S.A. | Crystalline forms and processes for their preparation |
| GB201316410D0 (en) | 2013-09-13 | 2013-10-30 | Bial Portela & Ca Sa | Processes for preparing peripherally-selective inhibitors of dopamine-?-hydroxylase and intermediates for use therein |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL82401A0 (en) * | 1986-05-06 | 1987-11-30 | Merrell Dow Pharma | Dopamine beta hydroxy-lase inhibiting imidazole derivatives and pharmaceutical compositions containing them |
| US4868210A (en) | 1988-03-30 | 1989-09-19 | Warner-Lambert Company | Antihyperlipidemic and antiatherosclerotic compounds and compositions |
| CZ290082B6 (en) * | 1994-04-26 | 2002-05-15 | Syntex (U. S. A.) Inc. | Benzocycloalkylazolethione derivatives, pharmaceutical preparation containing thereof, process of their preparation and intermediates of the preparation process |
-
2002
- 2002-10-11 GB GB0223719A patent/GB2393958A/en not_active Withdrawn
- 2002-10-18 GB GB0224306A patent/GB2394223B/en not_active Expired - Lifetime
-
2003
- 2003-10-10 DE DE60336276T patent/DE60336276D1/en not_active Expired - Lifetime
- 2003-10-10 KR KR1020127005102A patent/KR101350741B1/en active IP Right Grant
- 2003-10-10 AT AT07076125T patent/ATE505465T1/en active
- 2003-10-10 ES ES07076123T patent/ES2384118T3/en not_active Expired - Lifetime
- 2003-10-10 ES ES07076124T patent/ES2361939T3/en not_active Expired - Lifetime
- 2003-10-10 ES ES03256420T patent/ES2309279T3/en not_active Expired - Lifetime
- 2003-10-10 SI SI200331309T patent/SI1408038T1/en unknown
- 2003-10-10 DE DE60336275T patent/DE60336275D1/en not_active Expired - Lifetime
- 2003-10-10 AT AT07076122T patent/ATE500248T1/en not_active IP Right Cessation
- 2003-10-10 AT AT03256420T patent/ATE403652T1/en active
- 2003-10-10 DK DK07076125.9T patent/DK1908760T3/en active
- 2003-10-10 ES ES07076125T patent/ES2364919T3/en not_active Expired - Lifetime
- 2003-10-10 AT AT07076124T patent/ATE500247T1/en not_active IP Right Cessation
- 2003-10-10 DK DK03256420T patent/DK1408038T3/en active
- 2003-10-10 ES ES07076122T patent/ES2361938T3/en not_active Expired - Lifetime
- 2003-10-10 DE DE60336772T patent/DE60336772D1/en not_active Expired - Lifetime
- 2003-10-10 CN CNB2003801059426A patent/CN100393715C/en not_active Expired - Fee Related
- 2003-10-10 AR ARP030103711A patent/AR041589A1/en active IP Right Grant
- 2003-10-10 SI SI200331986T patent/SI1908760T1/en unknown
- 2003-10-10 AT AT07076123T patent/ATE550335T1/en active
- 2003-10-10 DE DE60322642T patent/DE60322642D1/en not_active Expired - Lifetime
-
2008
- 2008-10-09 HK HK08111214.9A patent/HK1116188A1/en not_active IP Right Cessation
- 2008-10-24 CY CY20081101204T patent/CY1108452T1/en unknown
-
2011
- 2011-07-01 CY CY20111100639T patent/CY1112457T1/en unknown
-
2014
- 2014-03-18 AR ARP140101283A patent/AR095674A2/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| GB2394223B (en) | 2007-05-16 |
| CY1108452T1 (en) | 2014-04-09 |
| AR095674A2 (en) | 2015-11-04 |
| DK1908760T3 (en) | 2011-07-25 |
| ES2384118T3 (en) | 2012-06-29 |
| DE60336276D1 (en) | 2011-04-14 |
| DE60336772D1 (en) | 2011-05-26 |
| DE60336275D1 (en) | 2011-04-14 |
| GB0224306D0 (en) | 2002-11-27 |
| CY1112457T1 (en) | 2015-12-09 |
| SI1908760T1 (en) | 2011-05-31 |
| AR041589A1 (en) | 2005-05-26 |
| CN100393715C (en) | 2008-06-11 |
| KR20120038014A (en) | 2012-04-20 |
| ATE550335T1 (en) | 2012-04-15 |
| DK1408038T3 (en) | 2008-11-24 |
| ATE505465T1 (en) | 2011-04-15 |
| GB2394223A (en) | 2004-04-21 |
| HK1116188A1 (en) | 2008-12-19 |
| ATE403652T1 (en) | 2008-08-15 |
| ES2361939T3 (en) | 2011-06-24 |
| ATE500247T1 (en) | 2011-03-15 |
| GB2393958A (en) | 2004-04-14 |
| GB0223719D0 (en) | 2002-11-20 |
| KR101350741B1 (en) | 2014-01-10 |
| CN1726211A (en) | 2006-01-25 |
| SI1408038T1 (en) | 2008-10-31 |
| ES2309279T3 (en) | 2008-12-16 |
| DE60322642D1 (en) | 2008-09-18 |
| ES2364919T3 (en) | 2011-09-16 |
| ES2361938T3 (en) | 2011-06-24 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |