CY1112457T1 - CHROMO- AND THIROXROMANO-3-YlO-1,3-dihydro-imidazole as inhibitors of dopamine-B-hydroxylation, and their production methods - Google Patents

CHROMO- AND THIROXROMANO-3-YlO-1,3-dihydro-imidazole as inhibitors of dopamine-B-hydroxylation, and their production methods

Info

Publication number
CY1112457T1
CY1112457T1 CY20111100639T CY111100639T CY1112457T1 CY 1112457 T1 CY1112457 T1 CY 1112457T1 CY 20111100639 T CY20111100639 T CY 20111100639T CY 111100639 T CY111100639 T CY 111100639T CY 1112457 T1 CY1112457 T1 CY 1112457T1
Authority
CY
Cyprus
Prior art keywords
thiroxromano
ylo
chromo
hydroxylation
dopamine
Prior art date
Application number
CY20111100639T
Other languages
Greek (el)
Inventor
David Alexander Learmonth
Da Silva Patricio Manuel Vieira Araujo Soares
Alexander Beliaev
Original Assignee
Bial-Portela & Ca, S.A.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from EP07076125A external-priority patent/EP1908760B1/en
Application filed by Bial-Portela & Ca, S.A. filed Critical Bial-Portela & Ca, S.A.
Publication of CY1112457T1 publication Critical patent/CY1112457T1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/22—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains four or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/409—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil having four such rings, e.g. porphine derivatives, bilirubin, biliverdine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/84—Sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond

Abstract

Περιγράφονται ενώσεις του τύπου I και μέθοδος παρασκευής αυτώνCompounds of formula I and a method for their preparation are described

CY20111100639T 2002-10-11 2011-07-01 CHROMO- AND THIROXROMANO-3-YlO-1,3-dihydro-imidazole as inhibitors of dopamine-B-hydroxylation, and their production methods CY1112457T1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB0223719A GB2393958A (en) 2002-10-11 2002-10-11 Peripherally-selective imidazole inhibitors of dopamine-beta-hydroxylase
GB0224306A GB2394223B (en) 2002-10-11 2002-10-18 Peripherally-selective inhibitors of dopamine-beta-hydroxylase and method of their preparation
EP07076125A EP1908760B1 (en) 2002-10-11 2003-10-10 Chromane and thiochromane-3-yl-1,3-dihydroimidazoles as inhibitors of dopamine-beta-hydroxylase and methods of their preparation

Publications (1)

Publication Number Publication Date
CY1112457T1 true CY1112457T1 (en) 2015-12-09

Family

ID=9945777

Family Applications (2)

Application Number Title Priority Date Filing Date
CY20081101204T CY1108452T1 (en) 2002-10-11 2008-10-24 IMIDAZOLI PRODUCTS AND USE THESE AS PERIODICALLY EXTRACTIVE INHIBITORS OF DOPOPAMIN-β-HYDROXYLUM
CY20111100639T CY1112457T1 (en) 2002-10-11 2011-07-01 CHROMO- AND THIROXROMANO-3-YlO-1,3-dihydro-imidazole as inhibitors of dopamine-B-hydroxylation, and their production methods

Family Applications Before (1)

Application Number Title Priority Date Filing Date
CY20081101204T CY1108452T1 (en) 2002-10-11 2008-10-24 IMIDAZOLI PRODUCTS AND USE THESE AS PERIODICALLY EXTRACTIVE INHIBITORS OF DOPOPAMIN-β-HYDROXYLUM

Country Status (11)

Country Link
KR (1) KR101350741B1 (en)
CN (1) CN100393715C (en)
AR (2) AR041589A1 (en)
AT (5) ATE550335T1 (en)
CY (2) CY1108452T1 (en)
DE (4) DE60336772D1 (en)
DK (2) DK1408038T3 (en)
ES (5) ES2364919T3 (en)
GB (2) GB2393958A (en)
HK (1) HK1116188A1 (en)
SI (2) SI1908760T1 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0708818D0 (en) * 2007-05-08 2007-06-13 Portela & Ca Sa Compounds
PT2655363T (en) * 2010-12-22 2017-07-13 Bial-Portela & Ca S A Crystalline forms and processes for their preparation
GB201316410D0 (en) * 2013-09-13 2013-10-30 Bial Portela & Ca Sa Processes for preparing peripherally-selective inhibitors of dopamine-?-hydroxylase and intermediates for use therein

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2581556B2 (en) * 1986-05-06 1997-02-12 メレルダウファーマスーティカルズ インコーポレーテッド Novel dopamine beta-hydroxylase inhibitor
US4868210A (en) 1988-03-30 1989-09-19 Warner-Lambert Company Antihyperlipidemic and antiatherosclerotic compounds and compositions
PT757677E (en) * 1994-04-26 2003-11-28 Syntex Llc BENZOCYCLOHEXYLIMIDAZOLETION DERIVATIVES

Also Published As

Publication number Publication date
GB0224306D0 (en) 2002-11-27
GB2393958A (en) 2004-04-14
HK1116188A1 (en) 2008-12-19
ATE505465T1 (en) 2011-04-15
GB0223719D0 (en) 2002-11-20
ATE500248T1 (en) 2011-03-15
ES2364919T3 (en) 2011-09-16
SI1408038T1 (en) 2008-10-31
KR20120038014A (en) 2012-04-20
ATE403652T1 (en) 2008-08-15
ES2361939T3 (en) 2011-06-24
ATE500247T1 (en) 2011-03-15
CN1726211A (en) 2006-01-25
AR041589A1 (en) 2005-05-26
ES2361938T3 (en) 2011-06-24
CY1108452T1 (en) 2014-04-09
GB2394223B (en) 2007-05-16
DE60336276D1 (en) 2011-04-14
AR095674A2 (en) 2015-11-04
ES2309279T3 (en) 2008-12-16
GB2394223A (en) 2004-04-21
KR101350741B1 (en) 2014-01-10
CN100393715C (en) 2008-06-11
DE60336772D1 (en) 2011-05-26
ES2384118T3 (en) 2012-06-29
DE60322642D1 (en) 2008-09-18
DK1408038T3 (en) 2008-11-24
DE60336275D1 (en) 2011-04-14
DK1908760T3 (en) 2011-07-25
ATE550335T1 (en) 2012-04-15
SI1908760T1 (en) 2011-05-31

Similar Documents

Publication Publication Date Title
EA200700096A1 (en) DERIVATIVES 2-CARBAMID-4-PHENYL THIAZOLE, METHOD FOR THEIR PRODUCTION AND THEIR APPLICATION IN THERAPY
EA200600621A1 (en) DERIVATIVES OF TETRAHYDRONAPTALINE, METHOD OF THEIR PRODUCTION AND THEIR USE AS ANTI-INFLAMMATORY MEANS
CY1105994T1 (en) ARRANGEMENT PENTANOLS, METHOD FOR THEIR PRODUCTION AND THEIR USE AS ANTI-INFLAMMATORY AGENTS
RS20050666A (en) Substituted n- arylheterocycles, method for production and use thereof as medicaments
IL172357A0 (en) Method for the production of substituted 3-aryl-butyl amine compounds
CY1110034T1 (en) 1,2,4,5-tetrahydro-3H-benzazepine derivatives, METHOD OF PRODUCING THESE AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THESE
CY1106598T1 (en) QUINOLINE AND ISOQUINOLINE DERIVATIVES, METHOD FOR THEIR PRODUCTION AND USE THEREOF AS ANTI-INFLAMMATORY AGENTS
YU5503A (en) Non-steroidal inflammation inhibitors
ECSP095220A (en) DERIVATIVES OF N-FENIL-2-PIRIMIDIN-AMINA
NO20054669L (en) Substituted quinobenzoxazine analogues
CY1109838T1 (en) METHOD FOR PREPARATION OF 3-O-PROTECTED MORPHINONES AND DIAVOL 3-O-PROTECTED MORPHINONES
CY1106544T1 (en) METHOD OF SYNTHESIS OF HYPERINDOPRIL AND ITS PHARMACEUTICALLY ACCEPTABLE SALTS
CY1107156T1 (en) NEW METHOD OF SYNTHESIS (7-Methoxy-3,4-dihydro-1-naphthalinyl) acetonitrile and application in the synthesis of angomelatin
CY1109740T1 (en) NEW METHOD OF PRODUCING COMPOSITION OF 1,3,4,5-tetrahydro-2H- 3-benzazepine-2-one AND APPLICATION TO THE COMPOSITION OF IBAVRADIN AND SALT SALK
CY1106471T1 (en) NEW METHOD OF SYNTHESIS OF PERINDROPRIL AND ITS PHARMACEUTICALLY ACCEPTABLE SALTS
GEP20115166B (en) 2-ARYLINDOLE DERIVATIVES AS mPGES-I INHIBITORS
EA200801893A1 (en) DERIVATIVES OF TETRAHYDRONAPTALINE, METHOD FOR THEIR PRODUCTION AND THEIR USE AS INFLAMMATION INHIBITORS
CY1107028T1 (en) INDANYL-Piperazine Derivatives METHOD OF PREPARING THESE AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
MX2007007446A (en) Processes for producing 4-aminoquinazolines.
DE50305693D1 (en) N-BENZOYLUREIDO-ZIMTS UREDERIVATE, PROCESS FOR THEIR PRODUCTION AND THEIR USE
EA200700550A1 (en) DERIVATIVES OF ALKYLIDENTETRAHYDRONAPTALINE, METHOD OF THEIR RECEIVING AND THEIR APPLICATION AS ANTI-INFLAMMATORY MEANS
CY1105790T1 (en) NEW METHOD FOR THE SYNTHESIS OF PEPIDOPRIL AND ITS PHARMACEUTICALLY ACCEPTABLE SALTS
EA200701852A1 (en) DERIVATIVES OF AMINO ACIDS
CY1112457T1 (en) CHROMO- AND THIROXROMANO-3-YlO-1,3-dihydro-imidazole as inhibitors of dopamine-B-hydroxylation, and their production methods
CY1108238T1 (en) METHOD OF COMPOSITION OF PERINDOPRIL AND ITS PHARMACEUTICAL SALTS