HK1116188A1 - Chromane and thiochromane-3-yl-1,3-dihydroimidazoles as inhibitors of dopamine-beta-hydroxylase and methods of their preparation - Google Patents
Chromane and thiochromane-3-yl-1,3-dihydroimidazoles as inhibitors of dopamine-beta-hydroxylase and methods of their preparationInfo
- Publication number
- HK1116188A1 HK1116188A1 HK08111214.9A HK08111214A HK1116188A1 HK 1116188 A1 HK1116188 A1 HK 1116188A1 HK 08111214 A HK08111214 A HK 08111214A HK 1116188 A1 HK1116188 A1 HK 1116188A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- preparation
- dihydroimidazoles
- thiochromane
- chromane
- hydroxylase
- Prior art date
Links
- FVVJXNLMRXNHCY-UHFFFAOYSA-N 3-(3,4-dihydro-2h-thiochromen-3-yl)-1,2-dihydroimidazole Chemical class C1NC=CN1C1CC2=CC=CC=C2SC1 FVVJXNLMRXNHCY-UHFFFAOYSA-N 0.000 title 1
- 108010015720 Dopamine beta-Hydroxylase Proteins 0.000 title 1
- 102100033156 Dopamine beta-hydroxylase Human genes 0.000 title 1
- VZWXIQHBIQLMPN-UHFFFAOYSA-N chromane Chemical compound C1=CC=C2CCCOC2=C1 VZWXIQHBIQLMPN-UHFFFAOYSA-N 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 2
- 206010007558 Cardiac failure chronic Diseases 0.000 abstract 1
- 208000024172 Cardiovascular disease Diseases 0.000 abstract 1
- 206010020772 Hypertension Diseases 0.000 abstract 1
- -1 R Ú is H Chemical group 0.000 abstract 1
- 125000002877 alkyl aryl group Chemical group 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/22—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains four or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/409—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil having four such rings, e.g. porphine derivatives, bilirubin, biliverdine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/84—Sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Epidemiology (AREA)
- Hospice & Palliative Care (AREA)
- Gastroenterology & Hepatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0223719A GB2393958A (en) | 2002-10-11 | 2002-10-11 | Peripherally-selective imidazole inhibitors of dopamine-beta-hydroxylase |
| GB0224306A GB2394223B (en) | 2002-10-11 | 2002-10-18 | Peripherally-selective inhibitors of dopamine-beta-hydroxylase and method of their preparation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HK1116188A1 true HK1116188A1 (en) | 2008-12-19 |
Family
ID=9945777
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HK08111214.9A HK1116188A1 (en) | 2002-10-11 | 2008-10-09 | Chromane and thiochromane-3-yl-1,3-dihydroimidazoles as inhibitors of dopamine-beta-hydroxylase and methods of their preparation |
Country Status (11)
| Country | Link |
|---|---|
| KR (1) | KR101350741B1 (es) |
| CN (1) | CN100393715C (es) |
| AR (2) | AR041589A1 (es) |
| AT (5) | ATE403652T1 (es) |
| CY (2) | CY1108452T1 (es) |
| DE (4) | DE60336275D1 (es) |
| DK (2) | DK1908760T3 (es) |
| ES (5) | ES2384118T3 (es) |
| GB (2) | GB2393958A (es) |
| HK (1) | HK1116188A1 (es) |
| SI (2) | SI1908760T1 (es) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0708818D0 (en) * | 2007-05-08 | 2007-06-13 | Portela & Ca Sa | Compounds |
| KR101941467B1 (ko) * | 2010-12-22 | 2019-01-23 | 바이알 - 포르텔라 앤드 씨에이 에스에이 | 결정형 및 이들의 제조방법 |
| GB201316410D0 (en) | 2013-09-13 | 2013-10-30 | Bial Portela & Ca Sa | Processes for preparing peripherally-selective inhibitors of dopamine-?-hydroxylase and intermediates for use therein |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2581556B2 (ja) * | 1986-05-06 | 1997-02-12 | メレルダウファーマスーティカルズ インコーポレーテッド | 新規なドパミンベ−タヒドロキシラ−ゼ抑制剤 |
| US4868210A (en) | 1988-03-30 | 1989-09-19 | Warner-Lambert Company | Antihyperlipidemic and antiatherosclerotic compounds and compositions |
| PT757677E (pt) * | 1994-04-26 | 2003-11-28 | Syntex Llc | Derivados de benzociclohexilimidazoletiona |
-
2002
- 2002-10-11 GB GB0223719A patent/GB2393958A/en not_active Withdrawn
- 2002-10-18 GB GB0224306A patent/GB2394223B/en not_active Expired - Lifetime
-
2003
- 2003-10-10 ES ES07076123T patent/ES2384118T3/es not_active Expired - Lifetime
- 2003-10-10 DE DE60336275T patent/DE60336275D1/de not_active Expired - Lifetime
- 2003-10-10 ES ES07076125T patent/ES2364919T3/es not_active Expired - Lifetime
- 2003-10-10 DE DE60336772T patent/DE60336772D1/de not_active Expired - Lifetime
- 2003-10-10 KR KR1020127005102A patent/KR101350741B1/ko active IP Right Grant
- 2003-10-10 SI SI200331986T patent/SI1908760T1/sl unknown
- 2003-10-10 AT AT03256420T patent/ATE403652T1/de active
- 2003-10-10 DK DK07076125.9T patent/DK1908760T3/da active
- 2003-10-10 AT AT07076125T patent/ATE505465T1/de active
- 2003-10-10 CN CNB2003801059426A patent/CN100393715C/zh not_active Expired - Fee Related
- 2003-10-10 DK DK03256420T patent/DK1408038T3/da active
- 2003-10-10 AT AT07076123T patent/ATE550335T1/de active
- 2003-10-10 DE DE60336276T patent/DE60336276D1/de not_active Expired - Lifetime
- 2003-10-10 ES ES07076122T patent/ES2361938T3/es not_active Expired - Lifetime
- 2003-10-10 AT AT07076124T patent/ATE500247T1/de not_active IP Right Cessation
- 2003-10-10 ES ES03256420T patent/ES2309279T3/es not_active Expired - Lifetime
- 2003-10-10 SI SI200331309T patent/SI1408038T1/sl unknown
- 2003-10-10 ES ES07076124T patent/ES2361939T3/es not_active Expired - Lifetime
- 2003-10-10 AT AT07076122T patent/ATE500248T1/de not_active IP Right Cessation
- 2003-10-10 AR ARP030103711A patent/AR041589A1/es active IP Right Grant
- 2003-10-10 DE DE60322642T patent/DE60322642D1/de not_active Expired - Lifetime
-
2008
- 2008-10-09 HK HK08111214.9A patent/HK1116188A1/xx not_active IP Right Cessation
- 2008-10-24 CY CY20081101204T patent/CY1108452T1/el unknown
-
2011
- 2011-07-01 CY CY20111100639T patent/CY1112457T1/el unknown
-
2014
- 2014-03-18 AR ARP140101283A patent/AR095674A2/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| ES2361938T3 (es) | 2011-06-24 |
| ES2361939T3 (es) | 2011-06-24 |
| KR20120038014A (ko) | 2012-04-20 |
| SI1408038T1 (sl) | 2008-10-31 |
| KR101350741B1 (ko) | 2014-01-10 |
| ATE550335T1 (de) | 2012-04-15 |
| ATE505465T1 (de) | 2011-04-15 |
| ATE500248T1 (de) | 2011-03-15 |
| DE60336276D1 (de) | 2011-04-14 |
| GB2393958A (en) | 2004-04-14 |
| ES2384118T3 (es) | 2012-06-29 |
| DK1408038T3 (da) | 2008-11-24 |
| CN1726211A (zh) | 2006-01-25 |
| DE60336275D1 (de) | 2011-04-14 |
| GB2394223A (en) | 2004-04-21 |
| ATE403652T1 (de) | 2008-08-15 |
| GB0224306D0 (en) | 2002-11-27 |
| CY1108452T1 (el) | 2014-04-09 |
| AR041589A1 (es) | 2005-05-26 |
| ES2364919T3 (es) | 2011-09-16 |
| CY1112457T1 (el) | 2015-12-09 |
| ATE500247T1 (de) | 2011-03-15 |
| SI1908760T1 (sl) | 2011-05-31 |
| GB2394223B (en) | 2007-05-16 |
| DE60322642D1 (de) | 2008-09-18 |
| ES2309279T3 (es) | 2008-12-16 |
| DE60336772D1 (de) | 2011-05-26 |
| AR095674A2 (es) | 2015-11-04 |
| CN100393715C (zh) | 2008-06-11 |
| GB0223719D0 (en) | 2002-11-20 |
| DK1908760T3 (da) | 2011-07-25 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| CORR | Corrigendum |
Free format text: CORRECTED DATA OF SECTION 20 TO JOURNAL OF : [72] LEARMONTH, DAVID ALEXANDER - SOARES DA SILVA, PATRICIO MANUEL VIEIRA ARAUJO - BELIAEV, ALEXANDER |
|
| PC | Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee) |
Effective date: 20221008 |