DE60327363D1 - Verringerung der dichte des brustgewebes durch 4-hydroxy tamoxifen - Google Patents

Verringerung der dichte des brustgewebes durch 4-hydroxy tamoxifen

Info

Publication number
DE60327363D1
DE60327363D1 DE60327363T DE60327363T DE60327363D1 DE 60327363 D1 DE60327363 D1 DE 60327363D1 DE 60327363 T DE60327363 T DE 60327363T DE 60327363 T DE60327363 T DE 60327363T DE 60327363 D1 DE60327363 D1 DE 60327363D1
Authority
DE
Germany
Prior art keywords
tamoxifes
hydroxy
density
reducing
breast tissue
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60327363T
Other languages
English (en)
Inventor
Jay Bua
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Laboratoires Besins International SAS
Original Assignee
Laboratoires Besins International SAS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Laboratoires Besins International SAS filed Critical Laboratoires Besins International SAS
Application granted granted Critical
Publication of DE60327363D1 publication Critical patent/DE60327363D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/138—Aryloxyalkylamines, e.g. propranolol, tamoxifen, phenoxybenzamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/38—Cellulose; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/30—Oestrogens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/32—Antioestrogens

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Inorganic Chemistry (AREA)
  • Dermatology (AREA)
  • Oncology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
DE60327363T 2002-12-18 2003-12-15 Verringerung der dichte des brustgewebes durch 4-hydroxy tamoxifen Expired - Lifetime DE60327363D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US43395802P 2002-12-18 2002-12-18
PCT/EP2003/015030 WO2004054558A2 (en) 2002-12-18 2003-12-15 Reduction of breast density with 4-hydroxy tamoxifen

Publications (1)

Publication Number Publication Date
DE60327363D1 true DE60327363D1 (de) 2009-06-04

Family

ID=32595254

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60327363T Expired - Lifetime DE60327363D1 (de) 2002-12-18 2003-12-15 Verringerung der dichte des brustgewebes durch 4-hydroxy tamoxifen

Country Status (6)

Country Link
US (1) US7485623B2 (de)
EP (3) EP2050443B1 (de)
JP (2) JP4684655B2 (de)
AU (1) AU2003296757A1 (de)
DE (1) DE60327363D1 (de)
WO (1) WO2004054558A2 (de)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2471400A1 (en) * 2001-12-20 2003-07-03 Femmepharma, Inc. Vaginal delivery of drugs
MXPA05006526A (es) * 2002-12-18 2006-02-17 Besins Int Lab Tratamiento de mastalgia con 4-hidroxi tamoxifen.
AU2004203700B2 (en) * 2003-01-02 2007-06-21 Femmepharma Holding Company, Inc. Pharmaceutical preparations for treatments of diseases and disorders of the breast
US9173836B2 (en) 2003-01-02 2015-11-03 FemmeParma Holding Company, Inc. Pharmaceutical preparations for treatments of diseases and disorders of the breast
EP1952810B1 (de) 2003-04-01 2014-01-08 Besins Healthcare Luxembourg SARL Behandlung von Brustkrebs mit 4-Hydroxy-Tamoxifen
PT1631275E (pt) 2003-06-09 2008-08-04 Ascend Therapeutics Inc Tratamento e prevenção da cicatrização excessiva com 4-hidroxi-tamoxifeno
US7968532B2 (en) * 2003-12-15 2011-06-28 Besins Healthcare Luxembourg Treatment of gynecomastia with 4-hydroxy tamoxifen
US7507769B2 (en) 2004-03-22 2009-03-24 Laboratoires Besins International Treatment and prevention of benign breast disease with 4-hydroxy tamoxifen
RU2357726C2 (ru) * 2004-03-22 2009-06-10 Лаборатуар Безен Энтернасьональ Лечение и профилактика доброкачественной опухоли груди 4-гидрокситамоксифеном
EP1579856A1 (de) * 2004-03-22 2005-09-28 Laboratoires Besins International 4-Hydroxytamoxifen zur Behandlung von benignen Brusterkrankungen
US20050208139A1 (en) * 2004-03-22 2005-09-22 Ascend Therapeutics, Inc. Chemically stable compositions of 4-hydroxy tamoxifen
EP1647271A1 (de) * 2004-10-14 2006-04-19 Laboratoires Besins International Gelzubereitung enthaltend 4-Hydroxy tamoxifen.
KR101294947B1 (ko) * 2004-10-14 2013-08-09 라보라뚜아르 베쟁 인터네셔널 4-히드록시 타목시펜 겔 제제
GB0602739D0 (en) * 2006-02-10 2006-03-22 Ccbr As Breast tissue density measure
US20080153789A1 (en) * 2006-12-26 2008-06-26 Femmepharma Holding Company, Inc. Topical administration of danazol
CN101861142A (zh) * 2007-11-22 2010-10-13 诺沃-诺迪斯克保健股份有限公司 含醛化合物对液体配制因子VII(a)多肽的稳定化
US20110003000A1 (en) * 2009-07-06 2011-01-06 Femmepharma Holding Company, Inc. Transvaginal Delivery of Drugs
JP6279104B2 (ja) * 2014-05-12 2018-02-14 クエスト ダイアグノスティックス インヴェストメンツ インコーポレイテッド 質量分析によるタモキシフェンおよびその代謝産物の定量化
JP7100019B2 (ja) 2016-08-19 2022-07-12 ザ ユナイテッド ステイツ オブ アメリカ， アズ リプレゼンテッド バイ ザ セクレタリー， デパートメント オブ ヘルス アンド ヒューマン サービシーズ 選択的エストロゲン受容体モジュレーター（ｓｅｒｍ）は、光受容体の変性に対する保護を付与する
CA3073836A1 (en) 2017-09-11 2019-03-14 Atossa Therapeutics, Inc. Methods for making and using endoxifen
WO2023026139A1 (en) * 2021-08-23 2023-03-02 Singh Divya Dhananjay Pharmaceutical composition comprising 4- hydroxytamoxifen for the treatment of mastalgia

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2558373B1 (fr) * 1984-01-20 1987-07-03 Mauvais Jarvis Pierre Medicament antioestrogene a base de 4-hydroxytamoxifene pour administration percutanee
EP0287690B1 (de) 1987-04-21 1992-09-02 HEUMANN PHARMA GMBH & CO Stabile Lösungsmitteladdukte von Z-1-(p-beta-Dimethylamino-ethoxyphenyl)-1-(p-hydroxyphenyl)-2-phenylbut-1-en
US5045553A (en) * 1987-06-24 1991-09-03 Fujisawa Pharmaceutical Company, Ltd. Pharmaceutical composition for percutaneous drug absorption and percutaneous drug absorption promoter
US5002938A (en) * 1988-03-21 1991-03-26 Bristol-Myers Squibb Company Antifungal gel formulations
DE3836862A1 (de) 1988-10-27 1990-05-03 Schering Ag Mittel zur transdermalen applikation von steroidhormonen
TW218849B (de) 1991-05-17 1994-01-11 Bristol Myers Squibb Co
JPH0679002A (ja) * 1993-12-14 1994-03-22 Hisamitsu Pharmaceut Co Inc 経皮投与用パッチシステム
US5613958A (en) 1993-05-12 1997-03-25 Pp Holdings Inc. Transdermal delivery systems for the modulated administration of drugs
DE4407742C1 (de) * 1994-03-08 1995-06-22 Hexal Pharma Gmbh Transdermales System in Form eines Pflasters mit einem Tamoxifen-Derivat
US5720963A (en) 1994-08-26 1998-02-24 Mary Kay Inc. Barrier disruption treatments for structurally deteriorated skin
DE4434165A1 (de) * 1994-09-24 1996-03-28 Cassella Ag Haarfärbemittel
US6083996A (en) * 1997-11-05 2000-07-04 Nexmed Holdings, Inc. Topical compositions for NSAI drug delivery
US6013270A (en) 1998-04-20 2000-01-11 The Procter & Gamble Company Skin care kit
DE10033853A1 (de) 2000-07-12 2002-01-31 Hexal Ag Transdermales therapeutisches System mit hochdispersem Siliziumdioxid
US6503894B1 (en) 2000-08-30 2003-01-07 Unimed Pharmaceuticals, Inc. Pharmaceutical composition and method for treating hypogonadism
PT1317921E (pt) 2001-12-07 2009-11-06 Besins Mfg Belgium Composição farmacêutica sob a forma de gel ou de solução à base de di-hidrotestosterona, seu processo de preparação e suas utilizações
MXPA05006526A (es) 2002-12-18 2006-02-17 Besins Int Lab Tratamiento de mastalgia con 4-hidroxi tamoxifen.
EP1952810B1 (de) 2003-04-01 2014-01-08 Besins Healthcare Luxembourg SARL Behandlung von Brustkrebs mit 4-Hydroxy-Tamoxifen
PT1631275E (pt) 2003-06-09 2008-08-04 Ascend Therapeutics Inc Tratamento e prevenção da cicatrização excessiva com 4-hidroxi-tamoxifeno
US7968532B2 (en) 2003-12-15 2011-06-28 Besins Healthcare Luxembourg Treatment of gynecomastia with 4-hydroxy tamoxifen
US20050208139A1 (en) 2004-03-22 2005-09-22 Ascend Therapeutics, Inc. Chemically stable compositions of 4-hydroxy tamoxifen
US7507769B2 (en) 2004-03-22 2009-03-24 Laboratoires Besins International Treatment and prevention of benign breast disease with 4-hydroxy tamoxifen
EP1647271A1 (de) 2004-10-14 2006-04-19 Laboratoires Besins International Gelzubereitung enthaltend 4-Hydroxy tamoxifen.

Also Published As

Publication number Publication date
EP1572171B1 (de) 2009-04-22
EP2050443A1 (de) 2009-04-22
US7485623B2 (en) 2009-02-03
JP4684655B2 (ja) 2011-05-18
AU2003296757A1 (en) 2004-07-09
WO2004054558A3 (en) 2004-10-28
EP1952809A3 (de) 2012-06-20
AU2003296757A8 (en) 2004-07-09
EP1572171A2 (de) 2005-09-14
WO2004054558A2 (en) 2004-07-01
EP2050443B1 (de) 2017-05-24
JP2006514645A (ja) 2006-05-11
US20040138314A1 (en) 2004-07-15
EP1952809B1 (de) 2017-08-02
JP2011052020A (ja) 2011-03-17
EP1952809A2 (de) 2008-08-06

Similar Documents

Publication Publication Date Title
DE60327363D1 (de) Verringerung der dichte des brustgewebes durch 4-hydroxy tamoxifen
DE60320021D1 (de) Schlingenbildung mittels nadelung durch trägeschichten
ATE389646T1 (de) Neue benzodioxole
DE60318769D1 (de) Maskenüberzug
NO20055657D0 (no) Nye bioisostaererav aktinonin
DE602004002176D1 (de) Brausekopf für Küchenspüle
ATE394140T1 (de) Verwendung neuer etonogestrelester
DE10394301D2 (de) Ultraschallreaktor
NO20044140D0 (no) New Composition
FR2887433B1 (fr) Plaque d'osteotomie tibiale d'addition
UA12146S (uk) Крісло м'яке
FR2881023B1 (fr) Rotor d'andaineur
ITMO20050317A1 (it) Coltello rotativo per l'eviscerazione di pesci o simili
EE00378U1 (et) Ujumislesta laba
FR2887755B1 (fr) Implant d'osteosynthese
SE0201678D0 (sv) Malmetoder
FI20022065A (fi) Hammaselimen regeneraatio
NO20050026L (no) Nye benzodioksoler
ITMO20030118A1 (it) Griglia per fornello
ITPI20050109A1 (it) Apparecchiatura per la realizzazione di un modello destinato al trattamento fitodepurativo di acque reflue
ITTN20040009A1 (it) Palo salvavita type 1
ITTO20040424A1 (it) Procedimento per la realizzazione di tifoseria virtuale
FI6126U1 (fi) Avoimen rakentamisen tehokas toteuttaminen
SE0201667D0 (sv) New composition
SE0201759D0 (sv) New Composition

Legal Events

Date Code Title Description
8364 No opposition during term of opposition