DE60318456D1 - ANALOGA VON OMEGA-3-PUFAs ABGELEITETEN LIPIDMEDIATOREN UND ANWENDUNGSVERFAHREN - Google Patents
ANALOGA VON OMEGA-3-PUFAs ABGELEITETEN LIPIDMEDIATOREN UND ANWENDUNGSVERFAHRENInfo
- Publication number
- DE60318456D1 DE60318456D1 DE60318456T DE60318456T DE60318456D1 DE 60318456 D1 DE60318456 D1 DE 60318456D1 DE 60318456 T DE60318456 T DE 60318456T DE 60318456 T DE60318456 T DE 60318456T DE 60318456 D1 DE60318456 D1 DE 60318456D1
- Authority
- DE
- Germany
- Prior art keywords
- omega
- lipid mediators
- analogue
- derived lipid
- analogues
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C59/40—Unsaturated compounds
- C07C59/58—Unsaturated compounds containing ether groups, groups, groups, or groups
- C07C59/64—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings
- C07C59/66—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings the non-carboxylic part of the ether containing six-membered aromatic rings
- C07C59/68—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings the non-carboxylic part of the ether containing six-membered aromatic rings the oxygen atom of the ether group being bound to a non-condensed six-membered aromatic ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
- C07C235/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton
- C07C235/28—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and unsaturated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
- C07C235/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton
- C07C235/32—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton containing six-membered aromatic rings
- C07C235/34—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton containing six-membered aromatic rings having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C59/40—Unsaturated compounds
- C07C59/42—Unsaturated compounds containing hydroxy or O-metal groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C59/40—Unsaturated compounds
- C07C59/42—Unsaturated compounds containing hydroxy or O-metal groups
- C07C59/48—Unsaturated compounds containing hydroxy or O-metal groups containing six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C59/40—Unsaturated compounds
- C07C59/58—Unsaturated compounds containing ether groups, groups, groups, or groups
- C07C59/64—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
- C07C69/73—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids
- C07C69/732—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids of unsaturated hydroxy carboxylic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
- C07C69/73—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids
- C07C69/734—Ethers
- C07C69/736—Ethers the hydroxy group of the ester being etherified with a hydroxy compound having the hydroxy group bound to a carbon atom of a six-membered aromatic ring
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Rheumatology (AREA)
- Pulmonology (AREA)
- Dermatology (AREA)
- Immunology (AREA)
- Urology & Nephrology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Ophthalmology & Optometry (AREA)
- Pain & Pain Management (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US38962202P | 2002-06-17 | 2002-06-17 | |
US389622P | 2002-06-17 | ||
PCT/US2003/019019 WO2003105776A2 (en) | 2002-06-17 | 2003-06-13 | ANALOGUES OF LIPID MEDIATORS DERIVED FROM OMEGA-3 PUFAs AND METHODS OF USE |
Publications (2)
Publication Number | Publication Date |
---|---|
DE60318456D1 true DE60318456D1 (de) | 2008-02-14 |
DE60318456T2 DE60318456T2 (de) | 2008-12-24 |
Family
ID=29736662
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE60318456T Expired - Lifetime DE60318456T2 (de) | 2002-06-17 | 2003-06-13 | ANALOGA VON OMEGA-3-PUFAs ABGELEITETEN LIPIDMEDIATOREN UND ANWENDUNGSVERFAHREN |
Country Status (7)
Country | Link |
---|---|
US (2) | US7378444B2 (de) |
EP (1) | EP1537069B1 (de) |
JP (1) | JP2005529945A (de) |
AT (1) | ATE382597T1 (de) |
AU (1) | AU2003238240A1 (de) |
DE (1) | DE60318456T2 (de) |
WO (1) | WO2003105776A2 (de) |
Families Citing this family (38)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ATE504557T1 (de) * | 2000-02-16 | 2011-04-15 | Brigham & Womens Hospital | Aspirin-ausgelöste lipidmediatoren |
US7030159B2 (en) * | 2001-12-18 | 2006-04-18 | The Brigham And Women's Hospital, Inc. | Approach to anti-microbial host defense with molecular shields with EPA and DHA analogs |
US7902257B2 (en) * | 2002-04-01 | 2011-03-08 | University Of Southern California | Trihydroxy polyunsaturated eicosanoid |
US7582785B2 (en) * | 2002-04-01 | 2009-09-01 | University Of Southern California | Trihydroxy polyunsaturated eicosanoid derivatives |
DK2022775T3 (en) * | 2002-04-01 | 2015-01-19 | Univ Southern California | polyunsaturated TRIHYDROXYEICOSANOIDER |
US8481772B2 (en) | 2002-04-01 | 2013-07-09 | University Of Southern California | Trihydroxy polyunsaturated eicosanoid derivatives |
US7759395B2 (en) * | 2002-08-12 | 2010-07-20 | The Brigham And Women's Hospital, Inc. | Use of docosatrienes, resolvins and their stable analogs in the treatment of airway diseases and asthma |
HUE041471T2 (hu) | 2002-08-12 | 2019-05-28 | Brigham & Womens Hospital | Rezolvinok: Biotemplátok terápiás beavatkozásokhoz |
WO2004078143A2 (en) * | 2003-03-05 | 2004-09-16 | The Brigham And Women's Hospital Inc. | Methods for identification and uses of anti-inflammatory receptors for eicosapentaenoic acid analogs |
EP1755537A4 (de) * | 2004-04-14 | 2009-12-09 | Univ Boston | Verfahren und zusammensetzungen zur prävention oder behandlung von periodontopathien |
KR20070040381A (ko) * | 2004-07-01 | 2007-04-16 | 셰펜스 아이 리써치 | 눈의 장애 및 상태를 치료하는 조성물 및 방법 |
US20070265341A1 (en) * | 2004-07-01 | 2007-11-15 | The Schepens Eye Research Institute Inc. | Compositions and methods for treating eye disorders and conditions |
US20060293288A1 (en) * | 2005-01-07 | 2006-12-28 | Serhan Charles N | Use of resolvins to treat gastrointestinal diseases |
WO2007041440A2 (en) | 2005-10-03 | 2007-04-12 | The Brigham And Women's Hospital, Inc. | Anti-inflammatory actions of neuroprotectin d1/protectin d1 and its natural stereoisomers |
EP1954291A1 (de) * | 2005-11-18 | 2008-08-13 | Trustees Of Boston University | Behandlung und prävention von knochenschwund mithilfe von resolvinen |
KR20090040323A (ko) * | 2006-07-19 | 2009-04-23 | 레솔빅스 파마슈티칼즈, 인코퍼레이티드 | 점막염의 치료를 위한 조성물과 방법 |
WO2008063772A2 (en) * | 2006-10-13 | 2008-05-29 | The Brigham And Women's Hospital Inc. | Resolvin d series and protectin d1 mitigate acute kidney injury |
US20080161274A1 (en) * | 2006-10-26 | 2008-07-03 | Resolvyx Pharmaceuticals, Inc. | Compounds and methods for inhibition of bone loss |
WO2008070129A2 (en) * | 2006-12-05 | 2008-06-12 | Resolvyx Pharmaceuticals, Inc. | Compositions and methods for the treatment of inflammatory disease |
WO2009038671A2 (en) * | 2007-09-14 | 2009-03-26 | Resolvyx Pharmaceuticals, Inc. | Oxylipin compounds for treating autoimmune diseases |
CN103191129A (zh) * | 2007-10-12 | 2013-07-10 | C.T.辨析有限公司 | 治疗眼睛病症的脂氧化物类化合物 |
AU2014201375B2 (en) * | 2007-10-12 | 2015-11-05 | Resolvyx Pharmaceuticals, Inc. | Omega-3 fatty acids, hydroxy polyunsaturated fatty acids, lipoxin compounds, or oxylipin compounds for the treatment of ophthalmic conditions |
WO2009154873A2 (en) * | 2008-04-25 | 2009-12-23 | The Brigham And Women's Hospital, Inc. | Use of novel lipid mediators to inhibit angiogenesis |
US8927747B2 (en) * | 2008-09-16 | 2015-01-06 | The Brigham And Women's Hospital, Inc. | 14-hydroxy-docosahexaenoic acid compounds |
US20120122816A1 (en) * | 2009-02-05 | 2012-05-17 | Resolvyx Pharmaceuticals, Inc. | Compositions and methods for organ preservation |
WO2011011882A1 (en) * | 2009-07-29 | 2011-02-03 | Phenomenome Discoveries Inc. | Hydroxy fatty acid compounds and uses thereof for disease treatment and diagnosis |
US8715648B2 (en) | 2011-02-16 | 2014-05-06 | Pivotal Therapeutics Inc. | Method for treating obesity with anti-obesity formulations and omega 3 fatty acids for the reduction of body weight in cardiovascular disease patients (CVD) and diabetics |
US8952000B2 (en) | 2011-02-16 | 2015-02-10 | Pivotal Therapeutics Inc. | Cholesterol absorption inhibitor and omega 3 fatty acids for the reduction of cholesterol and for the prevention or reduction of cardiovascular, cardiac and vascular events |
US8951514B2 (en) | 2011-02-16 | 2015-02-10 | Pivotal Therapeutics Inc. | Statin and omega 3 fatty acids for reduction of apolipoprotein-B levels |
US9119826B2 (en) | 2011-02-16 | 2015-09-01 | Pivotal Therapeutics, Inc. | Omega 3 fatty acid for use as a prescription medical food and omega 3 fatty acid diagniostic assay for the dietary management of cardiovascular patients with cardiovascular disease (CVD) who are deficient in blood EPA and DHA levels |
US8865685B2 (en) | 2011-06-30 | 2014-10-21 | Johnson & Johnson Vision Care, Inc. | Esters for treatment of ocular inflammatory conditions |
RU2667570C2 (ru) * | 2013-08-27 | 2018-09-21 | Ниссан Мотор Ко., Лтд. | Многозвенный поршневой кривошипно-шатунный механизм для двигателя внутреннего сгорания |
WO2017077528A2 (en) * | 2015-11-02 | 2017-05-11 | Salzman Lovelace Investments, Ltd. | Methods and pharmaceutical compositions for treatment of lung inflammation |
US10006925B2 (en) | 2016-05-30 | 2018-06-26 | Universal Diagnostics, S. L. | Methods and systems for metabolite and/or lipid-based detection of colorectal cancer and/or adenomatous polyps |
DK3454907T3 (da) | 2016-06-03 | 2020-10-19 | Thetis Pharmaceuticals Llc | Sammensætninger og fremgangsmåder relateret til salte af specialiserede pro-løsningsmediatorer af inflammation |
GB201611920D0 (en) * | 2016-07-08 | 2016-08-24 | Astrazeneca Ab | Pharmaceutical compositions |
JP2022504834A (ja) | 2018-10-09 | 2022-01-13 | ユニバーシティ オブ ロチェスター | 外陰膣障害の治療 |
WO2023168245A2 (en) | 2022-03-03 | 2023-09-07 | Thetis Pharmaceuticals Llc | Cyclodextrin complexes of specialized proresolving mediators |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5411951A (en) | 1984-10-04 | 1995-05-02 | Monsanto Company | Prolonged release of biologically active somatotropin |
US5441951A (en) * | 1994-06-15 | 1995-08-15 | Brigham & Women's Hospital | Lipoxin compounds |
ATE303355T1 (de) | 1999-03-18 | 2005-09-15 | Brigham & Womens Hospital | Lipoxinverbindungen und ihre anwendung |
ATE504557T1 (de) * | 2000-02-16 | 2011-04-15 | Brigham & Womens Hospital | Aspirin-ausgelöste lipidmediatoren |
AU2001249329A1 (en) | 2000-03-20 | 2001-10-03 | Brigham And Women's Hospital | Lipoxin analogs and methods for the treatment of periodontal disease |
US7030159B2 (en) | 2001-12-18 | 2006-04-18 | The Brigham And Women's Hospital, Inc. | Approach to anti-microbial host defense with molecular shields with EPA and DHA analogs |
DK2022775T3 (en) | 2002-04-01 | 2015-01-19 | Univ Southern California | polyunsaturated TRIHYDROXYEICOSANOIDER |
-
2003
- 2003-06-13 WO PCT/US2003/019019 patent/WO2003105776A2/en active IP Right Grant
- 2003-06-13 US US10/460,913 patent/US7378444B2/en active Active
- 2003-06-13 EP EP03737135A patent/EP1537069B1/de not_active Expired - Lifetime
- 2003-06-13 JP JP2004512684A patent/JP2005529945A/ja active Pending
- 2003-06-13 DE DE60318456T patent/DE60318456T2/de not_active Expired - Lifetime
- 2003-06-13 AT AT03737135T patent/ATE382597T1/de not_active IP Right Cessation
- 2003-06-13 AU AU2003238240A patent/AU2003238240A1/en not_active Abandoned
-
2008
- 2008-04-30 US US12/150,794 patent/US7595341B2/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
US7378444B2 (en) | 2008-05-27 |
EP1537069B1 (de) | 2008-01-02 |
US20080207753A1 (en) | 2008-08-28 |
US20040044050A1 (en) | 2004-03-04 |
AU2003238240A8 (en) | 2003-12-31 |
EP1537069A4 (de) | 2006-01-04 |
WO2003105776A3 (en) | 2004-09-16 |
ATE382597T1 (de) | 2008-01-15 |
JP2005529945A (ja) | 2005-10-06 |
AU2003238240A1 (en) | 2003-12-31 |
DE60318456T2 (de) | 2008-12-24 |
US7595341B2 (en) | 2009-09-29 |
EP1537069A2 (de) | 2005-06-08 |
WO2003105776A2 (en) | 2003-12-24 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition |