DE60305055D1 - Verwendung von ghrelin zur behandlung von unterernährung von gastrektomiepatienten - Google Patents
Verwendung von ghrelin zur behandlung von unterernährung von gastrektomiepatientenInfo
- Publication number
- DE60305055D1 DE60305055D1 DE60305055T DE60305055T DE60305055D1 DE 60305055 D1 DE60305055 D1 DE 60305055D1 DE 60305055 T DE60305055 T DE 60305055T DE 60305055 T DE60305055 T DE 60305055T DE 60305055 D1 DE60305055 D1 DE 60305055D1
- Authority
- DE
- Germany
- Prior art keywords
- treatment
- ghrelin
- reectomy
- guest
- patients
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 102000012004 Ghrelin Human genes 0.000 title abstract 3
- 101800001586 Ghrelin Proteins 0.000 title abstract 3
- GNKDKYIHGQKHHM-RJKLHVOGSA-N ghrelin Chemical compound C([C@H](NC(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)CN)COC(=O)CCCCCCC)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC=1N=CNC=1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N1[C@@H](CCC1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O)C1=CC=CC=C1 GNKDKYIHGQKHHM-RJKLHVOGSA-N 0.000 title abstract 3
- 230000035764 nutrition Effects 0.000 title 1
- 235000016709 nutrition Nutrition 0.000 title 1
- 241000700159 Rattus Species 0.000 abstract 2
- 230000037396 body weight Effects 0.000 abstract 2
- 208000030814 Eating disease Diseases 0.000 abstract 1
- 208000019454 Feeding and Eating disease Diseases 0.000 abstract 1
- 208000015580 Increased body weight Diseases 0.000 abstract 1
- 241001465754 Metazoa Species 0.000 abstract 1
- 210000000577 adipose tissue Anatomy 0.000 abstract 1
- 230000001539 anorectic effect Effects 0.000 abstract 1
- 206010061428 decreased appetite Diseases 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 230000010534 mechanism of action Effects 0.000 abstract 1
- 230000000580 secretagogue effect Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/25—Growth hormone-releasing factor [GH-RF], i.e. somatoliberin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Endocrinology (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Epidemiology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Marine Sciences & Fisheries (AREA)
- Nutrition Science (AREA)
- Obesity (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
- Gas Separation By Absorption (AREA)
- Solid-Sorbent Or Filter-Aiding Compositions (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP20020022705 EP1407779A1 (de) | 2002-10-10 | 2002-10-10 | Verwendung von Ghrelin zur Behandlung von vermindertem Körpergewicht und Körperfett in Individuen mit Gastrektomie |
| EP02022705 | 2002-10-10 | ||
| PCT/DK2003/000679 WO2004032952A1 (en) | 2002-10-10 | 2003-10-09 | Use of ghrelin for treating malnutrition in gastrectomized individuals |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE60305055D1 true DE60305055D1 (de) | 2006-06-08 |
| DE60305055T2 DE60305055T2 (de) | 2006-12-07 |
Family
ID=32010955
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE60305055T Expired - Lifetime DE60305055T2 (de) | 2002-10-10 | 2003-10-09 | Verwendung von ghrelin zur behandlung von unterernährung von gastrektomiepatienten |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US7592305B2 (de) |
| EP (2) | EP1407779A1 (de) |
| JP (1) | JP4177224B2 (de) |
| KR (1) | KR20050057650A (de) |
| CN (1) | CN1723035A (de) |
| AT (1) | ATE324904T1 (de) |
| AU (1) | AU2003299710A1 (de) |
| DE (1) | DE60305055T2 (de) |
| WO (1) | WO2004032952A1 (de) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BR0314619A (pt) * | 2002-09-18 | 2005-08-02 | Univ Montreal Ct Hospitalier Chum | Análogos de ghrh |
| USRE42624E1 (en) | 2003-06-18 | 2011-08-16 | Tranzyme Pharma Inc. | Methods of using macrocyclic modulators of the ghrelin receptor |
| WO2005097173A2 (en) * | 2004-04-07 | 2005-10-20 | Gastrotech Pharma A/S | Use of ghrelin for the treatment of hyperthyroidism |
| WO2005097174A2 (en) * | 2004-04-07 | 2005-10-20 | Gastrotech Pharma A/S | Uses of a combination of ghrelin and somatotropin for the treatment of cachexia |
| EP1750745A1 (de) * | 2004-05-11 | 2007-02-14 | The United States of America, represented by the Secretary, Department of Health and Human Services | Verfahren zur hemmung der expression von proinflammatorischem cytokin unter verwendung von ghrelin |
| EP1800689B1 (de) * | 2004-08-24 | 2016-12-28 | Daiichi Sankyo Company, Limited | Flüssige zubereitung von physiologisch aktivem peptid |
| WO2006058539A2 (en) * | 2004-11-30 | 2006-06-08 | Gastrotech Pharma A/S | Growth hormone secretagogue receptor 1a ligands |
| AU2007281131B2 (en) * | 2006-08-01 | 2012-11-29 | The Scripps Research Institute | Vaccines and methods for controlling adiposity |
| JP5649825B2 (ja) | 2007-01-31 | 2015-01-07 | デイナ ファーバー キャンサー インスティチュート，インコーポレイテッド | 安定化させたｐ５３ペプチドおよびその使用法 |
| EP2121003A1 (de) * | 2007-02-14 | 2009-11-25 | Karolinska Innovations AB | Zusammensetzungen zur erhöhung des körpergewichts, verwendung und verfahren |
| ES2430067T3 (es) | 2007-03-28 | 2013-11-18 | President And Fellows Of Harvard College | Polipéptidos cosidos |
| US8324151B2 (en) * | 2007-11-20 | 2012-12-04 | The Feinstein Institute For Medical Research | Treatment of sepsis and septic shock using ghrelin and growth hormone |
| US8013015B2 (en) * | 2008-10-02 | 2011-09-06 | Board Of Regents, The University Of Texas System | Small molecule inhibitors of ghrelin O-acyltransferase |
| ES2599168T3 (es) * | 2010-01-15 | 2017-01-31 | University Of Miyazaki | Grelina para promover la recuperación de un animal en tratamiento médico |
| KR20170058446A (ko) | 2010-08-13 | 2017-05-26 | 에일러론 테라퓨틱스 인코포레이티드 | 펩티도미메틱 거대고리 |
| WO2012108960A2 (en) * | 2011-02-09 | 2012-08-16 | The Scripps Research Institute | Ghrelin mimetic polypeptide hapten immunoconjugates having improved solubility and immunogenicity and methods of use thereof |
| RU2639523C2 (ru) | 2011-10-18 | 2017-12-21 | Эйлерон Терапьютикс, Инк. | Пептидомиметические макроциклы и их применение |
| CA2864120A1 (en) | 2012-02-15 | 2013-08-22 | Aileron Therapeutics, Inc. | Triazole-crosslinked and thioether-crosslinked peptidomimetic macrocycles |
| CA2862038C (en) | 2012-02-15 | 2021-05-25 | Aileron Therapeutics, Inc. | Peptidomimetic macrocycles |
| JP6526563B2 (ja) | 2012-11-01 | 2019-06-05 | エイルロン セラピューティクス，インコーポレイテッド | 二置換アミノ酸ならびにその調製および使用の方法 |
| WO2015048091A1 (en) * | 2013-09-24 | 2015-04-02 | The Board Of Regents Of The University Of Texas System | Orexin-control of bone formation and loss |
| MX2017003797A (es) | 2014-09-24 | 2017-06-15 | Aileron Therapeutics Inc | Macrociclos peptidomimeticos y usos de los mismos. |
| CN107614003A (zh) | 2015-03-20 | 2018-01-19 | 艾瑞朗医疗公司 | 拟肽大环化合物及其用途 |
| WO2023161226A1 (en) * | 2022-02-22 | 2023-08-31 | Pephexia Therapeutics Aps | Ghrelin agonists with improved potency |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE69637855D1 (de) | 1995-12-22 | 2009-04-16 | Novo Nordisk As | Verbindungen mit wachstumshormon-freisetzenden eigenschaften |
| HUP0100998A3 (en) | 1998-03-03 | 2001-12-28 | Novo Nordisk As | (2e)-5-amino-5-methylhex-2-enoic acid n-methyl-n-((1r)-1-(n-methyl-n-((1r)-1-(methylcarbamoyl)-2-phenylethyl)carbamoyl)-2-(2-naphtyl)ethyl)amide salts, methods for their preparation, pharmaceutical compositions comprising thereof and their use |
| WO1999058501A1 (en) | 1998-05-11 | 1999-11-18 | Novo Nordisk A/S | Compounds with growth hormone releasing properties |
| CA2347102A1 (en) | 1998-11-03 | 2000-05-11 | Novo Nordisk A/S | Compounds with growth hormone releasing properties |
| BR0012688A (pt) * | 1999-07-23 | 2002-04-16 | Kenji Kangawa | Novos peptìdios |
| WO2001056592A1 (en) * | 2000-02-01 | 2001-08-09 | Novo Nordisk A/S | Use of compounds for the regulation of food intake |
| US7244701B2 (en) * | 2000-06-16 | 2007-07-17 | Zealand Phama A/S | Diuretic peptide conjugate |
-
2002
- 2002-10-10 EP EP20020022705 patent/EP1407779A1/de not_active Withdrawn
-
2003
- 2003-10-09 US US10/530,866 patent/US7592305B2/en not_active Expired - Fee Related
- 2003-10-09 EP EP03756447A patent/EP1553969B1/de not_active Expired - Lifetime
- 2003-10-09 AT AT03756447T patent/ATE324904T1/de not_active IP Right Cessation
- 2003-10-09 DE DE60305055T patent/DE60305055T2/de not_active Expired - Lifetime
- 2003-10-09 CN CNA2003801057083A patent/CN1723035A/zh active Pending
- 2003-10-09 KR KR1020057006275A patent/KR20050057650A/ko not_active Application Discontinuation
- 2003-10-09 AU AU2003299710A patent/AU2003299710A1/en not_active Abandoned
- 2003-10-09 WO PCT/DK2003/000679 patent/WO2004032952A1/en not_active Application Discontinuation
- 2003-10-10 JP JP2003352592A patent/JP4177224B2/ja not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| JP4177224B2 (ja) | 2008-11-05 |
| US7592305B2 (en) | 2009-09-22 |
| EP1407779A1 (de) | 2004-04-14 |
| ATE324904T1 (de) | 2006-06-15 |
| DE60305055T2 (de) | 2006-12-07 |
| WO2004032952A1 (en) | 2004-04-22 |
| CN1723035A (zh) | 2006-01-18 |
| US20060217296A1 (en) | 2006-09-28 |
| EP1553969B1 (de) | 2006-05-03 |
| AU2003299710A1 (en) | 2004-05-04 |
| KR20050057650A (ko) | 2005-06-16 |
| JP2004277402A (ja) | 2004-10-07 |
| EP1553969A1 (de) | 2005-07-20 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DE60305055D1 (de) | Verwendung von ghrelin zur behandlung von unterernährung von gastrektomiepatienten | |
| DE602005026078D1 (de) | Verwendung von Antioxidantien zur Verhinderung von Oxidation und zur Reduzierung von Wirkstoffzersetzung in wirkstoffhaltigen medizinischen Artikeln | |
| DE602006017071D1 (de) | Zusammensetzungen und verfahren zur behandlung von herzkrankheiten | |
| SG146666A1 (en) | Methods of using regenerative cells in the treatment of peripheral vascular disease and related disorders | |
| ATE340568T1 (de) | Verwendung einer pharmazeutischen formulierung enthaltend milchsäure oder laktat und kalium zur behandlung von hirnödem und verletzungen des gehirns | |
| ATE477812T1 (de) | Verwendung von tryptophanreichen peptiden aus molkenproteinhydrolysate zur behandlung von übergewicht und fettleibigkeit | |
| DE602004017888D1 (de) | Verfahren zur behandlung von akuter und durch übermässige beanspruchung verursachter zerrung und verstauchung mit hyaluronsäure | |
| ATE225803T1 (de) | Peptid zur verringerung des triglyzeridspiegels des blutes und inhibitor für den anstieg des triglyzeridspiegels des blutes, der das peptid als aktiven bestandteil enthält | |
| ATE326534T1 (de) | Methode zur behandlung von muskelkrankheiten | |
| TW200501934A (en) | Therapeutic causing contraction of mucosal tissue, method of treating diseases relating to mucosal tissues, injector and therapeutic set | |
| HUP0202730A2 (hu) | Eljárás friss hús felületének kezelésére | |
| ATE183651T1 (de) | Verwendung von wachstumsfaktor igf-ii zur beahandlung von gastrointestinalen störungen | |
| DE60118769D1 (de) | Verwendung von langem pentraxin ptx3 zur behanlung von durch geänderte aktivität des fgf-2 wachstumsfaktors hervorgerufene krankheiten | |
| ATE487480T1 (de) | Perhexilin zur behandlung von chronischer herzinsuffizienz | |
| ATE386513T1 (de) | Verwendung von angelicin und seiner strukturellen analoga zur behandlung von thalassämie | |
| RU2577950C1 (ru) | Способ стимуляции заживления дермальных ожогов | |
| DE50213170D1 (de) | Verwendung eines Mittel zur Therapie der Herzhypertrophie | |
| DE60305534D1 (de) | Verwendung von docosahexaensäure als wirkstoff bei der behandlung von lipodystrophie | |
| RU2303985C2 (ru) | Биологически активный продукт пантового животноводства, способ его получения и способ оздоровления человека | |
| 赵坚新 et al. | Treatment of infantile morbid night crying by acupuncture at Zhongchong point in 100 cases | |
| WO2003097690A3 (en) | Pth derivatives resistant to skin proteases | |
| Gilden | No attrition in research on wasting therapies | |
| Guo et al. | Comprehensive rehabilitation of closed injury of brain | |
| DE69430807D1 (de) | Verfahren zur behandlung von lebererkrankungen und ähnlichen indikationen mit vasodilatierenden wirkstoffen | |
| Tien | Analgesic Effect of Acupuncture in Patients with Fibrodysphasia Ossificans |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition |