DE60238671D1 - Verwendung von glucocorticoid-rezeptor-spezifischen antagonisten zur behandlung von delirium - Google Patents
Verwendung von glucocorticoid-rezeptor-spezifischen antagonisten zur behandlung von deliriumInfo
- Publication number
- DE60238671D1 DE60238671D1 DE60238671T DE60238671T DE60238671D1 DE 60238671 D1 DE60238671 D1 DE 60238671D1 DE 60238671 T DE60238671 T DE 60238671T DE 60238671 T DE60238671 T DE 60238671T DE 60238671 D1 DE60238671 D1 DE 60238671D1
- Authority
- DE
- Germany
- Prior art keywords
- glucocorticoid receptor
- delirium
- treatment
- receptor antagonist
- specific antagonists
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 206010012218 Delirium Diseases 0.000 title abstract 3
- 239000005557 antagonist Substances 0.000 title 1
- 239000003862 glucocorticoid Substances 0.000 title 1
- 229940126013 glucocorticoid receptor antagonist Drugs 0.000 abstract 3
- 239000003850 glucocorticoid receptor antagonist Substances 0.000 abstract 3
- JYGXADMDTFJGBT-VWUMJDOOSA-N hydrocortisone Chemical compound O=C1CC[C@]2(C)[C@H]3[C@@H](O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 JYGXADMDTFJGBT-VWUMJDOOSA-N 0.000 abstract 2
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 229960000890 hydrocortisone Drugs 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
- VKHAHZOOUSRJNA-GCNJZUOMSA-N mifepristone Chemical compound C1([C@@H]2C3=C4CCC(=O)C=C4CC[C@H]3[C@@H]3CC[C@@]([C@]3(C2)C)(O)C#CC)=CC=C(N(C)C)C=C1 VKHAHZOOUSRJNA-GCNJZUOMSA-N 0.000 abstract 1
- 229960003248 mifepristone Drugs 0.000 abstract 1
- 230000003389 potentiating effect Effects 0.000 abstract 1
- 102000005962 receptors Human genes 0.000 abstract 1
- 108020003175 receptors Proteins 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
- A61P5/46—Drugs for disorders of the endocrine system of the suprarenal hormones for decreasing, blocking or antagonising the activity of glucocorticosteroids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Cardiology (AREA)
- Diabetes (AREA)
- Hospice & Palliative Care (AREA)
- Hematology (AREA)
- Psychiatry (AREA)
- Urology & Nephrology (AREA)
- Heart & Thoracic Surgery (AREA)
- Obesity (AREA)
- Oncology (AREA)
- Endocrinology (AREA)
- Communicable Diseases (AREA)
- Vascular Medicine (AREA)
- Anesthesiology (AREA)
- Epidemiology (AREA)
- Gastroenterology & Hepatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Steroid Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US28861901P | 2001-05-04 | 2001-05-04 | |
| US13780002A | 2002-05-01 | 2002-05-01 | |
| PCT/US2002/014318 WO2002096433A1 (en) | 2001-05-04 | 2002-05-06 | Methods for treating delirium using glucocorticoid receptor-specific antagonists |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE60238671D1 true DE60238671D1 (de) | 2011-02-03 |
Family
ID=26835589
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE60238671T Expired - Lifetime DE60238671D1 (de) | 2001-05-04 | 2002-05-06 | Verwendung von glucocorticoid-rezeptor-spezifischen antagonisten zur behandlung von delirium |
Country Status (11)
| Country | Link |
|---|---|
| EP (1) | EP1390037B1 (https=) |
| JP (2) | JP2005512949A (https=) |
| CN (1) | CN1527713A (https=) |
| AT (1) | ATE492281T1 (https=) |
| AU (1) | AU2002303652B2 (https=) |
| CA (1) | CA2446506C (https=) |
| DE (1) | DE60238671D1 (https=) |
| IL (2) | IL158744A0 (https=) |
| NO (1) | NO334736B1 (https=) |
| NZ (1) | NZ529456A (https=) |
| WO (1) | WO2002096433A1 (https=) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE60230936D1 (de) * | 2001-10-26 | 2009-03-05 | Organon Nv | Verwendung von (11beta, 17beta)-11-(1,3-Benzodioxol-5-yl)-17-Hydroxy-17-(1-Propinyl)-estra-4,9-dien-3-on zur Behandlung von schweren Depressionen |
| JP6053802B2 (ja) * | 2011-10-07 | 2016-12-27 | コーニンクレッカ フィリップス エヌ ヴェＫｏｎｉｎｋｌｉｊｋｅ Ｐｈｉｌｉｐｓ Ｎ．Ｖ． | 患者を監視し、患者のせん妄を検出する監視システム |
| CN116168840B (zh) * | 2023-04-23 | 2023-12-22 | 北京大学人民医院 | 一种预测术后谵妄发生风险的方法、设备及系统 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP3464012B2 (ja) * | 1993-04-05 | 2003-11-05 | 旭化成株式会社 | 精神症候治療剤 |
| IL110309A0 (en) * | 1993-07-15 | 1994-10-21 | Univ Kentucky Res Found | A method of protecting against neuron loss |
| AU747956B2 (en) * | 1997-10-06 | 2002-05-30 | Board Of Trustees Of The Leland Stanford Junior University | Methods for treating psychosis associated with glucocorticoid related dysfunction |
| IL139672A (en) * | 1998-05-15 | 2005-11-20 | Univ Leland Stanford Junior | Glucocorticoid receptor antagonists for the tretment of dementia |
| DE60232956D1 (de) * | 2001-03-23 | 2009-08-27 | Corcept Therapeutics Inc | Verfahren zur behandlung von stressbedingten erkrankungen unter verwendung von glucocorticoid-rezepto-spezifischen antagonisten |
-
2002
- 2002-05-06 WO PCT/US2002/014318 patent/WO2002096433A1/en not_active Ceased
- 2002-05-06 CA CA2446506A patent/CA2446506C/en not_active Expired - Fee Related
- 2002-05-06 EP EP02731689A patent/EP1390037B1/en not_active Expired - Lifetime
- 2002-05-06 AU AU2002303652A patent/AU2002303652B2/en not_active Ceased
- 2002-05-06 IL IL15874402A patent/IL158744A0/xx unknown
- 2002-05-06 AT AT02731689T patent/ATE492281T1/de active
- 2002-05-06 DE DE60238671T patent/DE60238671D1/de not_active Expired - Lifetime
- 2002-05-06 CN CNA028126726A patent/CN1527713A/zh active Pending
- 2002-05-06 JP JP2002592943A patent/JP2005512949A/ja active Pending
- 2002-05-06 NZ NZ529456A patent/NZ529456A/en not_active IP Right Cessation
-
2003
- 2003-11-04 NO NO20034916A patent/NO334736B1/no not_active IP Right Cessation
- 2003-11-04 IL IL158744A patent/IL158744A/en not_active IP Right Cessation
-
2008
- 2008-12-09 JP JP2008313766A patent/JP2009102346A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| EP1390037A1 (en) | 2004-02-25 |
| EP1390037A4 (en) | 2005-03-30 |
| NO20034916L (no) | 2004-01-05 |
| JP2009102346A (ja) | 2009-05-14 |
| AU2002303652B2 (en) | 2006-08-31 |
| HK1059036A1 (en) | 2004-06-18 |
| CA2446506C (en) | 2012-04-10 |
| WO2002096433A9 (en) | 2003-02-06 |
| IL158744A (en) | 2011-11-30 |
| JP2005512949A (ja) | 2005-05-12 |
| ATE492281T1 (de) | 2011-01-15 |
| WO2002096433A1 (en) | 2002-12-05 |
| IL158744A0 (en) | 2004-05-12 |
| CN1527713A (zh) | 2004-09-08 |
| NO334736B1 (no) | 2014-05-19 |
| NO20034916D0 (no) | 2003-11-04 |
| NZ529456A (en) | 2005-10-28 |
| CA2446506A1 (en) | 2002-12-05 |
| EP1390037B1 (en) | 2010-12-22 |
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