DE60237813D1 - Verfahren zum verbessern der effektivität medizinischer einrichtungen durch anhaften von medikamenten an deren oberfläche - Google Patents

Verfahren zum verbessern der effektivität medizinischer einrichtungen durch anhaften von medikamenten an deren oberfläche

Info

Publication number
DE60237813D1
DE60237813D1 DE60237813T DE60237813T DE60237813D1 DE 60237813 D1 DE60237813 D1 DE 60237813D1 DE 60237813 T DE60237813 T DE 60237813T DE 60237813 T DE60237813 T DE 60237813T DE 60237813 D1 DE60237813 D1 DE 60237813D1
Authority
DE
Germany
Prior art keywords
medicaments
effectiveness
improving
mounting
medical devices
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60237813T
Other languages
English (en)
Inventor
Stephen M Blinn
Barry Zide
Vincent Difilippo
Sean Kirkpatrick
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
TEL Epion Inc
Original Assignee
TEL Epion Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by TEL Epion Inc filed Critical TEL Epion Inc
Application granted granted Critical
Publication of DE60237813D1 publication Critical patent/DE60237813D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C23COATING METALLIC MATERIAL; COATING MATERIAL WITH METALLIC MATERIAL; CHEMICAL SURFACE TREATMENT; DIFFUSION TREATMENT OF METALLIC MATERIAL; COATING BY VACUUM EVAPORATION, BY SPUTTERING, BY ION IMPLANTATION OR BY CHEMICAL VAPOUR DEPOSITION, IN GENERAL; INHIBITING CORROSION OF METALLIC MATERIAL OR INCRUSTATION IN GENERAL
    • C23CCOATING METALLIC MATERIAL; COATING MATERIAL WITH METALLIC MATERIAL; SURFACE TREATMENT OF METALLIC MATERIAL BY DIFFUSION INTO THE SURFACE, BY CHEMICAL CONVERSION OR SUBSTITUTION; COATING BY VACUUM EVAPORATION, BY SPUTTERING, BY ION IMPLANTATION OR BY CHEMICAL VAPOUR DEPOSITION, IN GENERAL
    • C23C14/00Coating by vacuum evaporation, by sputtering or by ion implantation of the coating forming material
    • C23C14/02Pretreatment of the material to be coated
    • C23C14/021Cleaning or etching treatments
    • C23C14/022Cleaning or etching treatments by means of bombardment with energetic particles or radiation
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/14Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/14Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L31/16Biologically active materials, e.g. therapeutic substances
    • CCHEMISTRY; METALLURGY
    • C23COATING METALLIC MATERIAL; COATING MATERIAL WITH METALLIC MATERIAL; CHEMICAL SURFACE TREATMENT; DIFFUSION TREATMENT OF METALLIC MATERIAL; COATING BY VACUUM EVAPORATION, BY SPUTTERING, BY ION IMPLANTATION OR BY CHEMICAL VAPOUR DEPOSITION, IN GENERAL; INHIBITING CORROSION OF METALLIC MATERIAL OR INCRUSTATION IN GENERAL
    • C23CCOATING METALLIC MATERIAL; COATING MATERIAL WITH METALLIC MATERIAL; SURFACE TREATMENT OF METALLIC MATERIAL BY DIFFUSION INTO THE SURFACE, BY CHEMICAL CONVERSION OR SUBSTITUTION; COATING BY VACUUM EVAPORATION, BY SPUTTERING, BY ION IMPLANTATION OR BY CHEMICAL VAPOUR DEPOSITION, IN GENERAL
    • C23C14/00Coating by vacuum evaporation, by sputtering or by ion implantation of the coating forming material
    • C23C14/22Coating by vacuum evaporation, by sputtering or by ion implantation of the coating forming material characterised by the process of coating
    • C23C14/221Ion beam deposition
    • CCHEMISTRY; METALLURGY
    • C23COATING METALLIC MATERIAL; COATING MATERIAL WITH METALLIC MATERIAL; CHEMICAL SURFACE TREATMENT; DIFFUSION TREATMENT OF METALLIC MATERIAL; COATING BY VACUUM EVAPORATION, BY SPUTTERING, BY ION IMPLANTATION OR BY CHEMICAL VAPOUR DEPOSITION, IN GENERAL; INHIBITING CORROSION OF METALLIC MATERIAL OR INCRUSTATION IN GENERAL
    • C23CCOATING METALLIC MATERIAL; COATING MATERIAL WITH METALLIC MATERIAL; SURFACE TREATMENT OF METALLIC MATERIAL BY DIFFUSION INTO THE SURFACE, BY CHEMICAL CONVERSION OR SUBSTITUTION; COATING BY VACUUM EVAPORATION, BY SPUTTERING, BY ION IMPLANTATION OR BY CHEMICAL VAPOUR DEPOSITION, IN GENERAL
    • C23C14/00Coating by vacuum evaporation, by sputtering or by ion implantation of the coating forming material
    • C23C14/22Coating by vacuum evaporation, by sputtering or by ion implantation of the coating forming material characterised by the process of coating
    • C23C14/50Substrate holders
    • C23C14/505Substrate holders for rotation of the substrates
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/82Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/86Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
DE60237813T 2001-05-11 2002-05-13 Verfahren zum verbessern der effektivität medizinischer einrichtungen durch anhaften von medikamenten an deren oberfläche Expired - Lifetime DE60237813D1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US29038901P 2001-05-11 2001-05-11
US31765201P 2001-09-06 2001-09-06
PCT/US2002/015236 WO2002093988A1 (en) 2001-05-11 2002-05-13 Method and system for improving the effectiveness of medical devices by adhering drugs to the surface thereof

Publications (1)

Publication Number Publication Date
DE60237813D1 true DE60237813D1 (de) 2010-11-11

Family

ID=26966151

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60237813T Expired - Lifetime DE60237813D1 (de) 2001-05-11 2002-05-13 Verfahren zum verbessern der effektivität medizinischer einrichtungen durch anhaften von medikamenten an deren oberfläche

Country Status (5)

Country Link
US (1) US7105199B2 (de)
EP (2) EP2210626B1 (de)
JP (1) JP4617060B2 (de)
DE (1) DE60237813D1 (de)
WO (1) WO2002093988A1 (de)

Families Citing this family (83)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7713297B2 (en) 1998-04-11 2010-05-11 Boston Scientific Scimed, Inc. Drug-releasing stent with ceramic-containing layer
US7923055B2 (en) * 2001-05-11 2011-04-12 Exogenesis Corporation Method of manufacturing a drug delivery system
US20100036502A1 (en) * 2008-08-07 2010-02-11 Exogenesis Corporation Medical device for bone implant and method for producing such device
US8889169B2 (en) * 2001-05-11 2014-11-18 Exogenesis Corporation Drug delivery system and method of manufacturing thereof
US7666462B2 (en) * 2001-05-11 2010-02-23 Exogenesis Corporation Method of controlling a drug release rate
WO2003002243A2 (en) 2001-06-27 2003-01-09 Remon Medical Technologies Ltd. Method and device for electrochemical formation of therapeutic species in vivo
DE60334676D1 (de) 2003-02-21 2010-12-09 Sorin Biomedica Cardio Srl Verfahren zur Herstellung eines Stents und entsprechender Stent
US20050131513A1 (en) * 2003-12-16 2005-06-16 Cook Incorporated Stent catheter with a permanently affixed conductor
ES2764992T3 (es) 2005-04-04 2020-06-05 Flexible Stenting Solutions Inc Stent flexible
US20060233941A1 (en) * 2005-04-15 2006-10-19 Boston Scientific Scimed, Inc. Method of coating a medical device utilizing an ion-based thin film deposition technique, a system for coating a medical device, and a medical device produced by the method
US8840660B2 (en) 2006-01-05 2014-09-23 Boston Scientific Scimed, Inc. Bioerodible endoprostheses and methods of making the same
US8089029B2 (en) 2006-02-01 2012-01-03 Boston Scientific Scimed, Inc. Bioabsorbable metal medical device and method of manufacture
US20070224235A1 (en) 2006-03-24 2007-09-27 Barron Tenney Medical devices having nanoporous coatings for controlled therapeutic agent delivery
US8187620B2 (en) 2006-03-27 2012-05-29 Boston Scientific Scimed, Inc. Medical devices comprising a porous metal oxide or metal material and a polymer coating for delivering therapeutic agents
US8048150B2 (en) 2006-04-12 2011-11-01 Boston Scientific Scimed, Inc. Endoprosthesis having a fiber meshwork disposed thereon
US8815275B2 (en) 2006-06-28 2014-08-26 Boston Scientific Scimed, Inc. Coatings for medical devices comprising a therapeutic agent and a metallic material
WO2008002778A2 (en) 2006-06-29 2008-01-03 Boston Scientific Limited Medical devices with selective coating
WO2008017028A2 (en) 2006-08-02 2008-02-07 Boston Scientific Scimed, Inc. Endoprosthesis with three-dimensional disintegration control
WO2008033711A2 (en) 2006-09-14 2008-03-20 Boston Scientific Limited Medical devices with drug-eluting coating
US8057534B2 (en) 2006-09-15 2011-11-15 Boston Scientific Scimed, Inc. Bioerodible endoprostheses and methods of making the same
JP2010503485A (ja) 2006-09-15 2010-02-04 ボストン サイエンティフィック リミテッド 医療用デバイスおよび同デバイスの製造方法
ES2368125T3 (es) 2006-09-15 2011-11-14 Boston Scientific Scimed, Inc. Endoprótesis bioerosionable con capas inorgánicas bioestables.
JP2010503489A (ja) 2006-09-15 2010-02-04 ボストン サイエンティフィック リミテッド 生体内分解性内部人工器官およびその製造方法
CA2663762A1 (en) 2006-09-18 2008-03-27 Boston Scientific Limited Endoprostheses
US7981150B2 (en) 2006-11-09 2011-07-19 Boston Scientific Scimed, Inc. Endoprosthesis with coatings
EP2277563B1 (de) 2006-12-28 2014-06-25 Boston Scientific Limited Biologisch abbaubare endoprothesen und verfahren zur herstellung derselben.
US8070797B2 (en) 2007-03-01 2011-12-06 Boston Scientific Scimed, Inc. Medical device with a porous surface for delivery of a therapeutic agent
US8431149B2 (en) 2007-03-01 2013-04-30 Boston Scientific Scimed, Inc. Coated medical devices for abluminal drug delivery
US8067054B2 (en) * 2007-04-05 2011-11-29 Boston Scientific Scimed, Inc. Stents with ceramic drug reservoir layer and methods of making and using the same
US7976915B2 (en) 2007-05-23 2011-07-12 Boston Scientific Scimed, Inc. Endoprosthesis with select ceramic morphology
US7942926B2 (en) 2007-07-11 2011-05-17 Boston Scientific Scimed, Inc. Endoprosthesis coating
US8002823B2 (en) 2007-07-11 2011-08-23 Boston Scientific Scimed, Inc. Endoprosthesis coating
JP2010533563A (ja) 2007-07-19 2010-10-28 ボストン サイエンティフィック リミテッド 吸着抑制表面を有する内部人工器官
US8815273B2 (en) 2007-07-27 2014-08-26 Boston Scientific Scimed, Inc. Drug eluting medical devices having porous layers
US7931683B2 (en) 2007-07-27 2011-04-26 Boston Scientific Scimed, Inc. Articles having ceramic coated surfaces
US8221822B2 (en) 2007-07-31 2012-07-17 Boston Scientific Scimed, Inc. Medical device coating by laser cladding
US7988723B2 (en) 2007-08-02 2011-08-02 Flexible Stenting Solutions, Inc. Flexible stent
JP2010535541A (ja) 2007-08-03 2010-11-25 ボストン サイエンティフィック リミテッド 広い表面積を有する医療器具用のコーティング
US8052745B2 (en) 2007-09-13 2011-11-08 Boston Scientific Scimed, Inc. Endoprosthesis
US8377460B2 (en) * 2007-09-14 2013-02-19 Exogenesis Corporation Method for modifying the wettability and/or other biocompatibility characteristics of a surface of a biological material by the application of gas cluster ion beam technology and biological materials made thereby
US20100227523A1 (en) * 2007-09-14 2010-09-09 Exogenesis Corporation Methods for improving the bioactivity characteristics of a surface and objects with surfaces improved thereby
WO2009036373A2 (en) * 2007-09-14 2009-03-19 Exogenesis Corporation Method and system for modifying the wettability characteristics of a surface of a medical device by the application of gas cluster ion beam technology and medical devices made thereby
US9144627B2 (en) 2007-09-14 2015-09-29 Exogenesis Corporation Methods for improving the bioactivity characteristics of a surface and objects with surfaces improved thereby
EP2192993A4 (de) * 2007-10-01 2012-02-15 Exogenesis Corp Verfahren und system zur beschichtung der oberfläche eines medizinischen gerätes mit einem therapeutischen wirkstoff und auf diese weise hergestellte wirkstofffreisetzende medizinische geräte
US7938855B2 (en) 2007-11-02 2011-05-10 Boston Scientific Scimed, Inc. Deformable underlayer for stent
US8029554B2 (en) 2007-11-02 2011-10-04 Boston Scientific Scimed, Inc. Stent with embedded material
US8216632B2 (en) 2007-11-02 2012-07-10 Boston Scientific Scimed, Inc. Endoprosthesis coating
US20090186068A1 (en) * 2008-01-18 2009-07-23 Chameleon Scientific Corporation Atomic plasma deposited coatings for drug release
US20090226598A1 (en) * 2008-02-11 2009-09-10 Boston Scientific Scimed, Inc. Substrate Coating Apparatus Having a Solvent Vapor Emitter
JP5581311B2 (ja) 2008-04-22 2014-08-27 ボストン サイエンティフィック サイムド,インコーポレイテッド 無機材料のコーティングを有する医療デバイス及びその製造方法
WO2009132176A2 (en) 2008-04-24 2009-10-29 Boston Scientific Scimed, Inc. Medical devices having inorganic particle layers
US7998192B2 (en) 2008-05-09 2011-08-16 Boston Scientific Scimed, Inc. Endoprostheses
US8236046B2 (en) 2008-06-10 2012-08-07 Boston Scientific Scimed, Inc. Bioerodible endoprosthesis
WO2009155328A2 (en) 2008-06-18 2009-12-23 Boston Scientific Scimed, Inc. Endoprosthesis coating
US7985252B2 (en) 2008-07-30 2011-07-26 Boston Scientific Scimed, Inc. Bioerodible endoprosthesis
US20100036482A1 (en) * 2008-08-07 2010-02-11 Exogenesis Corporation Drug delivery system and method of manufacturing thereof
US8382824B2 (en) 2008-10-03 2013-02-26 Boston Scientific Scimed, Inc. Medical implant having NANO-crystal grains with barrier layers of metal nitrides or fluorides
US9149376B2 (en) 2008-10-06 2015-10-06 Cordis Corporation Reconstrainable stent delivery system
US8231980B2 (en) 2008-12-03 2012-07-31 Boston Scientific Scimed, Inc. Medical implants including iridium oxide
US8267992B2 (en) 2009-03-02 2012-09-18 Boston Scientific Scimed, Inc. Self-buffering medical implants
US8071156B2 (en) 2009-03-04 2011-12-06 Boston Scientific Scimed, Inc. Endoprostheses
US20100233227A1 (en) * 2009-03-10 2010-09-16 Boston Scientific Scimed, Inc. Medical devices having carbon drug releasing layers
WO2010105102A1 (en) * 2009-03-11 2010-09-16 Exogenesis Corporation Methods for improving the bioactivity characteristics of a surface and objects with surfaces improved thereby
EP2405891B1 (de) * 2009-03-11 2019-07-03 Exogenesis Corporation Verfahren zur modifikation der befeuchtbarkeit und/oder anderer biokompatibilitätseigenschaften der oberfläche eines biologischen materials durch anwendung einer gascluster-ionenstrahltechnologie sowie in diesem verfahren hergestellte biologische materialien
US8287937B2 (en) 2009-04-24 2012-10-16 Boston Scientific Scimed, Inc. Endoprosthese
WO2011119573A1 (en) 2010-03-23 2011-09-29 Boston Scientific Scimed, Inc. Surface treated bioerodible metal endoprostheses
US20130149459A1 (en) * 2010-07-02 2013-06-13 Aptar France Sas Method for the surface treatment of a fluid product dispensing device
US20170303383A1 (en) * 2010-08-23 2017-10-19 Exogenesis Corporation Method for neutral beam processing based on gas cluster ion beam technology and articles produced thereby
US10181402B2 (en) 2010-08-23 2019-01-15 Exogenesis Corporation Method and apparatus for neutral beam processing based on gas cluster ion beam technology and articles produced thereby
US9799488B2 (en) * 2010-08-23 2017-10-24 Exogenesis Corporation Method and apparatus for neutral beam processing based on gas cluster ion beam technology
US10670960B2 (en) 2010-08-23 2020-06-02 Exogenesis Corporation Enhanced high aspect ratio etch performance using accelerated neutral beams derived from gas-cluster ion beams
WO2013028529A1 (en) * 2011-08-19 2013-02-28 Exogenesis Corporation Drug delivery system and method of manufacturing thereof
US10202684B2 (en) 2010-08-23 2019-02-12 Exogenesis Corporation Method for neutral beam processing based on gas cluster ion beam technology and articles produced thereby
US11199769B2 (en) 2010-08-23 2021-12-14 Exogenesis Corporation Method and apparatus for neutral beam processing based on gas cluster ion beam technology
CN103180030B (zh) 2010-08-23 2017-04-12 艾克索乔纳斯公司 基于气体团簇离子束技术的中性射束处理方法和设备
US10825685B2 (en) 2010-08-23 2020-11-03 Exogenesis Corporation Method for neutral beam processing based on gas cluster ion beam technology and articles produced thereby
US10556042B2 (en) 2011-08-19 2020-02-11 Exogenesis Corporation Drug delivery system and method of manufacturing thereof
WO2013028761A1 (en) * 2011-08-22 2013-02-28 Exogenesis Corporation Drug delivery system and method of manufacturing thereof
US9114195B2 (en) 2011-08-22 2015-08-25 Exogenesis Corporation Method for modifying the wettability and other biocompatibility characteristics of a surface of a biological material by the application of beam technology and biological materials made thereby
JP2014525817A (ja) 2011-08-22 2014-10-02 エクソジェネシス コーポレーション 物体表面の生物活性特徴の向上方法ならびにそれにより向上された表面
RU2648961C2 (ru) * 2012-02-22 2018-03-28 Эксодженезис Корпорейшн Способ обработки пучком нейтральных частиц, основанный на технологии обработки пучком газовых кластерных ионов, и полученные таким образом изделия
GB2546319B (en) 2016-01-15 2019-07-03 Cook Medical Technologies Llc Coated medical device and method of coating such a device
DE112022000720T5 (de) * 2021-01-22 2023-11-16 Exogenesis Corporation Mit einem beschleunigten neutralen atomstrahl (bnas) modifiziertes polypropylen zur reduzierung der bakterienbesiedlung ohne antibiotika

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4968006A (en) * 1989-07-21 1990-11-06 Spire Corporation Ion implantation of spherical surfaces
US5123924A (en) 1990-04-25 1992-06-23 Spire Corporation Surgical implants and method
JP2662321B2 (ja) 1991-05-31 1997-10-08 科学技術振興事業団 超低速クラスターイオンビームによる表面処理方法
US5419760A (en) 1993-01-08 1995-05-30 Pdt Systems, Inc. Medicament dispensing stent for prevention of restenosis of a blood vessel
US5814194A (en) 1994-10-20 1998-09-29 Matsushita Electric Industrial Co., Ltd Substrate surface treatment method
US5837313A (en) * 1995-04-19 1998-11-17 Schneider (Usa) Inc Drug release stent coating process
US5609629A (en) * 1995-06-07 1997-03-11 Med Institute, Inc. Coated implantable medical device
JP3770970B2 (ja) * 1996-08-28 2006-04-26 昭和ゴム株式会社 アルゴンガスクラスターイオンビームによる医療用物品の表面処理方法
US5843172A (en) 1997-04-15 1998-12-01 Advanced Cardiovascular Systems, Inc. Porous medicated stent
US6331227B1 (en) * 1999-12-14 2001-12-18 Epion Corporation Enhanced etching/smoothing of dielectric surfaces
AU2001277862A1 (en) * 2000-07-10 2002-01-21 Epion Corporation Improving effectiveness of introaocular lenses by gcib
EP1301652B1 (de) * 2000-07-10 2013-09-11 Exogenesis Corporation Verbesserung der effektivität künstlicher hüftgelenke durch gcib
US6676989B2 (en) * 2000-07-10 2004-01-13 Epion Corporation Method and system for improving the effectiveness of medical stents by the application of gas cluster ion beam technology
US6716444B1 (en) * 2000-09-28 2004-04-06 Advanced Cardiovascular Systems, Inc. Barriers for polymer-coated implantable medical devices and methods for making the same
US6635082B1 (en) * 2000-12-29 2003-10-21 Advanced Cardiovascular Systems Inc. Radiopaque stent
US6641607B1 (en) * 2000-12-29 2003-11-04 Advanced Cardiovascular Systems, Inc. Double tube stent
US7077982B2 (en) * 2001-03-23 2006-07-18 Fuji Photo Film Co., Ltd. Molecular electric wire, molecular electric wire circuit using the same and process for producing the molecular electric wire circuit
US6764505B1 (en) * 2001-04-12 2004-07-20 Advanced Cardiovascular Systems, Inc. Variable surface area stent
US6863786B2 (en) * 2001-05-09 2005-03-08 Exogenesis Biomedical Technology Method and system for improving the effectiveness of artificial joints by the application of gas cluster ion beam technology
US20050025805A1 (en) * 2003-07-28 2005-02-03 Adam Heller Osmium compounds for reduction of adverse inflammation

Also Published As

Publication number Publication date
WO2002093988A1 (en) 2002-11-21
JP4617060B2 (ja) 2011-01-19
EP1393601B1 (de) 2010-09-29
US7105199B2 (en) 2006-09-12
US20020188324A1 (en) 2002-12-12
JP2004532081A (ja) 2004-10-21
EP2210626A1 (de) 2010-07-28
EP2210626B1 (de) 2015-01-21
EP1393601A1 (de) 2004-03-03
EP1393601A4 (de) 2007-03-21

Similar Documents

Publication Publication Date Title
DE60237813D1 (de) Verfahren zum verbessern der effektivität medizinischer einrichtungen durch anhaften von medikamenten an deren oberfläche
DE60312422D1 (de) Verbessertes Verfahren zum Einbetten von Dickschichtkomponenten
DE59914036D1 (de) Verfahren zum gesteuerten parallelbetrieb von gleichspannnungswandlern
DE60032438D1 (de) Verbessertes Verfahren zum Einbetten von passiven Bauteilen
DE60228542D1 (de) Verfahren und Vorrichtung zum Prüfen der Oberfläche von Substraten
DE69722961D1 (de) Verfahren zum herstellen von individuell angepassten medizinischen vorrichtungen
DE60329738D1 (de) Verfahren und System zum Drucken von integrierten Schaltungsplänen
DE69908853D1 (de) Verfahren sowie Vorrichtung zum Vergleichen von Mustern durch aktive, visuelle Rückkopplung
DE69906494T2 (de) Verfahren und vorrichtung zum ausrichten der torischen achse
DE60108413D1 (de) Verfahren zum positionieren von komponenten mit hilfe flüssiger antriebsmittel und strukturen hierfür
DE60319939D1 (de) Verfahren zum Fliess-Glätten leitender Anschlüsse
DE60235211D1 (de) Verfahren zum Vorlöschen von Rauschen eines Bildes.
ITMI20051058A1 (it) "metodo e sistema per fabbricare componenti mediante elettroerosione"
DE60044773D1 (de) Vorrichtung zum ausharten resisten
DE60329344D1 (de) Verfahren und Vorrichtung zum Herstellen von Metall-Schichten
DE59813943D1 (de) Verfahren zum Herstellen von elektronischen Elementen
DE50208275D1 (de) Verfahren zur Überprüfung der Struktur von Durchgangslöchern eines Bauteils
DE69913445D1 (de) Verfahren zum Entsperren der Nothaltvorrichtung eines Aufzuges
DE69930227D1 (de) Verfahren zum Herstellen eines elektronischen Bauelementes
ATE219169T1 (de) Vorrichtung zum oberflächenbehandeln durch tauchen
DE59914127D1 (de) Verfahren zum herstellen von halbleiterbauelementen
DE50311668D1 (de) Vorrichtung zum erzeugen von wirbeln sowie verfahren zum betreiben der vorrichtung
DE59500768D1 (de) Verfahren zum Herstellen von durch Feldeffekt steuerbaren Halbleiterbauelementen
FI20021253A0 (fi) Menetelmä jauhemaisten partikkelien käsittelyssä
DE60330472D1 (de) Vorrichtung zum Versprühen von Flüssigkeiten