DE60229960D1 - Herstellung kultivierter menschlicher mastzellen und basophilen zur hochdurchsatz-entdeckung kleiner arzneistoffmoleküle - Google Patents

Herstellung kultivierter menschlicher mastzellen und basophilen zur hochdurchsatz-entdeckung kleiner arzneistoffmoleküle

Info

Publication number
DE60229960D1
DE60229960D1 DE60229960T DE60229960T DE60229960D1 DE 60229960 D1 DE60229960 D1 DE 60229960D1 DE 60229960 T DE60229960 T DE 60229960T DE 60229960 T DE60229960 T DE 60229960T DE 60229960 D1 DE60229960 D1 DE 60229960D1
Authority
DE
Germany
Prior art keywords
cells
mast cells
screening
methods
basophiles
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60229960T
Other languages
English (en)
Inventor
Alexander B Rossi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Rigel Pharmaceuticals Inc
Original Assignee
Rigel Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rigel Pharmaceuticals Inc filed Critical Rigel Pharmaceuticals Inc
Application granted granted Critical
Publication of DE60229960D1 publication Critical patent/DE60229960D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0642—Granulocytes, e.g. basopils, eosinophils, neutrophils, mast cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/125—Stem cell factor [SCF], c-kit ligand [KL]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/20—Cytokines; Chemokines
    • C12N2501/23—Interleukins [IL]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/20—Cytokines; Chemokines
    • C12N2501/26—Flt-3 ligand (CD135L, flk-2 ligand)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2503/00—Use of cells in diagnostics
    • C12N2503/02—Drug screening

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Zoology (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Biotechnology (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
DE60229960T 2001-08-31 2002-08-29 Herstellung kultivierter menschlicher mastzellen und basophilen zur hochdurchsatz-entdeckung kleiner arzneistoffmoleküle Expired - Lifetime DE60229960D1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US31672301P 2001-08-31 2001-08-31
US10/053,355 US7070996B2 (en) 2001-08-31 2001-11-08 Production of cultured human mast cells and basophils for high throughput small molecule drug discovery
PCT/US2002/027628 WO2003020896A2 (en) 2001-08-31 2002-08-29 Production of cultured human mast cells and basophils for high throughput small molecule drug discovery

Publications (1)

Publication Number Publication Date
DE60229960D1 true DE60229960D1 (de) 2009-01-02

Family

ID=26731760

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60229960T Expired - Lifetime DE60229960D1 (de) 2001-08-31 2002-08-29 Herstellung kultivierter menschlicher mastzellen und basophilen zur hochdurchsatz-entdeckung kleiner arzneistoffmoleküle

Country Status (8)

Country Link
US (2) US7070996B2 (de)
EP (1) EP1427812B1 (de)
JP (1) JP4388372B2 (de)
AT (1) ATE414762T1 (de)
AU (1) AU2002327583A1 (de)
DE (1) DE60229960D1 (de)
DK (1) DK1427812T3 (de)
WO (1) WO2003020896A2 (de)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7029697B2 (en) 2001-02-14 2006-04-18 Northwestern University Controlled surface-associated delivery of genes and oligonucleotides
TWI329105B (en) 2002-02-01 2010-08-21 Rigel Pharmaceuticals Inc 2,4-pyrimidinediamine compounds and their uses
US20060105398A1 (en) * 2002-08-09 2006-05-18 Rigel Pharmaceuticals, Inc Methods of identifying compounds that modulate igg mediated mast cell activation
KR20120062863A (ko) * 2003-07-30 2012-06-14 리겔 파마슈티칼스, 인크. 자가면역 질환의 치료 또는 예방에 사용하기 위한 2,4-피리미딘디아민 화합물
JP2007536935A (ja) * 2004-05-14 2007-12-20 ベクトン・ディキンソン・アンド・カンパニー 間葉幹細胞の無血清増殖のための細胞培養環境
EP1781637A1 (de) * 2004-06-29 2007-05-09 Rigel Pharmaceuticals, Inc. 2-substituierte chinolinverbindungen und deren verwendungen als inhibitoren der ige-rezeptor-signalkaskade
EP1773981A1 (de) * 2004-07-12 2007-04-18 Sorin Group Italia S.R.L. Vorrichtung und verfahren zur anzucht menschlicher zellen
DK1984357T3 (da) 2006-02-17 2014-01-13 Rigel Pharmaceuticals Inc 2,4-pyrimidindiaminforbindelser til behandling eller forebyggelse af autoimmunsygdomme
US20100015615A1 (en) * 2008-04-30 2010-01-21 Sloan-Kettering Institute For Cancer Research Identification and Isolation of Adult Stem Cells and Related Methods of Use
US9096829B2 (en) 2009-03-12 2015-08-04 University Of South Florida Human mast cell line and uses thereof
JP5804280B2 (ja) * 2009-09-08 2015-11-04 国立大学法人京都大学 多能性幹細胞からの肥満細胞の製造方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2052035A (en) * 1932-03-21 1936-08-25 Thomas R Potter Combination game board and accessories
US4559310A (en) 1983-05-20 1985-12-17 Dana Farber Cancer Institute Assay methods and systems utilizing mast cell clones
US5554512A (en) 1993-05-24 1996-09-10 Immunex Corporation Ligands for flt3 receptors
US6190655B1 (en) 1993-12-03 2001-02-20 Immunex Corporation Methods of using Flt-3 ligand for exogenous gene transfer
FR2728584A1 (fr) 1994-12-22 1996-06-28 Centre Nat Rech Scient Procede de transfert de gene dans des cellules activees a partir d'un etat de repos
US6261841B1 (en) 1999-06-25 2001-07-17 The Board Of Trustees Of Northwestern University Compositions, kits, and methods for modulating survival and differentiation of multi-potential hematopoietic progenitor cells

Also Published As

Publication number Publication date
WO2003020896A2 (en) 2003-03-13
EP1427812A2 (de) 2004-06-16
DK1427812T3 (da) 2009-03-16
US7070996B2 (en) 2006-07-04
EP1427812A4 (de) 2005-04-27
EP1427812B1 (de) 2008-11-19
WO2003020896A3 (en) 2003-10-30
JP2005501552A (ja) 2005-01-20
US20070015280A1 (en) 2007-01-18
JP4388372B2 (ja) 2009-12-24
WO2003020896A9 (en) 2003-12-18
AU2002327583A1 (en) 2003-03-18
ATE414762T1 (de) 2008-12-15
US20030077824A1 (en) 2003-04-24

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