DE60227193D1 - Ein neues und effizientes verfahren zur herstellung von lamotrigine und ähnlichen 3,5-diamino-6-substituierten-1,2,4-triazinen - Google Patents

Ein neues und effizientes verfahren zur herstellung von lamotrigine und ähnlichen 3,5-diamino-6-substituierten-1,2,4-triazinen

Info

Publication number
DE60227193D1
DE60227193D1 DE60227193T DE60227193T DE60227193D1 DE 60227193 D1 DE60227193 D1 DE 60227193D1 DE 60227193 T DE60227193 T DE 60227193T DE 60227193 T DE60227193 T DE 60227193T DE 60227193 D1 DE60227193 D1 DE 60227193D1
Authority
DE
Germany
Prior art keywords
diamino
substituted
triazines
manufacture
lamotrigin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE60227193T
Other languages
English (en)
Inventor
Bhaskar Reddy Guntoori
Daqing Che
Keshava K Murthy
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Apotex Pharmachem Inc
Original Assignee
Apotex Pharmachem Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Apotex Pharmachem Inc filed Critical Apotex Pharmachem Inc
Application granted granted Critical
Publication of DE60227193D1 publication Critical patent/DE60227193D1/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D253/00—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00
    • C07D253/02—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00 not condensed with other rings
    • C07D253/06—1,2,4-Triazines
    • C07D253/065—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members
    • C07D253/07—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members with hetero atoms, or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D253/075—Two hetero atoms, in positions 3 and 5

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
DE60227193T 2001-12-24 2002-12-18 Ein neues und effizientes verfahren zur herstellung von lamotrigine und ähnlichen 3,5-diamino-6-substituierten-1,2,4-triazinen Expired - Fee Related DE60227193D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CA002366521A CA2366521C (en) 2001-12-24 2001-12-24 A new and efficient process for the preparation of lamotrigine and related 3,5-diamino-6-substituted-1,2,4-triazines
PCT/CA2002/001926 WO2003078407A1 (en) 2001-12-24 2002-12-18 A new and efficient process for the preparation of lamotrigine and related 3,5-diamino-6-substituted-1,2,4-triazines

Publications (1)

Publication Number Publication Date
DE60227193D1 true DE60227193D1 (de) 2008-07-31

Family

ID=4171022

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60227193T Expired - Fee Related DE60227193D1 (de) 2001-12-24 2002-12-18 Ein neues und effizientes verfahren zur herstellung von lamotrigine und ähnlichen 3,5-diamino-6-substituierten-1,2,4-triazinen

Country Status (10)

Country Link
US (1) US6586593B1 (de)
EP (1) EP1458692B1 (de)
AT (1) ATE398610T1 (de)
AU (1) AU2002367765B2 (de)
CA (1) CA2366521C (de)
DE (1) DE60227193D1 (de)
MX (1) MXPA04006216A (de)
NZ (1) NZ533734A (de)
PL (1) PL369896A1 (de)
WO (1) WO2003078407A1 (de)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU225667B1 (en) * 2002-09-20 2007-05-29 Richter Gedeon Nyrt Method for producing high-purity 3,5-diamino-6-(2,3-dichlorophenyl)-1,2,4-triazine
ES2209639B1 (es) * 2002-10-31 2005-08-01 Vita Cientifica, S.L. Procedimiento para la obtencion de un compuesto farmaceuticamente activo y obtencion de su intermedio.
GB2395483A (en) * 2003-07-03 2004-05-26 Jubilant Organosys Ltd Crystalline lamotrigine and its monohydrate
US20120142919A1 (en) * 2006-08-02 2012-06-07 Medichem, S.A. Method for synthesizing lamotrigine
EP2054396A1 (de) * 2006-08-14 2009-05-06 Lonza Ag Verfahren zur herstellung von lamotrigin
WO2009069073A1 (en) * 2007-11-28 2009-06-04 Alembic Limited An improved process for the preparation of lamotrigine

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB759014A (en) 1952-02-26 1956-10-10 Wellcome Found Improvements in triazines and their manufacture
AU530999B2 (en) 1979-06-01 1983-08-04 Wellcome Foundation Limited, The Substituted amino triazines and their use in treatment of cns disorders
CA1133938A (en) 1979-06-01 1982-10-19 Martin G. Baxter Substituted aromatic compounds
US5172981A (en) * 1991-05-22 1992-12-22 Coors Brewing Company Hydrostatic bearing apparatus
GB9426448D0 (en) 1994-12-30 1995-03-01 Wellcome Found Process
PT800520E (pt) 1994-12-30 2002-11-29 Wellcome Found Processo para a preparacao de lamotrigina
GB9812413D0 (en) 1998-06-10 1998-08-05 Glaxo Group Ltd Compound and its use
AU1292400A (en) 1998-12-14 2000-07-03 Sharad Kumar Vyas An improved process for the preparation of 3,5-diamino-6-(2,3-dichlorophenyl)-1,2,4-triazine
IL134730A (en) * 2000-02-25 2003-10-31 Chemagis Ltd Process for preparing substituted benzoyl cyanide amidinohydrazones

Also Published As

Publication number Publication date
US6586593B1 (en) 2003-07-01
MXPA04006216A (es) 2005-03-31
AU2002367765A1 (en) 2003-09-29
NZ533734A (en) 2005-12-23
AU2002367765B2 (en) 2008-11-13
CA2366521C (en) 2007-03-06
CA2366521A1 (en) 2003-06-24
ATE398610T1 (de) 2008-07-15
EP1458692A1 (de) 2004-09-22
EP1458692B1 (de) 2008-06-18
WO2003078407A1 (en) 2003-09-25
PL369896A1 (en) 2005-05-02

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee