DE60223729D1 - Verbindungen zur diagnose und überwachung von erkrankungen in zusammenhang mit der bildung von amyloidfibrillen - Google Patents

Verbindungen zur diagnose und überwachung von erkrankungen in zusammenhang mit der bildung von amyloidfibrillen

Info

Publication number
DE60223729D1
DE60223729D1 DE60223729T DE60223729T DE60223729D1 DE 60223729 D1 DE60223729 D1 DE 60223729D1 DE 60223729 T DE60223729 T DE 60223729T DE 60223729 T DE60223729 T DE 60223729T DE 60223729 D1 DE60223729 D1 DE 60223729D1
Authority
DE
Germany
Prior art keywords
fibrilles
amyloid
diagnosis
monitoring
compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60223729T
Other languages
English (en)
Other versions
DE60223729T2 (de
Inventor
Quinquer Jorge Setoain
Pena Carlos Piera
De Arellano Serna Isab Ramirez
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
CETIR CT MEDIC S A
Catalana de Dispensacion SA
Barnatron SA
Original Assignee
CETIR CT MEDIC S A
Catalana de Dispensacion SA
Barnatron SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by CETIR CT MEDIC S A, Catalana de Dispensacion SA, Barnatron SA filed Critical CETIR CT MEDIC S A
Publication of DE60223729D1 publication Critical patent/DE60223729D1/de
Application granted granted Critical
Publication of DE60223729T2 publication Critical patent/DE60223729T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/24—Oxygen atoms attached in position 8
    • C07D215/26—Alcohols; Ethers thereof
    • C07D215/30—Metal salts; Chelates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/041—Heterocyclic compounds
    • A61K51/044—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
    • A61K51/0455—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0474—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group
    • A61K51/0478—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group complexes from non-cyclic ligands, e.g. EDTA, MAG3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/24—Oxygen atoms attached in position 8
    • C07D215/26—Alcohols; Ethers thereof
    • C07D215/28—Alcohols; Ethers thereof with halogen atoms or nitro radicals in positions 5, 6 or 7

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Optics & Photonics (AREA)
  • Epidemiology (AREA)
  • Physics & Mathematics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Quinoline Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DE60223729T 2002-11-18 2002-11-18 Verbindungen zur diagnose und überwachung von erkrankungen in zusammenhang mit der bildung von amyloidfibrillen Expired - Lifetime DE60223729T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/ES2002/000537 WO2004045651A1 (es) 2002-11-18 2002-11-18 Compuestos utiles para el diagnostico y seguimiento de enfermedades relacionadas con la formación de fibrilas proteicas amiloides

Publications (2)

Publication Number Publication Date
DE60223729D1 true DE60223729D1 (de) 2008-01-03
DE60223729T2 DE60223729T2 (de) 2008-10-30

Family

ID=32319763

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60223729T Expired - Lifetime DE60223729T2 (de) 2002-11-18 2002-11-18 Verbindungen zur diagnose und überwachung von erkrankungen in zusammenhang mit der bildung von amyloidfibrillen

Country Status (8)

Country Link
US (1) US20080063599A1 (de)
EP (1) EP1563852B1 (de)
JP (1) JP2006514928A (de)
AU (1) AU2002350751C1 (de)
CA (1) CA2505506C (de)
DE (1) DE60223729T2 (de)
ES (1) ES2297024T3 (de)
WO (1) WO2004045651A1 (de)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5070038B2 (ja) 2004-02-24 2012-11-07 ザ ジェネラル ホスピタル コーポレーション 触媒性放射性フッ素化
US8257680B1 (en) * 2004-02-24 2012-09-04 The General Hospital Corporation Catalytic radiofluorination
US9017724B2 (en) 2004-02-24 2015-04-28 The General Hospital Corporation Catalytic radiofluorination
US8557776B2 (en) 2006-09-08 2013-10-15 Bayer Pharma AG Compounds and methods for 18F labeled agents
CA2978149C (en) 2008-03-21 2019-02-12 The General Hospital Corporation Inositol derivatives for the detection and treatment of alzheimer's disease and related disorders
WO2017027064A1 (en) 2015-08-12 2017-02-16 The General Hospital Corporation 8-hydroxyquinoline derivatives as diagnostic and therapeutic agents
CN110759952B (zh) * 2019-09-27 2021-04-20 广西师范大学 基于8-甲氧基喹啉构筑的钴配合物及其制备方法和应用

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4279887A (en) * 1978-11-29 1981-07-21 Medi-Physics, Inc. Amides useful as brain imaging agents
US4360509A (en) * 1979-12-19 1982-11-23 Byk-Mallinckrodt Cil B.V. Vivo radioassay process
US5045303A (en) * 1985-05-17 1991-09-03 Neorx Corporation Radiohalogenated small molecules for protein labeling
CZ292411B6 (cs) * 1996-08-13 2003-09-17 P. N. Gerolymatos S. A. Farmaceutický prostředek
JP3772506B2 (ja) * 1998-01-19 2006-05-10 三菱化学株式会社 キノリノール誘導体、その金属錯体およびそれを用いた有機電界発光素子
US20020025944A1 (en) * 2000-04-28 2002-02-28 Bush Ashley I. Use of clioquinol for the therapy of Alzheimer's disease
US6589504B1 (en) * 2000-09-22 2003-07-08 Pharmacia & Upjohn Company Compounds and methods for diagnosing and treating amyloid-related conditions

Also Published As

Publication number Publication date
EP1563852B1 (de) 2007-11-21
JP2006514928A (ja) 2006-05-18
ES2297024T3 (es) 2008-05-01
CA2505506A1 (en) 2004-06-03
US20080063599A1 (en) 2008-03-13
AU2002350751A1 (en) 2004-06-15
EP1563852A1 (de) 2005-08-17
DE60223729T2 (de) 2008-10-30
AU2002350751B2 (en) 2006-04-06
AU2002350751C1 (en) 2006-11-16
AU2002350751A8 (en) 2004-06-15
CA2505506C (en) 2008-07-08
WO2004045651A1 (es) 2004-06-03

Similar Documents

Publication Publication Date Title
DE602004026239D1 (de) Vorrichtung zur Messung der Herzfrequenz und deren Fertigungs- sowie Messverfahren
DE602004026280D1 (de) Chirurgischer drain mit sensoren zur überwachung des internen gewebezustands und zur überwachung von flüssigkeit in lumen
DE602004000683D1 (de) Fingerabdrucksensor und dessen Herstellungsverfahren
DE60310103D1 (de) Automatische detektion und überwachung von physischer bewegung an der äusseren begrenzung
DE60138759D1 (de) Vorrichtung zur diagnose und überwachung von augenkrankheiten
DE602005020209D1 (de) System zur Evaluierung von Herzstörungen
ATE553203T1 (de) Baumwolle ereignis mon 88913 und verbindungen und methoden zur detektion davon
DE602004028232D1 (de) Gerät zur überwachung von lungenödem
DE602004010407D1 (de) Fluorsubstituierter omega-carboxyaryldiphenylharnstoff zur behandlung und prävention von krankheiten und leiden
ATE484494T1 (de) Substituierte indolderivate für eine pharmazeutische zusammensetzung zur behandlung von atemwegserkrankungen
DE602005025249D1 (de) Reinigungsvorrichtung und verfahren zur herstellung selbiger
DE60231161D1 (de) Gerät zur Überwachung des Aussenbereiches um Fahrzeuge
DE60109311D1 (de) Kit zur simultanen diagnose mehrerer ansteckender krankheiten und verfahren zu seiner herstellung
DK1673750T3 (da) Sikkerhedsovervågningssystem
NO20030059D0 (no) Tidlig diagnose av konformasjonssykdommer
DE60223547D1 (de) Gangliosid-assoziierte rekombinante antikörper und deren verwendung bei der diagnose und behandlung von tumoren
ATE273954T1 (de) Verbindungen zur anwendung bei der behandlung entzündlicher erkrankungen
DE602005017324D1 (de) Kaskadierbares Halbleiterbauelement zur Ladungsüberwachung der Kondensatoren
DE602004003952D1 (de) Substituierte tetrahydrobenzothienopyrimidinamine verbindungen geeignet zur behandlung von hyper-proliferative disorders
NO20034464D0 (no) Fremgangsmåte for seismisk tomografisk overvåkning
DE502004009228D1 (de) Verfahren zur bestimmung der ansteuerspannung eine
DE60223729D1 (de) Verbindungen zur diagnose und überwachung von erkrankungen in zusammenhang mit der bildung von amyloidfibrillen
DE602004022153D1 (de) Verbindungen zur behandlung von obesitas
DE602004009169D1 (de) Verwendung von Cyanin-farbstoffen zur Diagnose von Krankheiten, welche mit Angiogenese assoziert sind
DE60122474D1 (de) Vorrichtung zur Reifenzustandsüberwachung

Legal Events

Date Code Title Description
8364 No opposition during term of opposition