DE60219053D1 - Herstellung von retinoiden - Google Patents

Herstellung von retinoiden

Info

Publication number
DE60219053D1
DE60219053D1 DE60219053T DE60219053T DE60219053D1 DE 60219053 D1 DE60219053 D1 DE 60219053D1 DE 60219053 T DE60219053 T DE 60219053T DE 60219053 T DE60219053 T DE 60219053T DE 60219053 D1 DE60219053 D1 DE 60219053D1
Authority
DE
Germany
Prior art keywords
derivative
retinal
trimethyl
cyclohex
enyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60219053T
Other languages
English (en)
Other versions
DE60219053T2 (de
Inventor
Alexander Radspieler
August Ruettimann
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
DSM IP Assets BV
Original Assignee
DSM IP Assets BV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by DSM IP Assets BV filed Critical DSM IP Assets BV
Application granted granted Critical
Publication of DE60219053D1 publication Critical patent/DE60219053D1/de
Publication of DE60219053T2 publication Critical patent/DE60219053T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C403/00—Derivatives of cyclohexane or of a cyclohexene or of cyclohexadiene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene or cyclohexadiene rings, e.g. vitamin A, beta-carotene, beta-ionone
    • C07C403/14—Derivatives of cyclohexane or of a cyclohexene or of cyclohexadiene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene or cyclohexadiene rings, e.g. vitamin A, beta-carotene, beta-ionone having side-chains substituted by doubly-bound oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C403/00—Derivatives of cyclohexane or of a cyclohexene or of cyclohexadiene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene or cyclohexadiene rings, e.g. vitamin A, beta-carotene, beta-ionone
    • C07C403/04—Derivatives of cyclohexane or of a cyclohexene or of cyclohexadiene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene or cyclohexadiene rings, e.g. vitamin A, beta-carotene, beta-ionone having side-chains substituted by halogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C403/00—Derivatives of cyclohexane or of a cyclohexene or of cyclohexadiene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene or cyclohexadiene rings, e.g. vitamin A, beta-carotene, beta-ionone
    • C07C403/06—Derivatives of cyclohexane or of a cyclohexene or of cyclohexadiene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene or cyclohexadiene rings, e.g. vitamin A, beta-carotene, beta-ionone having side-chains substituted by singly-bound oxygen atoms
    • C07C403/08—Derivatives of cyclohexane or of a cyclohexene or of cyclohexadiene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene or cyclohexadiene rings, e.g. vitamin A, beta-carotene, beta-ionone having side-chains substituted by singly-bound oxygen atoms by hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C403/00—Derivatives of cyclohexane or of a cyclohexene or of cyclohexadiene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene or cyclohexadiene rings, e.g. vitamin A, beta-carotene, beta-ionone
    • C07C403/06—Derivatives of cyclohexane or of a cyclohexene or of cyclohexadiene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene or cyclohexadiene rings, e.g. vitamin A, beta-carotene, beta-ionone having side-chains substituted by singly-bound oxygen atoms
    • C07C403/10—Derivatives of cyclohexane or of a cyclohexene or of cyclohexadiene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene or cyclohexadiene rings, e.g. vitamin A, beta-carotene, beta-ionone having side-chains substituted by singly-bound oxygen atoms by etherified hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C403/00—Derivatives of cyclohexane or of a cyclohexene or of cyclohexadiene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene or cyclohexadiene rings, e.g. vitamin A, beta-carotene, beta-ionone
    • C07C403/06—Derivatives of cyclohexane or of a cyclohexene or of cyclohexadiene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene or cyclohexadiene rings, e.g. vitamin A, beta-carotene, beta-ionone having side-chains substituted by singly-bound oxygen atoms
    • C07C403/12—Derivatives of cyclohexane or of a cyclohexene or of cyclohexadiene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene or cyclohexadiene rings, e.g. vitamin A, beta-carotene, beta-ionone having side-chains substituted by singly-bound oxygen atoms by esterified hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C403/00—Derivatives of cyclohexane or of a cyclohexene or of cyclohexadiene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene or cyclohexadiene rings, e.g. vitamin A, beta-carotene, beta-ionone
    • C07C403/22—Derivatives of cyclohexane or of a cyclohexene or of cyclohexadiene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene or cyclohexadiene rings, e.g. vitamin A, beta-carotene, beta-ionone having side-chains substituted by sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/09—Geometrical isomers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/16—Systems containing only non-condensed rings with a six-membered ring the ring being unsaturated

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
DE60219053T 2001-10-31 2002-10-24 Herstellung von retinoiden Expired - Lifetime DE60219053T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP01125965 2001-10-31
EP01125965 2001-10-31
PCT/EP2002/011878 WO2003037856A1 (en) 2001-10-31 2002-10-24 Manufacture of retinoids

Publications (2)

Publication Number Publication Date
DE60219053D1 true DE60219053D1 (de) 2007-05-03
DE60219053T2 DE60219053T2 (de) 2007-12-13

Family

ID=8179126

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60219053T Expired - Lifetime DE60219053T2 (de) 2001-10-31 2002-10-24 Herstellung von retinoiden

Country Status (9)

Country Link
US (1) US7067703B2 (de)
EP (1) EP1442014B1 (de)
KR (1) KR100939397B1 (de)
CN (1) CN1261411C (de)
AT (1) ATE357431T1 (de)
DE (1) DE60219053T2 (de)
ES (1) ES2282480T3 (de)
RU (1) RU2318805C2 (de)
WO (1) WO2003037856A1 (de)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2200699B1 (es) 2002-07-12 2005-10-01 Ragactives, S.L Procedimiento para la separacion de r(-) y s(+)-5-(2-((2-(etoxifenoxi)etil)amino)propil-2-metoxibenceno-sulfonamida.
FR2894577B1 (fr) * 2005-12-14 2008-02-22 Fabre Pierre Dermo Cosmetique Nouveaux composes polyinsatures, leur procede de preparation et les compositions les contenant.
EP3898583A1 (de) * 2018-12-20 2021-10-27 DSM IP Assets B.V. Spezifische ?,?-ungesättigte carboxylate
WO2020127158A1 (en) * 2018-12-20 2020-06-25 Dsm Ip Assets B.V. Improved process to produce specific a,b-unsaturated carboxylates
JP7456079B2 (ja) * 2019-04-15 2024-03-27 ディーエスエム アイピー アセッツ ビー．ブイ． レチナールを製造する新規な方法
JP2023506144A (ja) * 2019-12-23 2023-02-15 ディーエスエム アイピー アセッツ ビー．ブイ． 脱水素化方法
JP2023520137A (ja) * 2020-03-31 2023-05-16 ディーエスエム アイピー アセッツ ビー．ブイ． テルペノイド中間体の生成方法
US20230125156A1 (en) * 2020-03-31 2023-04-27 Dsm Ip Assets B.V. Process for production of vitamin a
BR112022025582A2 (pt) * 2020-06-19 2023-01-03 Dsm Ip Assets Bv Processo melhorado para produzir carboxilatos alfa, beta-insaturados específicos
CN114907246B (zh) * 2021-02-08 2024-02-06 复旦大学 一种维生素a及其衍生物与其氘代化合物的全合成方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2834813A (en) * 1953-04-21 1958-05-13 Ortho Pharma Corp Synthesis of vitamin a
US2945876A (en) * 1957-09-04 1960-07-19 Nopco Chem Co Vitamin a intermediates and process for obtaining same
US3013081A (en) * 1958-04-03 1961-12-12 Celanese Corp Purification of ketones
FR2622580B1 (fr) * 1987-10-29 1990-01-19 Centre Nat Rech Scient Procede de preparation du retinal
FR2710911B1 (fr) * 1993-10-07 1995-12-01 Rhone Poulenc Nutrition Animal Nouveaux intermédiaires de préparation de la vitamine A et des caroténoïdes et leur procédé de préparation.
US5929288A (en) * 1996-06-28 1999-07-27 Roche Vitamins Inc. Process for manufacturing polyene aldehydes
FR2780970B1 (fr) * 1998-07-10 2000-08-18 Rhone Poulenc Nutrition Animal Procede de preparation de la vitamine a
EP0978508B1 (de) 1998-08-05 2005-12-14 DSM IP Assets B.V. Herstellung von 4,4'-Diketo-carotinoiden

Also Published As

Publication number Publication date
DE60219053T2 (de) 2007-12-13
WO2003037856A1 (en) 2003-05-08
ATE357431T1 (de) 2007-04-15
RU2004116696A (ru) 2005-05-27
KR100939397B1 (ko) 2010-01-28
US20050014976A1 (en) 2005-01-20
ES2282480T3 (es) 2007-10-16
KR20050039711A (ko) 2005-04-29
RU2318805C2 (ru) 2008-03-10
CN1582273A (zh) 2005-02-16
EP1442014B1 (de) 2007-03-21
EP1442014A1 (de) 2004-08-04
US7067703B2 (en) 2006-06-27
CN1261411C (zh) 2006-06-28

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