DE60218642D1 - Verfahren zur Herstellung von Heparinestern - Google Patents

Verfahren zur Herstellung von Heparinestern

Info

Publication number
DE60218642D1
DE60218642D1 DE60218642T DE60218642T DE60218642D1 DE 60218642 D1 DE60218642 D1 DE 60218642D1 DE 60218642 T DE60218642 T DE 60218642T DE 60218642 T DE60218642 T DE 60218642T DE 60218642 D1 DE60218642 D1 DE 60218642D1
Authority
DE
Germany
Prior art keywords
heparin
esters
substituted
halogen atom
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60218642T
Other languages
English (en)
Other versions
DE60218642T2 (de
Inventor
Ferra Lorenzo De
Mauro Montorsi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Chemi SpA
Original Assignee
Chemi SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chemi SpA filed Critical Chemi SpA
Application granted granted Critical
Publication of DE60218642D1 publication Critical patent/DE60218642D1/de
Publication of DE60218642T2 publication Critical patent/DE60218642T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • C08B37/0075—Heparin; Heparan sulfate; Derivatives thereof, e.g. heparosan; Purification or extraction methods thereof
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • C08B37/0075—Heparin; Heparan sulfate; Derivatives thereof, e.g. heparosan; Purification or extraction methods thereof
    • C08B37/0078—Degradation products

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Materials Engineering (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • Organic Chemistry (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DE60218642T 2002-06-20 2002-06-20 Verfahren zur Herstellung von Heparinestern Expired - Lifetime DE60218642T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP02077534A EP1375524B1 (de) 2002-06-20 2002-06-20 Verfahren zur Herstellung von Heparinestern

Publications (2)

Publication Number Publication Date
DE60218642D1 true DE60218642D1 (de) 2007-04-19
DE60218642T2 DE60218642T2 (de) 2007-11-29

Family

ID=29716897

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60218642T Expired - Lifetime DE60218642T2 (de) 2002-06-20 2002-06-20 Verfahren zur Herstellung von Heparinestern

Country Status (4)

Country Link
EP (1) EP1375524B1 (de)
AT (1) ATE356150T1 (de)
DE (1) DE60218642T2 (de)
ES (1) ES2282368T3 (de)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2357601B1 (es) * 2011-01-26 2012-03-21 Laboratorios Farmacéuticos Rovi, S.A. Procedimiento de preparación de derivados de glicosaminoglicanos donadores de óxido n�?trico y su uso en tratamiento de úlceras crónicas.
WO2013044793A1 (zh) * 2011-09-26 2013-04-04 Xu Meiying 一种高纯度肝素苄酯盐及其制法和应用
CN110878129B (zh) * 2019-12-06 2022-02-01 中国科学院烟台海岸带研究所 一种氨基葡萄糖肝素盐及其应用

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2482611B1 (fr) * 1980-05-14 1986-03-07 Pharmindustrie Nouveaux polysaccharides sulfates, procedes pour leur preparation et leur utilisation comme medicaments
FR2482603A1 (fr) * 1980-05-14 1981-11-20 Pharmindustrie Nouveaux esters d'heparine utilisables pour la preparation de medicaments, et procedes pour leur preparation
US5011919A (en) * 1989-01-30 1991-04-30 Ajorca S.A. Modified heparins and obtention process
FR2663639B1 (fr) * 1990-06-26 1994-03-18 Rhone Poulenc Sante Melanges de polysaccharides de bas poids moleculaires procede de preparation et utilisation.
FR2811992B1 (fr) * 2000-07-21 2003-07-04 Aventis Pharma Sa Melanges de polysaccharides derives d'heparine, leur preparation et les compositions pharmaceutiques les contenant

Also Published As

Publication number Publication date
EP1375524B1 (de) 2007-03-07
ES2282368T3 (es) 2007-10-16
DE60218642T2 (de) 2007-11-29
ATE356150T1 (de) 2007-03-15
EP1375524A1 (de) 2004-01-02

Similar Documents

Publication Publication Date Title
CY1124357T1 (el) Προσδιορισμος ανισορροπιας αλληλουχιας νουκλεϊκων οξεων
ATE228508T1 (de) Verfahren zur herstellung von n-(amino-4,6- dihalogenpyrimidin)-formamiden
ATE145891T1 (de) Verfahren zur herstellung von alkoxyiminoacetamid-derivaten und ein zwischenproduckt dafür
DE602006009698D1 (de) Verfahren zur herstellung von expoxybutanol-zwischenprodukten
DE502005006163D1 (de) Verfahren zur herstellung quartärer ammoniumverbindungen hoher reinheit
ATE442363T1 (de) Verfahren zur herstellung von pyridinverbindungen
ATE537173T1 (de) Verfahren zur herstellung von cucurbiturilen
DE60218642D1 (de) Verfahren zur Herstellung von Heparinestern
ATE243685T1 (de) Verfahren zur herstellung von 2-chlor-5- chlormethylthiazol
DE602004012151D1 (de) Verfahren zur herstellung von chlorsulfonylisocyanat
DE59400866D1 (de) Verfahren zur Herstellung von Folsäure
DE69022211T2 (de) Verfahren zur Herstellung aromatischer Nitrile.
ATE519748T1 (de) Verfahren zur herstellung von chinazolin-4-on und derivaten davon
ATE106397T1 (de) Verfahren zur herstellung von 3,3- diarylacrylsäureamiden.
DE602004011341D1 (de) Verfahren zur herstellung von monosulfoniumsalzen, kationische polymerisierungsinitiatoren, vernetzb
ATE167668T1 (de) Verfahren zur herstellung von guaniden
DE69405439D1 (de) Verfahren zur Herstellung von Aminotriazin-Derivaten
DE69605873D1 (de) Verfahren zur Herstellung von Isothiocyanat-Derivaten
ATE360655T1 (de) Verfahren zur herstellung von präpolymeren auf der basis von polysulfiden und polyepoxiden
DE69719450T2 (de) Verfahren zur Herstellung von Arylvinylsulfonen
DE59206660D1 (de) Verfahren zur Herstellung von Halogenanthranilsäuren
ATE265441T1 (de) Verfahren für die herstellung von oxadiazolin- derivaten
DE60200816D1 (de) Verfahren zur Herstellung von Polyesterharzen
ATE265425T1 (de) Verfahren zur herstellung von n-(5-amino-2-cyano- 4-fluor-phenyl)-sulfonamiden
ATE383333T1 (de) Verfahren zur herstellung von biphenyl-4- carbonitril

Legal Events

Date Code Title Description
8364 No opposition during term of opposition