DE60216416D1 - Verfahren zum nachweis von chloralhydrat in dichloressigsäure - Google Patents

Verfahren zum nachweis von chloralhydrat in dichloressigsäure

Info

Publication number
DE60216416D1
DE60216416D1 DE60216416T DE60216416T DE60216416D1 DE 60216416 D1 DE60216416 D1 DE 60216416D1 DE 60216416 T DE60216416 T DE 60216416T DE 60216416 T DE60216416 T DE 60216416T DE 60216416 D1 DE60216416 D1 DE 60216416D1
Authority
DE
Germany
Prior art keywords
detecting
hydrate
acid
dichloroetic
chloroal
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60216416T
Other languages
English (en)
Other versions
DE60216416T2 (de
Inventor
Patrick Wheeler
C Capaldi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ionis Pharmaceuticals Inc
Original Assignee
Isis Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=23008188&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE60216416(D1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Isis Pharmaceuticals Inc filed Critical Isis Pharmaceuticals Inc
Publication of DE60216416D1 publication Critical patent/DE60216416D1/de
Application granted granted Critical
Publication of DE60216416T2 publication Critical patent/DE60216416T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N24/00—Investigating or analyzing materials by the use of nuclear magnetic resonance, electron paramagnetic resonance or other spin effects
    • G01N24/08—Investigating or analyzing materials by the use of nuclear magnetic resonance, electron paramagnetic resonance or other spin effects by using nuclear magnetic resonance
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R33/00—Arrangements or instruments for measuring magnetic variables
    • G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
    • G01R33/44—Arrangements or instruments for measuring magnetic variables involving magnetic resonance using nuclear magnetic resonance [NMR]
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R33/00—Arrangements or instruments for measuring magnetic variables
    • G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
    • G01R33/44—Arrangements or instruments for measuring magnetic variables involving magnetic resonance using nuclear magnetic resonance [NMR]
    • G01R33/46—NMR spectroscopy
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/19—Halogen containing
    • Y10T436/193333—In aqueous solution
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/19—Halogen containing
    • Y10T436/196666—Carbon containing compound [e.g., vinylchloride, etc.]

Landscapes

  • Physics & Mathematics (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • High Energy & Nuclear Physics (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Organic Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Condensed Matter Physics & Semiconductors (AREA)
  • Biotechnology (AREA)
  • Analytical Chemistry (AREA)
  • Immunology (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Pathology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Saccharide Compounds (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analyzing Non-Biological Materials By The Use Of Chemical Means (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DE60216416T 2001-01-30 2002-01-29 Verfahren zum nachweis von chloralhydrat in dichloressigsäure Expired - Lifetime DE60216416T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US26492001P 2001-01-30 2001-01-30
US264920P 2001-01-30
PCT/US2002/002503 WO2002061138A1 (en) 2001-01-30 2002-01-29 Methods for detection of chloral hydrate in dichloroacetic acid

Publications (2)

Publication Number Publication Date
DE60216416D1 true DE60216416D1 (de) 2007-01-11
DE60216416T2 DE60216416T2 (de) 2007-09-20

Family

ID=23008188

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60216416T Expired - Lifetime DE60216416T2 (de) 2001-01-30 2002-01-29 Verfahren zum nachweis von chloralhydrat in dichloressigsäure

Country Status (8)

Country Link
US (3) US6645716B2 (de)
EP (1) EP1356115B1 (de)
KR (1) KR20030071870A (de)
CN (1) CN1489633A (de)
AT (1) ATE346957T1 (de)
DE (1) DE60216416T2 (de)
ES (1) ES2276914T3 (de)
WO (1) WO2002061138A1 (de)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1356115B1 (de) * 2001-01-30 2006-11-29 Isis Pharmaceuticals, Inc. Verfahren zum nachweis von chloralhydrat in dichloressigsäure
US7169916B2 (en) * 2002-04-01 2007-01-30 Isis Pharmaceuticals, Inc. Chloral-free DCA in oligonucleotide synthesis
CA3026134A1 (en) * 2016-05-31 2017-12-07 Dna Genotek Inc. A composition, system and method for removal of detergents from aqueous solutions
CN110161156B (zh) * 2018-02-13 2022-12-09 特丰制药有限公司 高效液相测定水合氯醛含量的方法
CN110646456A (zh) * 2019-08-20 2020-01-03 中船重工（邯郸）派瑞特种气体有限公司 一种基于核磁共振定量测量双三氟甲基磺酰亚胺锂的方法
EP4153605A1 (de) 2020-05-21 2023-03-29 Changzhou Syntheall Pharmaceuticals Co., Ltd. Zusammensetzungen mit dichloressigsäure, verfahren zur herstellung davon und verwendungen davon
CN115436541B (zh) * 2022-09-29 2024-04-26 成都施贝康生物医药科技有限公司 一种水合氯醛的含量检测方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE610317C (de) * 1933-08-17 1935-03-07 Alais & Froges & Camarque Cie Verfahren zur Herstellung von Dichloressigsaeure
DE852997C (de) * 1951-07-15 1952-10-20 Lech Chemie Gersthofen Verfahren zur Herstellung reiner Dichloressigsaeure
US6005094A (en) * 1986-10-28 1999-12-21 Genta Incorporated Oligonucleotide analogues having improved stability at acid pH
DE4003014A1 (de) * 1990-02-02 1991-08-08 Hoechst Ag Verfahren zur umsetzung einer niedermolekularen hydroxiverbindung mit einem carbonsaeurehalogenid
US5760209A (en) 1997-03-03 1998-06-02 Isis Pharmaceuticals, Inc. Protecting group for synthesizing oligonucleotide analogs
US6069243A (en) * 1998-10-06 2000-05-30 Isis Pharmaceuticals, Inc. Process for oligonucleotide synthesis
EP1356115B1 (de) * 2001-01-30 2006-11-29 Isis Pharmaceuticals, Inc. Verfahren zum nachweis von chloralhydrat in dichloressigsäure
US7169916B2 (en) * 2002-04-01 2007-01-30 Isis Pharmaceuticals, Inc. Chloral-free DCA in oligonucleotide synthesis

Also Published As

Publication number Publication date
US20050113569A1 (en) 2005-05-26
ATE346957T1 (de) 2006-12-15
EP1356115B1 (de) 2006-11-29
KR20030071870A (ko) 2003-09-06
US20070196847A1 (en) 2007-08-23
ES2276914T3 (es) 2007-07-01
US7446193B2 (en) 2008-11-04
CN1489633A (zh) 2004-04-14
EP1356115A4 (de) 2004-06-23
US20020119483A1 (en) 2002-08-29
WO2002061138A1 (en) 2002-08-08
US7173123B2 (en) 2007-02-06
US6645716B2 (en) 2003-11-11
EP1356115A1 (de) 2003-10-29
DE60216416T2 (de) 2007-09-20

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Legal Events

Date Code Title Description
8363 Opposition against the patent