DE60212614D1 - Vorrichtung zur dosierung von reagenzien - Google Patents

Vorrichtung zur dosierung von reagenzien

Info

Publication number
DE60212614D1
DE60212614D1 DE60212614T DE60212614T DE60212614D1 DE 60212614 D1 DE60212614 D1 DE 60212614D1 DE 60212614 T DE60212614 T DE 60212614T DE 60212614 T DE60212614 T DE 60212614T DE 60212614 D1 DE60212614 D1 DE 60212614D1
Authority
DE
Germany
Prior art keywords
reaction
reagents
chamber
test chamber
mouth
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60212614T
Other languages
English (en)
Other versions
DE60212614T2 (de
Inventor
David James Squirrell
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
UK Secretary of State for Defence
Original Assignee
UK Secretary of State for Defence
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by UK Secretary of State for Defence filed Critical UK Secretary of State for Defence
Publication of DE60212614D1 publication Critical patent/DE60212614D1/de
Application granted granted Critical
Publication of DE60212614T2 publication Critical patent/DE60212614T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J4/00—Feed or outlet devices; Feed or outlet control devices
    • B01J4/02—Feed or outlet devices; Feed or outlet control devices for feeding measured, i.e. prescribed quantities of reagents
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/02—Food
    • G01N33/025—Fruits or vegetables
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
    • B01F35/71—Feed mechanisms
    • B01F35/713—Feed mechanisms comprising breaking packages or parts thereof, e.g. piercing or opening sealing elements between compartments or cartridges
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
    • B01F35/71—Feed mechanisms
    • B01F35/717—Feed mechanisms characterised by the means for feeding the components to the mixer
    • B01F35/7173—Feed mechanisms characterised by the means for feeding the components to the mixer using gravity, e.g. from a hopper
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
    • B01F35/71—Feed mechanisms
    • B01F35/717—Feed mechanisms characterised by the means for feeding the components to the mixer
    • B01F35/7174—Feed mechanisms characterised by the means for feeding the components to the mixer using pistons, plungers or syringes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/02—Burettes; Pipettes
    • B01L3/0289—Apparatus for withdrawing or distributing predetermined quantities of fluid
    • B01L3/0293—Apparatus for withdrawing or distributing predetermined quantities of fluid for liquids
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/52—Containers specially adapted for storing or dispensing a reagent
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L7/00—Heating or cooling apparatus; Heat insulating devices
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B10/00—Other methods or instruments for diagnosis, e.g. instruments for taking a cell sample, for biopsy, for vaccination diagnosis; Sex determination; Ovulation-period determination; Throat striking implements
    • A61B10/0096—Casings for storing test samples
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J8/00—Chemical or physical processes in general, conducted in the presence of fluids and solid particles; Apparatus for such processes
    • B01J8/02—Chemical or physical processes in general, conducted in the presence of fluids and solid particles; Apparatus for such processes with stationary particles, e.g. in fixed beds
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J8/00—Chemical or physical processes in general, conducted in the presence of fluids and solid particles; Apparatus for such processes
    • B01J8/02—Chemical or physical processes in general, conducted in the presence of fluids and solid particles; Apparatus for such processes with stationary particles, e.g. in fixed beds
    • B01J8/0278—Feeding reactive fluids
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J8/00—Chemical or physical processes in general, conducted in the presence of fluids and solid particles; Apparatus for such processes
    • B01J8/02—Chemical or physical processes in general, conducted in the presence of fluids and solid particles; Apparatus for such processes with stationary particles, e.g. in fixed beds
    • B01J8/0285—Heating or cooling the reactor
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J8/00—Chemical or physical processes in general, conducted in the presence of fluids and solid particles; Apparatus for such processes
    • B01J8/02—Chemical or physical processes in general, conducted in the presence of fluids and solid particles; Apparatus for such processes with stationary particles, e.g. in fixed beds
    • B01J8/04—Chemical or physical processes in general, conducted in the presence of fluids and solid particles; Apparatus for such processes with stationary particles, e.g. in fixed beds the fluid passing successively through two or more beds
    • B01J8/0446—Chemical or physical processes in general, conducted in the presence of fluids and solid particles; Apparatus for such processes with stationary particles, e.g. in fixed beds the fluid passing successively through two or more beds the flow within the beds being predominantly vertical
    • B01J8/0449—Chemical or physical processes in general, conducted in the presence of fluids and solid particles; Apparatus for such processes with stationary particles, e.g. in fixed beds the fluid passing successively through two or more beds the flow within the beds being predominantly vertical in two or more cylindrical beds
    • B01J8/0453—Chemical or physical processes in general, conducted in the presence of fluids and solid particles; Apparatus for such processes with stationary particles, e.g. in fixed beds the fluid passing successively through two or more beds the flow within the beds being predominantly vertical in two or more cylindrical beds the beds being superimposed one above the other
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J8/00—Chemical or physical processes in general, conducted in the presence of fluids and solid particles; Apparatus for such processes
    • B01J8/02—Chemical or physical processes in general, conducted in the presence of fluids and solid particles; Apparatus for such processes with stationary particles, e.g. in fixed beds
    • B01J8/04—Chemical or physical processes in general, conducted in the presence of fluids and solid particles; Apparatus for such processes with stationary particles, e.g. in fixed beds the fluid passing successively through two or more beds
    • B01J8/0492—Feeding reactive fluids
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0642—Filling fluids into wells by specific techniques
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0647—Handling flowable solids, e.g. microscopic beads, cells, particles
    • B01L2200/0668—Trapping microscopic beads
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0689—Sealing
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/10—Integrating sample preparation and analysis in single entity, e.g. lab-on-a-chip concept
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/14—Process control and prevention of errors
    • B01L2200/142—Preventing evaporation
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/16—Reagents, handling or storing thereof
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/04—Closures and closing means
    • B01L2300/041—Connecting closures to device or container
    • B01L2300/042—Caps; Plugs
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/04—Closures and closing means
    • B01L2300/041—Connecting closures to device or container
    • B01L2300/044—Connecting closures to device or container pierceable, e.g. films, membranes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/087—Multiple sequential chambers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/18—Means for temperature control
    • B01L2300/1805—Conductive heating, heat from thermostatted solids is conducted to receptacles, e.g. heating plates, blocks
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/18—Means for temperature control
    • B01L2300/1805—Conductive heating, heat from thermostatted solids is conducted to receptacles, e.g. heating plates, blocks
    • B01L2300/1827—Conductive heating, heat from thermostatted solids is conducted to receptacles, e.g. heating plates, blocks using resistive heater
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0475—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure
    • B01L2400/0478—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure pistons
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0475—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure
    • B01L2400/0487—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure fluid pressure, pneumatics
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/06—Valves, specific forms thereof
    • B01L2400/0677—Valves, specific forms thereof phase change valves; Meltable, freezing, dissolvable plugs; Destructible barriers
    • B01L2400/0683—Valves, specific forms thereof phase change valves; Meltable, freezing, dissolvable plugs; Destructible barriers mechanically breaking a wall or membrane within a channel or chamber
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/508—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above
    • B01L3/5082—Test tubes per se
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/508—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above
    • B01L3/5082—Test tubes per se
    • B01L3/50825—Closing or opening means, corks, bungs
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/508—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above
    • B01L3/5085—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above for multiple samples, e.g. microtitration plates
    • B01L3/50853—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above for multiple samples, e.g. microtitration plates with covers or lids
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/52—Containers specially adapted for storing or dispensing a reagent
    • B01L3/523—Containers specially adapted for storing or dispensing a reagent with means for closing or opening
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/52—Containers specially adapted for storing or dispensing a reagent
    • B01L3/527—Containers specially adapted for storing or dispensing a reagent for a plurality of reagents
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54366—Apparatus specially adapted for solid-phase testing
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
    • G01N35/1002—Reagent dispensers
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/11—Automated chemical analysis
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/25—Chemistry: analytical and immunological testing including sample preparation
    • Y10T436/25375—Liberation or purification of sample or separation of material from a sample [e.g., filtering, centrifuging, etc.]
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/25—Chemistry: analytical and immunological testing including sample preparation
    • Y10T436/2575—Volumetric liquid transfer
DE2002612614 2001-04-30 2002-04-18 "Reagens-Zufuhrsystem" Expired - Lifetime DE60212614T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB0110476 2001-04-30
GB0110476A GB0110476D0 (en) 2001-04-30 2001-04-30 Reagent delivery system
PCT/GB2002/001797 WO2002087762A1 (en) 2001-04-30 2002-04-18 Reagent delivery system

Publications (2)

Publication Number Publication Date
DE60212614D1 true DE60212614D1 (de) 2006-08-03
DE60212614T2 DE60212614T2 (de) 2007-07-05

Family

ID=9913678

Family Applications (1)

Application Number Title Priority Date Filing Date
DE2002612614 Expired - Lifetime DE60212614T2 (de) 2001-04-30 2002-04-18 "Reagens-Zufuhrsystem"

Country Status (14)

Country Link
US (6) US7638097B2 (de)
EP (1) EP1383602B1 (de)
JP (1) JP4147113B2 (de)
KR (1) KR100866016B1 (de)
CN (1) CN1289197C (de)
AT (1) ATE330703T1 (de)
AU (1) AU2002249430B2 (de)
CA (1) CA2445863C (de)
DE (1) DE60212614T2 (de)
ES (1) ES2266478T3 (de)
GB (1) GB0110476D0 (de)
HK (1) HK1068568A1 (de)
NZ (1) NZ529188A (de)
WO (1) WO2002087762A1 (de)

Families Citing this family (45)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0110476D0 (en) 2001-04-30 2001-06-20 Secr Defence Reagent delivery system
KR100704206B1 (ko) * 2004-05-27 2007-04-05 (주)마이크로디지탈 생물학적 액상 시료 추출 밀봉 보관용 튜브와 튜브 자동 실링장치
US7575721B2 (en) 2005-06-06 2009-08-18 Cepheid Method and apparatus for storing and dispensing reagent beads
US7727473B2 (en) * 2005-10-19 2010-06-01 Progentech Limited Cassette for sample preparation
US7754148B2 (en) 2006-12-27 2010-07-13 Progentech Limited Instrument for cassette for sample preparation
DE102005054924B4 (de) * 2005-11-17 2012-06-14 Siemens Ag Vorrichtung und Verfahren zum Extrahieren einer Abstrichprobe
GB0704035D0 (en) 2007-03-02 2007-04-11 Smiths Detection Watford Ltd Sample preparation apparatus
US9458451B2 (en) 2007-06-21 2016-10-04 Gen-Probe Incorporated Multi-channel optical measurement instrument
AU2008275617A1 (en) * 2007-07-12 2009-01-15 Smiths Detection Inc. Sample preparation apparatus
WO2010118539A2 (en) 2009-04-14 2010-10-21 Biocartis Sa Hifu induced cavitation with reduced power threshold
CA2752823C (en) 2009-04-15 2016-08-30 Biocartis Sa Protection of bioanalytical sample chambers
ES2822105T3 (es) 2009-04-15 2021-04-29 Biocartis Nv Sistema de detección óptica para monitorizar la reacción rtPCR
JP5766180B2 (ja) 2009-05-06 2015-08-19 ビオカルティ ナームローゼ フェノーツハップＢｉｏｃａｒｔｉｓ ＮＶ 試料キャリヤを切断するための装置
CA2760982C (en) 2009-05-15 2019-01-15 Biomerieux, Inc. System and methods for rapid identification and/or characterization of a microbial agent in a sample
US9150900B2 (en) 2009-05-15 2015-10-06 Biomerieux, Inc. Automated transfer mechanism for microbial detection apparatus
CA2977845C (en) 2010-02-23 2020-08-04 Luminex Corporation Apparatus and methods for integrated sample preparation, reaction and detection
BR112013001647A2 (pt) * 2010-07-23 2016-05-24 Beckman Coulter Inc sistema e método contendo unidades analíticas
WO2012084615A1 (de) 2010-12-20 2012-06-28 Boehringer Ingelheim Microparts Gmbh Verfahren zum mischen wenigstens einer probenlösung mit wenigstens einem reagenz und vorrichtung
CN107338189B (zh) 2011-05-04 2021-02-02 卢米耐克斯公司 用于集成的样品制备、反应和检测的设备与方法
JP2013104769A (ja) * 2011-11-14 2013-05-30 Tosoh Corp 分析装置で用いる容器用蓋体
US8585982B1 (en) * 2012-01-31 2013-11-19 The United States Of America As Represented By The Secretary Of The Navy Field colorimetric test device
GB2500658A (en) * 2012-03-28 2013-10-02 Dna Electronics Ltd Biosensor device and system
CN104471369B (zh) * 2012-07-06 2016-09-21 株式会社日立高新技术 核酸提取用成套工具及核酸提取装置
US11008628B1 (en) * 2013-02-18 2021-05-18 Labrador Diagnostics Llc Systems and methods for analyte testing and laboratory oversight
US9308508B2 (en) 2013-07-22 2016-04-12 Kianoosh Peyvan Sequential delivery device and method
PL3033128T3 (pl) 2013-08-16 2018-08-31 Vectura Gmbh System dozujący do urządzenia inhalacyjnego
EP3046663A4 (de) * 2013-09-18 2017-05-31 California Institute of Technology System und verfahren zur bewegungs- und zeitsteuerung
CN106660045B (zh) 2014-02-05 2020-02-21 达丽斯生物医学公司 具有逐步加压机构的样品制备模块
US20190022637A1 (en) * 2015-09-04 2019-01-24 Life Technologies Corporation Devices and Methods for Mesofluidic and/or Microfluidic Processes
WO2017160980A1 (en) * 2016-03-15 2017-09-21 Abbott Laboratories Sample processing devices, systems and methods
US10473674B2 (en) * 2016-08-31 2019-11-12 C A Casyso Gmbh Controlled blood delivery to mixing chamber of a blood testing cartridge
DE102016222028A1 (de) 2016-11-10 2018-05-17 Robert Bosch Gmbh Mikrofluidischer Behälter
DE102016122056B4 (de) * 2016-11-16 2021-02-18 Microfluidic Chipshop Gmbh Mikrofluidisches System zur Aufnahme, Abgabe und Bewegung von Fluiden
TWI611171B (zh) * 2016-12-14 2018-01-11 財團法人工業技術研究院 生物樣品處理裝置
GB201704747D0 (en) * 2017-01-05 2017-05-10 Illumina Inc Reagent mixing system and methods
CN106725633B (zh) * 2017-01-11 2019-07-09 温州中壹技术研究院有限公司 一种基因检测专用采样器
CN108226550B (zh) * 2018-01-22 2023-12-01 上海默礼生物医药科技有限公司 一种微型多仓室控制的化学发光试剂盒及其检测方法
USD864415S1 (en) 2018-01-30 2019-10-22 Becton, Dickinson And Company Particle sorting system
USD872296S1 (en) 2018-01-30 2020-01-07 Becton, Dickinson And Company Particle sorting module
USD882817S1 (en) * 2018-01-30 2020-04-28 Becton, Dickinson And Company Sample container
USD876668S1 (en) 2018-01-30 2020-02-25 Becton, Dickinson And Company Particle sorting module mount
CN108535062B (zh) * 2018-03-30 2020-11-24 江苏科华医疗器械科技有限公司 一种驱动平稳式收集尿液装置
EP3644064B1 (de) * 2018-10-23 2021-08-18 Roche Diagnostics GmbH Verfahren zur handhabung von laborprobenbehältern und vorrichtung zur handhabung von laborprobenbehältern
GB202017920D0 (en) * 2020-11-13 2020-12-30 Ttp Plc Sample analysis cartridge
CN113648957B (zh) * 2021-10-20 2022-01-18 拓信达(启东)医药生物科技有限公司 一种用于制备阿塔鲁伦的反应釜及其制备方法

Family Cites Families (53)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3893470A (en) * 1974-05-20 1975-07-08 Baldwin Gegenheimer Corp Liquid mixing and distributing apparatus
US4230685A (en) * 1979-02-28 1980-10-28 Northwestern University Method of magnetic separation of cells and the like, and microspheres for use therein
WO1980002205A1 (en) * 1979-03-30 1980-10-16 Tecator Instr Ab Device for measuring a certain amount of liquid
US4942017A (en) * 1985-11-22 1990-07-17 Turpen Laboratory Systems, Inc. Random access chemistry analyzer
US5110727A (en) 1987-04-03 1992-05-05 Cardiovascular Diagnostics, Inc. Method for performing coagulation assays accurately, rapidly and simply, using dry chemical reagents and paramagnetic particles
US4761266A (en) * 1987-06-22 1988-08-02 Kaiser Aluminum & Chemical Corporation Controlled addition of lithium to molten aluminum
US4990075A (en) 1988-04-11 1991-02-05 Miles Inc. Reaction vessel for performing sequential analytical assays
US5320808A (en) * 1988-08-02 1994-06-14 Abbott Laboratories Reaction cartridge and carousel for biological sample analyzer
US4980293A (en) * 1988-09-02 1990-12-25 Multi-Technology Inc. Dispensing reagents in a specimen well
US5075216A (en) * 1988-09-23 1991-12-24 Cetus Corporation Methods for dna sequencing with thermus aquaticus dna polymerase
US5229297A (en) * 1989-02-03 1993-07-20 Eastman Kodak Company Containment cuvette for PCR and method of use
US5043272A (en) * 1989-04-27 1991-08-27 Life Technologies, Incorporated Amplification of nucleic acid sequences using oligonucleotides of random sequence as primers
TW199858B (de) * 1990-03-30 1993-02-11 Fujirebio Kk
US5234811A (en) * 1991-09-27 1993-08-10 The Scripps Research Institute Assay for a new gaucher disease mutation
US5587128A (en) * 1992-05-01 1996-12-24 The Trustees Of The University Of Pennsylvania Mesoscale polynucleotide amplification devices
US5498392A (en) * 1992-05-01 1996-03-12 Trustees Of The University Of Pennsylvania Mesoscale polynucleotide amplification device and method
DE69314462T2 (de) * 1992-08-24 1998-05-20 Dade Microscan Inc Abdichtbarer behälter zum konservieren und behandeln analytischer proben
ES2194843T3 (es) * 1992-09-11 2003-12-01 Hoffmann La Roche Deteccion de acidos nucleicos en sangre.
US5565339A (en) * 1992-10-08 1996-10-15 Hoffmann-La Roche Inc. Compositions and methods for inhibiting dimerization of primers during storage of polymerase chain reaction reagents
US5599660A (en) * 1993-01-19 1997-02-04 Pharmacia Biotech Inc. Method and preparation for sequential delivery of wax-embedded, inactivated biological and chemical reagents
GB9301118D0 (en) 1993-01-21 1993-03-10 Secr Defence Enzyme linked assays
DE1130397T1 (de) * 1993-02-01 2002-04-04 Thermo Labsystems Oy Helsinki Ausrüstung zur Bestimmung eines Analyten in einer Probe
US5386021A (en) * 1993-04-16 1995-01-31 The United States Of America, As Represented By The Department Of Health & Human Services Mammalian guanine nucleotide binding protein with an ADP-rybosylation factor domain
US5462881A (en) * 1993-08-23 1995-10-31 Brandeis University Temporary liquid storage cavities in a centrifuge tube
US5525300A (en) * 1993-10-20 1996-06-11 Stratagene Thermal cycler including a temperature gradient block
US5512462A (en) * 1994-02-25 1996-04-30 Hoffmann-La Roche Inc. Methods and reagents for the polymerase chain reaction amplification of long DNA sequences
CA2184270C (en) * 1994-03-10 1999-08-17 Daniel Louis Kacian Method for suppressing inhibition of enzyme-mediated reactions by ionic detergents
US5652143A (en) 1995-06-07 1997-07-29 Accumed, Inc. Dual chamber blood culture bottle with break seal
US5744320A (en) * 1995-06-07 1998-04-28 Promega Corporation Quenching reagents and assays for enzyme-mediated luminescence
US5856174A (en) * 1995-06-29 1999-01-05 Affymetrix, Inc. Integrated nucleic acid diagnostic device
WO1997005492A1 (fr) * 1995-07-31 1997-02-13 Precision System Science Co., Ltd Recipient
US5661028A (en) * 1995-09-29 1997-08-26 Lockheed Martin Energy Systems, Inc. Large scale DNA microsequencing device
JP4912517B2 (ja) 1996-04-03 2012-04-11 アプライド バイオシステムズ リミテッド ライアビリティー カンパニー 複数の分析物の検出のためのデバイスおよび方法
US5885470A (en) * 1997-04-14 1999-03-23 Caliper Technologies Corporation Controlled fluid transport in microfabricated polymeric substrates
GB9618595D0 (en) 1996-09-06 1996-10-16 Central Research Lab Ltd Reaction cell
GB9620278D0 (en) 1996-09-28 1996-11-13 Central Research Lab Ltd Apparatus for chemical analysis
JPH10117764A (ja) 1996-10-17 1998-05-12 Technol Res Assoc Of Medical & Welfare Apparatus Ｄｎａ増幅装置
GB9716052D0 (en) * 1996-12-06 1997-10-01 Secr Defence Reaction vessels
US6514461B1 (en) * 1997-02-14 2003-02-04 Escreen, Inc. System for automatically testing a fluid specimen
US6077669A (en) * 1997-11-04 2000-06-20 Becton Dickinson And Company Kit and method for fluorescence based detection assay
EP1030736B1 (de) * 1997-11-14 2003-10-01 Gen-Probe Incorporated Arbeitsgerät zur analyse
JPH11183484A (ja) * 1997-12-17 1999-07-09 Olympus Optical Co Ltd 自動分析装置
US6238869B1 (en) * 1997-12-19 2001-05-29 High Throughput Genomics, Inc. High throughput assay system
US6251343B1 (en) * 1998-02-24 2001-06-26 Caliper Technologies Corp. Microfluidic devices and systems incorporating cover layers
US6372484B1 (en) * 1999-01-25 2002-04-16 E.I. Dupont De Nemours And Company Apparatus for integrated polymerase chain reaction and capillary electrophoresis
CA2374423C (en) * 1999-05-28 2013-04-09 Cepheid Apparatus and method for analyzing a liquid sample
US6268219B1 (en) * 1999-07-09 2001-07-31 Orchid Biosciences, Inc. Method and apparatus for distributing fluid in a microfluidic device
US6337435B1 (en) * 1999-07-30 2002-01-08 Bio-Rad Laboratories, Inc. Temperature control for multi-vessel reaction apparatus
AU6524100A (en) * 1999-08-06 2001-03-05 Thermo Biostar Inc. An automated point of care detection system including complete sample processingcapabilities
GB9922971D0 (en) 1999-09-29 1999-12-01 Secr Defence Reaction system
US6672458B2 (en) * 2000-05-19 2004-01-06 Becton, Dickinson And Company System and method for manipulating magnetically responsive particles fluid samples to collect DNA or RNA from a sample
GB0110476D0 (en) * 2001-04-30 2001-06-20 Secr Defence Reagent delivery system
ITMI20061636A1 (it) * 2006-08-22 2008-02-23 Danieli & C Officine Meccaniche Spa Bruciatore

Also Published As

Publication number Publication date
US8815181B2 (en) 2014-08-26
JP4147113B2 (ja) 2008-09-10
EP1383602A1 (de) 2004-01-28
US20150125939A1 (en) 2015-05-07
CA2445863A1 (en) 2002-11-07
US20100120131A1 (en) 2010-05-13
EP1383602B1 (de) 2006-06-21
WO2002087762A8 (en) 2003-12-31
NZ529188A (en) 2005-04-29
US20040209266A1 (en) 2004-10-21
CA2445863C (en) 2013-02-26
JP2004537714A (ja) 2004-12-16
US8298497B2 (en) 2012-10-30
CN1289197C (zh) 2006-12-13
KR100866016B1 (ko) 2008-10-31
KR20040015203A (ko) 2004-02-18
ATE330703T1 (de) 2006-07-15
DE60212614T2 (de) 2007-07-05
GB0110476D0 (en) 2001-06-20
AU2002249430B2 (en) 2005-03-03
CN1535182A (zh) 2004-10-06
US7638097B2 (en) 2009-12-29
US20100129898A1 (en) 2010-05-27
ES2266478T3 (es) 2007-03-01
US20100093069A1 (en) 2010-04-15
US8778283B2 (en) 2014-07-15
WO2002087762A1 (en) 2002-11-07
HK1068568A1 (en) 2005-04-29
US9067209B2 (en) 2015-06-30
US20130045527A1 (en) 2013-02-21

Similar Documents

Publication Publication Date Title
ATE330703T1 (de) Vorrichtung zur dosierung von reagenzien
DE50100406D1 (de) Vorrichtung zur Aufnahme und Abgabe von Flüssigkeitsproben
ATE430940T1 (de) Automatisches analysengerät
ATE356666T1 (de) Klinische analysevorrichtung mit keine waschvorgänge erfordernder reagenzabgabevorrichtung
DE59803938D1 (de) Vorrichtung zur sequentiellen ausgabe von fliessfähigen reagenzien
ATE369551T1 (de) Gerät zur abgabe definierter volumina
DE3785207T2 (de) Pumpvorrichtung zur abgabe von fluessigkeit bei hohem druck.
HK1101148A1 (en) A reagent cuvette
SG145758A1 (en) Apparatus for processing a fluid sample
ES2168370T3 (es) Dispositivo combinado de ensayo y de contenido de un reactivo.
PT1390492E (pt) Microestruturas e sua aplicação na evolução direccionada de biomoléculas
WO2005110574A3 (en) Solid product dissolver and method of use thereof
GB8726062D0 (en) Fluid dispensing devices
SG161287A1 (en) Dispensing apparatus and method of use thereof
DE60036277D1 (de) Testgerät zur durchführung von nukleinsäure-amplifikationsreaktionen
DE60212522D1 (de) Vorrichtung für die Entnahme von flüssigen Proben
HK1044373B (zh) 檢測儀
DE69503558T2 (de) Vorrichtung und Verfahren zur immunologischen Analyse
ATE20977T1 (de) Vorrichtung zur probevorbereitung fuer mehrfachanalyse.
ATE242056T1 (de) Vorrichtung zur aufnahme und abgabe einer definierten flüssigkeitsmenge
MX2007003245A (es) Tira de prueba biologica.
MXPA03004206A (es) Metodo de ensayo de lipido y reactivo para su uso en el mismo.
ATE79133T1 (de) Vorrichtung zur ausfuehrung mikrobiologischer tests.
DE50304233D1 (de) Vorrichtung zur dosierung von substanzen
ATE419063T1 (de) Testkarte und verfahren ihrer verwendung

Legal Events

Date Code Title Description
8364 No opposition during term of opposition