DE60210816D1 - Verfahren zur herstellung von 1-(carboxymethyl)-und 1(aminocarbonyl)-pyrimidin-4-on derivaten - Google Patents

Verfahren zur herstellung von 1-(carboxymethyl)-und 1(aminocarbonyl)-pyrimidin-4-on derivaten

Info

Publication number
DE60210816D1
DE60210816D1 DE60210816T DE60210816T DE60210816D1 DE 60210816 D1 DE60210816 D1 DE 60210816D1 DE 60210816 T DE60210816 T DE 60210816T DE 60210816 T DE60210816 T DE 60210816T DE 60210816 D1 DE60210816 D1 DE 60210816D1
Authority
DE
Germany
Prior art keywords
aminocarbonyl
pyrimidin
carboxymethyl
derivatives
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60210816T
Other languages
English (en)
Other versions
DE60210816T2 (de
Inventor
Keith Raymond Mulholland
Andrew R Ross
Graham Ralph Slater
Gillian Elizabeth Smith
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SmithKline Beecham Ltd
Original Assignee
SmithKline Beecham Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by SmithKline Beecham Ltd filed Critical SmithKline Beecham Ltd
Application granted granted Critical
Publication of DE60210816D1 publication Critical patent/DE60210816D1/de
Publication of DE60210816T2 publication Critical patent/DE60210816T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/56—One oxygen atom and one sulfur atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
DE60210816T 2001-08-14 2002-08-13 Verfahren zur herstellung von 1-(carboxymethyl)-und 1(aminocarbonyl)-pyrimidin-4-on derivaten Expired - Lifetime DE60210816T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB0119795.3A GB0119795D0 (en) 2001-08-14 2001-08-14 Novel process
GB0119795 2001-08-14
PCT/EP2002/009067 WO2003016287A2 (en) 2001-08-14 2002-08-13 Process for preparing 1-(carboxymethyl)- and 1-(aminocarbonyl)- pyrimidin-4-one derivatives

Publications (2)

Publication Number Publication Date
DE60210816D1 true DE60210816D1 (de) 2006-05-24
DE60210816T2 DE60210816T2 (de) 2006-10-05

Family

ID=9920363

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60210816T Expired - Lifetime DE60210816T2 (de) 2001-08-14 2002-08-13 Verfahren zur herstellung von 1-(carboxymethyl)-und 1(aminocarbonyl)-pyrimidin-4-on derivaten

Country Status (13)

Country Link
US (1) US7232902B2 (de)
EP (1) EP1456183B1 (de)
JP (1) JP4386723B2 (de)
AR (1) AR035111A1 (de)
AT (1) ATE323683T1 (de)
AU (1) AU2002333415A1 (de)
DE (1) DE60210816T2 (de)
ES (1) ES2260503T3 (de)
GB (1) GB0119795D0 (de)
HU (1) HUP0401296A3 (de)
PL (1) PL368870A1 (de)
TW (1) TW591019B (de)
WO (1) WO2003016287A2 (de)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0208280D0 (en) * 2002-04-10 2002-05-22 Glaxo Group Ltd Novel compounds
SI21507A (sl) 2003-05-16 2004-12-31 LEK farmacevtska dru�ba d.d. Postopek za pripravo spojin z ace inhibitornim delovanjem
US20080090851A1 (en) * 2006-10-13 2008-04-17 Colin Andrew Leach Bicyclic Heteroaromatic Compounds
US20080090852A1 (en) * 2006-10-13 2008-04-17 Colin Andrew Leach Bicyclic Heteroaromatic Compounds
US7705005B2 (en) * 2006-10-13 2010-04-27 Glaxo Group Limited Bicyclic heteroaromatic compounds
CN101986785A (zh) 2007-05-11 2011-03-16 托马斯杰弗逊大学 治疗和预防神经退行性疾病和紊乱的方法
US9029383B2 (en) 2007-05-11 2015-05-12 The Trustees Of The University Of Pennsylvania Methods of treatment of skin ulcers
US8962633B2 (en) 2007-05-11 2015-02-24 Thomas Jefferson University Methods of treatment and prevention of metabolic bone diseases and disorders
US8637524B2 (en) 2009-07-28 2014-01-28 Auspex Pharmaceuticals, Inc Pyrimidinone inhibitors of lipoprotein-associated phospholipase A2
UY33388A (es) * 2010-05-17 2011-12-01 Glaxo Group Ltd Nuevos procesos para la preparacion de compuestos de pirimidinona
AR084153A1 (es) 2010-12-06 2013-04-24 Glaxo Group Ltd Derivados de pirimidinona
JP2013545792A (ja) 2010-12-17 2013-12-26 グラクソ グループ リミテッド 眼疾患の処置および防止方法
WO2012129792A1 (zh) * 2011-03-30 2012-10-04 中国科学院上海药物研究所 嘧啶酮类化合物、其制备方法及药物组合物和用途
CN103619831B (zh) 2011-06-27 2016-05-04 中国科学院上海药物研究所 唑类杂环化合物、其制备方法、药物组合物和用途
BR112014001665A2 (pt) 2011-07-27 2017-02-14 Glaxo Group Ltd compostos de 2,3-di-hidroimidazo[1,2-c]pirimidin-5(1h)-ona utilizados como inibidores de lp-plaz
AU2012288865B2 (en) 2011-07-27 2015-10-01 Glaxo Group Limited Bicyclic pyrimidone compounds
CN102924290A (zh) * 2012-09-25 2013-02-13 同济大学 一种darapladib中间体的合成方法
KR20150108896A (ko) 2013-01-25 2015-09-30 글락소스미스클라인 인털렉츄얼 프로퍼티 디벨로프먼트 리미티드 Lp-pla2의 억제제로서의 비시클릭 피리미돈 화합물
US9296755B2 (en) 2013-01-25 2016-03-29 Glaxosmithkline Intellectual Property Development Limited 3,4-dihydro-1H-pyrimido[1,6-a]pyrimidin-6(2H)-one compounds and their therapeutic applications
CA2899091A1 (en) 2013-01-25 2014-07-31 Glaxosmithkline Intellectual Property Development Limited Compounds
WO2015087239A1 (en) 2013-12-11 2015-06-18 Ranbaxy Laboratories Limited Processes for the preparation of darapladib and its intermediates
WO2015092687A2 (en) 2013-12-17 2015-06-25 Ranbaxy Laboratories Limited Process for the purification of darapladib
WO2016012916A1 (en) 2014-07-22 2016-01-28 Glaxosmithkline Intellectual Property Development Limited 1,2,3,5-tetrahydroimidazo[1,2-c]pyrimidine derivatives useful in the treatment of diseases and disorders mediated by lp-pla2
WO2016012917A1 (en) 2014-07-22 2016-01-28 Glaxosmithkline Intellectual Property Development Limited 1,2,3,5-tetrahydroimidazo[1,2-c]pyrimidine derivatives useful in the treatment of diseases and disorders mediated by lp-pla2
EP4056571A4 (de) 2019-11-09 2024-01-24 Shanghai Simr Biotechnology Co Ltd Trizyklisches dihydroimidazopyrimidonderivat, verfahren zu seiner herstellung, pharmazeutische zusammensetzung und verwendung davon
CN115304620A (zh) 2021-05-07 2022-11-08 上海赛默罗生物科技有限公司 嘧啶酮衍生物、其制备方法、药物组合物和用途

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK1263740T3 (da) * 2000-02-16 2006-11-13 Smithkline Beecham Plc Pyrimidin-4-on-derivat som LDL-PLA2-inhibitor

Also Published As

Publication number Publication date
ES2260503T3 (es) 2006-11-01
AR035111A1 (es) 2004-04-14
ATE323683T1 (de) 2006-05-15
EP1456183A2 (de) 2004-09-15
AU2002333415A1 (en) 2003-03-03
PL368870A1 (en) 2005-04-04
TW591019B (en) 2004-06-11
GB0119795D0 (en) 2001-10-03
EP1456183B1 (de) 2006-04-19
WO2003016287A2 (en) 2003-02-27
DE60210816T2 (de) 2006-10-05
WO2003016287A3 (en) 2003-10-16
JP2005502660A (ja) 2005-01-27
JP4386723B2 (ja) 2009-12-16
HUP0401296A2 (hu) 2004-10-28
US20040242875A1 (en) 2004-12-02
HUP0401296A3 (en) 2004-11-29
US7232902B2 (en) 2007-06-19

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