DE602007014375D1 - Grignard-reaktionen in mikroreaktoren - Google Patents

Grignard-reaktionen in mikroreaktoren

Info

Publication number
DE602007014375D1
DE602007014375D1 DE602007014375T DE602007014375T DE602007014375D1 DE 602007014375 D1 DE602007014375 D1 DE 602007014375D1 DE 602007014375 T DE602007014375 T DE 602007014375T DE 602007014375 T DE602007014375 T DE 602007014375T DE 602007014375 D1 DE602007014375 D1 DE 602007014375D1
Authority
DE
Germany
Prior art keywords
microreactors
grignard reactions
grignard
reactions
microreactor
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
DE602007014375T
Other languages
English (en)
Inventor
Dominique Roberge
Nikolaus Bieler
Laurent Ducry
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Lonza AG
Original Assignee
Lonza AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lonza AG filed Critical Lonza AG
Publication of DE602007014375D1 publication Critical patent/DE602007014375D1/de
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F3/00—Compounds containing elements of Groups 2 or 12 of the Periodic Table
    • C07F3/02—Magnesium compounds
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F25/00—Flow mixers; Mixers for falling materials, e.g. solid particles
    • B01F25/40—Static mixers
    • B01F25/42—Static mixers in which the mixing is affected by moving the components jointly in changing directions, e.g. in tubes provided with baffles or obstructions
    • B01F25/421—Static mixers in which the mixing is affected by moving the components jointly in changing directions, e.g. in tubes provided with baffles or obstructions by moving the components in a convoluted or labyrinthine path
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F25/00—Flow mixers; Mixers for falling materials, e.g. solid particles
    • B01F25/40—Static mixers
    • B01F25/42—Static mixers in which the mixing is affected by moving the components jointly in changing directions, e.g. in tubes provided with baffles or obstructions
    • B01F25/421—Static mixers in which the mixing is affected by moving the components jointly in changing directions, e.g. in tubes provided with baffles or obstructions by moving the components in a convoluted or labyrinthine path
    • B01F25/423—Static mixers in which the mixing is affected by moving the components jointly in changing directions, e.g. in tubes provided with baffles or obstructions by moving the components in a convoluted or labyrinthine path by means of elements placed in the receptacle for moving or guiding the components
    • B01F25/4231—Static mixers in which the mixing is affected by moving the components jointly in changing directions, e.g. in tubes provided with baffles or obstructions by moving the components in a convoluted or labyrinthine path by means of elements placed in the receptacle for moving or guiding the components using baffles
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F33/00—Other mixers; Mixing plants; Combinations of mixers
    • B01F33/30—Micromixers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/0093—Microreactors, e.g. miniaturised or microfabricated reactors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B49/00—Grignard reactions
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781—Aspects relating to microreactors
    • B01J2219/00851—Additional features
    • B01J2219/00867—Microreactors placed in series, on the same or on different supports
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781—Aspects relating to microreactors
    • B01J2219/00873—Heat exchange
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781—Aspects relating to microreactors
    • B01J2219/00889—Mixing
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781—Aspects relating to microreactors
    • B01J2219/0095—Control aspects
    • B01J2219/00984—Residence time

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Dispersion Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
DE602007014375T 2006-07-18 2007-07-11 Grignard-reaktionen in mikroreaktoren Active DE602007014375D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP06014883A EP1889849A1 (de) 2006-07-18 2006-07-18 Reaktionen vom Grignardtyp in Mikroreaktoren
PCT/EP2007/006127 WO2008009378A2 (en) 2006-07-18 2007-07-11 Grignard reactions in microreactors

Publications (1)

Publication Number Publication Date
DE602007014375D1 true DE602007014375D1 (de) 2011-06-16

Family

ID=37450872

Family Applications (1)

Application Number Title Priority Date Filing Date
DE602007014375T Active DE602007014375D1 (de) 2006-07-18 2007-07-11 Grignard-reaktionen in mikroreaktoren

Country Status (18)

Country Link
US (1) US7939698B2 (de)
EP (3) EP1889849A1 (de)
JP (1) JP5512266B2 (de)
CN (2) CN101495488B (de)
AT (1) ATE508132T1 (de)
BR (1) BRPI0714394A2 (de)
CA (1) CA2655658A1 (de)
DE (1) DE602007014375D1 (de)
EA (1) EA200900126A1 (de)
ES (2) ES2399780T3 (de)
HK (2) HK1131786A1 (de)
IL (1) IL196112A (de)
MX (1) MX2009000618A (de)
MY (1) MY147861A (de)
PL (2) PL2044087T3 (de)
PT (1) PT2138500E (de)
SI (2) SI2138500T1 (de)
WO (1) WO2008009378A2 (de)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2338543B1 (de) 2002-07-19 2013-06-12 Baxter International Inc. Vorrichtung zur Peritonealdialyse
US7659414B2 (en) * 2007-07-20 2010-02-09 Rohm And Haas Company Method of preparing organometallic compounds
EP2534117A2 (de) * 2010-02-09 2012-12-19 Saltigo GmbH Verfahren zur allylierung und vinylierung von aryl-, heteroaryl-, alkyl- und alkenylhalogeniden unter übergangsmetallkatalyse
CN103896737A (zh) * 2014-03-31 2014-07-02 南京工业大学 一种利用微结构反应器制备炔丙醇的方法
CN110483243A (zh) * 2019-09-17 2019-11-22 西安近代化学研究所 一种1-（2-氯苯基）-2-（1-氯环丙基）-3-氯-2-丙醇的制备方法
CN114940687A (zh) * 2022-05-30 2022-08-26 杭州瀛拓科技有限公司 一种多取代乙烯基硅（氧）烷的连续流合成方法

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH08245641A (ja) * 1995-03-13 1996-09-24 Nitto Kasei Co Ltd グリニャール試薬
GB9723260D0 (en) * 1997-11-05 1998-01-07 British Nuclear Fuels Plc A method of performing a chemical reaction
DE10001317A1 (de) * 2000-01-14 2001-07-19 Merck Patent Gmbh Reaktion von Carbonylverbindungen mit metallorganischen Reagenzien
JP2004530044A (ja) * 2001-04-12 2004-09-30 アストラゼネカ アクチボラグ 微細工学的反応装置
DE10140857A1 (de) * 2001-08-21 2003-03-06 Clariant Gmbh Verfahren zur Herstellung von Aryl- und Alkyl-Bor-Verbindungen in Mikroreaktoren
GB0203653D0 (en) * 2002-02-15 2002-04-03 Syrris Ltd A microreactor
GB0206117D0 (en) * 2002-03-15 2002-04-24 Imaging Res Solutions Ltd Use of microfabricated devices
WO2006071470A2 (en) * 2004-12-03 2006-07-06 California Institute Of Technology Microfluidic devices with chemical reaction circuits
EP1676632A1 (de) * 2004-12-28 2006-07-05 Covion Organic Semiconductors GmbH Verfahren zur Herstellung von Polymeren

Also Published As

Publication number Publication date
CN102584514B (zh) 2015-05-06
HK1131786A1 (en) 2010-02-05
ES2399780T3 (es) 2013-04-03
SI2138500T1 (sl) 2013-02-28
CN101495488B (zh) 2012-08-22
MY147861A (en) 2013-01-31
CN102584514A (zh) 2012-07-18
WO2008009378A2 (en) 2008-01-24
EP1889849A1 (de) 2008-02-20
EP2138500B1 (de) 2012-11-21
EA200900126A1 (ru) 2009-10-30
EP2138500A1 (de) 2009-12-30
CA2655658A1 (en) 2008-01-24
ATE508132T1 (de) 2011-05-15
US7939698B2 (en) 2011-05-10
PL2138500T3 (pl) 2013-04-30
JP2010508239A (ja) 2010-03-18
PL2044087T3 (pl) 2011-10-31
EP2044087B1 (de) 2011-05-04
SI2044087T1 (sl) 2011-08-31
ES2365874T3 (es) 2011-10-11
CN101495488A (zh) 2009-07-29
WO2008009378A3 (en) 2008-03-20
IL196112A0 (en) 2009-09-01
EP2044087A2 (de) 2009-04-08
JP5512266B2 (ja) 2014-06-04
US20090270663A1 (en) 2009-10-29
PT2138500E (pt) 2013-01-07
IL196112A (en) 2013-06-27
HK1173718A1 (en) 2013-05-24
BRPI0714394A2 (pt) 2013-03-12
MX2009000618A (es) 2009-01-29

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