DE602007011745D1 - Mikrofluidische Vorrichtung, Mischverfahren und Verwendung der Vorrichtung - Google Patents

Mikrofluidische Vorrichtung, Mischverfahren und Verwendung der Vorrichtung

Info

Publication number
DE602007011745D1
DE602007011745D1 DE602007011745T DE602007011745T DE602007011745D1 DE 602007011745 D1 DE602007011745 D1 DE 602007011745D1 DE 602007011745 T DE602007011745 T DE 602007011745T DE 602007011745 T DE602007011745 T DE 602007011745T DE 602007011745 D1 DE602007011745 D1 DE 602007011745D1
Authority
DE
Germany
Prior art keywords
chamber
liquid
hydrophilic
chambers
correspondence
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
DE602007011745T
Other languages
German (de)
English (en)
Inventor
Mario Curcio
Micheal Glauser
Carlo Effenhauser
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Roche Diagnostics GmbH
Original Assignee
Roche Diagnostics GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Roche Diagnostics GmbH filed Critical Roche Diagnostics GmbH
Publication of DE602007011745D1 publication Critical patent/DE602007011745D1/de
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/0093—Microreactors, e.g. miniaturised or microfabricated reactors
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F33/00—Other mixers; Mixing plants; Combinations of mixers
    • B01F33/30—Micromixers
    • B01F33/3035—Micromixers using surface tension to mix, move or hold the fluids
    • B01F33/30351—Micromixers using surface tension to mix, move or hold the fluids using hydrophilic/hydrophobic surfaces
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F33/00—Other mixers; Mixing plants; Combinations of mixers
    • B01F33/30—Micromixers
    • B01F33/301—Micromixers using specific means for arranging the streams to be mixed, e.g. channel geometries or dispositions
    • B01F33/3017—Mixing chamber
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F33/00—Other mixers; Mixing plants; Combinations of mixers
    • B01F33/30—Micromixers
    • B01F33/302—Micromixers the materials to be mixed flowing in the form of droplets
    • B01F33/3021—Micromixers the materials to be mixed flowing in the form of droplets the components to be mixed being combined in a single independent droplet, e.g. these droplets being divided by a non-miscible fluid or consisting of independent droplets
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781—Aspects relating to microreactors
    • B01J2219/00783—Laminate assemblies, i.e. the reactor comprising a stack of plates
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781—Aspects relating to microreactors
    • B01J2219/00819—Materials of construction
    • B01J2219/00833—Plastic
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781—Aspects relating to microreactors
    • B01J2219/00819—Materials of construction
    • B01J2219/00837—Materials of construction comprising coatings other than catalytically active coatings
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781—Aspects relating to microreactors
    • B01J2219/00851—Additional features
    • B01J2219/00858—Aspects relating to the size of the reactor
    • B01J2219/0086—Dimensions of the flow channels
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781—Aspects relating to microreactors
    • B01J2219/00889—Mixing
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/0867—Multiple inlets and one sample wells, e.g. mixing, dilution
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/16—Surface properties and coatings
    • B01L2300/161—Control and use of surface tension forces, e.g. hydrophobic, hydrophilic
    • B01L2300/165—Specific details about hydrophobic, oleophobic surfaces
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/06—Valves, specific forms thereof
    • B01L2400/0694—Valves, specific forms thereof vents used to stop and induce flow, backpressure valves
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/08—Regulating or influencing the flow resistance
    • B01L2400/084—Passive control of flow resistance
    • B01L2400/088—Passive control of flow resistance by specific surface properties

Landscapes

  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Dispersion Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Clinical Laboratory Science (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
  • Micromachines (AREA)
DE602007011745T 2007-07-10 2007-07-10 Mikrofluidische Vorrichtung, Mischverfahren und Verwendung der Vorrichtung Active DE602007011745D1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP07013434A EP2016997B1 (en) 2007-07-10 2007-07-10 Microfluidic device, method of mixing and use of the device

Publications (1)

Publication Number Publication Date
DE602007011745D1 true DE602007011745D1 (de) 2011-02-17

Family

ID=38752765

Family Applications (1)

Application Number Title Priority Date Filing Date
DE602007011745T Active DE602007011745D1 (de) 2007-07-10 2007-07-10 Mikrofluidische Vorrichtung, Mischverfahren und Verwendung der Vorrichtung

Country Status (5)

Country Link
US (1) US8911683B2 (enExample)
EP (1) EP2016997B1 (enExample)
JP (1) JP5027070B2 (enExample)
AT (1) ATE494061T1 (enExample)
DE (1) DE602007011745D1 (enExample)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20070047388A1 (en) * 2005-08-25 2007-03-01 Rockwell Scientific Licensing, Llc Fluidic mixing structure, method for fabricating same, and mixing method
US8053191B2 (en) 2006-08-31 2011-11-08 Westend Asset Clearinghouse Company, Llc Iterative nucleic acid assembly using activation of vector-encoded traits
EP2213364A1 (en) * 2009-01-30 2010-08-04 Albert-Ludwigs-Universität Freiburg Phase guide patterns for liquid manipulation
WO2011056872A2 (en) 2009-11-03 2011-05-12 Gen9, Inc. Methods and microfluidic devices for the manipulation of droplets in high fidelity polynucleotide assembly
WO2011066185A1 (en) 2009-11-25 2011-06-03 Gen9, Inc. Microfluidic devices and methods for gene synthesis
US9217144B2 (en) 2010-01-07 2015-12-22 Gen9, Inc. Assembly of high fidelity polynucleotides
US8204172B1 (en) 2010-03-17 2012-06-19 General Electric Company System and method of prior image constrained image reconstruction using short scan image data and objective function minimization
US20140147346A1 (en) * 2010-08-20 2014-05-29 Girish Chitnis Laser treatment of a medium for microfluids and various other applications
EP2637780B1 (en) 2010-11-12 2022-02-09 Gen9, Inc. Protein arrays and methods of using and making the same
WO2012078312A2 (en) 2010-11-12 2012-06-14 Gen9, Inc. Methods and devices for nucleic acids synthesis
ES2640954T3 (es) * 2011-06-09 2017-11-07 Pp Energy Aps Dispositivo de elevación para conectar dos segmentos de pala de rotor de una turbina eólica
IL302248A (en) 2011-08-26 2023-06-01 Gen9 Inc Compositions and methods for high fidelity assembly of nucleic acids
US9150853B2 (en) 2012-03-21 2015-10-06 Gen9, Inc. Methods for screening proteins using DNA encoded chemical libraries as templates for enzyme catalysis
AU2013251701A1 (en) 2012-04-24 2014-10-30 Gen9, Inc. Methods for sorting nucleic acids and multiplexed preparative in vitro cloning
EP2864531B2 (en) 2012-06-25 2022-08-03 Gen9, Inc. Methods for nucleic acid assembly and high throughput sequencing
WO2014045482A1 (ja) * 2012-09-19 2014-03-27 日本電気株式会社 分析チップ、及び分析装置
FR2996544B1 (fr) 2012-10-08 2015-03-13 Ecole Polytech Circuit microfluidique permettant la mise en contact de gouttes de plusieurs fluides, et procede microfluidique correspondant.
JP5922791B2 (ja) * 2012-10-29 2016-05-24 京セラ株式会社 弾性表面波センサ
JP5839526B1 (ja) * 2015-02-06 2016-01-06 秋田県 微小液滴を形成する反応デバイス及びこれを用いた電界撹拌方法
US9604209B2 (en) 2015-03-19 2017-03-28 International Business Machines Corporation Microfluidic device with anti-wetting, venting areas
WO2019117102A1 (ja) 2017-12-11 2019-06-20 デンカ株式会社 液体試料検査キット用膜担体、液体試料検査キット、液体試料検査キットの製造方法、液体試料の検査方法及び膜担体
GB201801019D0 (en) * 2018-01-22 2018-03-07 Q Linea Ab Sample holder
WO2020208629A1 (en) * 2019-04-08 2020-10-15 Technion Research & Development Foundation Limited Multiplexed array of nanoliter droplet array devices
EP3998483A4 (en) * 2019-07-08 2023-01-25 Sekisui Chemical Co., Ltd. LIQUID DELIVERY PROCEDURE AND TEST CHIP
JP7561041B2 (ja) * 2020-04-28 2024-10-03 デクセリアルズ株式会社 検査チップ、及びその製造方法
CN113804658B (zh) * 2020-06-11 2023-06-06 京东方科技集团股份有限公司 微流控流道结构、检测系统及其使用方法
WO2022063847A1 (en) 2020-09-23 2022-03-31 Roche Diagnostics Gmbh Method for detecting an analyte with the help of metal nanoparticles on an electrode
EP4638006A1 (en) 2022-12-19 2025-10-29 Anchorline Biolabs, Inc. Capillary partitioning microfluidics
CN116687084B (zh) * 2023-04-13 2025-08-05 青岛大学 一种湿度可控的口罩及口罩湿度的控制方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5904824A (en) * 1997-03-07 1999-05-18 Beckman Instruments, Inc. Microfluidic electrophoresis device
DE69840997D1 (enExample) * 1997-03-12 2009-09-03 Kyoto Daiichi Kagaku Kk
DE10002500A1 (de) 2000-01-21 2001-07-26 Univ Albert Ludwigs Freiburg Kapillarkraftmischer
CA2430651C (en) * 2001-02-09 2010-10-12 Wisconsin Alumni Research Foundation Method and structure for microfluidic flow guiding
WO2005005961A1 (ja) * 2003-07-09 2005-01-20 Olympus Corporation 液体搬送処理デバイス及び液体搬送処理方法
US20070047388A1 (en) * 2005-08-25 2007-03-01 Rockwell Scientific Licensing, Llc Fluidic mixing structure, method for fabricating same, and mixing method
DE502006007372D1 (de) * 2006-05-22 2010-08-19 Micronas Gmbh Vorrichtung zum Mischen von Mikrotröpfchen

Also Published As

Publication number Publication date
EP2016997A1 (en) 2009-01-21
EP2016997B1 (en) 2011-01-05
US20090016932A1 (en) 2009-01-15
JP2009025301A (ja) 2009-02-05
ATE494061T1 (de) 2011-01-15
JP5027070B2 (ja) 2012-09-19
US8911683B2 (en) 2014-12-16

Similar Documents

Publication Publication Date Title
ATE494061T1 (de) Mikrofluidische vorrichtung, mischverfahren und verwendung der vorrichtung
DE60322891D1 (de) Mikrofluidstrukturen
DK1792655T3 (da) Mikrofluidisk indretning indeholdende en boblefælde
DE502005011085D1 (de) Mikrofluid-Vorrichtung und Verfahren zur Erzeugung diffusiv aufgebauter Gradienten
Ng et al. Electroosmotic flow of a power-law fluid in a non-uniform microchannel
ATE503929T1 (de) Elektrobenetzungs-pumpvorrichtung und ihre verwendung zum messen elektrischer aktivität
ATE556778T1 (de) Mikrofluidvorrichtung mit elektronischen dünnfilmbauelementen
DK1776464T3 (da) analyt.-testsytem til bestemmelse af koncentrationen af en analyt i en fysiologisk eller vandig væske
DE60036420D1 (de) Mikrofluidischer Artikel
DE602007013365D1 (de) Mikrofluidische Vorrichtung und Verfahren für Reaktionen nicht mischbarer Flüssigkeiten
MY155889A (en) Microfluidic method for measuring thermo-physical properties of a reservoir fluid
ATE485101T1 (de) Mikrofluidische folienstruktur zum dosierren von flüssigkeiten
JP2009025301A5 (enExample)
WO2006037033A3 (en) A microfluidic device for enabling the controlled growth of cells
ATE435436T1 (de) Vorrichtung zur bildung von variablen meniskusformen
GB0912296D0 (en) Assay
WO2014066862A3 (en) Devices and methods for layer-by-layer assembly
ATE432125T1 (de) Auf 2d-substraten basierende 3d-strukturen
RU2019117002A (ru) Способ структурирования смачивания и модели для безнасосного переноса и точного управления объемами жидкостей на пористых материалах и через них
WO2008005244A3 (en) High density permeable supports for high throughput screening
ATE440530T1 (de) Vorrichtung zum erhitzen von flüssigkeiten mit dampf
WO2009046125A3 (en) Floating electrode optoelectronic tweezers (feoet) for manipulatiing oil-immersed droplets
EP2496516A2 (en) Micro-channel structure method and apparatus
Vasilakis et al. Long-lasting FR-4 surface hydrophilisation towards commercial PCB passive microfluidics
Almeida et al. Virtual walls based on oil-repellent surfaces for low-surface-tension liquids